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A Polyvinyl Alcohol/Acrylamide Hydrogel with Enhanced Mechanical Properties Promotes Full-Thickness Skin Defect Healing by Regulating Immunomodulation and Angiogenesis Through Paracrine Secretion

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Engineering 2024年第6期37卷 138-151页

作者： Peng Wang Liping Qian Huixin liang Jianhao Huang Jing Jin Chunmei Xie Bin Xue Jiancheng Lai Yibo Zhang Lifeng jiang Lan Li Qing jiang State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China jiangsu Engineering Research Center for 3D Bioprinting Nanjing 210008China Institute of Medical 3D Printing Nanjing UniversityNanjing 210093China Centre for Experimental Animals Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China College of Aeroplane Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China National Laboratory of Solid State Microstructures Department of PhysicsNanjing UniversityNanjing 210093China Department of Chemical Engineering Stanford UniversityStanfordCA 94305USA Department of Orthopedic Surgery The Second Affiliated Hospital Zhejiang University School of MedicineOrthopedic Research Institute of Zhejiang UniversityKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang ProvinceHangzhou 310009China

Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential to restore the structural integrity and functionality of ***,the mechanical properties of hydrogel scaffolds and natural skin are substantially ***,we developed a polyvinyl alcohol(PVA)/acrylamide based interpenetrating network(IPN)hydrogel that was surface modified with polydopamine(PDA)and termed *** Dopa-gel exhibited mechanical properties similar to native skin tissue and a superior ability to modulate paracrine ***,a tough scaffold with tensile resistance was fabricated using this hydrogel by three-dimensional *** results showed that the interpenetration of PVA,alginate,and polyacrylamide networks notably enhanced the mechanical properties of the *** modification with PDA endowed the hydrogels with increased secretion of immunomodulatory and proangiogenic *** an in vivo model,Dopa-gel treatment accelerated wound closure,increased vascularization,and promoted a shift in macrophages from a proinflammatory M1 phenotype to a prohealing and anti-inflammatory M2 phenotype within the wound ***,the focal adhesion kinase(FAK)/extracellular signal-related kinase(ERK)signaling pathway may mediate the promotion of skin defect healing by increasing paracrine secretion via the ***,proangiogenic factors can be induced through Rho-associated kinase-2(ROCK-2)/vascular endothelial growth factor(VEGF)-mediated paracrine secretion under tensile stress *** together,these findings suggest that the multifunctional Dopa-gel,which has good mechanical properties similar to those of native skin tissue and enhanced immunomodulatory and angiogenic properties,is a promising scaffold for skin tissue regeneration.

关键词： Polyvinyl alcohol/acrylamide hydrogel Mechanical property enhancement Paracrine effect Skin regeneration Signaling pathways

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Interface interaction between SiO_(2) and magnetite under high temperature:particle migration and inhibition mechanism

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Journal of Iron and Steel Research International 2024年第3期31卷 561-572页

作者： Yao-zu Wang Jian-liang Zhang Qiang Cheng Hui-qing jiang Zheng-jian Liu Yu-bo Tan School of Intelligent Science and Technology University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Advanced Engineering University of Science and Technology BeijingBeijing 100083China

Silicon is one of the main gangue components in iron ore,usually in the form of quartz and *** studies have shown that SiO_(2) has a two-sided effect on the consolidation of pellets during high-temperature oxidation roasting of ***,it is very difficult to capture the structural evolution and migration mechanisms during high-tem-perature roasting process by existing experimental ***,the influence of SiO_(2) on the consolidation behavior of magnetite was studied through a series of roasting experiments and molecular dynamic *** results show that the consolidation index and particle growth index decrease with the increase in SiO_(2) content in the *** 1573 K,the liquid phase promotes the recrystallization growth of hematite at high *** dynamic study shows that it is difficult for quartz SiO_(2) to form sintering neck with Fe_(2)O_(3).When the calcination temperature is higher than 1400 K,the Fe_(2)O_(3)-Fe_(2)SiO_(4) system produces a considerable sintering neck structure after *** atomic migration ability of Fe_(2)SiO_(4) is much higher than that of Fe_(2)O_(3).The higher atomic migration ability of Fe_(2)SiO_(4) is the main reason for the formation of the sintering neck.

