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Ouabain at pathological concentrations might induce damage in human vascular endothelial cells

Acta Pharmacologica Sinica 2006年第2期27卷 165-172页

作者： Yan-ping ren~1 Ruo-wen HUANG zhuo-ren L(?) Geriatric-Cardiovascular Department,First Hospital of Xi’an Jiaotong University,Xi’an 710061,China Geriatric-Cardiovascular Department First Hospital of Xi'an Jiaotong University Xi'an China

Aim:To examine the time-and dose-dependent effects of ouabain on humanumbilical vein endothelial cells(HUVEC)in vivo,and the changes in aortic endot-helium and the different expression levels of Kv4.2 in ***:The prolif-eration of HUVEC and cell death were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide(MTT)assay,the incorporation of[~3H]TdR,trypan blue staining,and lactate dehydrogenase(LDH)*** response ofendothelial cells to ouabain was explored with a complementary DNA microarrayand a candidate gene was found."Ouabain-sensitive"hypertensive rats wereestablished by chronic administration of *** in the aortic endothe-lium were observed by electron microscopy,and the expression level of Kv4.2 indifferent animals was studied by using real-time quantitative reverse transcrip-tion-polymerase chain reaction(RT-PCR).Results:Ouabain stimulated the prolif-eration of HUVEC at physiological concentrations(0.3-0.9 nmol/L).Ouabain atpathological concentrations(0.9-1.8 nmol/L)inhibited proliferation and inducedcell death,mRNA profile analysis indicated that 340 genes were differentiallyexpressed after ouabain treatment:145 were upregulated,of which 6 wereupregulated significantly,including KCND2(encoding the potassium voltage-gated channel shal-related subfamily member 2).The upregulated genes weremainly related to cell metabolism and *** ouabain-sensitive hyper-tensive rats,the aortic endothelium was damaged and Kv4.2(coded by KCND2)was ***:The physiological role of ouabain in HUVECmight involve the control of growth and *** at pathologicalconcentrations might affect the structure and function of the vascular endothe-lium by modification of expression of the KCND2 gene,and participate vascularremodeling in hypertension.

关键词： ouabain endothelium hypertension potassium channels

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Dietary phytochemicals: As a potential natural source for treatment of Alzheimer's Disease

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Food Innovation and Advances 2023年第1期2卷 36-43页

作者： zhuo ren Haixia Yang Chenhui Zhu Daidi Fan Jianjun Deng Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringBiotech&Biomed Research InstituteSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China

Alzheimer's disease(AD)is a common neurodegenerative disease,which seriously impairs human health and *** present,scientists have proposed more than a dozen hypotheses about the pathogenesis of AD,including the tau propagation ***,the exact ultimate pathogenic factor of AD remains *** on the current hypotheses,some anti-AD drugs(e.g.,donepezil and Ketamine)have been developed and used in clinical treatment,which fall into two main categories,acetylcholinesterase inhibitors(AChEIs)and N-methyl-D-aspartate(NMDA)receptor antagonists,the former representative drug is donepezil,and the latter representative drug is *** these drugs have undesirable side effects,it is necessary to find safer alternatives for AD ***,dietary phytochemicals have the advantages of wide source,safety,and high biological activity,which is the natural route for screening anti-AD *** this study,several representatives’dietary phytochemicals with anti-AD effect,including resveratrol,lycopene,gallic acid,berberine,ginsenoside Rg1,pseudoginsenoside-F11,ginsenoside Rh2,artemisinin,and torularhodin were selected from the published data over the last 10 years and their potential molecular mechanisms and clinical applications reviewed in the treatment of AD.

关键词： drugs Alzheimer treatment

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动态复杂网络中节点影响力的研究进展

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物理学报 2020年第4期69卷 277-285页

作者：任卓明杭州师范大学阿里巴巴商学院复杂科学研究中心

节点影响力的识别和预测具有重要的理论意义和应用价值,是复杂网络的热点研究领域.目前大多数研究方法都是针对静态网络或动态网络某一时刻的快照进行的,然而在实际应用场景中,社会、生物、信息、技术等复杂网络都是动态演化的.因此在... 详细信息

节点影响力的识别和预测具有重要的理论意义和应用价值,是复杂网络的热点研究领域.目前大多数研究方法都是针对静态网络或动态网络某一时刻的快照进行的,然而在实际应用场景中,社会、生物、信息、技术等复杂网络都是动态演化的.因此在动态复杂网络中评估节点影响力以及预测节点未来影响力,特别是在网络结构变化之前的预测更具意义.本文系统地总结了动态复杂网络中节点影响力算法面临的三类挑战,即在增长网络中,节点影响力算法的计算复杂性和时间偏见;网络实时动态演化时,节点影响力算法的适应性;网络结构微扰或突变时,节点影响力算法的鲁棒性,以及利用网络结构演变阐释经济复杂性涌现的问题.最后总结了这一研究方向几个待解决的问题并指出未来可能的发展方向.

