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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan Yi-Lin Zhang zhuo-er qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

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SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl^(−) accumulation in respiratory epithelium

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Signal Transduction and Targeted Therapy 2022年第8期7卷 3080-3092页

作者： Lei Chen Wei-Jie Guan zhuo-er qiu Jian-Bang Xu Xu Bai Xiao-Chun Hou Jing Sun Su Qu Ze-Xin Huang Tian-Lun Lei Zi-Yang Huang Jincun Zhao Yun-Xin Zhu Ke-Nan Ye Zhao-Rong Lun Wen-Liang Zhou Nan-Shan Zhong Yi-Lin Zhang School of Life Sciences Sun Yat-sen UniversityGuangzhouChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina Guangzhou Laboratory GuangzhouChina

SARS-CoV-2,the culprit pathogen of COVID-19,elicits prominent immune responses and cytokine *** Cl^(−)is a crucial regulator of host defense,whereas the role of Cl^(−)signaling pathway in modulating pulmonary inflammation associated with SARS-CoV-2 infection remains *** using human respiratory epithelial cell lines,primary cultured human airway epithelial cells,and murine models of viral structural protein stimulation and SARS-CoV-2 direct challenge,we demonstrated that SARS-CoV-2 nucleocapsid(N)protein could interact with Smad3,which downregulated cystic fibrosis transmembrane conductance regulator(CFTR)expression via *** intracellular Cl^(−)concentration([Cl^(−)]i)was raised,resulting in phosphorylation of serum glucocorticoid regulated kinase 1(SGK1)and robust inflammatory *** or knockout of SGK1 abrogated the N protein-elicited airway ***,N protein promoted a sustained elevation of[Cl^(−)]i by depleting intracellular cAMP via upregulation of phosphodiesterase 4(PDE4).Rolipram,a selective PDE4 inhibitor,countered airway inflammation by reducing[Cl^(−)]*** findings suggested that Cl^(−)acted as the crucial pathological second messenger mediating the inflammatory responses after SARS-CoV-2 *** the Cl^(−)signaling pathway might be a novel therapeutic strategy for COVID-19.

关键词： inflammation respiratory epithelium

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Energy beam-based direct and assisted polishing techniques for diamond:A review

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International Journal of Extreme Manufacturing 2024年第1期6卷 93-124页

作者： zhuo Li Feng Jiang Zhengyi Jiang Zige Tian Tian qiu Tao Zhang qiuling Wen Xizhao Lu Jing Lu Hui Huang Institute of Manufacturing Engineering Huaqiao UniversityXiamen 361021People’s Republic of China School of Mechanical MaterialsMechatronic and Biomedical EngineeringUniversity of WollongongWollongongNSW 2522Australia College of Mechanical Engineering and Automation Huaqiao UniversityXiamen 361021People’s Republic of China State Key Laboratory of High Performance Tools Huaqiao UniversityXiamen 361021People’s Republic of China

Diamond is a highly valuable material with diverse industrial applications,particularly in the fields of semiconductor,optics,and high-power ***,its high hardness and chemical stability make it difficult to realize high-efficiency and ultra-low damage machining of *** address these challenges,several polishing methods have been developed for both single crystal diamond(SCD)and polycrystalline diamond(PCD),including mechanical,chemical,laser,and ion beam processing *** this review,the characteristics and application scope of various polishing technologies for SCD and PCD are ***,various energy beam-based direct and assisted polishing technologies,such as laser polishing,ion beam polishing,plasma-assisted polishing,and laser-assisted polishing,are *** current research progress,material removal mechanism,and infuencing factors of each polishing technology are *** some of these methods can achieve high material removal rates or reduce surface roughness,no single method can meet all the ***,the future development prospects and application directions of different polishing technologies are presented.

关键词： single crystal diamond polycrystalline diamond energy beam polishing technology material removal mechanism influencing factors

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High-capacity dilithium hydroquinone cathode material for lithium-ion batteries

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National Science Review 2024年第6期11卷 206-213页

作者： Yong Lu Haoqin Han zhuo Yang Youxuan Ni Zhicheng Meng qiu Zhang Hao Wu Weiwei Xie Zhenhua Yan Jun Chen Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) State Key Laboratory of Advanced Chemical Power SourcesCollege of ChemistryNankai University

