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National Science Review 2020年第4期7卷 763-774页

作者： Wenkang Zhang Guanbin Gao Zhongjie Ma zhuoying luo Meng He Taolei Sun State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology School of Chemistry Chemical Engineering and Life Science Wuhan University of Technology

The misfolding of amyloid-β（Aβ） peptides from the natural unfolded state to β-sheet structure is a critical step, leading to abnormal fibrillation and formation of endogenous Aβ plaques in Alzheimer's disease（AD）. Previous studies have reported inhibition of Aβ fibrillation or disassembly of exogenous Aβ fibrils in vitro. However, soluble Aβ oligomers have been reported with increased cytotoxicity; this might partly explain why current clinical trials targeting disassembly of Aβ fibrils by anti-Aβ antibodies have failed so *** we show that Au23（CR）14(a new Au nanocluster modified by Cys-Arg（CR） dipeptide) is able to completely dissolve exogenous mature Aβ fibrils into monomers and restore the natural unfolded state of Aβ peptides from misfolded β-sheets. Furthermore, the cytotoxicity of Aβ40fibrils when dissolved by Au23（CR）14is fully abolished. More importantly, Au23（CR）14is able to completely dissolve endogenous Aβ plaques in brain slices from transgenic AD model mice. In addition, Au23（CR）14has good biocompatibility and infiltration ability across the blood–brain barrier. Taken together, this work presents a promising therapeutics candidate for AD treatment, and manifests the potential of nanotechnological approaches in the development of nanomedicines.

关键词： gold nanoclusters Alzheimer’s disease restores fibril Aβ’s unfolded state abolished cytotoxicity dissolves endogenous Aβ plaques

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气候变化背景下云南省低碳经济发展研究

河南科学 2013年第12期31卷 2261-2265页

作者：刘敬龙罗卓英昆明理工大学土木工程学院昆明650500

利用层次分析法所构建的低碳经济评价指标体系分别从碳排放量、碳源控制、碳汇建设、低碳产业对云南省气候变化下的低碳经济发展进行综合评价.结果显示,1995—2011年云南省的低碳经济发展呈快速上升趋势,但是整体仍然处于相对低碳期.只... 详细信息

利用层次分析法所构建的低碳经济评价指标体系分别从碳排放量、碳源控制、碳汇建设、低碳产业对云南省气候变化下的低碳经济发展进行综合评价.结果显示,1995—2011年云南省的低碳经济发展呈快速上升趋势,但是整体仍然处于相对低碳期.只有通过控制人口、提高能源效率、优化能源结构、发展再生能源、调整经济结构、增加碳汇、合理消费等方面努力,才能实现经济、环境与社会和谐统一.

关键词：气候变化能源强度低碳经济碳排放

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超低频传播特性分析

舰船电子工程 2009年第2期29卷 148-150页

作者：罗卓颖刘翠海黄玉成王崇海军潜艇学院 92337部队 91208部队

基于超低频电磁波特点,分析超低频电磁波在地-电离层波导和海水中传播的特性,结合外军使用对超低频穿透海水的能力进行了定量研究,并分析了环境对超低频通信能力的影响。

关键词：超低频通信特性

Exploring device physics of perovskite solar cell via machine learning with limited samples

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Journal of Energy Chemistry 2024年第7期94卷 441-448页

作者： Shanshan Zhao Jie Wang Zhongli Guo Hongqiang luo Lihua Lu Yuanyuan Tian zhuoying Jiang Jing Zhang Mengyu Chen Lin Li Cheng Li School of Electronic Science and Engineering Xiamen UniversityXiamen 361005FujianChina Future Display Institute of Xiamen Xiamen 361005FujianChina

Perovskite solar cells(PsCs)have developed tremendously over the past ***,the key factors influencing the power conversion efficiency(PCE)of PSCs remain incompletely understood,due to the complexity and coupling of these structural and compositional *** this research,we demon-strate an effective approach to optimize PSCs performance via machine learning(ML).To address chal-lenges posed by limited samples,we propose a feature mask(FM)method,which augments training samples through feature transformation rather than synthetic *** this approach,squeeze-and-excitation residual network(SEResNet)model achieves an accuracy with a root-mean-square-error(RMSE)of 0.833%and a Pearson's correlation coefficient(r)of ***,we employ the permu-tation importance(PI)algorithm to investigate key features for ***,we predict PCE through high-throughput screenings,in which we study the relationship between PCE and chemical *** that,we conduct experiments to validate the consistency between predicted results by ML and experimental *** this work,ML demonstrates the capability to predict device performance,extract key parameters from complex systems,and accelerate the transition from laboratory findings to commercialapplications.

