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OXCT1 regulates NF-κB signaling pathway through β-hydroxybutyrate-mediated ketone body homeostasis in lung cancer

Genes & Diseases 2023年第2期10卷 352-355页

作者： zhuo lu Tianyu Han Tao Wang Mingxi Gan Caifeng Xie Bentong Yu Jian-Bin Wang College of Life Science Nanchang UniversityNanchangJiangxi 330031China School of Basic Medical Sciences Nanchang UniversityNanchangJiangxi 330031China Jiangxi Institute of Respiratory Disease The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Department of Thoracic Surgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Metabolic reprogramming is one of the hallmarks of cancer.1 Ketone bodies behave as alternative fuel for cancer cells to support survival and proliferation.2 3-Oxoacid CoA-transferase 1 (OXCT1) is a key enzyme that catalyzes the first and rate-limiting step of ketolysis. Recently, several studies have revealed the significance of OXCT1 in cancer development, though the underlying mechanisms remain largely unknown.3 In this study, we revealed a novel regulatory mechanism for tumorigenesis that OXCT1 regulated SREBP1-TRIM21-p65 axis through ketone body homeostasis in non-small cell lung cancer (NSCLC). In terms of mechanism, we found that OXCT1 could activate NF-κB signaling pathway by suppressing transcriptional activity of the sterol regulatory element binding protein 1 (SREBP1). As a transcription factor, SREBP1 could bind to the promoter of E3 ubiquitin ligase TRIM21, which mediated the ubiquitination of p65. Furthermore, we demonstrated that OXCT1 could maintain the homeostasis of β-hydroxybutyrate (β-HB), which acted as a signaling metabolite to activate SREBP1. Thus, β-HB connected OXCT1 with SREBP1 to activate NF-κB signaling pathway and promoted tumor initiation and progression. Taken together, these findings highlight a previously unappreciated mechanism for activation of NF-κB signaling by OXCT1 and ketone body, and demonstrate that targeting OXCT1 can inhibit NSCLC tumorigenesis.

关键词： homeostasis lung ketone

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Parameter estimation for MIMO system based on MUSIC and ML methods

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Frontiers of Electrical and Electronic Engineering in China 2009年第2期4卷 161-165页

作者： Wei DONG Jiandong LI zhuo lu Linjing ZHAO Information Science Institute State Key Laboratory of Integrated Service NetworksXidian UniversityXi’an 710071China

The frequency offset and channel gain estimation problem for multiple-input multiple-output(MIMO)systems in the case of flat-fading channels is *** on the multiple signal classification(MUSIC)and the maximum likelihood(ML)methods,a new joint estimation algorithm of frequency offsets and channel gains is *** new algorithm has three steps.A subset of frequency offsets is first estimated with the MUSIC *** frequency offsets in the subset are then identified with the ML ***,channel gains are calculated with the ML *** algorithm is a one-dimensional search scheme and therefore greatly decreases the complexity of joint ML estimation,which is essentially a multi-dimensional search scheme.

关键词： multiple-input multiple-output(MIMO) multiple signal classification(MUSIC) frequency offsets channel estimation maximum likelihood(ML)estimation

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Qi, Channels and Collaterals

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中国针灸 1995年第S2期15卷 365-366页

作者： lu Gang Pan Jun(zhuo lu Hospital of TCM Hebei, 075600)

Ｑｉ，ＣｈａｎｎｅｌｓａｎｄＣｏｌｌａｔｅｒａｌｓＱｉ，ＣｈａｎｎｅｌｓａｎｄＣｏｌｌａｔｅｒａｌｓ￥ＬｕＧａｎｇ；ＰａｎＪｕｎ（ＺｈｕｏＬｕＨｏｓｐｉｔａｌｏｆＴＣＭＨｅｂｅｉ，０７５６００）Ｃｈａｎｎｅｌｓａｎｄ...