Lithiated organic cathode materials show great promise for practical applications in lithium-ion batteries owing to their Li-reservoir characteristics. However, the reported lithiated organic cathode materials still suffer from strict synthesis conditions and low capacity. Here we report a thermal intermolecular rearrangement method without organic solvents to prepare dilithium hydroquinone（Li2Q）, which delivers a high capacity of 323 m Ah g-1with an average discharge voltage of 2.8 V. The reversible conversion between orthorhombic Li2Q and monoclinic benzoquinone during charge/discharge processes is revealed by in situ X-ray diffraction. Theoretical calculations show that the unique Li–O channels in Li2Q are beneficial for Li+ion diffusion. In situ ultraviolet-visible spectra demonstrate that the dissolution issue of Li2Q electrodes during charge/discharge processes can be handled by separator modification, resulting in enhanced cycling stability. This work sheds light on the synthesis and battery application of high-capacity lithiated organic cathode materials.

关键词： lithium-ion batteries cathode materials lithiated organic materials dilithium hydroquinone separator modification

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A review of ToF-based LiDAR

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Journal of Semiconductors 2024年第10期45卷 7-19页

作者： Jie Ma Shenglong zhuo Lei qiu Yuzhu Gao Yifan Wu Ming Zhong Rui Bai Miao Sun Patrick Yin Chiang The College of Electronics and Information Engineering Tongji UniversityShanghai 200092China State Key Laboratory of ASIC&System Fudan UniversityShanghai 201203China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore Lyne Technologies Shanghai 201203China

In recent years,propelled by the rapid iterative advancements in digital imaging technology and the semiconductor industry,encompassing microelectronic design,manufacturing,packaging,and testing,time-of-flight(ToF)-based imaging systems for acquiring depth information have garnered considerable attention from both academia and *** technology has emerged as a focal point of research within the realm of 3D *** to its relatively straightforward principles and exceptional performance,ToF technology finds extensive applications across various domains including human−computer interaction,autonomous driving,industrial inspection,medical and healthcare,augmented reality,smart homes,and 3D reconstruction,among ***,the increasing maturity of ToF-based LiDAR systems is evident in current *** paper comprehensively reviews the fundamental principles of ToF technology and LiDAR systems,alongside recent research *** elucidates the innovative aspects and technical challenges encountered in both transmitter(TX)and receiver(RX),providing detailed discussions on corresponding ***,the paper explores prospective avenues for future research,offering valuable insights for subsequent investigations.

关键词： time of flight light detection and ranging transmitter receiver

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Challenges and prospects for room temperature solid-state sodiumsulfur batteries

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Nano Research 2024年第3期17卷 1402-1426页

作者： Yashuang qiu Jing Xu Research Center of Grid Energy Storage and Battery Application School of Electrical and Information EngineeringZhengzhou UniversityZhengzhou 450001China

Room temperature sodium-sulfur(Na-S)batteries,known for their high energy density and low cost,are one of the most promising next-generation energy storage ***,the polysulfide shuttling and uncontrollable Na dendrite growth as well as safety issues caused by the use of organic liquid electrolytes in Na-S cells,have severely hindered their ***-state electrolytes instead of liquid electrolytes are considered to be the most direct and effective solution to solve the above ***,its practical application is still greatly challenged due to the poor interfacial compatibility between the all-solid-state electrolytes and the anode/cathode,ionic conductivity,and the shuttle effect caused by the presence of liquid phase in the quasi-solid-state *** paper presents a comprehensive review of solid-state Na-S batteries from the perspective of regulating interfacial compatibility and improving ionic conductivity as well as suppressing polysulfide *** to different components,solid-state electrolytes were divided into five categories:solid inorganic electrolytes,solid polymer electrolytes,polymer/inorganic solid hybrid electrolytes,gel polymer electrolytes,and liquid–solid inorganic hybrid ***,the prospect of developing high performance solid-state electrolytes to improve the cycling stability of room temperature Na-S cells is envisaged.

关键词： sodium-sulfur batteries solid-state electrolytes ionic conductivity polysulfide shuttling interfacial compatibility

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Electrochemical conversion of organic compounds and inorganic small molecules

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Science China Chemistry 2024年第10期67卷 3223-3246页

作者： Weimei Zeng Youai qiu Department of Chemistry Nankai UniversityTianjin 300071China

Electrochemical synthesis presents a facile and sustainable strategy to produce valuable *** review summarizes the most recent advances in electrosynthesizing value-added compounds with inorganic small ***“small molecules”refers to a broad spectrum of chemicals,we mainly focus on the electrochemical conversion of CO_(2),H_(2)O/D_(2)O,NH_(3)and SO_(2)until March *** review intends to compare the results and display general trends throughout the field,with an emphasis on the substrate scope and mechanical ***,we propose several techniques and protocols that can enable a more fundamental understanding of the electrochemical reaction involving inorganic small molecules and help drive this methodology toward commercialization.

