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A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration

Bioactive Materials 2024年第4期34卷 181-203页

作者： zhuowen hao Qinyu Feng Yi Wang Ying Wang Hanke Li Yingkun Hu Tianhong Chen Junwu Wang Renxin Chen Xuan Lv Zhiqiang Yang Jiayao Chen Xiaodong Guo Jingfeng Li Department of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan430060China Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Supramolecular peptide nanofiber hydrogels are emerging biomaterials for tissue engineering,but it is difficult to fabricate multi-functional systems by simply mixing several short-motif-modified supramolecular peptides because relatively abundant motifs generally hinder nanofiber cross-linking or the formation of long *** bioactive factors to the assembling backbone is an ideal strategy to design multi-functional supramolecular peptides in spite of challenging synthesis and ***,a multi-functional supramolecular peptide,P1R16,is developed by coupling a bioactive factor,parathyroid hormone related peptide 1(PTHrP-1),to the basic supramolecular peptide RADA16-I via solid-phase *** is found that P1R16 self-assembles into long nanofibers and co-assembles with RADA16-I to form nanofiber hydrogels,thus coupling PTHrP-1 to hydrogel matrix.P1R16 nanofiber retains osteoinductive activity in a dose-dependent manner,and P1R16/RADA16-I nanofiber hydrogels promote osteogenesis,angiogenesis and osteoclastogenesis in vitro and induce multi-functionalized osteoregeneration by intramembranous ossification and bone remodeling in vivo when loaded to collagen(Col)*** red blood marrow formation,ideal osteointegration and adapted degradation are observed in the 50%P1R16/Col scaffold ***,this study provides a promising strategy to develop multi-functional supramolecular peptides and a new method to topically administrate parathyroid hormone or parathyroid hormone related peptides for non-healing bone defects.

关键词： Supramolecular peptide nanofiber hydrogels Parathyroid hormone Self-assembly Co-assembly Bone tissue engineering

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甲状旁腺素及甲状旁腺素相关肽在骨组织工程中的原位应用

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生物医学工程学杂志 2021年第5期38卷 1028-1034页

作者：郝卓文(综述) 李景峰(审校) 武汉大学中南医院脊柱与骨肿瘤科武汉430071

甲状旁腺素(PTH)具有调节骨重构、促血管生成等多重作用,是一种极具应用潜力的骨修复活性因子。近年来,随着支架材料负载策略、甲状旁腺素相关肽(PTHrPs)的发展,支架材料原位负载PTH或PTHrPs治疗促进骨缺损愈合逐渐成为可能。本文基于... 详细信息

甲状旁腺素(PTH)具有调节骨重构、促血管生成等多重作用,是一种极具应用潜力的骨修复活性因子。近年来,随着支架材料负载策略、甲状旁腺素相关肽(PTHrPs)的发展,支架材料原位负载PTH或PTHrPs治疗促进骨缺损愈合逐渐成为可能。本文基于系统间歇性PTH(iPTH)应用于骨组织工程的现状与挑战,就PTH的原位负载策略及PTHrPs的构建两方面进行阐述,并探讨了该领域存在的问题及未来的研究方向,以期促进支架材料原位负载PTH或PTHrPs的临床应用。

关键词：甲状旁腺素甲状旁腺素相关肽骨愈合骨再生原位负载策略

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Self‑Assembling Peptide Nanofibers Anchored Parathyroid Hormone Derivative for Bone Tissue Engineering

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Advanced Fiber Materials 2024年第2期6卷 583-606页

作者： zhuowen hao Tianhong Chen Ying Wang Qinyu Feng Jiayao Chen Hanke Li Junwu Wang Zepu Wang Zheyuan Zhang Renxin Chen Guang Shi Zhenwei Zou Lin Cai Tonghe Zhu Jingfeng Li Department of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China Frontier Institute of Medical&Pharmaceutical Science and Technology School of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceShanghai 201620China Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan 430060China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Institute of Radiation Oncology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Parathyroid hormone(PTH)has been used for bone regeneration through intermittent subcutaneous injection;however,the topical administration of PTH for bone repair remains challenging because of the overactivation of ***,a PTH derivative,i.e.,PTHrP-1,which exhibits enhanced osteogenesis and relatively reduced osteoclastogenesis,is anchored to RADA16-I to fabricate a novel self-assembling peptide,called ***,P1R16 self-assembles into long nanofibers with PTHrP-1 exposed to the side end,which interacts with Type I collagen(Col)to form P1R16-Col *** RADA16 segment in P1R16 helps the sustained release of P1R16 from the ***,the P1R16 self-assembling peptide nanofibers exhibit multiple *** nanofibers promote stem cell proliferation and recruitment,and then direct stem cell fate towards osteogenic differentiation but not adpipogenic differentiation,improving the quality of the regenerated *** nanofibers further promote bone regeneration through bone remodeling between osteoblasts and ***,the P1R16 self-assembling peptide nanofibers also promote the proliferation and recruitment of endothelial cells,which facilitate the vascularization of implants to support bone regeneration ***,the P1R16 self-assembling peptide nanofibers maintain multiple functions,including pro-proliferation,direction of stem cell fate,bone remodeling and vascularization,showing considerable promise for bone tissue engineering to repair bone defects or fractures.

