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Large animal models for Huntington's disease research

Zoological Research 2024年第2期45卷 275-283页

作者： Bofeng Han Weien liang Xiao-jiang Li Shihua Li Sen Yan Zhuchi Tu Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan University Key Laboratory of CNS Regeneration(Jinan University)-Ministry of EducationGuangdong Key Laboratory of Non-Human Primate ResearchGuangzhouGuangdong 510632China Department of Pathophysiology School of MedicineJinan UniversityGuangzhouGuangdong 510632China

Huntington'sdisease(HD)isahereditary neurodegenerative disorder for which there is currently no ***,the development of appropriate disease models is critical to thoroughly investigate disease *** genetic basis of HD involves the abnormal expansion of CAG repeats in the huntingtin(HTT)gene,leading to the expansion of a polyglutamine repeat in the HTT *** HTT carrying the expanded polyglutamine repeat undergoes misfolding and forms aggregates in the brain,which precipitate selective neuronal loss in specific brain *** models play an important role in elucidating the pathogenesis of neurodegenerative disorders such as HD and in identifying potential therapeutic *** to the marked species differences between rodents and larger animals,substantial efforts have been directed toward establishing large animal models for HD *** models are pivotal for advancing the discovery of novel therapeutic targets,enhancing effective drug delivery methods,and improving treatment *** have explored the advantages of utilizing large animal models,particularly pigs,in previous *** then,however,significant progress has been made in developing more sophisticated animal models that faithfully replicate the typical pathology of *** the current review,we provide a comprehensive overview of large animal models of HD,incorporating recent findings regarding the establishment of HD knock-in(KI)pigs and their genetic *** also explore the utilization of large animal models in HD research,with a focus on sheep,non-human primates(NHPs),and *** objective is to provide valuable insights into the application of these large animal models for the investigation and treatment of neurodegenerative disorders.

关键词： Huntington's disease Large animal models Sheep Non-human primates Transgenic pigs

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A comparative study of data-driven battery capacity estimation based on partial charging curves

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Journal of Energy Chemistry 2024年第1期88卷 409-420,I0010页

作者： Chuanping Lin Jun Xu Delong jiang Jiayang Hou Ying liang Xianggong Zhang Enhu Li Xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Shaanxi Key Laboratory of Intelligent Robots School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049ShaanxiChina Department of Electrical Engineering and Automation Luoyang Institute of Science and TechnologyLuoyang 471023HenanChina Wuhan Institute of Marine Electric Propulsion China State Shipbuilding Corporation LimitedWuhan 430064HubeiChina Gresgying Digital Technology Ltd. Xi’an 710086ShaanxiChina

With its generality and practicality, the combination of partial charging curves and machine learning(ML) for battery capacity estimation has attracted widespread attention. However, a clear classification,fair comparison, and performance rationalization of these methods are lacking, due to the scattered existing studies. To address these issues, we develop 20 capacity estimation methods from three perspectives:charging sequence construction, input forms, and ML models. 22,582 charging curves are generated from 44 cells with different battery chemistry and operating conditions to validate the performance. Through comprehensive and unbiased comparison, the long short-term memory(LSTM) based neural network exhibits the best accuracy and robustness. Across all 6503 tested samples, the mean absolute percentage error(MAPE) for capacity estimation using LSTM is 0.61%, with a maximum error of only 3.94%. Even with the addition of 3 m V voltage noise or the extension of sampling intervals to 60 s, the average MAPE remains below 2%. Furthermore, the charging sequences are provided with physical explanations related to battery degradation to enhance confidence in their application. Recommendations for using other competitive methods are also presented. This work provides valuable insights and guidance for estimating battery capacity based on partial charging curves.