Ｑｉ，ＣｈａｎｎｅｌｓａｎｄＣｏｌｌａｔｅｒａｌｓＱｉ，ＣｈａｎｎｅｌｓａｎｄＣｏｌｌａｔｅｒａｌｓ￥ＬｕＧａｎｇ；ＰａｎＪｕｎ（ＺｈｕｏＬｕＨｏｓｐｉｔａｌｏｆＴＣＭＨｅｂｅｉ，０７５６００）Ｃｈａｎｎｅｌｓａｎｄｃｏｌｌａｔｅｒａｌｓｓｔｅｍｆｒ...

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Comparative Study of the Magnetic Properties and Glass-Forming Ability of Fe-Based Bulk Metallic Glass with Minor Mn, Co, Ni, and Cu Additions

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Acta Metallurgica Sinica(English Letters) 2016年第9期29卷 834-839页

作者： Md Anisur Rahman Yun-zhuo lu Qiang luo Shou-Jiang Qu Feng-Xia Ye Yi-Xuan Wu Jun Shen School of Materials Science and Engineering Tongji University School of Materials Science and Engineering Dalian Jiaotong University

Fe43MsCra5Mo14C15B6Y2 （M = Mn, Co, Ni, and Cu in at.%） bulk metallic glasses （BMGs） are synthesized using the suction casting technique, and the glass-forming ability （GFA）, microstructure, and thermal and magnetic properties of these glasses are extensively examined using X-ray diffraction, differential scanning calorimeter, and vibrating sample magnetometer techniques. Among the four BMG alloys, Fe43NisCr15Mo14C15B6Y2 exhibits the lowest coercivity and the highest saturation magnetization, Curie temperature, effective magnetic moment, and GFA. By contrast, Fe43MnsCrlsMo14C15B6Y2 presents the poorest magnetic properties, such as the highest coercivity and the lowest saturation magnetization, Curie temperature, and effective magnetic moment. Fe43Cu5Cr15MolaC15B6Y2 demonstrates the lowest thermal stability and GFA. The observed thermal, structural, and magnetic properties of these BMG alloys are discussed in terms of the kinetics of BMG synthesization and the formation of different ferromagnetic, ferrimagnetic, and antiferromagnetic phases.

关键词： Bulk metallic glasses Saturation magnetization Effective magnetic moment Coercivity Glass-forming ability

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Mutants only Partially Represent Characteristics of Calcium-ReleaseActivated Calcium Channel Gating

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Chinese Journal of Chemical Physics 2021年第6期34卷 915-924,I0005页

作者： Jun Huo Ben-zhuo lu Hao Dong Kuang Yaming Honors School Nanjing UniversityNanjing 210023China CEMS LSECNCMISAcademy of Mathematics and Systems ScienceChinese Academy of SciencesSchool of Mathematical SciencesUniversity of Chinese Academy of SciencesBeijing 100190China Institute for Brain Sciences Nanjing UniversityNanjing 210023China State Key Laboratory of Analytical Chemistry for Life Science Nanjing UniversityNanjing 210023China Engineering Research Center of Protein and Peptide Medicine of Ministry of Education Nanjing UniversityNanjing 210023China

Calcium-release-activated calcium(CARC)channels are one of the major pathways of calcium entry in non-excitable *** a decade or two of research,its regulatory mechanism is not yet thoroughly *** slow progress is due to the complexity of its pores(i.e.,Orai)on one hand and the difficulty in capturing its regulatory complex on the other *** a result,possible gating mechanisms have often been speculated by exploring the structure and properties of constitutive open ***,there is much debate about how they can truly reflect the gating of CRAC channels under physiological *** the present study,we combined molecular dynamics simulations with free energy calculations to study three dOrai mutants(G170P,H206A,and P288A),and further calculated their current-voltage *** show that these constructs adopt different approaches to maintain their conductive *** they have unique pore structures and distinctive rectification properties and ion selectivity for cations compared to wild-type *** conclude that although the mutants may partially capture the gating motion characteristics of wild-type pores,the information obtained from these mutants is likely not a true reflection of CRAC channel gating under physiological conditions.