关键词： Sintering neck Crystal growth Consolidation Molecular dynamics SiO_(2)

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Formation mechanism of fault accommodation zones under combined stress in graben basin:Implications from geomechanical modeling

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Petroleum Science 2024年第1期21卷 54-76页

作者： Qi-Qiang Ren Jin-liang Gao Rong-Tao jiang Jin Wang Meng-Ping Li Jian-Wei Feng Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China jianghan Oilfield Oil and Gas Production Capacity Construction Management Center Chongqing408000China Sinopec Chongqing Fuling Shale Gas Exploration and Development Company Chongqing408000China College of Energy Chengdu University of TechnologyChengdu 610059SichuanChina School of Geoscience China University of Petroleum(East China)Qingdao 266580ShandongChina

A fault accommodation zone is a type of structure that is defined as regulating displacement and strain between faults *** numbers of fault accommodation zones are being identified in graben basins,indicating the potential exploration target and petroleum accumulation *** study aims to analyze the formation mechanism and development of fault accommodation zones under combined stress by a numerical simulation method considering geomechanical *** three-dimensional(3-D)seismic interpretation and fractal dimension method,exampled with the Dongxin fault zone,the fault activity and fault combination pattern were conducted to quantitatively characterize the activity difference in fault accommodation *** with mechanical experiment test,a geomehcanical model was established for fault accommodation zones in a graben *** the paleostress numerical simulations and structural physical simulation experiment,the developmental characteristics and genetic mechanism of fault accommodation zones were *** by multi movements and combined stresses,three significant tectonic evolution stages of the Dongxing Fault Zone(DXFZ)were distinguished:During the E_(s)^(3)sedimentary period,the large difference in the stress,strain,and rupture distribution in various faults were significant,and this stage was the key generation period for the prototype of the DXFZ,including the FAZ between large-scale *** the E_(s)^(2)sedimentary period,the EW-trending symmetric with opposite dipping normal faults and the NE-SW trending faults with large scale were furtherly *** junction area of two secondary normal faults were prone to be ruptured,performing significant period for inheriting and developing characteristics of fault accommodation *** the Es1 sedimentary period,the high-order faults in the DXFZ exhibited the obvious fault depressions and strike-slip activity,and the fault accommodation zones were

关键词： Fault accommodation zone Graben basin Fault activity Tectonic physical simulation experiment Finite element numerical simulation Dongxin fault zone

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Real-time distance field acceleration based free-viewpoint video synthesis for large sports fields

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Computational Visual Media 2024年第2期10卷 331-353页

作者： Yanran Dai Jing Li Yuqi jiang Haidong Qin Bang liang Shikuan Hong Haozhe Pan Tao Yang School of Telecommunications Engineering Xidian UniversityXi’an 710071China National Engineering Laboratory for Integrated AeroSpace-Ground-Ocean Big Data Application Technology SAIIPthe School of Computer ScienceNorthwestern Polytechnical UniversityXi’an 710129China

Free-viewpoint video allows the user to view objects from any virtual perspective,creating an immersive visual *** technology enhances the interactivity and freedom of multimedia ***,many free-viewpoint video synthesis methods hardly satisfy the requirement to work in real time with high precision,particularly for sports fields having large areas and numerous moving *** address these issues,we propose a freeviewpoint video synthesis method based on distance field *** central idea is to fuse multiview distance field information and use it to adjust the search step size *** step size search is used in two ways:for fast estimation of multiobject three-dimensional surfaces,and synthetic view rendering based on global occlusion *** have implemented our ideas using parallel computing for interactive display,using CUDA and OpenGL frameworks,and have used real-world and simulated experimental datasets for *** results show that the proposed method can render free-viewpoint videos with multiple objects on large sports fields at 25 ***,the visual quality of our synthetic novel viewpoint images exceeds that of state-of-the-art neural-rendering-based methods.

