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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan Yi-Lin Zhang zhuo-er qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

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SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl^(−) accumulation in respiratory epithelium

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Signal Transduction and Targeted Therapy 2022年第8期7卷 3080-3092页

作者： Lei Chen Wei-Jie Guan zhuo-er qiu Jian-Bang Xu Xu Bai Xiao-Chun Hou Jing Sun Su Qu Ze-Xin Huang Tian-Lun Lei Zi-Yang Huang Jincun Zhao Yun-Xin Zhu Ke-Nan Ye Zhao-Rong Lun Wen-Liang Zhou Nan-Shan Zhong Yi-Lin Zhang School of Life Sciences Sun Yat-sen UniversityGuangzhouChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina Guangzhou Laboratory GuangzhouChina

SARS-CoV-2,the culprit pathogen of COVID-19,elicits prominent immune responses and cytokine *** Cl^(−)is a crucial regulator of host defense,whereas the role of Cl^(−)signaling pathway in modulating pulmonary inflammation associated with SARS-CoV-2 infection remains *** using human respiratory epithelial cell lines,primary cultured human airway epithelial cells,and murine models of viral structural protein stimulation and SARS-CoV-2 direct challenge,we demonstrated that SARS-CoV-2 nucleocapsid(N)protein could interact with Smad3,which downregulated cystic fibrosis transmembrane conductance regulator(CFTR)expression via *** intracellular Cl^(−)concentration([Cl^(−)]i)was raised,resulting in phosphorylation of serum glucocorticoid regulated kinase 1(SGK1)and robust inflammatory *** or knockout of SGK1 abrogated the N protein-elicited airway ***,N protein promoted a sustained elevation of[Cl^(−)]i by depleting intracellular cAMP via upregulation of phosphodiesterase 4(PDE4).Rolipram,a selective PDE4 inhibitor,countered airway inflammation by reducing[Cl^(−)]*** findings suggested that Cl^(−)acted as the crucial pathological second messenger mediating the inflammatory responses after SARS-CoV-2 *** the Cl^(−)signaling pathway might be a novel therapeutic strategy for COVID-19.

关键词： inflammation respiratory epithelium

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Two-dimensional lateral magnetic tunnel junction with ultrahigh tunneling magnetoresistance

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Nano Research 2025年第2期18卷 958-964页

作者： qiu-qiu Li Zhi-Fu Duan Wen-Wen Liu Rong Yang Bo Li Ke-qiu Chen Changsha Semiconductor Technology and Application Innovation Research Institute College of Semiconductors(College of Integrated Circuits)Hunan UniversityChangsha 410082China Department of Applied Physics School of Physics and ElectronicsHunan UniversityChangsha 410082China Research Institute of Hunan University in Chongqing Chongqing 401120China Shenzhen Research Institute of Hunan University Shenzhen 518063China

Giant tunneling magnetoresistance(TMR)has always been a pursuit in the research of magnetic tunnel junctions(MTJ).Two-dimensional(2D)magnetic materials have been used to construct lateral MTJ with high *** we investigated the crystal structure and magnetic property of CrSI monolayer,and found that it is a ferromagnetic semiconductor with a Curie temperature of about 180 *** CrSI monolayer with Li adsorption(Li-CrSI)show ferromagnetic half-metallic with a high Curie temperature of 300 *** we designed a lateral Li CrSI/CrSI/Li-CrSI monolayer *** TMR of the MTJs along b transport direction is 3 orders of magnitude times larger than that of the a transport direction,which should result from the different spin filtering ability along the two *** TMR of b transport direction in the MTJ is 7.67×10^(14),which is significantly higher than that of any reported lateral MTJs based on 2D *** results provide a promising avenue for designing lateral MTJs with giant TMR and high Curie temperature.

