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Spatial and temporal distribution of Neolithic sites in coastal China:Sea level changes, geomorphic evolution and human adaption

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Science China Earth Sciences 2018年第2期61卷 123-133页

作者： ZHENG HongBo ZHOU YouSheng YANG Qing HU zhujun LING GuangJiu ZHANG JuZhong GU ChunGuang WANG YingYing CAO YeTing HUANG XianRong CHENG Yue ZHANG XiaoYu wu WenXiang Research Center for Earth System Science Yunnan University School of Geography Science Nanjing Normal University Department for the History of Science and Scientific Archaeology University of Science and Technology of China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences

The East China coastal plain is one of the most important Neolithic culture areas in China, where rich archaeological sites including those producing the earliest domesticated rice are observed. It is also a place where landscape has experienced dramatic evolution during the Holocene when both sea level and climate changed, such that it is an ideal place for studying human-environment interaction. This study investigated over 2000 sites of pre-history and Shang and Zhou Dynasties, with 655 of which being Neolithic ages, by using DEM and GIS methods. The results suggest that the spatial and temporal distribution of Neolithic sites has largely been controlled by landscape evolution(particularly changes in coastal line), which ultimately governed by sea level changes. During early Holocene, Neolithic sites sparsely distributed in the intermountain basins of east Zhejiang Province, far from the influence of ocean. Over the period of 9–7 ka, the coastal plain(including the shelf) was largely submerged,only the feet of low hills to the south and southwest of the study area, and islands protruding the estuary, cradled limited number of settlements with characteristic "maritime components". At about 7 ka, sea level rise decelerated prominently, while sediments supply in the drainage remained high value, the combination of which led to land formation and propagation. Vast space during this period facilitated the growth of settlements in both size and number. In the mean time, however, the coastal plain was vulnerable to extreme environmental events such as storms and flooding owning to its geomorphic nature, which exerted great influence on the rise and fall of Neolithic culture.

关键词： East China coastal plain Neolithic Spatial and temporal distribution of Neolithic sites Sea level change Geomorphic evolution

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Analysis of prevailing pertussis strains from different regions in China after the application of acellular vaccines

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Chinese Medical Journal 2023年第13期136卷 1618-1620页

作者： Yamin Liu Bei Jiang Yu Guo Yuan Gao Jing Qian Chunhua Qie zhujun Shao Ying Li Qi wu Department of Respiratory and Critical Care Medicine Tianjin Medical University General HospitalTianjin 300052China Institute of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Infectious Disease Clinical School of the Second People’s HospitalTianjin Medical UniversityTianjin 300192China Department of Clinical Laboratory Nankai HospitalTianjin 300100China National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory for Infectious Disease Prevention and Control Beijing 102206China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases HangzhouZhejiang 310005China

To the Editor:With the extensive uptake of pertussis vaccine,morbidity and mortality related to pertussis have decreased *** application of acellular vaccines(ACVs)occurred later in China than in developed countries;correspondingly,the pertussis resurgence in China also began *** latest global genotype dynamic prediction model cannot explain the *** genotype change trend in China.[1]Chinese *** strains gradually formed their own unique developmental branches.[2]Here,a phylogenetic tree of prevailing *** strains from three different regions of China was visualized by EvolView(http://***/***).A total of 199 isolated *** strains were used for the phylogenetic *** ***-pertussis strain isolated from Tianjin was used as the out-group,and Chinese strain(CS),which is widely used as a vaccine strain for ACV production in China,was used as the reference *** particular,we analyzed the multilocus sequence typing(MLST)and macrolide-resistance-conferring gene mutations.