关键词： Lithium-ion battery Partial charging curves Capacity estimation Data-driven Sampling frequency

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Epidemiological analysis of the clinicopathologic characteristics,treatment,and prognosis of 2648 jaw cysts in West China

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Chinese Medical Journal 2024年第9期137卷 1124-1126页

作者： Hui Li Zuoqiang Liu Linli jiang jiangyu liang Lei Liu Department of Oral and Maxillofacial Surgery State Key Laboratory of Oral Disease&National Center for Stomatology&National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China Department of Biomaterials Sciences and Prosthodontics School of DentistryUniversity of MichiganAnn ArborMIUnited States

To the Editor:The jaw cyst is one of the most common benign tumors in the oral and maxillofacial region.[1]To date,several studies have reported on jaw cysts in general populations from Italy,Brazil,Greece,and the United States in accordance with the 4th World Health Organization(WHO)classication of head and neck tumors.[2]However,there are no clinicopathological studies of odontogenic and non-odontogenic cysts in a large Chinese population in relation to the latest WHO classi***,few epidemiological studies have analyzed treatment plans and the possible postoperative complications of jaw ***,this study aimed to perform a detailed and extended epidemiological analysis of jaw cysts in a large population in West China.

关键词： clinic treatment pathologic

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Responses of plant diversity and soil microorganism diversity to nitrogen addition in the desert steppe,China

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Journal of Arid Land 2024年第3期16卷 447-459页

作者： YE He HONG Mei XU Xuehui liang Zhiwei jiang Na TU Nare WU Zhendan College of Grassland Resources and EnvironmentInner Mongolia Agricultural UniversityInner Mongolia Key Laboratory of Soil Quality and Nutrient ResourcesHohhot 010018China Key Laboratory of Agricultural Ecological Security and Green Development at University of Inner Mongolia Hohhot 010018China

Nitrogen(N)deposition is a significant aspect of global change and poses a threat to terrestrial *** impact of plant-soil microbe relationships to N deposition has recently attracted considerable *** microorganisms have been proven to provide nutrients for specific plant growth,especially in nutrient-poor desert steppe ***,the effects of N deposition on plant-soil microbial community interactions in such ecosystems remain poorly *** investigate these effects,we conducted a 6-year N-addition field experiment in a Stipa breviflora *** steppe in Inner Mongolia Autonomous Region,*** N treatment levels(N0,N30,N50,and N100,corresponding to 0,30,50,and 100 kg N/(hm2•a),respectively)were applied to simulate atmospheric N *** results showed that N deposition did not significantly affect the aboveground biomass of desert steppe plants.N deposition did not significantly reduce the alfa-diversity of plant and microbial communities in the desert steppe,and low and mediate N additions(N30 and N50)had a promoting effect on *** variation pattern of plant Shannon index was consistent with that of the soil bacterial Chao1 index.N deposition significantly affected the beta-diversity of plants and soil bacteria,but did not significantly affect fungal *** conclusion,N deposition led to co-evolution between desert steppe plants and soil bacterial communities,while fungal communities exhibited strong stability and did not undergo significant *** findings help clarify atmospheric N deposition effects on the ecological health and function of the desert steppe.

关键词： soil microorganisms plant-microbial community interaction plant diversity nitrogen deposition desert steppe

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Supersaturation-driven self-assembly formation of ceftriaxone sodium spherulites:From amorphous form to spherulites

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Particuology 2024年第7期90卷 10-19页

作者： Shankun liang Yuchao Niu Xueyan Hu Wu Xiao Xuehua Ruan Gaohong He Xiaobin jiang State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian116024China School of Chemical Engineering at Panjin Dalian University of TechnologyPanjin124221China

Drug particles with spherical morphology possess amazing advantages in terms of particle flowability,mechanical properties,drug solubility,and *** growth mechanism of drug spherulite is of great importance for the preparation and regulation of ***,ceftriaxone sodium spherulites were fabricated by the antisolvent crystallization method using dropwise addition of ceftriaxone sodium solution to *** observation of the whole crystallization process combined with electron microscopy technique revealed the spherical growth process from amorphous form to *** the supersaturation of the crystallization system was adjusted,the ceftriaxone sodium crystals transformed from amorphous form to *** the process of antisolvent crystallization with acetone as antisolvent,when the theoretical supersaturation degree S was higher than 2.62,the crystallization system tended to appear amorphous form;when S was between 2.57 and 2.62,the amorphous form transformed into clustered spherulites;when S was less than 2.57,the surface of spherulites will be covered with flaky crystal,which transformed into urchin-like *** the understanding of the spherical growth mechanism,the ceftriaxone sodium spherulites prepared in this research with modified supersaturation control had a low residue of antisolvent acetone,and the flowability was significantly improved.