关键词： two-dimensional materials magnetic tunnel junctions CrSI monolayer tunneling magnetoresistance Li atom adsorption

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Spatial confinement:An effective strategy to improve H_(2)O and SO_(2) resistance of the expandable graphite-modified TiO_(2)-supported Pt nanocatalysts for CO oxidation

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Journal of Environmental Sciences 2025年第2期148卷 57-68页

作者： Hongtai Zhu Wenge qiu RuiWu Kai Li Hong He Key Laboratory of Beijing on Regional Air Pollution Control Beijing Key Laboratory for Green Catalysis and SeparationBeijing University of TechnologyBeijing 100124China Advanced E-Catal.Corporation Ltd.Beijing 100025China

The expandable graphite(EG)modified TiO_(2) nanocomposites were prepared by the high shearmethod using the TiO_(2) nanoparticles(NPs)and EG as precursors,in which the amount of EG doped in TiO_(2) was 10 wt.%.Followed by the impregnation method,adjusting the pH of the solution to 10,and using the electrostatic adsorption to achieve spatial confinement,the Pt elementswere mainly distributed on the exposed TiO_(2),thus generating the Pt/10EG-TiO_(2)-10 *** best CO oxidation activity with the excellent resistance to H_(2)O and SO_(2) was obtained over the Pt/10EG-TiO_(2)-10 catalyst:CO conversion after 36 hr of the reaction was ca.85%under the harsh condition of 10 vol.%H_(2)O and 100 ppm SO_(2) at a high gaseous hourly space velocity(GHSV)of 400,000 hr−*** properties of the catalystswere characterized by various *** results showed that the electrostatic adsorption,which riveted the Pt elements mainly on the exposed TiO_(2) of the support surface,reduced the dispersion of Pt NPs on EG and achieved the effective dispersion of Pt NPs,hence significantly improving CO oxidation activity over the Pt/10EG-TiO_(2)-10 *** 10 wt.%EG doped in TiO_(2) caused the TiO_(2) support to form a more hydrophobic surface,which reduced the adsorption of H_(2)O and SO_(2) on the catalyst,greatly inhibited deposition of the TiOSO4 and formation of the PtSO4 species as well as suppressed the oxidation of SO_(2),thus resulting in an improvement in the resistance to H_(2)O and SO_(2) of the Pt/10EG-TiO_(2)-10 catalyst.

关键词： Expandable graphite Electrostatic adsorption Titania supported platinum CO oxidation Resistance to H_(2)O and SO_(2)

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An investigation on the wind profiles and gravity wave dynamics in MLT region based on the meteor radars from the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 29-38页

作者： Tai Liu Zhe Wang MengXi Shi Willie Soon ShiCan qiu Department of Geophysics College of the Geology Engineering and GeomaticsChang’an UniversityXi’an 710054China Center for Environmental Research and Earth Sciences(CerES) SalemMA 01970USA Institute of Earth Physics and Space Science(ELKH EPSS) 9400SopronHungary

The meteor radar can detect the zenith angle,azimuth,radial velocity,and altitude of meteor trails so that one can invert the wind profiles in the mesosphere and low thermosphere(MLT)region,based on the Interferometric and Doppler *** this paper,the horizontal wind field,gravity wave(GW)disturbance variance,and GW fluxes are analyzed through the meteor radar observation from 2012−2022,at Mohe(53.5°N,122.4°E)and Zuoling(30.5°N,114.6°E)stations of the(Chinese)Meridian *** Lomb−Scargle periodogram method has been utilized to analyze the periodic variations for time series with observational data *** results show that the zonal winds at both stations are eastward dominated,while the meridional winds are southward *** variance of GW disturbances in the zonal and meridional directions increases gradually with height,and there is a strong pattern of annual *** zonal momentum flux of GW changes little with height,showing weak annual *** meridional GW flux varies gradually from northward to southward with height,and the annual periodicity is *** both stations,the maximum values of zonal and meridional wind occur close to the peak heights of GW flux,with opposite *** observational evidence is consistent with the filtering *** horizontal wind velocity,GW flux,and disturbance variance of the GW at Mohe are overall smaller than those at Zuoling,indicating weaker activities in the MLT at *** power spectral density(PSD)calculated by the Lomb−Scargle periodogram shows that there are 12-month period and 6-month period in horizontal wind field,GW disturbance variance and GW flux at both stations,and especially there is also a 4-month cycle in the disturbance *** PSD of the 12-month and 6-month cycles exhibits maximum values below 88 km and above 94 km.