关键词： prevailing application pertussis

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Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in China

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Chinese Medical Journal 2014年第3期127卷 412-416页

作者： Gu Jun Li Maolan Dong Ping Lu Jianhua Tan zhujun wu Xiangsong Mu Jiasheng Zhang Lin wu Wenguang Ding Qichen Yang Jiahua Cao Yang Ding Qian Weng Hao Liu Yingbin Department of General Surgery and Laboratory of General Surgery Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China Institute of Biliary Tract Disease Shanghai Jiao Tong University School of Medicine Shanghai 200092 China

Background The insulin-like growth factor signaling pathway plays an important role in the modulation of cell growth and *** aim of this study was to investigate the role of polymorphisms of the insulin-like growth factor 2 （IGF2） and IGF-binding protein 3 （IGFBP3） genes,which encode key proteins of this pathway,as risk factors for gastric carcinoma （GC）.Methods A case-control study including 404 histologically confirmed GC patients and 424 healthy controls of the same ethnicity was conducted to retrospectively investigate the genetic polymorphisms of two genes,IGF2＋820A＞G （rs680） and IGFBP3 A-202C （rs2854744）.Adjusted odds ratios （ORs） and 95％ confidence intervals （C/s） were calculated using Logistic *** The IGF2 genetic variants examined contributed to GC risk individually （OR,1.26; 95％ CI,1.08-1.46）.The genotype frequencies of IGFBP3 A-202C were not significantly different between the cancer cases and controls （P ＞0.05）.Compared to the IGF2 AA genotype,carriers of one variant combined genotype were more pronounced among young subjects （＜60 years）,male subjects,never smokers,and those with a family history of cancer （OR=1.36,95％ CI=1.09-1.72,P ＜0.05; OR=1.61,95％ C/=1.28-2.08,P ＜0.05; OR=1.46,95％ C/=1.11-1.98,P ＜0.05; OR=1.53,95％ C/=0.91-2.6,P ＜0.05; respectively）.Moreover,when the combined effects of the risk genotypes were investigated,significant associations were detected between highrisk genotypes in IGF2 and IGFBP3 （OR,2.47; 95％ CI,1.75-3.49）.Conclusions Our results suggest that polymorphic variants of the IGF2 genes modulate gastric *** the IGF2 and IGFBP3 variants are evaluated toaether,a areater effect on GC risk is observed.

关键词： gastric carcinoma insulin-like growth factor 2 IGFBP3 polymorphisms Logistic regression

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体外反搏对典型冠状动脉疾病作用效果的集中参数建模仿真

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医用生物力学 2024年第1期39卷 24-31页

作者：王碧天孙竺君王亚伟刘晗浩伍贵富樊瑜波北京航空航天大学生物与医学工程学院北京生物医学工程高精尖创新中心教育部生物力学与力生物学重点实验室北京100191 中山大学附属第八医院心内科广东深圳518033

目的研究增强型体外反搏(enhanced external counter pulsation,EECP)疗法对典型冠脉血管病及微血管心绞痛的血流动力学影响。方法使用集中参数建模方法,建立包含导管动脉与心肌微循环的右优势型冠脉生理模型。分别仿真单支狭窄、三... 详细信息

目的研究增强型体外反搏(enhanced external counter pulsation,EECP)疗法对典型冠脉血管病及微血管心绞痛的血流动力学影响。方法使用集中参数建模方法,建立包含导管动脉与心肌微循环的右优势型冠脉生理模型。分别仿真单支狭窄、三支狭窄及微血管心绞痛等病理情况。建立EECP干预模型,结合上述病理模型,仿真EECP对病理模型的血流动力学作用。结果建立的冠脉生理模型、病理模型及EECP干预模型仿真结果与相关文献中的实验数据相符合。EECP对3种病理情况都有改善冠脉血流的效果。对单支狭窄,EECP在左主干冠脉狭窄程度达到80%~85%之后便无法使血流恢复正常水平。对三支狭窄,若3条分支狭窄程度有1支超过90%,则无法使用EECP治疗。对微血管心绞痛,EECP有效的临界情况是充血心肌血流量>1.03 mL/(min·g)、冠状动脉血流储备>1.64。结论建立的EECP干预冠脉血管病模型符合预期,所获仿真数据对EECP的临床操作具有一定参考价值。

