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Effect of titanium dioxide nanoparticles on zebrafish embryos and developing retina

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 917-923页

作者： Ya-Jie Wang Zi-Zi He yang-Wu Fang yang Xu Ya-Nan Chen Guan-Qun Wang Yong-Qiang yang zhuo yang Yu-Hao Li Key Laboratory of Tumor Microenviroment and Neurovascular Regulation Nankai University School of Medicine State Key Laboratory of Medicinal Chemical Biology College of ChemistryNankai University

AIM: To investigate the impact of titanium dioxide nanoparticles(Ti O2NPs) on embryonic development and retinal ***: The agglomeration and sedimentation of Ti O2 NPs solutions at different dilutions were observed,and the ultraviolet-visible spectra of their supernatants were measured. Zebrafish embryos were experimentally exposed to Ti O2 NPs until 72 h postfertilization(hpf). The retinal neurogenesis and distribution of the microglia were analyzed by immunohistochemistry and whole mount in situ ***: The 1 mg/L was determined to be an appropriate exposure dose. Embryos exposed to Ti O2 NPs had a normal phenotype. The neurogenesis was initiated on time, and ganglion cells, cones and rods were well differentiated at 72 hpf. The expression of fms m RNA and the 4C4 antibody, which were specific to microglia in the central nervous system(CNS), closely resembled their endogenous ***: These data demonstrate that short-term exposure to Ti O2 NPs at a low dose does not lead to delayed embryonic development or retinal neurotoxicity.

关键词： titanium dioxide nanoparticles retina microglia zebrafish

Metalloprotein-inspired supramolecular photodynamic nanodrugs by multicomponent coordination for deep penetration and enhanced biofilm eradication

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Nano Research 2023年第5期16卷 7312-7322页

作者： zhuo-Ran yang Jingyi Xiong Sirui Wei Kehan Du Huimin Qin Teng Ma Niannian Lv Xinyu Yu Hao Jiang Jintao Zhu Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China Department of Neurosurgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Bacterial infections exacerbate the formation of bacterial biofilms,leading to resistance to traditional drugs,persistent infection,and even threatening patient’s *** antimicrobial materials against drug-resistant bacterial biofilms are highly *** this study,a photodynamic nanodrug with bacterial targeting was constructed by cooperative coordination of zinc ion with an antimicrobial peptide with hydrophobic tripeptides on the side chains and the photosensitizer chlorin *** supramolecular nanodrug with a uniform spherical structure possessed high photosensitizer loading capacity and enhanced photodynamic efficacy,which could deep penetrate and eradicate methicillin-resistant Staphylococcus aureus(MRSA)biofilms upon 655 nm laser ***,in vivo experiments verified the efficient elimination of MRSA biofilms on implanted *** study provides a novel strategy to fabricate metalloprotein-inspired supramolecular photodynamic nanodrugs against drugresistant bacterial biofilms-associated infections in vivo.

关键词： photodynamic therapy supramolecular assembly coordination deep penetration biofilm eradication

High-capacity dilithium hydroquinone cathode material for lithium-ion batteries

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National Science Review 2024年第6期11卷 206-213页

作者： Yong Lu Haoqin Han zhuo yang Youxuan Ni Zhicheng Meng Qiu Zhang Hao Wu Weiwei Xie Zhenhua Yan Jun Chen Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) State Key Laboratory of Advanced Chemical Power SourcesCollege of ChemistryNankai University

Lithiated organic cathode materials show great promise for practical applications in lithium-ion batteries owing to their Li-reservoir characteristics. However, the reported lithiated organic cathode materials still suffer from strict synthesis conditions and low capacity. Here we report a thermal intermolecular rearrangement method without organic solvents to prepare dilithium hydroquinone（Li2Q）, which delivers a high capacity of 323 m Ah g-1with an average discharge voltage of 2.8 V. The reversible conversion between orthorhombic Li2Q and monoclinic benzoquinone during charge/discharge processes is revealed by in situ X-ray diffraction. Theoretical calculations show that the unique Li–O channels in Li2Q are beneficial for Li+ion diffusion. In situ ultraviolet-visible spectra demonstrate that the dissolution issue of Li2Q electrodes during charge/discharge processes can be handled by separator modification, resulting in enhanced cycling stability. This work sheds light on the synthesis and battery application of high-capacity lithiated organic cathode materials.