关键词： meteor radar wind field gravity wave Lomb−Scargle method

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Ozonolysis of ketoprofen in polluted water:Reaction pathways,kinetics,removal efficiency,and health effects

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Journal of Environmental Sciences 2025年第1期147卷 451-461页

作者： Qiong Mei Zhaoxu qiu Jinchan Jiang Mingxue Li Qizhao Wang Maoxia He School of Land Engineering Shaanxi Key Laboratory of Land ConsolidationChang’an UniversityXi’an 710064China School of Water and Environment Chang’an UniversityXi’an 710054China Environment Research Institute Shandong UniversityQingdao 266237China Weihai Water Conservancy Service Center Weihai 264200China

Ketoprofen(KET),as a non-steroidal anti-inflammatory drug frequently detected in aqueous environments,is a threat to human health due to its accumulation and low biodegradability,which requires the transformation and degradation of KET in aqueous *** this paper,the reaction process of ozone-initiated KET degradation in water was investigated using density functional theory(DFT)method at the M06-2X/6-311++g(3df,2p)//M06-2X/6-31+g(d,p)*** detailed reaction path of KET ozonation is *** thermodynamic results show that ozone-initiated KET degradation is *** ultraviolet irradiation,the reaction of ozone with water can also produce OH radicals(HO·)that can react with *** degradation reaction of KET caused by HO·was further *** kinetic calculation illustrates that the reaction rate(1.99×10-1(mol/L)^(-1)sec^(-1))of KET ozonation is relatively slow,but the reaction rate of HO·reaction is relatively high,which can further improve the degradation *** this basis,the effects of pollutant concentration,ozone concentration,natural organic matter,and pH value on degradation efficiency under UV/O3 process were *** ozonolysis reaction of KET is not sensitive to pH and is basically ***,the toxicity prediction of oxidation compounds produced by degradation reaction indicates that most of the degradation products are harmless,and a few products containing benzene rings are still toxic and have to be *** study serves as a theoretical basis for analyzing the migration and transformation process of anti-inflammatory compounds in the water environment.

关键词： Ozonolysis,Ketoprofen Degradation mechanisms OH radicals Aquatic toxicity Degradation efficiency

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Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 510006GuangdongChina Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang 515200GuangdongChina Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of TechnologyGuangzhou 510006GuangdongChina

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo_(2)O_(4)spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo_(2)O_(4)spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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Bond length and interface failure mechanism of anchor cable under continuous radial pressure conditions

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International Journal of Mining Science and Technology 2025年第2期35卷 231-247页

作者： Jian Ouyang Xiuzhi Shi Xianyang qiu Zongguo Zhang Zeyu Li School of Resources and Safety Engineering Central South UniversityChangsha 410083China

The anchoring capacity of the anchor cable is closely related to the bonding length and radial pressure *** field pull-out tests,theoretical analysis,numerical simulation,and industrial tests,this study clarifies the relationship between radial pressure and bonding length for the ultimate pullout force and reveals the microscopic failure process of the resin-rock interface in the anchoring *** results show that the ultimate load increases with the increase of bonding length in three different stages:rapid,slow,and uniform *** new mechanical model developed considering radial pressure describes the inverse relationship between radial pressure and the plastic zone on the bonding section,and quantifies the reinforcing effect of confining pressure on the anchoring *** the pull-out process of the anchor cable,the generation of failure cracks is in the order of orifice,bottom,and middle of the *** pressure can effectively enhance the ultimate pull-out force,alleviate the oscillation increase of pull-out force,and inhibit resin cracking,but will produce an external crushing *** also reveals the synergistic effect between bonding length and radial pressure,and successfully carries out industrial tests of anchor cable support,which ensures the stability of the stope roof and provides an important reference for the design of anchor cable support in deep high-stress mines.