关键词：增长网络实时动态网络网络结构微扰节点影响力

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Jet shape modification at LHC energies by JEWEL

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Chinese Physics C 2019年第5期43卷 107-113页

作者： ren-zhuo Wan Lei Ding Xi Gui Fan Yang Shuang Li Dai-Cui Zhou Nano Optical Material and Storage Device Research Center School of Electronic and Electrical Engineering Wuhan Textile University College of Science China Three Gorges University Key Laboratory of Quark and Lepton Physics (MOE) and Institute of Particle Physics Central China Normal University

Jet shape measurements are employed to explore the microscopic evolution mechanisms of parton-medium interaction in ultra-relativistic heavy-ion collisions. In this study, jet shape modifications are quantified in terms of the fragmentation function F(z), relative momentum p_T^(rel), density of charged particles p(r), jet angularity girth, jet momentum dispersion p_T^(disp),and LeS ub for proton-proton(pp) collisions at 0.9, 2.76. 5.02, 7,and 13 TeV, as well as for lead-lead collisions at 2.76 TeV and 5.02 TeV by JEWEL. A differential jet shape parameter Dgirth is proposed and studied at a smaller jet radius r < 0.3. The results indicate that the medium has the dominant effect on jet shape modification, which also has a weak dependence on the center-of-mass energy. Jet fragmentation is enhanced significantly at very low z < 0.02, and fragmented jet constituents are linearly spread to larger jet-radii for p_T^(rel) < 1. The waveform attenuation phenomena is observed in p_T^(rel),girth, and Dgirth distributions. The results obtained for D_(girth) from pp to Pb + Pb, where the wave-like distribution in pp collision is ahead of Pb + Pb collisions at small jetradii, indicates a strong medium effect.

关键词： quark gluon plasma jet quenching jet suppression jet shape modifications jet structure

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Neuronal PPARαdeficiency-induced axonal mitochondrial transport defects underly isch⁃emic stroke pathology

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中国药理学与毒理学杂志 2021年第9期35卷 681-682页

作者： XU Lan-xi zhuo ren-gong JIN Xin YANG Li-chao School of Medicine Xiamen UniversityXiamen 361005China

OBJECTIVE Peroxisome proliferator activated receptor alpha(PPARα)is an important protective factor in neurovascular diseases such as ischemic *** PPARαexpression is higher in neurons than astrocytes and microglia,the pathophysiological functions of neuronal specific-PPARαin isch⁃emic stroke remains ***,we report that neuronal PPARαdeficiency is a key factor of neuronal ***αexpression markedly decreased in neurons after ischemic *** AND RESULTS Neuronal-specific PPARαknockout(NCKO)exacerbates neuronal damage and brain ischemic ***αdefi⁃ciency disrupts axonal microtubule organization and mitochondrial transport by decreasing the expression of dynein light chain Tctex-type 1(Dynlt1),which is implicated in cytoprotective role with damaged ***,resto⁃ration of Dynlt1 expression in neurons of NCKO mice rescue mitochondrial transport disorder,cognitive deficits and brain ischemic injury asso⁃ciated with PPARα*** These results reveal a critical role for neuronal PPARαin ischemic brain injury by modulating axonal mitochondrial transportation.

关键词： peroxisome proliferator activated receptor alpha mitochondrial dysfunction axonal transport neuronal injury ischemic stroke

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乙交酯与2-氢-2-氧-1,3,2-二氧磷杂环己烷的开环共聚研究

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高等学校化学学报 1998年第5期19卷 830-832页

作者： FAN Chang-Lie MEI Ying LIU Zhen-Hua zhuo ren-Xi Department of Chemistry Wuhan UniversityWuhan430072

聚乙醇酸及其与乳酸的共聚物是一类无毒、有良好的生物相容性和生物可降解材料,它们广泛地用作药物控释体系的载体,牙科植入材料[1,2].但由于聚乙醇酸的高度可结晶性,使其不溶于包括三氟乙酸在内的几乎所有的有机溶剂,因此通过共聚来改... 详细信息

聚乙醇酸及其与乳酸的共聚物是一类无毒、有良好的生物相容性和生物可降解材料,它们广泛地用作药物控释体系的载体,牙科植入材料[1,2].但由于聚乙醇酸的高度可结晶性,使其不溶于包括三氟乙酸在内的几乎所有的有机溶剂,因此通过共聚来改进其物化性质的研究一直方...

关键词：乙交酯 TMP 开环聚合开环共聚聚合共聚

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Large angle radiation effect on jet measurement in pp collisions at s^(1/2)=7 TeV at the LHC

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Chinese Physics C 2018年第11期42卷 58-62页

作者： ren-zhuo Wan Si-Yuan Wang Shuang Li Yi-Ming Feng Feng Liu Fan Yang Dai-Cui Zhou Nano-Optical Material and Storage Device Research Center School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200China Key Laboratory of Quark and Lepton Physics（MOE）and Institute of Particle Physics Central China Normal UniversityWuhan 430079China College of Science China Three Gorges UniversityYichang 443002China

Jet measurement is an ideal probe to explore the properties of the hot dense matter created in ultra- relativistic heavy-ion collisions. Recent results at the LHC show that large angle radiation is non-negligible, but the mechanisms and phenomenology of large angle radiation are still unclear and hotly debated. Considering the coexistence and competition of different physics mechanisms qualitatively, it is assumed that the radiation angle is enhanced randomly over a wide range based on the collinear approximation. Its effects on di-jet momentum imbalance, jet fragmentation function and jet shape are studied in pp collisions at 7 TeV. The results show that di-jet asymmetry is insensitive to large angle radiation, while jet shape and jet fragmentation functions are more sensitive and could explain experimental data well. We conclude that de-collimated radiation cannot be ignored for soft jets, and there is a contribution from large angle radiation （Ф 〉 0.7） of about 8%, which is significant for jet intrinsic structure measurement at PT,jeT 〈80 GeV/c.

