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A phase 3,double-blind,randomized placebo-controlled efficacy and safety study of abiraterone acetate in chemotherapynaı¨ve patients with mCRPC in China,Malaysia,Thailand and Russia

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Asian Journal of Urology 2017年第2期4卷 75-85页

作者： Dingwei Ye Yiran Huang Fangjian Zhou Keji Xie Vsevolod Matveev Changling Li Boris Alexeev Ye Tian Mingxing Qiu Hanzhong Li Tie Zhou Peter De Porre Margaret Yu Vahid Naini Hongchuan Liang zhuli wu Yinghao Sun Department of Urology Fudan University Shanghai Cancer CenterShanghaiChina Department of Urology Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhouGuangdongChina Guangzhou First Municipal People’s Hospital GuangzhouGuangdongChina Department of Urology Russian Academy of Medical SciencesMoscowRussia Department of Urology Cancer Institute(Hospital)Peking Union Medical College and Chinese Academy of Medical SciencesBeijingChina Department of Oncology Moscow Oncology Research InstituteMoscowRussia Department of Stomatology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Urology Sichuan Academy of Medical Science&Sichuan Provincial People’s HospitalChengduSichuanChina Department of Oncology Peking Union Medical College HospitalBeijingChina Department of Urology Changhai HospitalSecond Military Medical UniversityShanghaiChina Department of Oncology Janssen Research&DevelopmentBeerseBelgium Department of Medical Oncology Janssen Research&DevelopmentSan DiegoCAUSA Department of Urology Janssen Research&DevelopmentBeijingChina

Objective:This double-blind,placebo-controlled phase 3 study was designed to compare efficacy and safety of abiraterone acetate+prednisone(abiraterone)to prednisone alone in chemotherapy-naı¨ve,asymptomatic or mildly symptomatic metastatic castrationresistant prostate cancer(mCRPC)patients from China,Malaysia,Thailand and ***:Adult chemotherapy-naı¨ve patients with confirmed prostate adenocarcinoma,Eastern Cooperative Oncology Group(ECOG)performance status(PS)grade 0e1,ongoing androgen deprivation(serum testosterone<50 ng/dL)with prostate specific antigen(PSA)or radiographic progression were randomized to receive abiraterone acetate(1000 mg,QD)t prednisone(5 mg,BID)or placebo t prednisone(5 mg,BID),until disease progression,unacceptable toxicity or consent *** endpoint was improvements in time to PSA progression(TTPP).Results:Totally,313 patients were randomized(abiraterone:n Z 157;prednisone:n Z 156);and baseline characteristics were *** clinical cut-off(median follow-up time:3.9 months),80% patients received treatment(abiraterone:n Z 138,prednisone:n Z 112).Median time to PSA progression was not reached with abiraterone versus 3.8 months for prednisone,attaining 58%reduction in PSA progression risk(HR=0.418;p<0.0001).Abirateronetreated patients had higher confirmed PSA response rate(50%vs.21%;relative odds=2.4;p<0.0001)and were 5 times more likely to achieve radiographic response than prednisonetreated patients(22.9%vs.4.8%,p=0.0369).Median survival was not *** common(≥10% abiraterone ***-treated)adverse events:bone pain(7%vs.14%),pain in extremity(6%vs.12%),arthralgia(10%vs.8%),back pain(7%vs.11%),and hypertension(15%vs.14%).Conclusion:Interim analysis confirmed favorable benefit-to-risk ratio of abiraterone in chemotherapy-naı¨ve men with mCRPC,consistent with global study,thus supporting use of abiraterone in this patient population.

关键词： Abiraterone Chemotherapy-naı¨ve Metastatic castrationresistant prostate cancer Prostate specific antigen Prednisone

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间歇采样灵巧噪声重复转发干扰研究

雷达科学与技术 2018年第3期16卷 311-316页

作者：吴筑莉熊鑫余国文郭淑芬空军预警学院湖北武汉430019

为研究如何对线性调频脉冲压缩雷达进行有效干扰,针对间歇采样重复转发干扰假目标分布相对均匀易被雷达识别、次假目标群衰减较大等问题,提出一种间歇采样灵巧噪声重复转发干扰。首先,从理论上分析了基于间歇采样的灵巧噪声重复转发干... 详细信息