关键词： Perovskite solar cell Machine learning Device physics Performance prediction Limited samples

Prevalence and dynamic features of psychological issues among Chinese healthcare workers during the COVID-19 pandemic:a systematic review and cumulative meta-analysis

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General Psychiatry 2021年第3期34卷 120-128页

作者： Huijuan Zhang Wei Li Hui Li Caidi Zhang Jinjing luo Yikang Zhu Hui Wu zhuoying Zhu Yifeng Xu Jijun Wang Chunbo Li Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Clinical Research Center Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Medical Psychology Shanghai General HospitalShanghai Jiao Tong UniversityShanghaiChina Institute of Psychology and Behavioral Science Shanghai Jiao Tong UniversityShanghaiChina Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina

Background The COVID-19 pandemic has placed tremendous pressure on healthcare workers who are at the frontline in the battle against it,causing various forms of psychological *** To outline the prevalence and dynamic changing features of medical workers’psychological issues and to review the related national policies during the COVID-19 pandemic in *** We systematically searched for studies on the psychological states of Chinese medical staff from 1 January 2020 to 8 May *** aggregate prevalence of each psychological issue was calculated and plotted to observe the changes over *** on psychological support for medical staff during the pandemic were reviewed to explore their link to the prevalence of psychological *** In total,26 studies were included in this study.A total of 22062 medical workers were surveyed from 31 January to 27 February *** staff exhibited a substantial prevalence of anxiety symptoms,depression symptoms,stress-related symptoms and sleep problems during the survey period,with aggregate prevalence rates of 27.0%,26.2%,42.1%and 34.5%,*** meta-analyses revealed that the prevalence of psychological distress peaked at the beginning of the pandemic and subsequently exhibited a slow downward *** Chinese medical staff displayed significant psychological disturbance during the outbreak of the COVID-19 pandemic,which was especially severe at the early *** supportive policies may help alleviate ongoing psychological problems in healthcare workers.

关键词： distress workers dynamic

自愿参与型环境规制与企业绿色技术创新——经济政策不确定性及CEO开放性的调节作用

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生态经济 2024年第8期40卷 171-177页

作者：罗志红虞卓莹东华理工大学资源与环境经济研究中心江西南昌330013

企业绿色技术创新是推动经济社会发展绿色化、低碳化的重要引擎。基于2012—2021年我国A股上市公司数据,考察了自愿参与型环境规制对绿色技术创新的影响及内在作用机制,并检验了经济政策不确定性、CEO开放性的调节作用。结果表明,自愿... 详细信息

企业绿色技术创新是推动经济社会发展绿色化、低碳化的重要引擎。基于2012—2021年我国A股上市公司数据,考察了自愿参与型环境规制对绿色技术创新的影响及内在作用机制,并检验了经济政策不确定性、CEO开放性的调节作用。结果表明,自愿参与型环境规制有利于企业绿色技术创新。进一步机制分析发现,自愿参与型环境规制通过缓解融资约束和提高企业内部控制质量双重机制对企业绿色技术创新产生促进作用。调节机制检验结果显示,自愿参与型环境规制对企业绿色技术创新的正向影响,在经济不确定性较低、CEO开放程度较高时表现得更为明显。研究结论不仅有助于深化自愿型环境规制和企业绿色技术创新关系的认识,还为加快推动企业绿色转型、实现高质量发展提供决策参考。

关键词：自愿参与型环境规制经济政策不确定性 CEO开放性绿色技术创新

The Sedimentary Evolution During Late Triassic-Jurassic Period and the Hydrocarbon Exploration Direction in the Eastern Part of the Qiangtang Basin, Tibet

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Acta Geologica Sinica(English Edition) 2020年第S01期94卷 35-35页