关键词： Spherulite Ceftriaxone sodium Antisolvent crystallization Supersaturation Online observation

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Semantic-aware coordinated transmission in cohesive clustered satellites: utility of information perspective

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Science China(Information Sciences) 2024年第09期67卷 338-339页

作者： liang XU Jian JIAO Shiyao jiang Ye WANG Qinyu ZHANG Guangdong Provincial Key Laboratory of Aerospace Communication and Networking Technology Harbin Institute of Technology (Shenzhen) Pengcheng Laboratory

The cohesive clustered satellite(CCS) concept integrates diverse satellite payloads from different orbits, such as communication, remote sensing, and navigation satellites, into mobile, geometrically stable clusters for efficient collaborative networking [1]. By aggregating, reconstructing, and orchestrating heterogeneous satellite resources, such as computation, communication, and storage [2], the CCS enables resource ultra-sharing and provides information-centric and goal-oriented intelligent on-demand services [3] for a range of emerging Earth observation and deep space exploration missions [4].

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Mechanical properties and acoustic emission characteristics of soft rock with different water contents under dynamic disturbance

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International Journal of Coal Science & Technology 2024年第3期11卷 135-148页

作者： Yujing jiang Lugen Chen Dong Wang Hengjie Luan Guangchao Zhang Ling Dong Bin liang State Key Laboratory of Mining Disaster Prevention and Control Co-Founded By Shandong Province and the Ministry of Science and Technology Shandong University of Science and TechnologyQingdao266590China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing100083China Inner Mongolia Shanghaimiao Mining Co. Ltd.Ordos016299China

Uniaxial compression tests and cyclic loading acoustic emission tests were conducted on 20%,40%,60%,80%,dry and saturated muddy sandstone by using a creep impact loading system to investigate the mechanical properties and acoustic emission characteristics of soft rocks with different water contents under dynamic *** mechanical properties and acoustic emission characteristics of muddy sandstones at different water contents were *** of experimental studies show that water is a key factor in the mechanical properties of rocks,softening them,increasing their porosity,reducing their brittleness and increasing their *** uniaxial compression,the macroscopic damage characteristics of the muddy sandstone change from mono-bevel shear damage and‘X’type conjugate bevel shear damage to a roadway bottom-drum type damage as the water content *** perturbation has a strengthening effect on the mechanical properties of samples with 60%and less water content,and a weakening effect on samples with 80%and more water content,but the weakening effect is not *** damage characteristics of dry samples remain unchanged,water samples from shear damage and tensile–shear composite damage gradually transformed into cleavage damage,until saturation transformation monoclinic shear *** evolution of acoustic emission energy and event number is mainly divided into four stages:loading stage(Ⅰ),dynamic loading stage(Ⅱ),yield failure stage(Ⅲ),and post-peak stage(Ⅳ),the acoustic emission characteristics of the stages were different for different water *** characteristic value of acoustic emission key point frequency gradually decreases,and the damage degree of the specimen increases,corresponding to low water content—high main frequency—low damage and high water content—low main frequency—high damage.

关键词： Dynamic disturbance Soft rock Cyclic loading Acoustic emission Water content

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A potential threat from biodegradable microplastics: mechanism of cadmium adsorption and desorption in the simulated gastrointestinal environment

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 63-75页

作者： Timing jiang Xiang Wu Shushan Yuan Changfei Lai Shijie Bian Wenbo Yu Sha liang Jingping Hu liang Huang Huabo Duan Yafei Shi Jiakuan Yang School of Environmental Science&Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Resources and Environmental Science Hubei UniversityWuhan 430062China Hubei Provincial Engineering Laboratory for Solid Waste Treatment Disposal and Recycling Wuhan 430074China School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan 430068China State Key Laboratory of Coal Combustion Huazhong University of Science and TechnologyWuhan 430074China