为研究如何对线性调频脉冲压缩雷达进行有效干扰,针对间歇采样重复转发干扰假目标分布相对均匀易被雷达识别、次假目标群衰减较大等问题,提出一种间歇采样灵巧噪声重复转发干扰。首先,从理论上分析了基于间歇采样的灵巧噪声重复转发干扰效果,然后进行了仿真实验。结合理论分析和仿真实验结果可知,间歇采样灵巧噪声转发干扰在具备原间歇采样重复转发干扰特性的基础上,使假目标幅度和分布随机,不易被雷达识别。同时,通过灵巧噪声卷积调制,干扰无需测频自动瞄准雷达信号,干扰能量利用率高,明显优于传统的射频噪声干扰;通过调节噪声时宽,可以有效选择进行欺骗干扰或压制干扰,干扰方式较为灵活。

关键词：数字射频存储技术匹配滤波间歇采样重复转发干扰灵巧噪声

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针对“互联网+”的高校数学教学对策

黑龙江科学 2020年第19期11卷 84-85页

作者：李文洪伍朱莉江西科技师范大学数学与计算机学院南昌330038

数学信息化教学具有重要意义,其有利于教学创新,提高教学效率,能够促进差异化教学的落实,促进学生的个性化发展,符合时代人才培养原则。应实现互联网与高校数学教学模式的重组。提出了提高数学教师信息化教学能力的具体措施:应将教育与... 详细信息

数学信息化教学具有重要意义,其有利于教学创新,提高教学效率,能够促进差异化教学的落实,促进学生的个性化发展,符合时代人才培养原则。应实现互联网与高校数学教学模式的重组。提出了提高数学教师信息化教学能力的具体措施:应将教育与实践相结合,加强立体化教育资源共享,完善激励与保障机制。

关键词：互联网+ 高等数学教学模式对策

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一种抗多假目标干扰的自适应恒虚警检测方法

空军预警学院学报 2018年第6期32卷 391-396页

作者：熊鑫余国文郭淑芬吴筑莉空军预警学院 93498部队

针对广义删除均值(GCMLD)恒虚警检测器排序时间较长、干扰目标落入单侧滑窗会降低检测性能等问题,研究了一种将前后滑窗统一处理、简化判决过程的改进GCMLD方法——简化删除均值(SCMLD)恒虚警检测方法.从对抗角度出发,利用移频调制多假... 详细信息

针对广义删除均值(GCMLD)恒虚警检测器排序时间较长、干扰目标落入单侧滑窗会降低检测性能等问题,研究了一种将前后滑窗统一处理、简化判决过程的改进GCMLD方法——简化删除均值(SCMLD)恒虚警检测方法.从对抗角度出发,利用移频调制多假目标干扰,对SCMLD-CFAR和传统的CA-CFAR、SO-CFAR以及OS-CFAR进行对比仿真,验证了它在对抗环境中无需干扰数量这一先验信息就能自动进行目标检测的自适应能力,并通过CFAR损失在数值上具体分析了SCMLD-CFAR在多假目标干扰条件下的抗干扰性能.研究结果表明,SCMLD-CFAR抗多假目标干扰能力明显优于两种传统CFAR.

关键词：简化删除均值恒虚警多假目标干扰 CFAR损失自适应

LFM脉压雷达的间歇采样灵巧噪声转发干扰研究

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空军预警学院学报 2017年第5期31卷 354-359页

作者：吴筑莉余国文熊鑫郭淑芬空军预警学院武汉430019

为研究线性调频脉压雷达有效相干干扰,提出一种间歇采样灵巧噪声转发干扰.首先根据干扰信号特征,理论上分析了基于间歇采样的灵巧噪声转发干扰效果,然后进行了仿真实验.理论分析和仿真结果表明,间歇采样灵巧噪声转发干扰产生的假目标幅... 详细信息

为研究线性调频脉压雷达有效相干干扰,提出一种间歇采样灵巧噪声转发干扰.首先根据干扰信号特征,理论上分析了基于间歇采样的灵巧噪声转发干扰效果,然后进行了仿真实验.理论分析和仿真结果表明,间歇采样灵巧噪声转发干扰产生的假目标幅度和距离分布更具随机性,并且可通过调节噪声时宽改变假目标覆盖距离范围和覆盖范围内的假目标密度,干扰方式更为灵活.