作者： LIU Ruohan HE Bizhu ZHENG Menglin luo Xiaoping PENG Yang YUN Xiaorui CHEN Weiwei YU zhuoying MNR Key Laboratory of Deep-Earth Dynamics Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China Petroleum Exploration and Development Institute Xinjiang Oilfield CompanyKaramay 834000China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu 610059China

Based on the field outcrops surveyed,combined with recent published the regional tectonic evolution and geochronology data,we analyzed the lithologies and rock associations of strata,identified the sedimentary facies types,and discussed the distribution sedimentary facies and the hydrocarbon accumulation in the eastern Qiangtang basin during the Late Triassic–*** by regional unconformities,there are two tectono-stratigraphic units(from the Carnian to the Norian and from the Rhaetian to the Kimmeridgian,respectively)in the eastern part of Qiangtang *** systematically described the distribution range,thickness variation and lithological characteristics of different formations in the tectonostratigraphic *** Late Triassic-Jurassic is dominated by marine facies and marine-continental transitional *** marine-continental transitional facies include deltaic and tidallagoon *** facies including gentle carbonate slope,evaporative platform,restricted platform,littoral,neritic,bathyal and abysmal *** Carnian stage is dominated by littoral–neritic–bathyal–abysmal facies in the north Qiangtang depression otherwise the littoral–neritic facies in the south Qiangtang *** early Norian stage is dominated by carbonate gentle slope-mixed continental shelf *** late Norian,Bajocian,Callovian and Kimmeridgian stage are dominated by tidal flat-delta facies in the north Qiangtang depression and littoral-neritic facies in the south Qiangtang *** Bathonian and Oxfordian stage are dominated by evaporative platform-restricted platform-mixed continental shelf *** sedimentary facies formed zones from north to south and extended in an E–W *** Eastern Lower Uplift(ELU)played an important role in the division zones of sedimentary facies from north to *** the Bathonian and Oxfordian,the ELU developed below the sea level and controlled the distribution of restricted platform,evaporative platform and p

关键词： late Triassic-Jurassic sedimentary facies sedimentary evolution hydrocarbon prospect eastern Lower Uplift region eastern part of the Qiangtang basin

慢性阻塞性肺病患者择期开颅手术后肺炎的发生率和影响因素及用E值法探讨效应值的稳健性

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中国感染与化疗杂志 2022年第5期22卷 531-537页

作者：黄小倩谭康明杜倬婴罗剑锋复旦大学公共卫生学院生物统计教研室上海200032 上海市肺科医院医务处复旦大学附属华山医院神经外科

目的分析慢性阻塞性肺病(COPD)患者在接受择期开颅手术后肺炎(postoperative pneumonia)的发生率,以及影响术后肺炎发生的因素,并对未测得的混杂因素进行敏感性分析,检验结果的稳健性。方法回顾性收集7所医院2014—2020年接受开颅手术... 详细信息

目的分析慢性阻塞性肺病(COPD)患者在接受择期开颅手术后肺炎(postoperative pneumonia)的发生率,以及影响术后肺炎发生的因素,并对未测得的混杂因素进行敏感性分析,检验结果的稳健性。方法回顾性收集7所医院2014—2020年接受开颅手术的COPD患者的疾病信息,用多重插补法来填补缺失数据,用多因素logistic回归分析手术后肺炎的独立危险因素,用E值法检验结果的稳健性。结果共纳入患者405例,发生术后肺炎127例,发生率为31.36%。单因素分析中,较长的手术时间、麻醉时间、插管时间、ICU入住时间,较高的术前评估麻醉分级(ASA分级),是否入住ICU,合并有慢性支气管炎,围手术期使用异丙托溴铵、沙丁胺醇或特布他林、茶碱、布地奈德或倍氯米松、氨溴索或溴己新或N-乙酰半胱氨酸,术后使用抗生素,上述因素均跟手术后肺炎的发生有关。多因素分析中,ICU入住时间(OR=1.35,95%CI:1.11~1.65,P<0.01)、术后预防性使用抗生素(OR=4.27,95%CI:1.09~16.68,P=0.04)、术后治疗性使用抗生素(OR=19.61,95%CI:4.86~79.11,P<0.01)、进入ICU(OR=2.75,95%CI:1.22~6.22,P<0.01)是导致术后肺炎发生的独立危险因素,敏感性分析的E值分别为1.60、3.55、8.32、2.70。结论对于合并COPD且接受了择期开颅手术的患者,术后肺炎发病率较高,影响术后肺炎发生的高危因素较多,要从多方面加强对这类患者的治疗与护理;E值法是一种有效的敏感性分析工具,值得使用。