It has been demonstrated that microplastics (MPs) can accumulate heavy metals from the environment and transfer them into organisms via the food chain. However, adsorption and desorption capacities for biodegradable MPs relative to those for conventional MPs remain poorly understood. In this study, cadmium (Cd(II)) adsorption and desorption characteristics of polylactic acid (PLA), a typical biodegradable MP, were investigated. Two conventional MPs, i.e., polypropylene (PP) and polyamide (PA) were used for comparison. The maximum Cd(II) adsorption capacities of the MPs studied in the adsorption experiments decreased in the order PA (0.96 ± 0.07 mg/g) > PLA (0.64 ± 0.04 mg/g) > PP (0.22 ± 0.03 mg/g). The Pseudo-second-order kinetic model and Freundlich isothermal model described the Cd(II) adsorption behaviors of PLA MPs well. X-ray photoelectron spectroscopy and two-dimensional Fourier transform infrared correlation spectroscopy analysis indicated that oxygen functional groups were the major and preferential binding sites of PLA MPs, which contributed to their high Cd(II) adsorption capacities. Simulated gastric and intestinal fluids both significantly enhanced the desorption capacities of the examined MPs. Notably, degradation of the PLA MPs during in vitro human digestion made the Cd(II) on the PLA MPs more bioaccessible (19% in the gastric phase and 62% in the intestinal phase) than Cd(II) on the PP and PA MPs. These results indicate the remarkable capacities of biodegradable MPs to accumulate Cd(II) and transfer it to the digestive system and show that biodegradable MPs might pose more severe threats to human health than conventional nonbiodegradable MPs.

关键词： Biodegradable microplastics Cadmium Adsorption and desorption Gastrointestinal environment Two-dimensional correlation spectroscopy Bioaccessibility

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InSAR-derived surface deformation characteristics and mining subsidence parameters in mountain coal mines

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Journal of Mountain Science 2024年第9期21卷 3139-3156页

作者： jiang Xiaowei SHI Wenbing liang Feng GUI Jingjing LI Jiawei Key Laboratory of Karst Georesources and Environment Ministry of EducationGuizhou UniversityGuiyang 550025China College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China Mountain Geohazard Prevention R&D Center of Guizhou Province Guiyang 550025China

Mining-induced surface deformation disrupts ecological balance and impedes economic *** study employs SBAS-InSAR with 107-view of ascending and descending SAR data from Sentinel-1,spanning February 2017 to September 2020,to monitor surface deformation in the Fa’er Coal Mine,Guizhou *** on the surface deformation time series reveals the relationship between underground mining and surface *** geological conditions,mining activities,duration,and ranges,the study determines surface movement parameters for the coal *** asserts that mining depth significantly influences surface movement parameters in mountainous mining *** mining depth elevates the strike movement angle on the deeper side of the burial depth by 22.84°,while decreasing by 7.74°on the shallower *** movement angles decrease by 4.06°,while downhill movement angles increase by 15.71°.This emphasizes the technology's suitability for local mining design,which lays the groundwork for resource development,disaster prevention,and ecological protection in analogous contexts.

关键词： Time-series InSAR Surface deformation Subsurface mining Mining subsidence

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The hard X-ray nanoprobe beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 79-88页

作者： Yan He Hui jiang Dong-Xu liang Zhi-Sen jiang Huai-Na Yu Hua Wang Cheng-Wen Mao Jia-Nan Xie Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The hard X-ray nanoprobe beamline BL13U is a phase-Ⅱ beamline project at the Shanghai Synchrotron Radiation *** beamline aims to enable comprehensive experiments at high spatial resolutions ranging from 50 to 10 nm. The X-ray energy range of the beamline, 5–25 keV, can detect most elements in the periodic table. Two operating modes were designed to accommodate the experimental requirements of high-energy resolution or high photon flux, respectively. X-ray nanofluorescence, nanodiffraction, and coherent diffraction imaging are developed as the main experimental techniques for BL13U. This paper describes the beamline optics, end station configurations, experimental methods under development, and preliminary test results. This comprehensive overview aims to provide a clear understanding of the beamline capabilities and potential applications.

关键词： Shanghai synchrotron radiation facility Hard X-ray nanoprobe X-ray nanofocusing

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