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Orthotopic liver transplantation as a rescue operation for recurrent hepatocellular carcinoma after partial hepatectomy

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World Journal of Gastroenterology 2008年第27期14卷 4370-4376页

作者： zhuo shao Rocio Lopez Bo Shen Guang-Shun Yang Department of Biliary Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China Digestive Disease Center Cleveland Clinic Cleveland OH 44195 United States

AIM: To compare post-orthotopic liver transplantation (OLT) survival between patients with recurrent hepatocellular carcinoma (HCC) after partial hepatectomy and those who received de novo OLT for HCC and to assess the risk factors associated with post-OLT mortality. METHODS: From July 2003 to August 2005, 77 consecutive HCC patients underwent OLT, including 15 patients with recurrent HCC after partial hepatectomy for tumor resection (the rescue OLT group) and 62 patients with de novo OLT for HCC (the de novo OLT group). Thirty-three demographic, clinical, histological, laboratory, intra-operative and post-operative variables were analyzed. Survival was calculated by the Kaplan- Meier method. Univariable and multivariable analyses were also performed. RESULTS: The median age of the patients was 49.0 years. The median follow-up was 20 mo. Three patients (20.0%) in the rescue OLT group and 15 patients (24.2%) in the de novo OLT group died during the follow-up period (P = 0.73). The 30-day mortality of OLT was 6.7% for the rescue OLT group vs 1.6% for the de novo OLT group (P = 0.27). Cox proportional hazards model showed that pre-OLT hyperbilirubinemia, the requirement of post-OLT transfusion, the size of the tumor, and family history of HCC were significantly associated with a higher hazard for mortality. CONCLUSION: There are no significant differences in survival/mortality rates between OLT as de novo therapy and OLT as a rescue therapy for patients with hcc. Pre-OLT hyperbilirubinemia, post-OLT requirement of transfusion, large tumor size and family history of HCC are associated with a poor survival outcome.

关键词： Orthotopic liver transplantation Liver cancer Resection Recurrence Survival

Greedy feature replacement for online value function approximation

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第3期15卷 223-231页

作者： Feng-fei ZHAO Zheng QIN zhuo shao Jun FANG Bo-yan REN Department of Computer Science and Technology Tsinghua University School of Software Tsinghua University Department of Physics and State Key Laboratory of Low-Dimensional Quantum Physics Tsinghua University

Reinforcement learning(RL) in real-world problems requires function approximations that depend on selecting the appropriate feature representations. Representational expansion techniques can make linear approximators represent value functions more effectively; however, most of these techniques function well only for low dimensional problems. In this paper, we present the greedy feature replacement(GFR), a novel online expansion technique, for value-based RL algorithms that use binary features. Given a simple initial representation, the feature representation is expanded incrementally. New feature dependencies are added automatically to the current representation and conjunctive features are used to replace current features greedily. The virtual temporal difference(TD) error is recorded for each conjunctive feature to judge whether the replacement can improve the approximation. Correctness guarantees and computational complexity analysis are provided for GFR. Experimental results in two domains show that GFR achieves much faster learning and has the capability to handle large-scale problems.

关键词： Reinforcement learning Function approximation Feature dependency Online expansion Feature replacement

Pearprocess:A new phenotypic tool for stone cell trait evaluation in pear fruit

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Journal of Integrative Agriculture 2020年第6期19卷 1625-1634页

作者： XUE Yong-song XU shao-zhuo XUE Cheng WANG Run-ze ZHANG Ming-yue LI Jia-ming ZHANG shao-ling WU Jun Center of Pear Engineering Technology Research State Key Laboratory of Crop Genetics and Germplasm EnhancementNanjing Agricultural UniversityNanjing 210095P.R.China

The content of stone cells is an important factor for pear breeding as a high content indicates severely reduced fruit quality in terms of fruit *** the frozen-HCI method is currently a common method used to evaluate stone cell content in pears,it is limited in incomplete separation of stone cell and pulp and is time consuming and *** research is a promising strategy in modern scientific research for phenotypic data collect!on and is increasingly used in studying *** far,we lack a quantitative tool that can effectively determine stone cell content in pear *** developed a program,Pearprocess,based on an imaging protocol using computer vision and image processing algorithms applied to digital *** photos of hand-cut sections of pear fruit stained with phloroglucin-HCI(Wiesner's reagent),Pearprocess can extract and analyze image-based data to quantify the stone cell-related traits measured in this study:number,size,area and density of stone *** quantified these traits for 395 pear accessions by Pearprocess and revealed large variation in different pear varieties and *** number of stone cells varied greatly from value of 138 to 2866,the density of stone cells ranged from 0.0019 to 0.0632 cm2 cm-2,the distribution of stone cell area ranged from 0.06 to 2.02 cm2,and the stone cell size was between 2e-4 and 1e-3 ***,trait data were correlated with fruit taste *** found that stone cell density is likely the most important factor affecting the taste of pear *** summary,Pearprocess is a new cost-effective web-application for semi-automated quantification of two-dimensional phenotypic traits from digital imagery using an easy imaging *** simpler,feasible and accurate method to evaluate stone cell traits of fruit is a promising new tool for use in evaluating future germplasms for crop breeding programs.