关键词： free-viewpoint video view synthesis camera array distance field sports video

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Thermoelectric transport properties of p-type Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3) high entropy compounds

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Rare Metals 2024年第7期43卷 3415-3421页

作者： Feng jiang Cheng-liang Xia Yong-Bin Zhu Jun Li Yue Chen Wei-Shu Liu Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

The introduction of entropy concept into thermoelectric materials recently has attracted broad ***,we showed the phase diagram of the ternary systems of Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3).Among the high entropy compounds (HECs),we have identified an intrinsic p-type region near our previously reported Bi_(0.8)Sb_(0.8)In_(0.4)Se_(3) in the phase diagram.

关键词： entropy (3) compounds

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A Novel Recommendation Algorithm Integrates Resource Allocation and Resource Transfer in Weighted Bipartite Network

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Big Data Mining and Analytics 2024年第2期7卷 357-370页

作者： Qiang Sun Leilei Shi Lu Liu Zixuan Han liang jiang Yan Wu Yeling Zhao School of Computer Science and Communication Engineering Jiangsu UniversityZhenjiang 212013China School of Computing and Mathematical Sciences University of LeicesterLeicesterLE17RHUK School of Ocean College Jiangsu University of Science and TechnologyZhenjiang 212003China School of Finance and Economics Jiangsu UniversityZhenjiang 212013China

Grid-based recommendation algorithms view users and items as abstract nodes,and the information utilised by the algorithm is hidden in the selection relationships between users and *** these relationships can be easily handled,much useful information is overlooked,resulting in a less accurate recommendation *** aim of this paper is to propose improvements on the standard substance diffusion algorithm,taking into account the influence of the user’s rating on the recommended item,adding a moderating factor,and optimising the initial resource allocation vector and resource transfer matrix in the recommendation *** average ranking score evaluation index is introduced to quantify user satisfaction with the recommendation *** are conducted on the MovieLens training dataset,and the experimental results show that the proposed algorithm outperforms classical collaborative filtering systems and network structure based recommendation systems in terms of recommendation accuracy and hit rate.

关键词： cloud computing link prediction bipartite graph network recommendation algorithm cold start problem

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Evaluation of laboratory and environmental exposure systems for protein modification upon gas pollutants and environmental factors

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Journal of Environmental Sciences 2024年第9期143卷 213-223页

作者： Zhiwei Pan ShiyiWu Qiaoze Zhu Fobang Liu Yongjian liang Chenglei Pei Haoyu jiang Yingyi Zhang Senchao Lai The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationSchool of Environment and EnergySouth China University of TechnologyGuangzhou 510006China Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China Guangzhou Sub-branch of Guangdong Ecological and Environmental Monitoring Center Guangzhou 510006China State Key Laboratory of Organic Geochemistry Guangdong Key Laboratory of Environmental Protection and Resources Utilizationand Joint Laboratory of the Guangdong-Hong Kong-Macao Greater Bay Area for the EnvironmentGuangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China School of Marine Sciences Sun Yat-sen UniversityZhuhai 519082China

Chemical modifications of proteins induced by ambient ozone(O_(3))and nitrogen oxides(NOx)are of public health concerns due to their potential to trigger respiratory *** laboratory and environmental exposure systems have been widely used to investigate their relevant mechanism in the *** bovine serum albumin(BSA)as a model protein,we evaluated the two systems and aimed to reduce the uncertainties of both the reactants and products in the corresponding kinetic *** the laboratory simulation system,the generated gaseous pollutants showed negligible *** layers of BSA were coated on the flow tube with protein extraction recovery of 87.4%.For environmental exposure experiment,quartz fiber filter was selected as the upper filter with low gaseous O_(3)(8.0%)and NO_(2)(1.7%)losses,and cellulose acetate filter was appropriate for the lower filter with protein extraction efficiency of 95.2%.The protein degradation process was observed without the exposure to atmospheric oxidants and contributed to the loss of protein monomer mass fractions,while environmental factors(e.g.,molecular oxygen and ultraviolet)may cause greater protein monomer *** on the evaluation,the study exemplarily applied the two systems to protein modification and both showed that O_(3) promotes the protein oligomerization and nitration,while increased temperature can accelerate the oligomerization and increased relative humidity can inhibit the nitration in the environmental exposure *** developed laboratory and environmental systems are suitable for studying protein modifications formed under different atmospheric conditions.A combination of the two will further reveal the actual mechanism of protein modifications.