关键词：线性调频脉压雷达匹配滤波间歇采样直接转发干扰灵巧噪声转发干扰

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： Yun Li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

A Verifiable Trust-Based CP-ABE Access Control Scheme for Cloud-Assisted Renewable Energy Systems

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Computers, Materials & Continua 2025年第1期82卷 1211-1232页

作者： Jiyu Zhang Kehe wu Ruomeng Yan Zheng Tian Yizhen Sun Yuxi wu Yaogong Guo Department of Control and Computer Engineering North China Electric Power UniversityBeijing102206China State Grid Information&Communication Company of Hunan Electric Power Corporation Changsha410118China State Grid Hunan Electric Power Corporation Chenzhou Power Supply Branch Chenzhou423000China

Renewable Energy Systems(RES)provide a sustainable solution to climate warming and environmental pollution by enhancing stability and reliability through status acquisition and analysis on cloud platforms and intelligent processing on edge servers(ES).However,securely distributing encrypted data stored in the cloud to terminals that meet decryption requirements has become a prominent research ***,managing attributes,including addition,deletion,and modification,is a crucial issue in the access control scheme for *** address these security concerns,a trust-based ciphertext-policy attribute-based encryption(CP-ABE)device access control scheme is proposed for RES(TB-CP-ABE).This scheme effectivelymanages the distribution and control of encrypted data on the cloud through robust attribute key *** introducing trust management mechanisms and outsourced decryption technology,the ES system can effectively assess and manage the trust worthiness of terminal devices,ensuring that only trusted devices can participate in data exchange and access sensitive ***,the ES system dynamically evaluates trust scores to set decryption trust thresholds,thereby regulating device data access permissions and enhancing the system’s *** validate the security of the proposed TB-CP-ABE against chosen plaintext attacks,a comprehensive formal security analysis is conducted using the widely accepted random oraclemodel under the decisional q-Bilinear Diffie-Hellman Exponent(q-BDHE)***,comparative analysis with other schemes demonstrates that the TB-CP-ABE scheme cuts energy/communication costs by 43%,and scaleswell with rising terminals,maintaining average latency below 50ms,ensuring real-time service *** proposed scheme not only provides newinsights for the secure management of RES but also lays a foundation for future secure energy solutions.

关键词： Access control renewable energy systems(RES) ciphertext-policy attribute-based encryption(CP-ABE) security

Hourglass-GCN for 3D Human Pose Estimation Using Skeleton Structure and View Correlation

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Computers, Materials & Continua 2025年第1期82卷 173-191页

作者： Ange Chen Chengdong wu Chuanjiang Leng Faculty of Robot Science and Engineering Northeastern UniversityShenyang110169China

Previous multi-view 3D human pose estimation methods neither correlate different human joints in each view nor model learnable correlations between the same joints in different views explicitly,meaning that skeleton structure information is not utilized and multi-view pose information is not completely ***,existing graph convolutional operations do not consider the specificity of different joints and different views of pose information when processing skeleton graphs,making the correlation weights between nodes in the graph and their neighborhood nodes *** Graph Convolutional Networks(GCNs)cannot extract global and deeplevel skeleton structure information and view correlations *** solve these problems,pre-estimated multiview 2D poses are designed as a multi-view skeleton graph to fuse skeleton priors and view correlations explicitly to process occlusion problem,with the skeleton-edge and symmetry-edge representing the structure correlations between adjacent joints in each viewof skeleton graph and the view-edge representing the view correlations between the same joints in different *** make graph convolution operation mine elaborate and sufficient skeleton structure information and view correlations,different correlation weights are assigned to different categories of neighborhood nodes and further assigned to each node in the *** on the graph convolution operation proposed above,a Residual Graph Convolution(RGC)module is designed as the basic module to be combined with the simplified Hourglass architecture to construct the Hourglass-GCN as our 3D pose estimation ***-GCNwith a symmetrical and concise architecture processes three scales ofmulti-viewskeleton graphs to extract local-to-global scale and shallow-to-deep level skeleton features *** results on common large 3D pose dataset Human3.6M and MPI-INF-3DHP show that Hourglass-GCN outperforms some excellent methods in 3D pose estimati

关键词： 3D human pose estimation multi-view skeleton graph elaborate graph convolution operation Hourglass-GCN

Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli Gu Kijung Sung Chengbiao wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic