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Self-controlled Study of Onychomycosis Treated with Long-pulsed Nd：YAG 1064-nm Laser Combined with Itraconazole

Chinese Medical Journal 2016年第16期129卷 1929-1934页

作者： Yan Li Jing Xu Jun-Ying Zhao feng-Lin zhuo Department of Dermatology Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Dermatology Capital Institute of Pediatrics Beijing 100020 China

Background： Onychomycosis is a fungal infection of the nail plate and subungual area. In this study, we examined the efficacy of laser treatment using self-controlled study programs involving a long-pulsed Nd：YAG 1064-nm laser combined with oral medication. Methods： Self-controlled strategies were followed in this study. The patients received treatment with oral itraconazole in conjunction with long-pulsed Nd：YAG 1064-nm laser treatment at the nails of the unilateral limb once a week for a total of four times. A total of 84 affected nails were divided into Group A （mild to moderate） and Group B （severe） according to disease severity. Affected nails with the same Scoring Clinical Index for Onychomycosis scores were selected to compare the therapeutic effects of the pure medication treatment group and the combination treatment group with a 24-week follow-up period. Results： In Group A, at the 8th, 16th, and 24th weeks of follow-up, the efficacies in the pure medication treatment group were 81.0%, 81.0%, and 90.5%, respectively, while those in the combination treatment group were 100%, 95.2%, and 90.5%, respectively. The differences between groups were not significant （8th week： χ2 =4.421, P 〉 0.05; 16th week： χ2 = 2.043, P 〉 0.05; 24th week： χ2= 0.00, P 〉 0.05）. In Group B, at the 8th, 16th, and 24th weeks of follow-up, the efficacies in the pure medication treatment group were 61.9%, 66.7%, and 52.4%, respectively, while those in the combination treatment group were 95.2%, 90.5%, and 100%, respectively. The differences between groups at the 8th and 24th weeks of follow-up were statistically significant （8th week： χ2=6.929, P 〈 0.05; 24th week： χ2=13.125, P 〈 0.05）. Conclusions： For patients with mild or moderate onychomycosis, we recommended a pure medication treatment or combination treatment with medication and laser. For those patients with severe onychomycosis, we recommended a combination of medication and laser therapy.

关键词： ltraconazole Laser Treatment Nd-YAG Laser Onychomycosis

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雅江木灰地区片状组构岩石强度各向异性特征

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四川地质学报 2024年第1期44卷 73-79页

作者：时斌赵建军王运生肖华波刘豪放唐涛冯卓成都理工大学地质灾害防治与地质环境保护国家重点实验室成都610059 中国电建集团成都勘测设计研究院有限公司成都610072

受区域变质及后期岩浆活动影响,雅江木灰地区变质砂岩岩组主要岩性表现为千枚岩、片岩、片麻岩,片柱状矿物呈定向构造具有典型的各向异性特征。根据岩石薄片鉴定及单轴抗压实验,对岩石各向异性及对应强度特征进行研究,得到如下认识:该... 详细信息

受区域变质及后期岩浆活动影响,雅江木灰地区变质砂岩岩组主要岩性表现为千枚岩、片岩、片麻岩,片柱状矿物呈定向构造具有典型的各向异性特征。根据岩石薄片鉴定及单轴抗压实验,对岩石各向异性及对应强度特征进行研究,得到如下认识:该地区区域低温变质作用形成的变质砂岩经后期岩浆侵入接触变质作用,进一步变质为千枚岩、片岩、片麻岩,矿物成分为石英、长石、辉石、角闪石、云母;受片柱状矿物含量影响,岩石平行面理和垂直面理单轴抗压强度相差较大,各性异性较强;考虑片状矿物影响系数、柱状矿物影响系数、改造作用系数,提出了各向异性系数计算公式。所得结果对于认识片状组构岩石强度的各向异性和岩石强度参数取值具有一定指导意义。

关键词：片状组构岩石岩石学特征各向异性单轴压缩相关性分析

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Magnetism of NaYbS_(2):From finite temperatures to ground state

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 92-104页

作者： Weizhen zhuo Zheng Zhang Mingtai Xie Anmin Zhang Jianting Ji feng Jin Qingming Zhang School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Rare-earth chalcogenide compounds ARECh_(2)(A=alkali or monovalent metal,RE=rare earth,Ch=O,S,Se,Te)are a large family of quantum spin liquid(QSL)candidate ***2is a representative member of the *** key issues on NaYbS_(2),particularly how to determine the highly anisotropic spin Hamiltonian and describe the magnetism at finite temperatures and the ground state,remain to be *** this paper,we conducted an in-depth and comprehensive study on the magnetism of NaYbS_(2) from finite temperatures to the ground ***,we successfully detected three crystalline electric field(CEF)excitation energy levels using low-temperature Raman scattering *** them with the CEF theory and magnetization data,we worked out the CEF parameters,CEF energy levels,and CEF *** further determined a characteristic temperature of~40 K,above which the magnetism is dominated by CEF excitations while below which the spinexchange interactions play a main *** characteristic temperature has been confirmed by the temperature-dependent electron spin resonance(ESR)***-temperature ESR experiments on the dilute magnetic doped crystal of NaYb_(0.1)Lu_(0.9)S_(2) further helped us to determine the accurate ***,we quantitatively obtained the spin-exchange interactions in the spin Hamiltonian by consistently simulating the magnetization and specific heat ***,the above studies allow us to explore the ground state magnetism of NaYbS_(2) by using the density matrix renormalization *** combined numerical calculations and experimental results to demonstrate that the ground state of NaYbS_(2) is a Dirac-like QSL.

关键词： rare-earth chalcogenide anisotropic spin Hamiltonian quantum spin liquid

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Imaging internal density structure of the Laoheishan volcanic cone with cosmic ray muon radiography

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Nuclear Science and Techniques 2022年第7期33卷 115-124页

作者： Ya-Ping Cheng Ran Han Zhi-Wei Li Jing-Tai Li Xin Mao Wen-Qiang Dou Xin-zhuo feng Xiao-Ping Ou-Yang Bin Liao Fang Liu Lei Huang Science and Technology on Reliability and Environmental Engineering Laboratory Beijing Institute of Spacecraft Environment EngineeringBeijing100094China School of Nuclear Science and Engineering North China Electric Power University2 BeiNong RoadBeijing102206China College of nuclear science and technology Beijing Normal University19 Xinjiekou outer St.Beijing100875China Aerospace Information Research Institute Chinese Academy of Sciences9 Dengzhuang South RoadBeijing100094China

Muon radiography is a promising technique for imaging the internal density structures of targets such as tunnels,pyramids,and volcanoes up to a scale of a few hundred meters by measuring the flux attenuation of cosmic ray muons after they have traveled through these *** this study,we conducted experimental muon radiography of one of the volcanoes in the Wudalianchi area in Northeast China to image its internal density *** muon detector used in this study was composed of plastic scintillators and silicon *** approximately one and a half months of observing the crater and conduit of the Laoheishan volcano cone in Wudalianchi from September 23^(rd) to November 10^(th) 2019,more than 3 million muon tracks fulfilling the data selection criteria were *** on the muon samples and high-resolution topography obtained through aerial photogrammetry using an unmanned aerial vehicle,a density image of the Laoheishan volcano cone was *** results obtained in this experiment demonstrate the feasibility of using a radiography technique based on plastic scintillator *** obtain the density distribution,we performed a detailed background analysis and found that low-energy charged particles dominated the background *** higher densities were found near the surface of the volcanic cone,whereas relatively lower densities were found near the center of the volcanic *** experiment in this study is the first volcano muon tomography study performed in *** work provides an important reference for future research.

关键词： Muon radiography Muon transmission imaging Density

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Microstructure and Mechanical Behavior of Mg-Based Bimetal Plates with High Formability Sleeve by Co-extrusion

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 499-512页

作者： Yue-Hui Dang Sheng-Lin Liu Xiao-Lei Ai Xiao-Wei feng Bo feng zhuo Tian Ying-Fei Lin Huan-Tao Chen Kai-Hong Zheng School of Materials Science and Engineering Chang’an UniversityShaanxi 710064China Guangdong Key Laboratory of Metal Toughening Technology and Application Institute of New MaterialsGuangdong Academy of SciencesGuangzhou 510650China

In this study,microstructure and mechanical behavior of two types of Mg-based bimetal plates with a high formability sleeve were systematically studied,with a great emphasis on the effect of the interface characteristic and the sleeve fraction on the plasticity of composite *** rule of mixtures(ROM)for elongation was also *** results show that when there is no or thin diffusion layer with thickness of about 3μm,Mg-based bimetal plates have a good plasticity with elongation of about 19-24%,and the ROM predicted elongations are very close to the experimental *** contrast,with a diffusion layer about 95-155μm thick,Mg-based bimetal plates exhibit a poor plasticity with elongation of about 11-17%,and the experimental elongations largely deviate from the ROM *** plasticity of Mg-based bimetal plates increases with increasing sleeve *** study provides new insights on the plastic deformation of Mg-based bimetal composites with a high formability sleeve.

关键词： Mg-based composites Co-extrusion Microstructure Mechanical behavior Plastic deformation

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Symmetry transformation of nonlinear optical current of tilted Weyl nodes and application to ferromagnetic MnBi_(2)Te_(4)

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Chinese Physics B 2024年第4期33卷 160-171页

作者：卢倬成冯济 International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China

A Weyl node is characterized by its chirality and *** develop a theory of how nth-order nonlinear optical conductivity behaves under transformations of anisotropic tensor and tilt, which clarifies how chirality-dependent and-independent parts of optical conductivity transform under the reversal of tilt and *** on this theory, we propose ferromagnetic Mn Bi2Te4as a magnetoelectrically regulated, terahertz optical device, by magnetoelectrically switching the chiralitydependent and-independent DC *** results are useful for creating nonlinear optical devices based on the topological Weyl semimetals.

关键词： nonlinear optical response topological Weyl semimetals chiral anomaly

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In-situ growth of MIL-53(Fe) on charcoal sponge as a highly efficient and recyclable photocatalyst for removal of Cr(Ⅵ)

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Rare Metals 2024年第9期43卷 4344-4355页

作者： zhuo-Fan Yu Ye Yang Hai-feng Zhuang Sheng-Dao Shan Mihail-Simion Beldean-Galea Qing-Quan Xue Xiao-feng Shen Shi-Jie Li Key Laboratory of Recycling and Eco-Treatment of Waste Biomass of Zhejiang Province School of Environmental and Natural Resources Zhejiang University of Science and Technology Faculty of Environmental Science and Engineering Babes-Bolyai University Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province Interdisciplinary Research Academy (IRA) Zhejiang Shuren University National Engineering Research Center for Marine Aquaculture Institute of Innovation & Application Zhejiang Ocean University

The application of metalDorganic frameworks(MOFs) is hindered by several crucial factors, including low photocatalytic efficiency, poor stability and challenges in recycling. In this study, MIL-53(Fe) was grown in situ on a charcoal sponge(CS) with a large surface area,excellent mechanical properties, and high photocatalytic efficiency using a solvothermal method, thus addressing the above-mentioned shortcomings of MOF ***, CS/MIL-53(Fe) has an amazing light-harvesting capacity in the visible range, leading to a significant improvement in the utilization of light. The results of the experiments indicate that CS/MIL-53(Fe) displays a higher photocatalytic activity(87% Cr(VI)) when exposed to visible light than CS(58%) or MIL-53(Fe)(27%),attributing to the increased separation of photogenerated carriers. e-is the main reactive radical and dominates the photocatalytic reduction process, rooting from that e-can reduce Cr(VI) to low-toxicity Cr(III). This study presents a novel method for constructing photocatalysts with large surface areas, superior mechanical characteristics, and enhanced photocatalytic performance. Additionally, it achieves the resource utilization of agricultural and forestry waste.

关键词： Charcoal sponge Cr(VI) Light absorption MIL-53(Fe) Photocatalysis

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Measuring residents’ anxiety under urban redevelopment in China: An investigation of demographic variables

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Frontiers of Engineering Management 2021年第1期8卷 48-59页

作者： Jinbo SONG Chen QIAN zhuo feng Liang MA School of Economics and Management Dalian University of TechnologyDalian 116024China School of Management Shanghai UniversityShanghai 200444China

Residents’concerns and feelings play pivotal roles in smoothly promoting urban ***,as an intuitive feeling toward uncertainties,generally exists among residents who are confronted with redevelopment,and this feeling has gradually attracted scholars’***,relatively few studies have focused on the multidimensional view of this concept and its influencing *** upon a large-scale questionnaire survey conducted in 13 pilot areas in China,this study refines and verifies five prominent dimensions of anxiety,namely,housing conditions,monetary compensation,public services,life adaptation,and public participation level,through factor analysis and one-sample/-*** finding contributes to achieving a complete understanding of anxiety,and the scales developed for measuring these dimensions lay the foundation for further empirical studies on *** individual and collective effects of age,job,and region variables on anxiety dimensions are demonstrated via independent-sample/-test and analysis of variance,which clarifies the formation process of anxiety and highlights the importance of these contextual *** strategies for policymaking and engineering management,including establishing reasonable compensation standards,providing equal public services,and delivering highquality housing,are proposed to relieve residents5 *** strategies are expected to consider further the sensitive group,such as the elderly,farmers,and casual workers.

关键词： urban redevelopment anxiety dimension influencing factors ANOVA policymaking

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Solid-state NMR reveals the structural transformation of the TDP-43 amyloidogenic region upon fibrillation

Solid-state NMR reveals the structural transformation of the...

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2021年全国生物相分离和相变学术研讨会

作者： Jun-xia Lu Xiao-feng zhuo School of Life Science and Technology Shanghai Tech University

TDP-43 is a primary pathological hallmark protein of amyotrophic lateral sclerosis and frontotemporal lobar degeneration,which may exist in the form of amyloid inclusions in the cells of *** addition to serving as a biomarker for these diseases,TDP-43 can also directly trigger *** previously determined the amyloidogenic core region of TDP-43(residues 311-360) and showed by solution NMR that this region includes two α-helices [(321-330) and(335-343)] in *** suggested that the helix-to-sheet structural transformation initiates TDP-43 *** the present study,X-ray diffraction shows that TDP-43(311-360) aggregates adopt a cross-β ***(Trx) fused TDP-43(311-360) can undergo liquid-liquid phase separation(LLPS) before fibrillation,suggesting that phase separation is an intermediate step before amyloid ***-state NMR(SSNMR),carried out to elucidate the structural changes of TDP-43(311-360) at the atomic level,indicates five β-strands of the amyloids formed,with the major two β-strands contributed by the first helical region in the solution *** NMR evidence is also in support of the fibril having a parallel in-register conformation,implying a mechanism in which the helix-helix interactions in LLPS are converted into β-strand parallel lateral association upon *** studies have assigned many key inter-residue interactions that contribute to the stability of the fibril,including F316 with 1318 and Q327 and W334 with A325,A326,A329 and *** with H-detection reveals a unique close interaction between the indole Nε1-Hε1 of W334 and the side-chain carbonyl of *** interaction could be a very important factor in initiating TDP-43(311-360) folding/misfolding in LLPS.

关键词： TDP-43(311-360) TDP-16(267-414) Liquid-liquid phase separation Amyloid fibril solid-state NMR

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子宫内膜异位症相关信号通路及中医药疗法干预研究

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西部中医药 2024年第4期37卷 86-90页

作者：庞瑞康冯卓何列涛邹卓成许富何就杰覃宁婧广西中医药大学针灸推拿学院广西南宁530001 广州中医药大学广东广州510006 广西中医药大学第一附属医院广西南宁530000

收集近年来国内外相关文献,分析丝裂原活化蛋白激酶通路、Janus激酶2/转录活化因子3通路、磷脂酰肌醇-3-激酶/丝苏氨酸蛋白激酶通路、Wnt蛋白/β-连环蛋白通路、核转录因子kappa B通路信号通路与子宫内膜异位症生理病理机制的关系,并阐... 详细信息

收集近年来国内外相关文献,分析丝裂原活化蛋白激酶通路、Janus激酶2/转录活化因子3通路、磷脂酰肌醇-3-激酶/丝苏氨酸蛋白激酶通路、Wnt蛋白/β-连环蛋白通路、核转录因子kappa B通路信号通路与子宫内膜异位症生理病理机制的关系,并阐述包括中药、针灸等在内的中医药疗法在治疗子宫内膜异位症中的干预机制,为临床治疗提供新的思路与研究靶点。

关键词：子宫内膜异位症信号通路中医药针灸研究进展

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