关键词： quark gluon plasma jet quenching di-jet large angle radiation jet shape

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Ouabain induces cardiac remodeling in rats independent of blood pressure

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Acta Pharmacologica Sinica 2007年第3期28卷 344-352页

作者： Xing JIANG~(2,4) Yan-ping ren~3 zhuo-ren L~32 Geriatric-Cardiovascular Department,the People Hospital of Shaanxi Province and the Third Hospital of Xi'an Jiaotong University Xi'an 710068,China 3 Geriatric-Cardiovascular Department,First Hospital of Xi'an Jiaotong University Xi'an 710061,China Geriatric-Cardiovascular Department the People Hospital of Shaanxi Province and the Third Hospital of Xi'an Jiaotong University Xi'an China Geriatric-Cardiovascular Department First Hospital of Xi'an Jiaotong University Xi'an China

Aim:To investigate the ouabain's effects on cardiac remodeling in ***:Male Sprague-Dawley rats were treated with *** blood pressure(SBP)was recorded *** 4 and 6 weeks,echocardiography were performed,hemodynamic parameters were measured by invasive cardiac catheterization,changes in cardiac ultrastructure were analyzed using transmission electronmicroscopy,the collagen fraction of the left ventricle was assessed with Picrosiriusred stain,and RT-PCR was applied to evaluate the mRNA level of myosin heavychain-αand-βin the left ***:Having been treated with ouabain for4 weeks,there was no significant difference in the mean SBP of the two ***,left ventricular hypertrophy,myocardial ultrastructure deterioration,and extracellular matrix remodeling were induced by ouabain treatment;meanwhile,cardiac systolic and diastolic performance were both ***,thecardiac MHC-β mRNA was upregulated by ouabain treatment,whereas MHC-αmRNA was *** 4 weeks,the mean SBP in the ouabain groupbegan to increase and was significantly higher than that in control group after 6weeks(P<0.01);the rats' cardiac structure and function were ***:These results suggested that ouabain induces alterations in cardiacstructure and function,and the effects happened before the increase of *** results indicated that ouabain induced cardiac remodeling in ratsindependent of blood pressure.

关键词： ouabain cardiac remodeling hypertension

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氨基苯甲酸修饰的DTPA螯合物及其弛豫性能

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高等学校化学学报 1998年第10期19卷 1593-1596页

作者：魏俊发卓仁禧武汉大学化学系

用邻－、对－氨基苯甲酸修饰二乙三胺五乙酸（ＤＴＰＡ），分别得到两种分子中携带芳香基团的双酰胺型ＤＴＰＡ衍生物，合成了它们的顺磁性金属离子螯合物，并研究了其中部分螯合物的ｉｎｖｉｔｒｏＮＭＲＴ１弛豫率（Ｒ１）．结果表明... 详细信息

用邻－、对－氨基苯甲酸修饰二乙三胺五乙酸（ＤＴＰＡ），分别得到两种分子中携带芳香基团的双酰胺型ＤＴＰＡ衍生物，合成了它们的顺磁性金属离子螯合物，并研究了其中部分螯合物的ｉｎｖｉｔｒｏＮＭＲＴ１弛豫率（Ｒ１）．结果表明，Ｇｄ（Ⅲ）ＤＴＰＡ－Ｂ４ＡＢＡ２－和ＧｄＤＴＰＡ－Ｂ２ＡＢＡ２－对水质子的弛豫率Ｒ１分别为５．５和５．４Ｌ·ｍｍｏｌ－１·ｓ－１，接近相应的母体螯合物ＧｄＤＴＰＡ２－的Ｒ１值５．２Ｌ·ｍｍｏｌ－１·ｓ－１．

关键词：氨基苯甲酸钆螯合物造影剂 MRI DTPA 肝胆靶向

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快速温度敏感聚(N-异丙基丙烯酰胺-co-丙烯酰胺)水凝胶的制备及性能研究

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高等学校化学学报 2000年第8期21卷 1309-1311页

作者：张先正卓仁禧教育部生物医用高分子材料重点实验室武汉大学化学系武汉430072

于 4 8℃下制备快速温度敏感聚 ( N -异丙基丙烯酰胺 -co-丙烯酰胺 )水凝胶 ,其在室温具有较大的平衡溶胀率 .

关键词：温度敏感水凝胶 PCNIPA-(O-AA) LCST

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