关键词： Self-assembling peptide Nanofiber Parathyroid hormone Bioactive factor Bone regeneration

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The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu Chunhua Pan hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang Wei Wang Xuheng Chen Junfang Bao Qiuyue hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： haonan Zhang Cheng hao Tongtong Fu Dian Yu Jane Howe Kaiwen Chen Ning Yan hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng hao Hongmei Duan Fei hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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Laser-Induced Highly Stable Conductive Hydrogels for Robust Bioelectronics

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NANO-MICRO LETTERS 2025年第1期17卷 1-4页

作者： Li, Yibo Zhou, hao Yang, Huayong Xu, Kaichen Zhejiang Univ Sch Mech Engn State Key Lab Fluid Power & Mechatron Syst Hangzhou 310058 Peoples R China

Despite the promising progress in conductive hydrogels made with pure conducting polymer, great challenges remain in the interface adhesion and robustness in long-term monitoring. To address these challenges, Prof. Seung Hwan Ko and Taek-Soo Kim's team introduced a laser-induced phase separation and adhesion method for fabricating conductive hydrogels consisting of pure poly(3,4-ethylenedioxythiophene):polystyrene sulfonate on polymer substrates. The laser-induced phase separation and adhesion treated conducting polymers can be selectively transformed into conductive hydrogels that exhibit wet conductivities of 101.4 S cm-1 with a spatial resolution down to 5 mu m. Moreover, they maintain impedance and charge-storage capacity even after 1 h of sonication. The micropatterned electrode arrays demonstrate their potential in long-term in vivo signal recordings, highlighting their promising role in the field of bioelectronics.

关键词： Laser processing Conductive hydrogels Stable interface Bio-interfacing electrodes Bioelectronic application

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A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu hao Gao Qingqing Wang Pengfei Lv Sam S.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

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Dynamic tensile behaviour and crack propagation of coal under coupled static-dynamic loading

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International Journal of Mining Science and Technology 2020年第5期30卷 659-668页

作者： Xianjie hao Weisheng Du Yixin Zhao zhuowen Sun Qian Zhang Shaohua Wang Haiqing Qiao Beijing Key Laboratory for Precise Mining of Inter-grown Energy and Resources China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Water Resource Protection and Utilization in Coal Mining Beijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology-BeijingBeijing 100083China School of Energy and Mining Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing 100084China

The fracture behaviour and crack propagation features of coal under coupled static-dynamic loading conditions are important when evaluating the dynamic failure of *** this study,coupled static-dynamic loading tests are conducted on Brazilian disc(BD)coal specimens using a modified split Hopkinson pressure bar(SHPB).The effects of the static axial pre-stress and loading rate on the dynamic tensile strength and crack propagation characteristics of BD coal specimens are *** average dynamic indirect tensile strength of coal specimens increases first and then decreases with the static axial pre-stress *** no static axial pre-stress is applied,or the static axial pre-stress is 30%of the static tensile strength,the dynamic indirect tensile strength of coal specimens shows an increase trend as the loading rate *** the static axial pre-stress is 60%of the static tensile strength,the dynamic indirect tensile strength shows a fluctuant trend as the loading rate *** to the crack propagation process of coal specimens recorded by high-speed camera,the impact velocity influences the mode of crack propagation,while the static axial pre-stress influences the direction of crack *** failure of coal specimens is a coupled tensile-shear failure under high impact *** there is no static axial pre-stress,tensile cracks occur in the vertical loading *** the static axial pre-stress is applied,the number of cracks perpendicular to the loading direction decreases,and more cracks occur in the parallel loading direction.

关键词： Coal Coupled static-dynamic loading SHPB Dynamic fracture behaviour Crack propagation

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