关键词： lithium-ion batteries cathode materials lithiated organic materials dilithium hydroquinone separator modification

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从物理学角度认知计算神经动力学（英文）

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2019年第9期20卷 639-659页

作者： Jun MA zhuo-qin yang Li-jian yang Jun TANG Department of Physics Lanzhou University of TechnologyLanzhou730050China School of Mathematics and Systems Science Beihang UniversityBeijing100191China Department of Physics Central China Normal UniversityWuhan430079China School of Physics China University of Mining and TechnologyXuzhou221116China

目的:基于物理学基本原理解释神经元电活动过程中存在的物理效应,解释突触生物功能活化过程的物理机制,以及分析神经元建模中的电磁场效应(图1)。探讨神经元建模、胶质细胞调控、突触可塑性和神经元群体电活动的网络效应。创新点:1.论... 详细信息

目的:基于物理学基本原理解释神经元电活动过程中存在的物理效应,解释突触生物功能活化过程的物理机制,以及分析神经元建模中的电磁场效应(图1)。探讨神经元建模、胶质细胞调控、突触可塑性和神经元群体电活动的网络效应。创新点:1.论证荷控和磁控忆阻器非线性函数在物理神经元模型构建中的作用。2.提出神经元突触耦合的物理机制就是电场和磁场耦合(图3)。3.研究神经元电路混合突触耦合的物理实现(图2)以及能量存储与泵浦。方法:依据物理学电磁感应定律和赫姆霍兹定理论证神经元电活动过程产生的电磁感应效应以及能量输运过程。基于忆阻器物理特性和量纲一致原理来构建物理神经元模型,从物理角度解释突触功能实现过程的物理机制。结论:在神经元电活动过程中需考虑电磁感应效应;场耦合可以调控神经元突触耦合作用;在神经元网络中信号传递需考虑物理场耦合过程。

关键词：神经元神经网络自突触哈密顿能量电磁感应

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Dexmedetomidine Attenuates High Glucose-induced HK-2 Epithelial-mesenchymal Transition by Inhibiting AKT and ERK

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Biomedical and Environmental Sciences 2020年第5期33卷 323-330页

作者： PAN Qi Zheng LI Kai yang zhuo Dong GAO Ming SHI Jia Hong REN Shu Ping ZHAO Guo Qing Department of Anesthesiology China-Japan Union HospitalJilin UniversityChangchun 130033JilinChina Department of Occupational and Environmental Health School of Public HealthJilin UniversityChangchun 130021JilinChina Department of Ultrasound China-Japan Union HospitalJilin UniversityChangchun 130033JilinChina

Objective To explore the protective effects of dexmedetomidine(Dex)against high glucose-induced epithelial-mesenchymal transition in HK-2 cells and relevant *** HK-2 cells were exposed to either glucose or glucose+Dex for 6 *** production of ROS,morphology of HK-2 cells,and cell cycle were ***,the expression of AKT,p-AKT,ERK,pERK,PI3 K,E-Cadherin,Claudin-1,andα-SMA were determined and compared between HK-2 cells exposed to glucose and those exposed to both glucose and Dex with or without PI3 K/AKT pathway inhibitor LY294002 and ERK pathway inhibitor *** Compared with HK-2 cells exposed to high level of glucose,the HK-2 cells exposed to both high level of glucose and Dex showed:(1)lower level of ROS production;(2)cell morphology was complete;(3)more cells in G1 phase;(4)lower expression of p-AKT,p-ERK andα-SMA,higher expression of ECadherin and ***3 K/AKT inhibitor LY294002 and ERK inhibitor U0126 decreased the expression of p-AKT,p-ERK andα-SMA,and increased the expression of E-Cadherin and *** Dex can attenuate high glucose-induced HK-2 epithelial-mesenchymal transition by inhibiting AKT and ERK.