关键词：集中参数模型冠脉血管病微血管心绞痛增强型体外反搏

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平面激波冲击并排液滴的三维数值模拟研究

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力学学报 2022年第11期54卷 2958-2969页

作者：吴润龙李祝军丁航中国科学技术大学近代力学系合肥230026

采用三维守恒清晰界面数值方法,研究平面激波冲击并排液滴的动力学过程.研究的焦点在于激波接触液滴后的复杂波系结构生成,以及并排液滴相互耦合作用诱导的单个液滴非对称界面演化.首先,分析并排液滴之间界面通道内的波系结构发展,发现... 详细信息

采用三维守恒清晰界面数值方法,研究平面激波冲击并排液滴的动力学过程.研究的焦点在于激波接触液滴后的复杂波系结构生成,以及并排液滴相互耦合作用诱导的单个液滴非对称界面演化.首先,分析并排液滴之间界面通道内的波系结构发展,发现在冲击初期由于反射激波相交而形成新的反射激波以及马赫杆;这些流动现象与液滴另外一侧(非通道侧)由激波反射所形成的弯曲波阵面截然不同,而且所导致的液滴横向两侧流场差异是中后期冲击过程液滴两侧界面非对称演化的主要原因.其次,研究冲击中期时,特别是入射激波已运动至液滴下游并远离并排液滴,界面形态的演化过程和规律,揭示通道下游出口处由于气流膨胀导致的界面闭合、以及随后气流阻塞导致的界面破碎等新的流动现象.最后,研究液滴间距对并排液滴相互作用的影响规律,发现液滴间距大小与通道内压力峰值具有明显的关联关系.研究表明,更小的液滴间距不仅带来更大的压力峰值,而且使得峰值出现的时间更早.

关键词：激波液滴可压缩两相流守恒清晰界面方法界面变形

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the National Natural Science Foundation of China(41877029,41961130383);Royal SocietyNewton Advanced Fellowship(NAF\R1\191017);wuhan Science and Technology Bureau(2019020701011469).

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Soil Ecology Letters 2022年第3期4卷 224-236页

作者： Shuzhen Li Xiongfeng Du Kai Feng Yueni wu Qing He zhujun Wang Yangying Liu Danrui Wang Xi Peng Zhaojing Zhang Arthur Escalas Yuanyuan Qu Ye Deng CAS Key Laboratory of Environmental Biotechnology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian116024China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Institute for Marine Science and Technology Shandong UniversityQingdao 266237China MARBEC Universitéde MontpellierCNRSIRDIFREMERMontpellier Cedex 534090France

Due to the tremendous diversity of microbial organisms in topsoil,the estimation of saturated richness in a belowground ecosystem is still ***,we intensively surveyed the 16S rRNA gene in four 1 m2 sampling quadrats in a typical grassland,with 141 biological or technical replicates generating over 11 million sequences per *** these massive data sets and using both non-asymptotic extrapolation and non-parametric asymptotic approaches,results revealed that roughly 15919±193,27193±1076 and 56985±2347 prokaryotic species inhabited in 1 m2 topsoil,classifying by DADA2,UPARSE(97%cutoff)and Deblur,respectively,and suggested a huge difference among these clustering *** 500000 sequences were required to catch 50%species in 1 m2,while any estimator based on 500000 sequences would still lose about a third of total *** sequencing depth will greatly underestimate both observed and estimated *** least~911000,~3461000,and~1878000 sequences were needed for DADA2,UPARSE,and Deblur,respectively,to catch 80%species in 1 m2 topsoil,and the numbers of sequences would be nearly twice to three times on this basis to cover 90%*** contrast,α-diversity indexes characterized by higher order of Hill numbers,including Shannon entropy and inverse Simpson index,reached saturation with fewer than 100000 sequences,suggesting sequencing depth could be varied greatly when focusing on exploring differentα-diversity characteristics of a microbial *** findings were fundamental for microbial studies that provided benchmarks for the extending surveys in large scales of terrestrial ecosystems.

