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Bioinspired Tactile Sensation Based on Synergistic Microcrack-Bristle Structure Design toward High Mechanical Sensitivity and Direction-Resolving Capability

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Research 2024年第1期2023卷 611-624页

作者： Yiqun Zhang Qi Liu Wenjuan Ren Yangyang Song Hua Luo Yangyang Han Liang He Xiaodong Wu zhuqing wang School of Mechanical Engineering Sichuan UniversityChengdu 610065China Med+X Center for Manufacturing West China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China

Natural tactile sensation is complex,which involves not only contact force intensity detection but also the perception of the force direction,the surface texture,and other mechanical ***,the vast majority of the developed tactile sensors can only detect the normal force,but usually cannot resolve shear force or even distinguish the directions of the ***,we present a new paradigm of bioinspired tactile sensors for resolving both the intensity and the directions of mechanical stimulations via synergistic microcrack-bristle structure design and cross-shaped configuration *** microcrack sensing structure gives high mechanical sensitivity to the tactile sensors,and the synergistic bristle structure further amplifies the sensitivity of the *** cross-shaped configuration engineering of the synergistic microcrack-bristle structure further endows the tactile sensors with good capability to detect and distinguish the directions of the applied mechanical *** as-fabricated tactile sensors exhibit a high sensitivity(25.76 N^(−1)),low detection limit(5.4 mN),desirable stability(over 2,500 cycles),and good capability to resolve both mechanical intensity and directional *** promising application scenarios,surface texture recognition and biomimetic path explorations are successfully demonstrated with these tactile *** newly proposed tactile sensation strategy and technology have great potential applications in ingenious tactile sensation and construction of various robotic and bionic prostheses with high operational dexterity.

关键词： crack sensation directions

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Multiple evaluations of atmospheric behavior between Criegee intermediates and HCHO: Gas-phase and air-water interface reaction

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Journal of Environmental Sciences 2023年第5期127卷 308-319页

作者： Tianlei Zhang Mingjie Wen Chao Ding Yongqi Zhang Xiaohui Ma zhuqing wang Makroni Lily Junhai Liu Rui wang Institute of Theoretical and Computational Chemistry Shaanxi Key Laboratory of CatalysisSchool of Chemical&Environment ScienceShaanxi University of TechnologyHanzhong 723001China School of Environmental Science and Engineering Institute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Shandong Key Laboratory of Biophysics Institute of BiophysicsDezhou UniversityDezhou 253023China Environmental Research Institute Shandong UniversityQingdao 266237China Qinba Mountains of Bio-Resource Collaborative Innovation Center of Southern Shaanxi Province Shaanxi University of TechnologyHanzhong 723001China

Given the high abundance of water in the atmosphere,the reaction of Criegee intermediates(CIs)with(H_(2)O)_(2) is considered to be the predominant removal pathway for ***,recent experimental findings reported that the reactions of CIs with organic acids and carbonyls are faster than *** the same time,the interface behavior between CIs and carbonyls has not been reported so ***,the gas-phase and air-water interface behavior between Criegee intermediates and HCHO were explored by adopting high-level quantum chemical calculations and Born-Oppenheimer molecular dynamics(BOMD)*** chemical calculations evidence that the gas-phase reactions of CIs+HCHO are submerged energy or low energy barriers *** rate ratios speculate that the HCHO could be not only a significant tropospheric scavenger of CIs,but also an inhibitor in the oxidizing ability of CIs on SO_(x) in dry and highly polluted areas with abundant HCHO *** reactions of CH_(2)OO with HCHO at the droplet’s surface follow a loop structure mechanism to produce i)SOZ(■),ii)BHMP(HOCH_(2)OOCH_(2)OH),and iii)HMHP(HOCH_(2)OOH).Considering the harsh reaction conditions between CIs and HCHO at the interface(i.e.,the two molecules must be sufficiently close to each other),the hydration of CIs is still their main atmospheric loss *** results could help us get a better interpretation of the underlying CIs-aldehydes chemical processes in the global polluted urban atmospheres.

关键词： Criegee intermediates HCHO Atmospheric behavior Air-water interface Chemical processes

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强直性脊柱炎患者外周血Dickkopf-1相关蛋白、基质金属蛋白酶3水平的临床意义

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中国临床实用医学 2024年第2期15卷 35-39页

作者：陈娜马娟娟陈欢焦鹏超王祝青北京中医药大学孙思邈医院体检科铜川727099 北京中医药大学孙思邈医院检验科铜川727099

目的分析强直性脊柱炎(AS)患者外周血Dickkopf-1相关蛋白(DKK-1)、基质金属蛋白酶3(MMP-3)水平的临床意义。方法本研究为回顾性队列研究,选取2021年5月至2023年5月北京中医药大学孙思邈医院经检验科检验的98例AS患者,男65例,女33例,年龄... 详细信息

目的分析强直性脊柱炎(AS)患者外周血Dickkopf-1相关蛋白(DKK-1)、基质金属蛋白酶3(MMP-3)水平的临床意义。方法本研究为回顾性队列研究,选取2021年5月至2023年5月北京中医药大学孙思邈医院经检验科检验的98例AS患者,男65例,女33例,年龄(41.56±11.82)岁,年龄范围为18~65岁。检测患者外周血DKK-1和MMP-3水平,采用Spearman相关系数分析患者外周血DKK-1、MMP-3水平与关节病变严重程度分级的相关性,采用Pearson相关性分析患者外周血DKK-1、MMP-3水平与AS病情活动情况的相关性。结果根据X线检查关节病变严重程度分级,将患者分为Ⅰ级组(n=23)、Ⅱ级组(n=28)、Ⅲ级组(n=26)、Ⅳ级组(n=21)。DKK-1水平比较,Ⅰ级组[(984.21±63.98)pg/ml]>Ⅱ级组[(861.56±36.77)pg/ml]>Ⅲ级组[(756.75±30.87)pg/ml]>Ⅳ级组[(610.67±58.22)pg/ml],差异有统计学意义(P<0.05);MMP-3水平比较中,Ⅰ级组[(40.42±7.89)pg/ml]<Ⅱ级组[(53.43±3.98)pg/ml]<Ⅲ级组[(65.98±4.20)pg/ml]<Ⅳ级组[(81.47±5.41)pg/ml],差异有统计学意义(P<0.05)。经Spearman相关性分析,患者外周血DKK-1水平与X线检查关节病变严重程度分级呈负相关(r=-0.689,P=0.002),MMP-3水平与X线检查关节病变严重程度分级呈正相关(r=0.711,P=0.001)。根据巴斯强直性脊柱炎疾病活动指数(BASDAI)评分将患者AS病情活动情况分为静止期组(n=59,BASDAI评分<4分)与活动期组(n=39,BASDAI评分≥4分),活动期组患者外周血DKK-1水平[(729.64±124.27)pg/ml]低于静止期组[(861.09±124.96)pg/ml],MMP-3水平[(70.38±11.59)μg/L]高于静止期组[(52.67±13.76)μg/L],差异有统计学意义(P<0.05)。经Pearson相关性分析,患者外周血DKK-1水平与AS病情活动情况呈负相关(r=-0.706,P=0.001),MMP-3水平与AS病情活动情况呈正相关(r=0.735,P<0.001)。结论AS患者外周血DKK-1、MMP-3水平与其病情严重程度、疾病活动情况密切相关,为临床及时诊治提供客观依据。

关键词：基质金属蛋白酶3 疾病严重程度强直性脊柱炎 Dickkopf-1相关蛋白疾病活动情况

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转化生长因子β信号通路与非综合征型唇腭裂发病风险的基因-基因及基因-环境交互作用

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北京大学学报（医学版） 2024年第3期56卷 384-389页

作者：侯天姣周治波王竹青王梦莹王斯悦彭和香郭煌达李奕昕章涵宇秦雪英武轶群郑鸿尘李静吴涛朱洪平北京大学公共卫生学院流行病与卫生统计学系北京100191 重大疾病流行病学教育部重点实验室(北京大学) 北京100191 北京大学口腔医院·口腔医院口腔颌面外科国家口腔医学中心国家口腔疾病临床医学研究中心口腔生物材料和数字诊疗装备国家工程研究中心口腔数字医学北京市重点实验室国家卫生健康委员会口腔医学计算机应用工程技术研究中心国家药品监督管理局口腔材料重点实验室北京100081 北京大学公共卫生学院营养与食品卫生学系北京100191 北京大学口腔医院·口腔医院儿童口腔科国家口腔医学中心国家口腔疾病临床医学研究中心口腔生物材料和数字诊疗装备国家工程研究中心口腔数字医学北京市重点实验室国家卫生健康委员会口腔医学计算机应用工程技术研究中心国家药品监督管理局口腔材料重点实验室北京100081

目的:探索亚裔人群中转化生长因子β(transforming growth factor-β,TGF-β)信号通路基因多态性与非综合征型唇裂合并或不合并腭裂(non-syndromic cleft lip with or without cleft palate,NSCL/P)的关联及可能存在的基因-基因、基因-... 详细信息

目的:探索亚裔人群中转化生长因子β(transforming growth factor-β,TGF-β)信号通路基因多态性与非综合征型唇裂合并或不合并腭裂(non-syndromic cleft lip with or without cleft palate,NSCL/P)的关联及可能存在的基因-基因、基因-环境交互作用。方法:选取1038个NSCL/P核心家系作为研究对象。对TGF-β信号通路上的10个基因的343个单核苷酸多态性(single nucleotide polymorphism,SNP)位点进行了传递不平衡检验(transmission disequilibrium test,TDT),采用条件Logistic回归模型进行基因-基因交互作用分析和基因-环境交互作用分析。研究收集的环境因素包括患儿母亲孕期吸烟、被动吸烟、乙醇摄入量以及维生素使用情况。由于患儿母亲孕期吸烟和饮酒暴露率较低(<3%),因此,仅对母亲孕期被动吸烟及补充多种维生素这两个环境因素与基因之间的交互作用进行了分析。采用Bonferroni法对结果进行多重检验校正,显著性的阈值设置为P=1.46×10-4。结果:共有4个基因的23个SNP位点与NSCL/P之间存在关联(P<0.05),但经过Bonferroni多重检验校正后,这些关联均未达到统计学显著性水平。经过Bonferroni多重检验校正之后,6对SNP[rs4939874(SMAD2)与rs1864615(TGFBR2),rs2796813(TGFB2)与rs2132298(TGFBR2),rs4147358(SMAD3)与rs1346907(TGFBR2),rs4939874(SMAD2)与rs1019855(TGFBR2),rs4939874(SMAD2)与rs12490466(TGFBR2),以及rs2009112(TGFB2)与rs4075748(TGFBR2)]存在显著的统计学交互作用(P<1.46×10-4),基因-环境交互作用的分析没有达到多重检验校正阈值的显著结果。结论:未发现TGF-β通路基因多态性与NSCL/P的关联,该通路上部分基因可能通过基因-基因交互作用影响NSCL/P的发病风险。未来仍需其他独立研究的证据支持,以进一步的探索其中潜在的生物学机制。

关键词：非综合征型唇腭裂转化生长因子β信号通路全基因组关联研究核心家系

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Free-walking:Pedestrian inertial navigation based on dual foot-mounted IMU

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Defence Technology（防务技术） 2024年第3期33卷 573-587页

作者： Qu wang Meixia Fu Jianquan wang Lei Sun Rong Huang Xianda Li zhuqing Jiang Yan Huang Changhui Jiang School of Automation Science and Electrical Engineering University of Science and Technology BeijingBeijing100083China Shunde Innovation School University of Science and Technology BeijingFo Shan528399China Research Institute of China Unicom Beijing100190China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing100876China Department of Automation Tsinghua University Beijing100084China GEOLOC Laboratory Universite Gustave EiffelParis77454France

The inertial navigation system(INS),which is frequently used in emergency rescue operations and other situations,has the benefits of not relying on infrastructure,high positioning frequency,and strong real-time ***,the intricate and unpredictable pedestrian motion patterns lead the INS localization error to significantly diverge with *** paper aims to enhance the accuracy of zero-velocity interval(ZVI)detection and reduce the heading and altitude drift of foot-mounted INS via deep learning and equation constraint of dual *** at the observational noise problem of low-cost inertial sensors,we utilize a denoising autoencoder to automatically eliminate the inherent *** at the problem that inaccurate detection of the ZVI detection results in obvious displacement error,we propose a sample-level ZVI detection algorithm based on the U-Net neural network,which effectively solves the problem of mislabeling caused by sliding *** at the problem that Zero-Velocity Update(ZUPT)cannot suppress heading and altitude error,we propose a bipedal INS method based on the equation constraint and ellipsoid constraint,which uses foot-to-foot distance as a new observation to correct heading and altitude *** conduct extensive and well-designed experiments to evaluate the performance of the proposed *** experimental results indicate that the position error of our proposed method did not exceed 0.83% of the total traveled distance.

关键词： Indoor positioning Inertial navigation system(INS) Zero-velocity update(ZUPT) Internet of things(IoTs) Location-based service(LBS)

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Reorganization of 3D genome architecture provides insights into pathogenesis of early fatty liver disease in laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1086-1100页

作者： Yanli Liu zhuqing Zheng Chaohui wang Yumeng wang Xi Sun Zhouzheng Ren Xin Yang Xiaojun Yang College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Agricultural Biotechnology Jingchu University of TechnologyJingmen 448000China

Background Fatty liver disease causes huge economic losses in the poultry industry due to its high occurrence and lethality ***-dimensional(3D)chromatin architecture takes part in disease processing by regulating tran-scriptional *** study is carried out to investigate the alterations of hepatic 3D genome and H3K27ac profiling in early fatty liver(FLS)and reveal their effect on hepatic transcriptional reprogramming in laying *** Results show that FLS model is constructed with obvious phenotypes including hepatic visible lipid deposi-tion as well as higher total triglyceride and cholesterol in serum.A/B compartment switching,topologically associat-ing domain(TAD)and chromatin loop changes are identified by high-throughput/resolution chromosome conforma-tion capture(HiC)*** genes of these alternations in hepatic 3D genome organization significantly enrich pathways related to lipid metabolism and hepatic damage.H3K27ac differential peaks and differential expres-sion genes(DEGs)identified through RNA-seq analysis are also enriched in these ***,certain DEGs are found to correspond with changes in 3D chromatin structure and H3K27ac binding in their *** motif analysis reveals that candidate transcription factors are implicated in regulating transcriptional ***,disturbed folate metabolism is observed,as evidenced by lower folate levels and altered enzyme *** Our findings establish a link between transcriptional reprogramming changes and 3D chromatin struc-ture variations during early FLS formation,which provides candidate transcription factors and folate as targets for FLS prevention or treatment.

关键词： 3D chromatin architecture Fatty liver disease Folate H3K27ac profiling Transcription reprogramming

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Photochemical production of ozone in marine boundary layer in the sea of Japan:Results of the Rishiri Fall Experiment campaign

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Science China Chemistry 2009年第12期52卷 2366-2372页

作者： QI Bin wang zhuqing TAKAMI Akinori HATAKEYAMA Shiro School of Chemistry and Materials Sciences Shaanxi Normal UniversityXi’an 710062China National Institute for Environmental Studies 16-2 OnogawaTsukubaIbaraki 305-8506Japan

The Rishiri Fall Experiment (RISFEX ) campaign was performed in September 2003 at Rishiri island (45.07 N,141.12 E,and 35 m asl) in the sea of Japan to investigate photochemical production of ozone in the marine boundary layer. Total peroxy radicals ROx (HO2 + RO2) and NOx (NO + NO2) were measured together with other chemical species and physical parameters relevant to ozone production. The ozone production rate (P(O3)) was estimated from measured peroxy radicals and was found to be highly variable between days,with 30-min averaged midday values varying from 0.2 to 1.7 ppbv/h (ppbv refers to part per billion by volume). The daytime mean P(O3) for the air masses from relatively clean NE sector is close to zero,but significantly higher for air masses from more polluted W and SE sector,suggesting the impact of transport of pollutants on the remote local ozone production. The experimentally determined P(O3) is compared with those derived from a time-dependent box model based on Regional Atmospheric Chemistry Modeling (RACM),and both the methods give the results generally in agreement. The model calculation shows that HO2 + NO reaction contributes most to ozone production,ca. 60% at midday,followed by the reactions of CH3O2 and ISOP (peroxy radicals formed from isoprene) with NO which account for ca. 13% and 10% to ozone production,respectively,at noon. Sensitivity analysis indicates that the ozone production during the measurement period is within NOx-limited regime.