关键词： Calcium-release-activated calcium channel Gating mechanism Molecular dynamics simulations Mutant Free energy profile

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Enhancement of Virus Replication in An Influenza A Virus NS1-Expresssing 293 Cell Line

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Biomedical and Environmental Sciences 2016年第3期29卷 224-228页

作者： ZHU Wu Yang TAO Xiao Yan LYU Xin Jun YU Peng Cheng lu zhuo Zhuang National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention State Key Laboratory for Infectious Disease Prevention and Control Chinese Center for Disease Control and Prevention

The nonstructural protein 1 （NS1） of influenza A virus, which is absent from the viral particle, but highly expressed in infected cells, strongly antagonizes the interferon （IFN）-mediated antiviral response. We engineered an NS1-expressing 293 （293-NS1） cell line with no response to IFN stimulation. Compared with the parental 293 cells,

关键词： NS Enhancement of Virus Replication in An Influenza A Virus NS1-Expresssing 293 Cell Line IFN Figure

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Abnormal intra-network architecture in extra-striate cortices in amblyopia: a resting state fMRI study

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Eye and Vision 2019年第1期6卷 156-163页

作者： zhuo lu Yufeng Huang Qilin lu Lixia Feng Benedictor Alexander Nguchu Yanming Wang Huijuan Wang Geng Li Yifeng Zhou Bensheng Qiu Jiawei Zhou Xiaoxiao Wang Center for Biomedical Engineering University of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science University of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China CAS Key Laboratory of Brain Function and Diseases and School of Life Sciences University of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China Shenyang Aerospace University ShenyangLiaoning 110136People’s Republic of China Department of Ophthalmology First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiPeople’s Republic of China Asia Pediatric Ophthalmologist Association Rm 2006CC Wu Bldg.302-308 Hennessy Rd.WanchaiHong KongPeople’s Republic of China School of Ophthalmology and Optometry and Eye hospital Wenzhou Medical UniversityWenzhouZhejiang 325003People’s Republic of China

Background:Amblyopia(lazy eye)is one of the most common causes of monocular visual *** investigation has shown that amblyopes suffer from a range of deficits not only in the primary visual cortex but also the extra-striate visual ***,amblyopic brain processing deficits in large-scale information networks especially in the visual network remain ***:Through resting state functional magnetic resonance imaging(rs-fMRI),we studied the functional connectivity and efficiency of the brain visual processing networks in 18 anisometropic amblyopic patients and 18 healthy controls(HCs).Results:We found a loss of functional correlation within the higher visual network(HVN)and the visuospatial network(VSN)in ***,compared with HCs,amblyopic patients exhibited disruptions in local efficiency in the V3v(third visual cortex,ventral part)and V4(fourth visual cortex)of the HVN,as well as in the PFt,hIP3(human intraparietal area 3),and BA7p(Brodmann area 7 posterior)of the *** significant alterations were found in the primary visual network(PVN).Conclusion:Our results indicate that amblyopia results in an intrinsic decrease of both network functional correlations and local efficiencies in the extra-striate visual networks.

关键词： Amblyopia fMRI Resting state Extra-striate cortices Visuospatial network Graph analysis

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Stable Li storage in micron-sized SiO_(x) particles with rigid-flexible coating

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Journal of Energy Chemistry 2022年第1期31卷 309-314,I0009页

作者： Ming-Yan Yan Zhu Liu zhuo-Ya lu Lin-Bo Huang Ke-Cheng Jiang Hong-Liang Li Sen Xin Quan Xu Yu-Guo Guo CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China College of Materials Science and Engineering State Key Laboratory of Biopolysaccharide Fiber Forming and Eco-TextileQingdao UniversityQingdao 266071ShandongChina Beijing IAmetal New Energy Technology Co. LtdBeijing 100190China Dongguan TAFEL New Energy Technology Co. LtdDonggiian 523000.GuangdongChina

