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Establishment of FAP-overexpressing Cells for FAP-targeted Theranostics

Current Medical Science 2023年第3期43卷 623-630页

作者： Hui-ru JIAN Wen-hao NIU zhuo-shuo xu Jia-xu ZHU Xin PAN Yi-rui ZHANG Ping LEI Fa-qing HUANG Yong HE Department of Nuclear Medicine Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430062China The First Affiliated Hospital of Yangtze University Jingzhou 434000China Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective Fibroblast activation protein(FAP)has been widely studied and exploited for its clinical *** of the difficulties in interpreting reports of FAP-targeted theranostics is due to the lack of accurate controls,making the results less specific and less *** study aimed to establish a pair of cell lines,in which one highly expresses FAP(HT1080-hFAP)and the other has no detectable FAP(HT1080-vec)as control,to accurately evaluate the specificity of the FAP-targeted theranostics in vitro and in *** The cell lines of the experimental group(HT1080-hFAP)and no-load group(HT1080-vec)were obtained by molecular construction of the recombinant plasmid *** expression of hFAP in HT1080 cells was detected by PCR,Western blotting and flow ***-8,Matrigel transwell invasion assay,scratch test,flow cytometry and immunofluorescence were used to verify the physiological function of *** activities of human dipeptidyl peptidase(DPP)and human endopeptidase(EP)were detected by ELISA in HT1080-hFAP *** imaging was performed in bilateral tumor-bearing nude mice models to evaluate the specificity of *** RT-PCR and Western blotting demonstrated the mRNA and protein expression of hFAP in HT1080-hFAP cells but not in HT1080-vec *** cytometry confirmed that nearly 95%of the HT1080-hFAP cells were FAP *** engineered hFAP on HT1080 cells had its ability to retain enzymatic activities and a variety of biological functions,including internalization,proliferation-,migration-,and invasion-promoting *** HT1080-hFAP xenografted tumors in nude mice bound and took up^(68)GA-FAPI-04 with superior *** image contrast and tumor-organ ratio were obtained by PET *** HT1080-hFAP tumor retained the radiotracer for at least 60 *** This pair of HT1080 cell lines was successfully established,making it feasible for accurate evaluation and visualization of therapeutic and diagnostic

关键词： fibroblast activation protein 68GA-FAPI-04 reporter gene positron emission computed tomography image

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Superhydrophobic and corrosion-resistant siloxane-modified MgAl-LDHs coatings on magnesium alloy prepared under mild conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 450-463页

作者： Wenxi Zhang Zhangzelong zhuo Dan xu Liang Wu Zhihui Xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China College of Materials Science and Engineering/National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

We have developed a superhydrophobic and corrosion-resistant LDH-W/PFDTMS composite coating on the surface of Mg *** composite comprised a tungstate-intercalated(LDH-W)underlayer that was grown at low temperature(relative to hydrothermal reaction conditions)under atmospheric pressure and an outer polysiloxane layer created from a solution containing perfluorodecyltrimethoxysilane(PFDTMS)using a simple immersion *** successful intercalation of tungstate into the LDH phase and the following formation of the polysiloxane layer were confirmed through X-ray diffraction(XRD),Fourier transform infrared(FTIR)spectroscopy,and X-ray photoelectron spectroscopy(XPS).The corrosion resistance of the LDH-W film,both before and after the PFDTMS modification,was evaluated using electrochemical impedance spectroscopy(EIS),Tafel curves,and immersion *** results showed that Mg coated with LDH-W/PFDTMS exhibited significantly enhanced corrosion protection compared to the unmodified LDHW film,with no apparent signs of corrosion after exposure to 3.5wt%NaCl solution for 15 ***,the LDH-W/PFDTMS coating demonstrated superior superhydrophobicity and self-cleaning properties against water and several common beverages,as confirmed by static contact angle and water-repellency *** results offer valuable insights into preparing superhydrophobic and corrosion-resistant LDH-based composite coatings on Mg alloy surfaces under relatively mild reaction conditions.