关键词： Dexmedetomidine Epithelial-mesenchymal transition High glucose Oxidative stress HK-2 cells

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Clinical Application of Double Ovulation Stimulation in Patients with Diminished Ovarian Reserve and Asynchronous Follicular Development Undergoing Assisted Reproduction Technology

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Current Medical Science 2023年第2期43卷 304-312页

作者： Yi-zhuo yang Ming ZHANG Sha MU Xin-meng Guo Hui WANG Zhe TANG Hong-mei PENG Department of Obstetrics and Gynecology First Medical Center of the Chinese People’s Liberation Army General HospitalBeijing100853China College of Medicine Nankai UniversityTianjin300071China

Objective This study aimed to compare the clinical effects of double ovulation stimulation(DouStim)applied during the follicular and luteal phases with the antagonist protocol in patients with diminished ovarian reserve(DOR)and asynchronous follicular development undergoing assisted reproductive technology(ART).Methods The clinical data of patients with DOR and asynchronous follicular development receiving ART from January 2020 to December 2021 were retrospectively *** patients were divided into two groups according to their ovulation stimulation protocol:DouStim group(n=30)and antagonist group(n=62).Assisted reproduction and clinical pregnancy outcomes were compared between the two *** In the DouStim group,the number of oocytes retrieved,metaphase II(MII)oocytes,two-pronuclei(2PN),day 3(D3)embryos,D3 high-quality embryos as well as blastocyst formation,implantation,and human chorionic gonadotropin-positive rates were significantly greater than those in the antagonist group(all P0.05).Except for the early medical abortion rate,the DouStim group generally had favorable *** the DouStim group,the dosage and duration of gonadotropin and the fertilization rate were significantly greater in the first ovulation stimulation induction than in the second ovulation stimulation induction(P<0.05).Conclusion The DouStim protocol efficiently and economically obtained more mature oocytes and high-quality embryos for patients with DOR and asynchronous follicular development.

关键词： diminished ovarian reserve double ovulation stimulation follicular phase stimulation luteal phase stimulation

Common bile duct morphology is associated with recurrence of common bile duct stones in Billroth II anatomy patients

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World Journal of Clinical Cases 2021年第26期9卷 7671-7681页

作者： Xu Ji Wen Jia Qian Zhao Yao Wang Shu-Ren Ma Lu Xu Ying Kan yang Cao Bao-Jun Fan zhuo yang Department of Digestive Endoscopy General Hospital of Northern Theater CommandShenyang 110840Liaoning ProvinceChina Postgraduate College Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Postgraduate College Liaoning University of Traditional Chinese MedicineShenyang 110847Liaoning ProvinceChina Postgraduate College Jinzhou Medical UniversityJinzhou 121001Liaoning ProvinceChina

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is the primary choice for removing common bile duct(CBD)stones in Billroth II anatomy *** recurrence of CBD stones is still a challenging *** To evaluate CBD morphology and other predictors affecting CBD stone *** A retrospective case-control analysis was performed on 138 CBD stones patients with a history of Billroth II gastrectomy,who underwent therapeutic ERCP for stone extraction at our center from January 2011 to October *** morphology and other predictors affecting CBD stone recurrence were examined by univariate analysis and multivariate logistic regression *** CBD morphology(P<0.01)and CBD diameter≥1.5 cm(odds ratio[OR]=6.15,95%confidence interval[CI]:1.87-20.24,P<0.01)were the two independent risk *** multivariate analysis,the recurrence rate of patients with S type was 16.79 times that of patients with straight type(OR=16.79,95%CI:4.26-66.09,P<0.01),the recurrence rate of patients with polyline type was 4.97 times that of patients with straight type(OR=4.97,95%CI:1.42-17.38,P=0.01),and the recurrence rate of S type patients was 3.38 times that of patients with polyline type(OR=3.38,95%CI:1.07-10.72,P=0.04).CONCLUSION CBD morphology,especially S type and polyline type,is associated with increased recurrence of CBD stones in Billroth II anatomy patients.