关键词：术后肺炎择期开颅手术慢性阻塞性肺病 E值法

经济政策不确定性、ESG表现与资源型企业绿色技术创新

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黑龙江工业学院学报（综合版） 2023年第12期23卷 62-70页

作者：罗志红虞卓莹东华理工大学经济与管理学院江西南昌330013

以2012-2021年资源型上市公司为研究样本,基于ESG表现视角探究经济政策不确定性对绿色技术创新的影响机制,并实证检验了媒体关注的调节作用。研究结果表明:经济政策不确定性对企业绿色技术创新有显著的促进效应,且对实质性绿色技术创新... 详细信息

以2012-2021年资源型上市公司为研究样本,基于ESG表现视角探究经济政策不确定性对绿色技术创新的影响机制,并实证检验了媒体关注的调节作用。研究结果表明:经济政策不确定性对企业绿色技术创新有显著的促进效应,且对实质性绿色技术创新的促进效应更强。进一步研究发现,经济政策不确定性通过提升ESG表现来提高企业绿色技术创新水平,媒体关注起到正向调节作用。产权差异分析发现,经济政策不确定性对绿色技术创新的驱动作用在国有企业中更为明显,媒体关注则强化了该激励效应。研究结论拓展了经济政策不确定性对企业绿色技术创新的相关研究,有助于制定和完善政府经济政策,引导企业绿色创新发展。

关键词：经济政策不确定性 ESG表现媒体关注绿色技术创新

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含双温敏单体的耐220℃高温降失水剂

油田化学 2024年第1期41卷 1-9页

作者：李早元陈建黄盛杜培伟蒋卓颖罗龙油气藏地质及开发工程全国重点实验室(西南石油大学) 四川成都610500 中石化西南石油工程有限公司固井分公司四川德阳618000

针对目前油井水泥降失水剂高温条件下耐温性差的问题,通过分子结构设计,以丙烯酰胺(AM)、对苯乙烯磺酸钠(SSS)、双温敏单体N,N-二甲基丙烯酰胺(DMAA)与N,N-二乙基丙烯酰胺(DEAA)为原料,通过水溶液自由基聚合法制备了一种耐高温降失水剂(... 详细信息

针对目前油井水泥降失水剂高温条件下耐温性差的问题,通过分子结构设计,以丙烯酰胺(AM)、对苯乙烯磺酸钠(SSS)、双温敏单体N,N-二甲基丙烯酰胺(DMAA)与N,N-二乙基丙烯酰胺(DEAA)为原料,通过水溶液自由基聚合法制备了一种耐高温降失水剂(LHF-1L)。以失水量为评价指标,对合成条件进行了优选,同时对LHF-1L进行了结构表征和性能评价。结果表明,在AM、SSS、DMAA、DEAA物质的量比为4∶6∶2∶0.5,引发剂为单体总质量0.75%的过硫酸钾(KPS)溶液,反应物溶液pH值为7,反应温度为65℃,反应时间为4 h的条件下制得的LHF-1L的降滤失性能最佳。在220℃、7%加量下的失水量为42 mL。FT-IR、TG和GPC测试结果表明,4个单体均成功参与聚合并生成目标产物。当温度达到273℃后,LHF-1L才出现明显的热损失,其多分散系数为1.396,数均分子量为171 351 g/mol。此外,LHF-1L对水泥浆流动度和水泥石抗压强度发展的影响较小。在220℃下,在水泥浆中加入7%LHF-1L后的失水量仍能控制在50 mL以内。在150℃、94.4 MPa下,LHF-1L不会使水泥浆急剧增稠和超缓凝,稠化曲线正常,未发生异常胶凝现象。采用双温敏单体制备LHF-1L,增强了其在高温下的温敏疏水缔合作用,从而提高了高温降滤失性能,可以满足高温条件下的固井技术需求。

关键词：降失水剂双温敏单体自由基共聚高温油井水泥固井