关键词： atmosphere ocean boundary layer O3 production rate photochemistry

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Production of radicals in the ozonolysis of propene in air

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Science China Chemistry 2009年第3期52卷 356-361页

作者： QI Bin YANG Bing wang zhuqing YANG HongYan LIU Lu School of Chemistry and Material Sciences Shaanxi Normal UniversityXi’an 710062China

Radical production in the ozonolysis of propene in air was monitored directly by a peroxy radical chemical amplification (PERCA) instrument at room temperature (298±2 K) and atmospheric pressure (1×105 Pa). The ozonolysis reactions were conducted in a flow tube under pseudo-first-order conditions for ozone. The decay in ozone was calculated based on reaction time tr and effective rate constant keff (keff = k1[C3H6]0)) for the ozone-propene reaction. The total radical yields relative to consumed ozone were determined to be 0.97±0.17 (σ). A box model was used to simulate radical production in the ozone-propene reaction. The model-derived radical yields agree well with those from experiment within the uncertainty of the two methods. In addition, the yields for OH, HO2 and CH3O2 were obtained from the measured total radical yields and radical partitioning derived from the box model. The yield is 0.39±0.08 (σ) for OH, 0.19±0.04 (σ) for HO2, and 0.39±0.08 (σ) for CH3O2. This work suggests that the previously measured radical yield by indirect method for the ozonolysis of propene may be underes-timated.

关键词： yield radical ozonolysis propene PERCA

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Water effect on peroxy radical measurement by chemical amplification: Experimental determination and chemical mechanism

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Science China Chemistry 2008年第3期51卷 282-288页

作者： QI Bin LIU Lu CHAO YuTao wang zhuqing YANG HongYan School of Chemistry and Material Sciences Shaanxi Normal UniversityXi’an 710062China

The water effect on peroxy radical measurement by chemical amplification was determined experimentally for HO2 and HO2+OH, respectively at room temperature (298±2) K and atmospheric pressure (1×105 Pa). No significant difference in water effect was observed with the type of radicals. A theoretical study of the reaction of HO2·H2O adduct with NO was performed using density functional theory at CCSD(T)/6-311 G(2d, 2p)//B3LYP/6-311 G(2d, 2p) level of theory. It was found that the primary reaction channel for the reaction is HO2·H2O+NO→HNO3+H2O (R4a). On the basis of the theoretical study, the rate constant for (R4a) was calculated using Polyrate Version 8.02 program. The fitted Arrenhnius equation for (R4a) is k = 5.49×107 T 1.03exp(?14798/T) between 200 and 2000 K. A chemical model incorporated with (R4a) was used to simulate the water effect. The water effect curve obtained by the model is in accordance with that of the experiment, suggesting that the water effect is probably caused mainly by (R4a).

关键词： peroxy radical chemical amplification water effect model density functional theory

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Chemistry of daytime HOx radicals in marine boundary layer in the sea of Japan:Based on the ratio between the reactivity of HC and NOx

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Science China Chemistry 2012年第3期55卷 426-434页

作者： wang zhuqing ZHENG Yi YANG Bing CHEN YaShao QI Bin Shandong Provincial Key Laboratory of Ocean Environment Monitoring Technology Shandong Academy of Sciences Institute of Oceanographic InstrumentationQingdao 266001China Key Laboratory of Applied Surface and Colloid Chemistry(Shaanxi Normal University) Ministry of Education School of Chemistry and Materials Science Xi'an 710062China

The ratio between the reactivity of HC and NOx,i.e.,Φ=ΣkOH+HCi[HCi]/(kOH+NO[NO]+kOH+NO2[NO2]),is used to study the chemistry of HOx radicals (HO2 and OH) in the marine boundary layer (MBL).Data analysis shows that HOx production and OH/HO2 ratio strongly depend on Φ.The OH radical concentration presents an ascending tendency in low Φ region but a declining one in high Φ region,while HO2 radical increases with increasing Φ under low Φ conditions but appears to be nearly constant with the variation of Φ under high Φ *** observed OH/HO2 ratio shows a continuous decrease with the increase of Φ.Model studies are conducted to illuminate the behavior of HOx radicals in different Φ regions,and the results represent general agreement with the observed variations of HOx radicals and can well explain the observed behavior of HOx *** study demonstrates that Φ could be used as an efficient parameter to ascertain the behavior of HOx radicals in the clean marine boundary layer.

关键词：自由基化学海洋边界层 HOX NOx 反应 HC 日本海比例

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