关键词： Pearprocess software quantitative tool stone cell traits

The extracellular secretion of miR-1825 wrapped by exosomes increases CLEC5A expression:A potential oncogenic mechanism in ovarian cancer

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BIOCELL 2023年第5期47卷 1039-1050页

作者： QIAOLING WU ZHAOLEI CUI HONGMEI XIA SHAN JIANG JING BAI zhuo shao YANG SUN Department of Gynecology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Gynecology Shengli Clinical Medical College of Fujian Medical UniversityFuzhouChina Laboratory of Biochemistry and Molecular Biology Research Department of Clinical LaboratoryClinical Oncology School of FujianMedical UniversityFujian Cancer HospitalFuzhouChina Geneplus-Beijing Institute BeijingChina

Background:Ovarian cancer(OC)is a leading cause of gynecological cancer-linked deaths *** miR-1825 and its target gene C-type lectin domain family 5 member A(CLEC5A)are associated with tumorigenesis in cancers that was further ***:Exosomal miR-1825 expression in exosomes and its impact on overall survival(OS)prediction were determined using Gene Expression Omnibus(GEO)and The Cancer Genome Atlas(TCGA)*** genes of miR-1825 were searched in five prediction databases and prognostically significant differentially expressed genes were *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were carried *** ability of CLEC5A to predict OS was evaluated using univariate and multivariate Cox regression analyses and Kaplan-Meier *** CLEC5A expression pattern in OC was validated using *** CIBERSORT algorithm was used to compare the immune cell landscape,and the results were validated in a GEO ***,the predicted half maximal inhibitory concentration(IC50)values for five commonly used chemotherapy agents were also ***:MiR-1825 level was higher in exosomes derived from OC cells and served as a tumor *** CLEC5A gene was found to be a target of miR-1825,the upregulation of which was correlated with a poor prognosis.M2 macrophage infiltration was significantly enhanced in the CLEC5A high expression group,while T follicular helper cell infiltration was reduced in *** the predicted IC50 for cisplatin and doxorubicin was higher in the CLEC5A high expression group,that of docetaxel,gemcitabine,and paclitaxel was ***:MiR-1825,a promising OC biomarker,may promote OC progression by increasing CLEC5A expression via exosome-mediated efflux from tumor cells.

关键词： Exosome MicroRNA-1825 C-type lectin domain family 5 member A PI3K-Akt pathway Tumor immune microenvironment

成本最优化工作流技术驱动的研发协同软件即服务应用

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计算机集成制造系统 2013年第8期19卷 1748-1754页

作者：武星卓少剑张武上海大学计算机工程与科学学院上海200072

为了向研发协同用户提供可组合、可裁剪的云服务和云应用,同时提高服务质量,压缩运行成本,研究并提出成本最优化工作流技术驱动的研发协同软件即服务应用架构。提出将研发协同平台的功能模块软件即服务化形成典型的软件即服务应用,同时... 详细信息

为了向研发协同用户提供可组合、可裁剪的云服务和云应用,同时提高服务质量,压缩运行成本,研究并提出成本最优化工作流技术驱动的研发协同软件即服务应用架构。提出将研发协同平台的功能模块软件即服务化形成典型的软件即服务应用,同时提出软件即服务应用的多租户管理方法,以及基于Markov链的工作流成本最优化策略。实例研究表明,所提出的研发协同的软件即服务应用的架构是准确可行的,并且可以最优化研发协同成本。

关键词：软件即服务工作流成本最优化云计算研发协同

Single-channel vector magnetic information detection method based on diamond NV color center

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Chinese Physics B 2021年第8期30卷 275-281页

作者： Qin-Qin Wang Rui-Rong Wang Jin-Ping Liu shao-zhuo Lin Liang-Wei Wu Hao Guo Zhong-Hao Li Huan-Fei Wen Jun Tang Zong-Min Ma Jun Liu Key Laboratory of Instrumentation Science and Dynamic Measurement School of Instrument and ElectronicsNorth University of ChinaTaiyuan 030051China

A method of detecting the single channel triaxial magnetic field information based on diamond nitrogen-vacancy(NV)color center is ***,the incident angle of the bias magnetic field which can achieve the equal frequency difference optically-detected magnetic resonance(ODMR)spectrum of diamond NV color center is calculated theoretically,and the triaxial magnetic information solution model is also ***,the microwave time-controlled circuit module is designed to generate equal timing and equal frequency difference microwave pulse signals in one *** with the optical detection magnetic resonance technology,the purpose of sequentially locking and detecting the four formant signals on one side of the diamond NV color center(m_(s)=-1 state signal)is achieved,and the vector magnetic field information detection is accomplished by combining the triaxial magnetic information solution *** system can obtain magnetic field detection in a range of 0 mT-0.82 *** system's magnetic noise sensitivity is 14.2 nT/Hz^(1/2),and the deviation angle errors of magnetic field detectionθ_(x) andθ_(y) are 1.3° and 8.2° respectively.