Micrometre-sized electrode materials have distinct advantages for battery applications in terms of energy density,processability,safety and *** the silicon monoxide anode that undergoes electrochemical alloying reaction with Li,the Li(de)intercalation by micron-sized active particles usually accompanies with a large volume variation,which pulverizes the particle structure and leads to rapidly faded storage *** this work,we proposed to stabilize the electrochemistry *** of the micron-SiO_(x) anode by forming a rigid-flexible bi-layer coati ng on the particle *** coati ng consists of pyrolysis carbon as the inner layer and polydopamine as the outer *** the inner layer guarantees high structural rigidity at particle surface and provides efficient pathway for electron conduction,the outer layer shows high flexibility for maintaining the integrity of micrometre-sized particles against drastic volume variation,and together they facilitate formation of stable solid electrolyte interface on the SiO_(x) particles.A composite an ode prepared by mixing the coated micron-SiOx with graphite delivered improved Li storage performance,and promised a high-capacity,long-life LiFePO_(4)/SiO_(x)-graphite pouch *** strategy provides a general and feasible solution for building high-energy rechargeable batteries from micrometre-sized electrode materials with significant volume variation.

关键词： Lithium-ion batteries Anodes Micron-SiOx Rigid and flexible coating

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保险行业声誉风险监管与企业社会责任关系研究

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求是学刊 2016年第3期43卷 67-72页

作者：吕卓东北财经大学金融学院辽宁大连116025

保险行业的声誉是由行业内部的全部参与者和利益相关者共同营造的,因此对于保险业声誉的研究需要站在全行业的高度,从制度层面和道德层面全面维护保险行业形象,建设保险行业声誉。文章根据公共物品理论、利益相关者理论和社会责任理论,... 详细信息

保险行业的声誉是由行业内部的全部参与者和利益相关者共同营造的,因此对于保险业声誉的研究需要站在全行业的高度,从制度层面和道德层面全面维护保险行业形象,建设保险行业声誉。文章根据公共物品理论、利益相关者理论和社会责任理论,将保险行业声誉视为公共物品,由过去单纯研究保险公司声誉风险拓展为基于行业高度探究声誉风险监管的制度机制和企业社会责任的道德机制及其相互影响关系。

关键词：保险行业声誉风险监管制度社会责任

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高等教育促进区域协调发展:影响机制与经验证据

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大学教育科学 2024年第2期 77-87页

作者：卢卓华中科技大学教育科学研究院武汉430074

高等教育为促进区域协调发展提供了新动能。基于高等教育影响区域协调发展的内在机理,采用2010—2021年中国31个省份的面板数据实证检验高等教育对区域协调发展的影响,可以发现:高等教育对区域协调发展具有显著促进作用,且该结论通过了... 详细信息

高等教育为促进区域协调发展提供了新动能。基于高等教育影响区域协调发展的内在机理,采用2010—2021年中国31个省份的面板数据实证检验高等教育对区域协调发展的影响,可以发现:高等教育对区域协调发展具有显著促进作用,且该结论通过了一系列稳健性检验;高等教育主要通过提升劳动力技能水平、提高技术创新能力与促进文化资本积累三个路径,间接地推动区域协调发展;高等教育存在显著空间溢出效应,不仅能够推动本地区协调发展,还能够提升相邻地区协调发展水平,且地区间的作用强于地区内。异质性分析表明,高等教育对区域协调发展的促进作用主要存在于东中部地区。为充分发挥高等教育的驱动效应,各级政府及其相关部门应努力提升高等教育发展水平,增强高等教育影响区域协调发展的传导效果,注重高等教育空间溢出效应的有效发挥。

关键词：高等教育区域协调发展影响机制空间溢出效应

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