关键词： Grassland Topsoil Prokaryote Richness α-diversity Hill number

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κ-Carrageenan exacerbatesTNBS-induced inflammation in BALB/c mice

κ-Carrageenan exacerbatesTNBS-induced inflammation in BALB/...

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全国第二届海洋与陆地多糖多肽及天然创新药物研发学术会议

作者： zhujun Zhu Wei wu Xin Gao Tingting Niu Haimin Chen Key Laboratory of Applied Marine Biotechnology of Zhejiang Province Ningbo university

Carrageenan is a traditional ingredient that has been widely usedin the food *** aggravating effect of K-carrageenan on2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced intestinal inflammationwas investigated in amouse *** administration ofκ-carrageenan to BALB/c mice prior to the induction of TNBS colitis resulted in an aggravation of body weight loss and a decrease in the survival *** analysis and scanning electron microscopy revealed that the colonic inflammation was aggravated by the administration ofκ-*** ratio of CD4+CD25+CD127dim/CD4+of the carrageenan+TNBS group was significantly lower than that of the TNBS *** expression of critical inflammatory cytokines,interleukin-2(IL-2),tumor necrosis factor(TNF),and interleukin-6(IL-6)significantly increased,and interleukin-10(IL-10)significantly decreased in TNBS-induced inflammation after K-carrageenan administration.K-Carrageenan,together with TNBS,suppressed the expression of forkhead box(FOX)p3 and increased the expression of Toll-like receptor 4(TLR4)and Nuclear factor-KB(NF-κB)in the colonic mucosa of the experimental ***,we verified the result by real-time quantitative RT-PCR in molecular *** conclusion,κ-carrageenan aggravated TNBS-induced intestinal inflammation in BALB/c *** effect is associated with anactivation of the TLR4-NF-κB pathway,a decreased ratio of Treg cells,and the immunomodulator mechanism of carrageenan depending on T lymphocyte cytokine network switch Th2 type anti-inflammatory response toward to Thl type inflammatory response by elevation of IL-2 and reduction on IL-10 level.

关键词： κ-carrageenan TNBS intestinal inflammation Th1

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Soil microbiome mediated nutrients decline during forest degradation process

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Soil Ecology Letters 2019年第1期1卷 59-71页

作者： Yangying Liu Shang Wang zhujun Wang Zhaojing Zhang Huayu Qin Ziyan Wei Kai Feng Shuzhen Li Yueni wu Huaqun Yin Hui Li Ye Deng Key Laboratory of Environmental Biotechnology Research Center for Eco-Environmental ScienceChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China State Key Laboratory of Forest and Soil Ecology Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China

Degradation succession in forests is an important and serious land use/cover change problem in ecology,and during these processes soil microbial communities mediate the recycling of most important *** reveal the effect of degradation succession processes on soil microbial community diversity,structure,and species interrelationships,we collected abundant samples(21 per vegetation type)in broad-leaved forest,coniferous forest,and meadow to observe the microbial community *** results showed that diversity and structure of soil prokaryotic and fungal communities responded differently to different forest degradation processes,diversity of soil microbial communities increased during degradation *** microbial communities abundance changes may indicate that prokaryotic communities showed a living strategies change as an ecological adaption to harsh conditions during forest degradation *** for fungal communities,their abundance changes may indicate that environmental selection pressure and plant selectivity during forest degradation *** in soil prokaryotic communities and fungal communities were both correlated with soil carbon and nitrogen *** soil microbial interaction network analysis indicated more complex species interrelationships formed due to the loss of soil nutrients during degradation succession processes,suggesting soil microbial communities might form more complex and stable networks to resist the external disturbance of soil nutrient *** results suggested soil microorganisms,including bacteria,archaea and fungi,all involved in the soil nutrient decline during the forest degradation process.