关键词： nitrogen-vacancy(NV)color center vector electron spin magnetic detection

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Wilson病的肝移植治疗(附五例报告)

第二军医大学学报 2007年第10期28卷 1159-1160页

作者：邵卓杨广顺第二军医大学东方肝胆外科医院胆道二科上海200438

肝豆状核变性(hepatolenticular degeneration, HLD)是一种常染色体隐性遗传病,发病率约1:30 000左右[1],于1912年首次由Wilson报道,故又被称为Wilson病(WD).该病发病年龄一般为12岁左右,主要特征为铜代谢障碍导致的体内铜蓄积,从而引... 详细信息

肝豆状核变性(hepatolenticular degeneration, HLD)是一种常染色体隐性遗传病,发病率约1:30 000左右[1],于1912年首次由Wilson报道,故又被称为Wilson病(WD).该病发病年龄一般为12岁左右,主要特征为铜代谢障碍导致的体内铜蓄积,从而引起患者原因不明的肝硬化以及相关的神经、精神症状,不经治疗病死率可达100%[2].自2002年10月至2005年2月间,本科共收治5例WD患者,均予肝移植手术治疗,取得一定疗效,现报告如下.

关键词： Wilson病肝移植活体肝移植

针刺对脑缺血再灌注损伤相关免疫细胞活动的调节作用

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中国康复理论与实践 2012年第5期18卷 414-416页

作者：邵卓益刘喆浙江中医药大学第三临床医学院浙江杭州市310053

缺血性脑血管病是临床的常见病和多发病,且病残率、病死率和复发率高。近年来研究表明,脑缺血再灌注后的炎症反应是导致继发性损伤的关键,免疫细胞作为脑缺血再灌注后炎症因子的靶细胞,向缺血区域浸润、聚集后,导致继发性神经元损伤和... 详细信息

缺血性脑血管病是临床的常见病和多发病,且病残率、病死率和复发率高。近年来研究表明,脑缺血再灌注后的炎症反应是导致继发性损伤的关键,免疫细胞作为脑缺血再灌注后炎症因子的靶细胞,向缺血区域浸润、聚集后,导致继发性神经元损伤和梗死面积的扩大,引起脑组织损伤。针刺调节脑缺血再灌注损伤相关免疫细胞活动的研究正逐步深入。

关键词：针刺脑缺血再灌注炎症反应免疫细胞综述

益气活血解毒方对幼龄自发性高血压大鼠内皮功能的影响

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中国实验方剂学杂志 2010年第8期16卷 154-156页

作者：岳桂华卓少元广西中医学院附属瑞康医院南宁530011 广西中医学院南宁530001

目的:研究益气活血解毒方对幼龄自发性高血压大鼠内皮功能的影响,探讨益气活血解毒方预防高血压病的机制。方法:雄性6周幼龄自发性高血压大鼠(SHR)16只随机分为益气活血解毒方组、模型组,治疗6周,分别检测治疗前后的各组大鼠血压,酶联... 详细信息

目的:研究益气活血解毒方对幼龄自发性高血压大鼠内皮功能的影响,探讨益气活血解毒方预防高血压病的机制。方法:雄性6周幼龄自发性高血压大鼠(SHR)16只随机分为益气活血解毒方组、模型组,治疗6周,分别检测治疗前后的各组大鼠血压,酶联免疫吸附(ELISA)法测定血清血管性假血友病因子(vWF)、内皮素-1(ET-1),硝酸还原法测定一氧化氮(NO)的含量,黄嘌呤及黄嘌呤氧化酶反应系统检测超氧化物歧化酶(SOD),硫代巴比妥酸比色法检测丙二醛(MDA)。并设同龄Wistar-Kyoto(WKY)大鼠8只做空白对照比较。结果:幼龄SHR血浆中vWF和MDA升高,NO和SOD降低,益气活血解毒方可以降低幼龄SHR血浆vWF和MDA,升高NO和SOD。结论:幼龄SHR已存在内皮功能不全,益气活血解毒方早期应用能改善SHR血管内皮功能。

关键词：幼龄自发性高血压大鼠血管性假血友病因子一氧化氮超氧化物歧化酶丙二醛内皮素-1