关键词： Mg alloy corrosion coating layered double hydroxide

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Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-Man Chen shuo Zhang Shi-Qi Gao Michael xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

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Emission characteristics of biogenic volatile organic compounds in a subtropical pristine forest of southern China

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Journal of Environmental Sciences 2025年第2期148卷 665-682页

作者： Xi Chen Daocheng Gong Youjing Lin Qiao xu Yujin Wang Shiwei Liu Qinqin Li Fangyuan Ma Jiangyong Li shuo Deng Hao Wang Boguang Wang Institute for Environmental and Climate Research Jinan UniversityGuangzhou 511443China Guangdong Provincial Observation and Research Station for Atmospheric Environment and Carbon Neutrality in Nanling Forests China Australia-China Centre for Air Quality Science and Management(Guangdong) Guangzhou 511443China Hainan Provincial Ecological and Environmental Monitoring Center Haikou 571126China

Emission characteristics of biogenic volatile organic compounds(BVOCs)from dominant tree species in the subtropical pristine forests of China are extremely *** we conducted in situ field measurements of BVOCs emissions from representative mature evergreen trees by using dynamic branch enclosures at four altitude gradients(600-1690ma.s.l.)in the Nanling Mountains of southern *** characteristics as well as seasonal and altitudinal variations were *** emission rates and canopyscale emission factors were then *** showed that BVOCs emission intensities in the wet season were generally higher than those in the dry *** were the dominant BVOCs emitted from most broad-leaved trees,accounting for over 70%of the *** superba,Yushania basihirsuta and Altingia chinensis had relatively high emission intensities and secondary pollutant formation *** localized emission factors of isoprene were comparable to the defaults in the Model of Emissions of Gases and Aerosols fromNature(MEGAN),while emission factors of monoterpenes and sesquiterpenes were 2 to 58 times of those in the *** results can be used to update the current BVOCs emission inventory in MEGAN,thereby reducing the uncertainties of BVOCs emission estimations in forested regions of southern China.

关键词： Biogenic volatile organic compounds(BVOCs) Dynamic enclosure system Nanling Mountains Emission factors Emission rates Chemical reactivity

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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： shuo Li Zhaohan xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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In situ preparation of composite gel electrolytes with high room-temperature ionic conductivity and homogeneous Na+flux for sodium metal batteries

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Science China Chemistry 2025年

作者： Yuzhuo Ding Longbin Li shuo xu Binghua Zhou Jing Wang Yiwang Chen Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education College of Chemistry and MaterialsJiangxi Normal University College of Chemistry and Chemical Engineering Gannan Normal University School of Chemical Engineering Jiangxi Normal University Film Energy Chemistry for Jiangxi Provincial Key Laboratory Institute of Polymer and Energy Chemistry Nanchang University

Gel polymer electrolytes（GPEs） are conceived to be a good way to build safer lithium/sodium metal batteries by substituting traditional liquid electrolytes. However, it is still very difficult for GPEs to simultaneously achieve high room-temperature ionic conductivity, uniform Na+flow, superior interfacial compatibility, and increased mechanical strength. Herein, a composite gel electrolyte（KNT-PTGPE） with high ionic conductivity of 4.06 mS cm-1is prepared through chemical crosslinking strategy and the introduction of inorganic nanoparticles. The hybrid gel polymer network is formed by in situ cross-linking modified TiO2（KNT）, three-armed trimethylolpropane trimethacrylate and poly（ethylene glycol） diacrylate. The resulting 3D interpenetrating network facilitates the absorption of liquid electrolytes and improves the mechanical properties of electrolyte. Theoretical calculation and in situ measurements reveal that the homogeneous TiO2fillers with abundant Lewis acid site and polymer network are involved in the solvation process of Na+, thus constructing a fast Na+transport channel. Consequently, a stable plating/stripping process lasting over 900 h is achieved due to the uniform distribution of Na+flux and the good mechanical properties of the electrolyte, and the assembled cell exhibits an excellent long-term cycling stability. The approach offers more opportunities to design GPEs for high performance SMBs.