关键词： Microbial communities Degradation succession Soil nutrients High-throughput sequencing Molecular ecological networks

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Towards intrinsically pure graphene grown on copper

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Nano Research 2022年第2期15卷 919-924页

作者： Xiaozhi Xu Ruixi Qiao Zhihua Liang Zhihong Zhang Ran Wang Fankai Zeng Guoliang Cui Xiaowen Zhang Dingxin Zou Yi Guo Can Liu Ying Fu Xu Zhou Muhong wu zhujun Wang Yue Zhao Enke Wang Zhilie Tang Dapeng Yu Kaihui Liu Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of Physics and Telecommunication EngineeringSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter South China Normal UniversityGuangzhou 510006China State Key Laboratory for Mesoscopic Physics Frontiers Science Center for Nano-optoelectronicsSchool of PhysicsPeking UniversityBeijing 100871China International Centre for Quantum Materials Collaborative Innovation Centre of Quantum MatterPeking UniversityBeijing 100871China Shenzhen Institute for Quantum Science and Engineering and Department of PhysicsSouthern University of Science and TechnologyShenzhen 518055China Songshan Lake Materials Laboratory Institute of PhysicsChinese Academy of SciencesGuangdong 523808China School of Physical Science and Technology ShanghaiTech UniversityShanghai 200031China

The state-of-the-art semiconductor industry is built on the successful production of silicon ingot with extreme purity as high as 99.999999999%,or the so-called"eleven nines".The coming high-end applications of graphene in electronics and optoelectronics will inevitably need defect-free pure graphene as *** to its two-dimensional(2D)characteristics,graphene restricts all the defects on its surface and has the opportunity to eliminate all kinds of defects,i.e.,line defects at grain boundaries and point or dot defects in grains,and produce intrinsically pure *** the past decade,epitaxy growth has been adopted to grow graphene by seamlessly stitching of aligned grains and the line defects at grain boundaries were eliminated ***,as for the equally common dot and point defects in graphene grain,there are rare ways to detect or reduce them with high throughput and ***,we report a methodology to realize the production of ultrapure graphene grown on copper by eliminating both the dot and point defects in graphene *** dot defects,proved to be caused by the silica particles shedding from quartz tube during the high-temperature growth,were excluded by a designed heat-resisting box to prevent the deposition of particles on the copper *** point defects were optically visualized by a mild-oxidation-assisted method and further reduced by etching-regrowth process to an ultralow level of less than 1/1,000 μm^(2).Our work points out an avenue for the production of intrinsically pure graphene and thus lays the foundation for the large-scale graphene applications at the integrated-circuit level.

关键词： pure graphene point defect mild-oxidation copper

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在线电生强氧化剂钴Ⅲ化学发光法测定地塞米松磷酸钠

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分析化学 2001年第3期29卷 267-270页

作者：吴蔓莉李保新章竹君陕西师范大学化学系!西安710062

本文基于Co3 +在硫酸介质中能氧化地塞米松磷酸钠产生化学发光这一特性 ,建立了一种流动注射化学发光测定地塞米松磷酸钠的新方法。其中不稳定的强氧化剂Co3 +是通过在硫酸介质中恒电流电解CoSO4 在线产生的 ,从而消除了由于试剂不稳定... 详细信息

本文基于Co3 +在硫酸介质中能氧化地塞米松磷酸钠产生化学发光这一特性 ,建立了一种流动注射化学发光测定地塞米松磷酸钠的新方法。其中不稳定的强氧化剂Co3 +是通过在硫酸介质中恒电流电解CoSO4 在线产生的 ,从而消除了由于试剂不稳定性带来的一些不利因素。该方法测定地塞米松磷酸钠的线性范围为 1～ 2 0mg/L ,检出限为 3 .2× 10 -7g/mL(DL =3S/r) ,相对标准偏差小于 5 %。该方法已成功地用于地塞米松磷酸钠注射液中地塞米松磷酸钠的测定。

关键词：流动注射化学发光地塞米松磷酸钠在线电生三价钴

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