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Integrated strategies for chemotherapy cycles in nasopharyngeal carcinoma patients: Real-world data from two epidemic centers guiding decision-making

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Chinese Journal of Cancer Research 2023年第2期35卷 126-139页

作者： Zejiang Zhan Yingying Huang Jiayu Zhou zhuochen cai Haoyang Huang Ying Deng Wenze Qiu Xun Cao Xi Chen Chixiong Liang Lulu Zhang Xiang Guo Taize Yuan Xing Lyu Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Centerthe State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Radiation Oncology Affiliated Cancer Hospital and Institute of Guangzhou Medical UniversityGuangzhou 510095China Department of Critical Care Medicine Sun Yat-sen University Cancer Centerthe State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Radiation Oncology Guangzhou Concord Cancer CenterGuangzhou 510045China

objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not *** study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and ***:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)*** enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the *** developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk ***:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,***-year survivals were similar among the three groups after PSM and confirmed by *** 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other *** exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by ***:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC

关键词： Nasopharyngeal carcinoma treatment modality chemotherapy cycle survival toxicity costeffectiveness real world

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检测羊肠道病毒RT-PCR方法的建立及初步应用

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中国兽医学报 2021年第10期41卷 1949-1952页

作者：董坤胡俊英李卓宸蔡梦露章凡王玮玉王浴光王新平吉林大学动物医学学院教育部人兽共患病研究重点实验室吉林长春130062

羊肠道病毒(caprine enterovirus,CEV)感染为国内外新发疫病,其诊断方法尚缺乏研究。本研究依据CEV-JL14毒株的基因组序列,设计合成了1对特异性引物,建立了检测CEV的RT-PCR方法,并对其特异性、敏感性和重复性进行测定,同时应用该方法对... 详细信息

羊肠道病毒(caprine enterovirus,CEV)感染为国内外新发疫病,其诊断方法尚缺乏研究。本研究依据CEV-JL14毒株的基因组序列,设计合成了1对特异性引物,建立了检测CEV的RT-PCR方法,并对其特异性、敏感性和重复性进行测定,同时应用该方法对疑似CEV感染的临床样品进行检测。结果显示,建立的检测CEV感染的RT-PCR方法具有特异性好、敏感性高、快速和简便等特点,最低检出限为1.13×10^(3)copies/μL。以建立的RT-PCR方法对通过ELISA方法确定的6份阳性样品和22份阴性样品进行检测,结果显示两者的符合率为100%。本研究建立的RT-PCR方法可用于CEV感染的诊断和流行病学调查。

关键词：羊肠道病毒 EV-G20 反转录-聚合酶链式反应

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