关键词： Radial pressure Anchor cable Bond length Numerical simulation Interface failure Microscopic process

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Constructing Pr-doped CoOOH catalytic sites for efficient electrooxidation of 5-hydroxymethylfurfural

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Journal of Energy Chemistry 2025年第1期100卷 234-244页

作者： Botao Fan Hao Zhang Bang Gu Feng qiu qiue Cao Wenhao Fang School of Chemical Science and Technology Yunnan UniversityKunming 650091YunnanChina National Center for International Research on Photoelectric and Energy Materials School of Materials and EnergyYunnan UniversityKunming 650091YunnanChina

Electrocatalytic conversion of renewable biomass is emerging as a promising route for sustainable chemical production;hence it urgently calls for developing efficient electrocatalysts with low potentials and high current ***,a Pr-doped Co(OH)_(2)hexagonal sheet(Pr/Co=1/9,in mole)is synthesized by electrodeposition as highly performant catalyst for 5-hydroxymethylfurfural(HMF)oxidation reaction(HMFOR)to produce 2,5-furandicarboxylic acid(FDCA).This novel and low-cost catalyst possesses a rather low onset potential of 1.05 V(***)and requires only 1.10 V(***)to reach a current density of 10 mA cm^(-2)for HMFOR,significantly outperforming Co(OH)_(2)benchmark(i.e.,210 mV higher to reach10 m A cm^(-2)).The origin of Pr promotion effect as well as the evolution of CoOOH catalytic sites and HMFOR process has been deeply elucidated by physical characterizations,kinetic experiments,in situ electrochemical techniques,and theoretical *** unique Pr-ameliorated CoOOH active centers enable 100%conversion of HMF,99.6%selectivity of FDCA,and 99.7%Faraday efficiency,with a superior cycling durability toward *** can be one of the most outstanding results for Co-based HMFOR catalysts to date in the *** this work can help open up new horizons for constructing novel and efficient Co-based electrocatalysts by the utilization of lanthanide elements.

关键词： Biomass conversion Electrocatalysis 2,5-Furandicarboxylic acid Doped Co catalyst Co3+active sites Charge transfer rate

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Cotransport of nanoplastics with nZnO in saturated porous media:From brackish water to seawater

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Journal of Environmental Sciences 2025年第2期148卷 541-552页

作者： Yuanzhang Hou Yange Wang Yidi Zhang Zhibo Lu Zhenbo Zhang Zhiqiang Dong Yuping qiu Department of Environmental Science College of Environmental Science and EngineeringTongji UniversityState Key Laboratory of Pollution Control and Resources ReuseShanghai Institute of Pollution Control and Ecological SecurityShanghai 200092China School of Medicine Tongji UniversityShanghai 200065China Municipal Environmental Protection Engineering Co. Ltd of CERC Shanghai GroupShanghai 201906China China Railway Engineering Group Co. Beijing 100039China

The ocean serves as a repository for various types of artificial ***(NPs)and nano zinc oxide(nZnO),which are frequently employed in personal care products and food packaging materials,are likely simultaneously released and eventually into the ocean with surface ***,their mutual influence and shared destiny in marine environment cannot be *** study examined how nanomaterials interacted and transported through sea sand in various salinity *** showed that NPs remained dispersed in brine,while nZnO formed *** seawater of 35 practical salinity units(PSU),nZnO formed heteroaggregates with NPs,inhibiting NPs mobility and decreasing the recovered mass percentage(Meff)from 24.52%to 12.65%.In 3.5 PSU brackish water,nZnO did not significantly aggregate with NPs,and thus barely affected their ***,NPs greatly enhanced nZnO transport with Meff increasing from 14.20%to 25.08%,attributed to the carrier effect of higher mobility *** from brackishwater to seawater was simulated in salinity change experiments and revealed a critical salinity threshold of 10.4 PSU,below which the mobility of NPs was not affected by coexisting nZnO and above which nZnO strongly inhibited NP *** study highlights the importance of considering the mutual influence and shared destiny of artificial nanoparticles in the marine environment and how their interaction and cotransport are dependent on changes in seawater salinity.

关键词： Homoaggregate Heteroaggregate Transport Sea sand Salinity threshold

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