关键词： Protein modification Laboratory simulation Environmental exposure Oligomerization Nitration

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Fault Diagnosis Method of Rolling Bearing Based on ESGMD-CC and AFSA-ELM

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Structural Durability & Health Monitoring 2024年第1期18卷 37-54页

作者： Jiajie He Fuzheng Liu Xiangyi Geng Xifeng liang Faye Zhang Mingshun jiang School of Traffic&Transportation Engineering Central South UniversityChangsha410075China Project Management Department CRRC Advanced Composites Co.Ltd.Qingdao266108China School of Control Science and Engineering Shandong UniversityJinan250061China

Incomplete fault signal characteristics and ease of noise contamination are issues with the current rolling bearing early fault diagnostic methods,making it challenging to ensure the fault diagnosis accuracy and reliability.A novel approach integrating enhanced Symplectic geometry mode decomposition with cosine difference limitation and calculus operator(ESGMD-CC)and artificial fish swarm algorithm(AFSA)optimized extreme learning machine(ELM)is proposed in this paper to enhance the extraction capability of fault features and thus improve the accuracy of fault ***,SGMD decomposes the raw vibration signal into multiple Symplectic geometry components(SGCs).Secondly,the iterations are reset by the cosine difference limitation to effectively separate the redundant components from the representative ***,the calculus operator is performed to strengthen weak fault features and make them easier to extract,and the singular value decomposition(SVD)weighted by power spectrum entropy(PSE)can be utilized as the sample feature ***,AFSA iteratively optimized ELM is adopted as the optimized classifier for fault *** superior performance of the proposed method has been validated by various experiments.

关键词： Symplectic geometry mode decomposition calculus operator cosine difference limitation fault diagnosis AFSAELM model

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Tracking Nonstationary Streaming Data via Exponentially Weighted Moving Average Stochastic Gradient Descent

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Journal of Systems Science & Complexity 2024年

作者： QIAN Chengde jiang Haiyan liang Decai School of Statistics and Data Science Nankai University Department of Machine Learning Mohamed Bin Zayed University of Artificial Intelligence (MBZUAI)

In many applications involving data streams, the sequences of data arise from highly dynamic and often unstable real-life processes, rendering untenable the standard assumption that current and future data come from the same distribution. In response, new methodologies, such as dynamic online learning, have been proposed in order to account for the nonstationary features in the data-generating process. Motivated by the stability and statistical efficiency of the notable stochastic approximation method, average stochastic gradient descent(ASGD) in time-invariant systems, the authors propose an exponentially weighted moving average(EWMA)-based stochastic gradient descent(SGD) which accommodates the dynamic structure by introducing a forgetting factor and replacing the simple averaging step in ASGD with an EWMA step. Provided that the dynamic drift is Lipschitz continuous, the mean squared tracking error rate of the proposed method achieves the optimal rate in the nonparametric statistical paradigm. The proposed framework also allows us to derive the dynamic regret bound and asymptotic normality with a path variation constraint in a natural manner. Numerical analysis has been conducted to verify the performance of the proposed method. In particular, the proposed method is much more robust to the selection of learning rates compared with the ordinary SGD method.

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Emergency physicians’ occupational risks in China

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World Journal of Emergency Medicine 2024年第3期15卷 232-234页

作者： Huaying jiang Jia Chang Rong Huang Xiayi liang Manning Song Hejing Yuan Shuo Wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100105China Operation Room Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China School of Marxism Beijing University of Chinese MedicineBeijing 100105China Department of Infectious Diseases(Fever Clinic) Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China

With the rapid development of emergency medicine,emergency physicians are working around the clock,[1]including additional workloads due to sudden public health emergencies and *** risks for emergency physicians are s... 详细信息

关键词： physician acute occupational

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