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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

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Assembly-free reads accurate identification(AFRAID)approach outperforms other methods of DNA barcoding in the walnut family(Juglandaceae)

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Plant Diversity 2025年第1期47卷 115-126页

作者： Yanlei Liu Kai Chen Lihu Wang Xinqiang Yu Chao xu Zhili Suo Shiliang Zhou shuo Shi Wenpan Dong School of Landscape and Ecological Engineering Hebei University of EngineeringHandan 056038China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China College of Life Science Hebei Normal UniversityShijiazhuang 050024China School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China

DNA barcoding has been extensively used for species ***,species identification of mixed samples or degraded DNA is limited by current DNA barcoding *** this study,we use plant species in Juglandaceae to evaluate an assembly-free reads accurate identification(AFRAID)method of species identification,a novel approach for precise species identification in ***,we determined(1)the accuracy of DNA barcoding approaches in delimiting species in Juglandaceae,(2)the minimum size of chloroplast dataset for species discrimination,and(3)minimum amount of next generation sequencing(NGS)data required for species *** found that species identification rates were highest when whole chloroplast genomes were used,followed by taxon-specific DNA barcodes,and then universal DNA *** identification of 100%was achieved when chloroplast genome sequence coverage reached 20%and the original sequencing data reached 500,000 *** accurately identified species for all samples tested after 500,000 clean reads,with far less computing time than common *** results provide a new approach to accurately identify species,overcoming limitations of traditional DNA *** method,which uses next generation sequencing to generate partial chloroplast genomes,reveals that DNA barcode regions are not necessarily fixed,accelerating the process of species identification.

关键词： DNA barcode Species identification Random DNA barcode Juglandaceae Assembly-free

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Integrating behavioral interventions for Tourette’s syndrome:Current status and prospective

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World Journal of Psychiatry 2025年第3期15卷 8-12页

作者： Xiao-Man Chen shuo Zhang Michael xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Clinical Medicine International Education SchoolShenyang 110004Liaoning ProvinceChina

In the evolving landscape of Tourette’s syndrome(TS)treatment,behavioral therapies have emerged as essential to address the comorbid psychological issues,as well as motor and vocal *** editorial comments on the study by Wang et al,which showed that cognitive-behavioral therapy(CBT)combined with habit reversal training significantly improved anxiety and tic severity in children with *** highlight the current status and future perspectives of behavioral interventions such as CBT,and comprehensive behavioral intervention for tics,demonstrating their efficacy in alleviating TS symptoms and improving patients'quality of *** the multifaceted nature of TS,our discussion integrates empirical evidence from various studies to provide a comprehensive perspective on the role of behavioral therapy in the management of this complex *** editorial concludes by emphasizing the need for innovative strategies that may address the limitations of existing treatments and advocates a multidisciplinary approach that combines behavioral,pharmacological,and neurobiological interventions to improve outcomes for patients with TS.

关键词： Tourette's syndrome Tics Behavioral therapy Habit reversal training Psychological disorders Comprehensive behavioral intervention for tics Neurodiversity

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Early prediction cardiac arrest in intensive care units:the value of laboratory indicator trends

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World Journal of Emergency Medicine 2025年第1期16卷 67-70页

作者： Wentao Sang Jiaxin Ma xuan Zhang shuo Wu Chang Pan Jiaqi Zheng Wen Zheng Qiuhuan Yuan Jian Zhang Jingjing Ma Feng xu Department of Emergency Medicine Qilu HospitalShandong UniversityJinan 250012China Chest Pain Center Qilu HospitalShandong UniversityJinan 250012China Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu HospitalShandong UniversityJinan 250012China Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu HospitalShandong UniversityJinan 250012China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical Sciencesthe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu HospitalShandong UniversityJinan 250012China

The incidence of in-hospital cardiac arrest (IHCA) has increased over the past decade,with more than half occurring in intensive care units (ICUs).^([1])ICU cardiac arrest (ICU-CA)presents unique challenges,with worse outcomes than those in monitored wards,highlighting the need for early detection and intervention.^([2])Up to 80%of patients exhibit signs of deterioration hours before IHCA.^([3])Although early warning scores based on vital signs are useful,their eff ectiveness in ICUs is limited due to abnormal physiological parameters.^([4])Laboratory markers,such as sodium,potassium,and lactate,are predictive of poor outcomes,^([5])but static measurements may not capture the patient’s *** in laboratory indicators,such as variability and extremes,may offer better predictive value.^([6])This study aimed to evaluate ICU-CA predictive factors,with a focus on vital signs and trends of laboratory indicators.

关键词： prediction signs arrest

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