关键词： electrochemical synthesis inorganic small molecule organic synthesis carbon dioxide water

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Novel rockburst prediction criterion with enhanced explainability employing CatBoost and nature-inspired metaheuristic technique

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Underground Space 2024年第6期19卷 101-118页

作者： Yingui qiu Jian Zhou School of Resources and Safety Engineering Central South UniversityChangsha 410083China

Rockburst is a major challenge to hard rock engineering at great *** and timely assessment of rockburst risk can avoid unnecessary casualties and property *** the existence of various methods for rockburst assessment,there remains an urgent need for a comprehensive and reliable criterion that is easy to both apply and *** a new rockburst criterion based on simple parameters can potentially fill this *** its advantages,this criterion can facilitate a more effective and efficient prediction of rockburst potential,thereby contributing significantly to enhancing safety *** this paper,combined with the internal and external factors of rockburst,four control variables(i.e.,integrity index,stress index,brittleness index,and elastic energy index)were selected to be incorporated into a comprehensive rockburstability index(RBSI).Based on 116 sets of rockburst cases,the rockburst potential was accurately quantified and predicted using the categorical boosting(CatBoost)model and the nature-inspired metaheuristic African vultures optimization algorithm(AVOA).In its performance validation,the criterion achieved the highest accuracy of 90.48%,verifying the reliability and effectiveness of the proposed RBSI ***,an interpretive method was applied to analyze the variable influence on the criterion,facilitating the explanation of predictions and the analysis of the formula’s robustness under different *** general,compared with existing criterion methods involving relevant indicators,the newly proposed RBSI criterion enhances the accuracy of rockburst potential prediction,and it can effectively and swiftly evaluate the preliminary risk of ***,a graphical user interface was developed to provide a clear visualization of the assessment of rockburst potential.

关键词： Rockburst criterion CatBoost Metaheuristic optimization Model interpretation Graphical user interface

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Enhanced service stability and thermoelectric performance in Cu_(2)−δSebased composites

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Science China Materials 2024年第7期67卷 2369-2370页

作者： Pengfei qiu Xun Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

Thermoelectric(TE)materials can directly convert the industrial waste heat into useful electricity based on the Seebeck effect,providing a promising way to tackle the environmental pollution and global energy crisis[1].In the past several decades,many new high-performance TE materials have been discovered to enrich the TE *** them,Cu_(2)−δSe-based TE materials,which are in line with the“phonon-liquid electron-crystal”concept,have sparked widespread interest due to the high TE figure-of-merit(ZT)and the combination of elements that are nontoxic and earth-abundant[2].In 2012,Liu et al.[3]reported a ZT of 1.5 at 1000 K in the stoichiometric Cu_(2)*** alloying S at the Se-site,the ZT was enhanced to around 2.0 at 1000 K[4].Via incorporating carbon nanotubes,the ZT was further enhanced to 2.4 at 1000 K[5].Moreover,Yang et al.[6]and Zhou et al.[7]reported that the ZT of Cu_(2)Se/BiCuSeO composites can reach 2.7–2.8 around 1000 K.

关键词： composites BiCuSeO performance

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y-Tuning: an efficient tuning paradigm for large-scale pre-trained models via label representation learning

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Frontiers of Computer Science 2024年第4期18卷 107-116页

作者： Yitao LIU Chenxin AN Xipeng qiu School of Computer Science Fudan UniversityShanghai 200433China

With current success of large-scale pre-trained models(PTMs),how efficiently adapting PTMs to downstream tasks has attracted tremendous attention,especially for PTMs with billions of *** work focuses on designing parameter-efficient tuning paradigms but needs to save and compute the gradient of the whole computational *** this paper,we propose y-Tuning,an efficient yet effective paradigm to adapt frozen large-scale PTMs to specific downstream tasks.y-Tuning learns dense representations for labels y defined in a given task and aligns them to fixed feature *** computing the gradients of text encoder at training phrase,y-Tuning is not only parameterefficient but also *** results show that for DeBerTaxxL with 1.6 billion parameters,y-Tuning achieves performance more than 96%of full fine-tuning on GLUE Benchmark with only 2%tunable parameters and much fewer training costs.

关键词： pre-trained model lightweight fine-tuning paradigms label representation

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