关键词： Endoscopic retrograde cholangiopancreatography Common bile duct stones Recurrence Billroth II anatomy Common bile duct morphology Risk factors

SMALL KERNEL4 is required for mitochondrial cox1 transcript editing and seed development in maize

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Journal of Integrative Plant Biology 2020年第6期62卷 777-792页

作者： Hong-Chun Wang Aqib Sayyed Xin-Yuan Liu Yan-zhuo yang Feng Sun Yong Wang Miaodi Wang Bao-Cai Tan Key Laboratory of Plant Development and Environment Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China

In land plants,cytidine-to-uridine(C-to-U)editing of organellar transcripts is an important posttranscriptional process,which is considered to remediate DNA genetic mutations to restore the coding of functional *** repeat(PPR)proteins have key roles in C-to-U *** to its large number,however,the biological functions of many PPR proteins remain to be *** characterizing a small kernel4(smk4)mutant,here we report the function of Smk4 and its role in maize growth and *** mutation of Smk4 slows plant growth and development,causing small plants,delayed flowering time,and small *** revealed that Smk4 encodes a new E-subclass PPR protein,and localization indicated that SMK4 is exclusively localized in *** of Smk4 function abolishes C-to-U editing at position 1489 of the cytochrome c oxidase1(cox1)transcript,causing an amino acid change from serine to proline at 497 in ***1 is a core component of mitochondrial complex ***,complex IV activity is reduced in the smk4,along with drastically elevated expression of alternative oxidases(AOX).These results indicate that SMK4 functions in the C-to-U editing of cox1-1489,and this editing is crucial for mitochondrial complex IV activity,plant growth,and kernel development in maize.

关键词： cox1 editing maize

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Stereotactic aspiration for hypertensive intracerebral haemorrhage in a Chinese population:a retrospective cohort study

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Stroke & Vascular Neurology 2019年第1期4卷 14-21页

作者： Xuyang Zhang Shaolong Zhou Qiang Zhang Xudong Fu Yuehui Wu Jiasheng Liu Bo Liang zhuo yang Xinjun Wang Department of Neurosurgery The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Radiation Oncology and Comprehensive Cancer Center The University of MichiganAnn ArborMichiganUSA Department of Neurosurgery Neihuang People’s HospitalNeihuangChina

Objective We aimed to compare the therapeutic effects of stereotactic aspiration and best medical management in patients who developed supratentorial hypertensive intracerebral haemorrhage(HICH)with a volume of haemorrhage between 20 and 40 *** The clinical data of 220 patients with supratentorial HICH with a volume between 20 and 40 mL were retrospectively *** them,142 received stereotactic aspiration surgery(stereotactic aspiration group)and 78 received best medical management(conservative group).All were followed up for 6 *** logistic regression and Kaplan-Meier survival curves were used to compare the outcome between the two *** The rebleeding rate was lower in the group that had stereotactic aspiration when compared with the group with medical treatment(6[4.2%]vs 9[11.5%],χ2=4.364,p=0.037).After 6 months,although the mortality rate did not differ significantly between the two groups(8 cases[5.6%]vs 10 cases[12.8%],χ2=3.461,p=0.063),the rate of a favourable outcome was higher in the group who received stereotactic aspiration(χ2=15.870,p=0.000).Logistic regression identified that medical treatment(OR=1.64,p=0.000)was an independent risk factor for an unfavourable *** Kaplan-Meier curves indicated that the median favourable outcome time in the stereotactic aspiration group was 59.5 days compared with that in the medically treated group(87.0 days).The log-rank test indicated that the prognosis at 6 months was better for those treated with stereotactic haematoma aspiration(χ2=29.866,p=0.000).However,the 6-month survival rate was similar between the two groups(χ2=3.253,p=0.068).Conclusions Stereotactic haematoma aspiration significantly improved the quality of life,although did not effectively reduce the rate of *** selected appropriately,patients with HICH may benefit from this type of surgical intervention.

关键词： hypertensive mortality Stereo