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Journal of Energy Chemistry 2024年第2期89卷 195-207,I0006页

作者： zhuangzhuang jia.yuanyuan min Peng Qin Wenxin Mei Xiangdong Meng Kaiqiang Jin Jinhua Sun Qingsong Wang State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026AnhuiChina Gotion High-Tech Co. Ltd.Hefei 230012AnhuiChina

The safety valve is an important component to ensure the safe operation of lithium-ion batteries(LIBs).However,the effect of safety valve type on the thermal runaway(TR)and gas venting behavior of LIBs,as well as the TR hazard severity of LIBs,are not *** this paper,the TR and gas venting behavior of three 100 A h lithium iron phosphate(LFP)batteries with different safety valves are investigated under *** to previous studies,the main contribution of this work is in studying and evaluating the effect of gas venting behavior and TR hazard severity of LFP batteries with three safety valve *** significant results are obtained:(Ⅰ)the safety valve type dominates over gas venting pressure of battery during safety venting,the maximum gas venting pressure of LFP batteries with a round safety valve is 3320 Pa,which is one order of magnitude higher than other batteries with oval or cavity safety valve;(Ⅱ)the LFP battery with oval safety valve has the lowest TR hazard as shown by the TR hazard assessment model based on gray-fuzzy analytic hierarchy *** study reveals the effect of safety valve type on TR and gas venting,providing a clear direction for the safety valve design.

关键词： Lithium iron phosphate battery Safety valve Thermal runaway Gas venting behavior Thermal runaway hazard severity Gray-fuzzy analytic hierarchy process

Cognitive Jammers Assisted Covert Communication in Cognitive Radio Networks

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China Communications 2024年第9期21卷 75-89页

作者： Liu Changjun Shi jia Tie zhuangzhuang Wang Yongchao The State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China

In this work,we investigate the covert communication in cognitive radio(CR)networks with the existence of multiple cognitive jammers(CJs).Specifically,the secondary transmitter(ST)helps the primary transmitter(PT)to relay information to primary receiver(PR),as a reward,the ST can use PT's spectrum to transmit private information against the eavesdropper(Eve)under the help of one selected cognitive jammer(CJ).Meanwhile,we propose three jammer-selection schemes,namely,link-oriented jammer selection(LJS),min-max jammer selection(MMJS)and random jammer selection(RJS).For each scheme,we analyze the average covert throughput(ACT)and covert outage probability(COP).Our simulation results show that CJ is helpful to ST's covert communication,the expected minimum detection error probability and ACT can be significantly improved with the increase of false alarm of ***,the LJS scheme achieves best performance in ACT and COP,followed by RJS scheme,and MMJS scheme shows the worst performance.

关键词： cognitive jammer cognitive radio covert communication performance analysis

Elaborate Design of Two Novel Fluorescent Zinc-based Metal-Organic Frameworks for Highly Efficient Tetracycline Antibiotics Detection

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Chemical Research in Chinese Universities 2024年第3期40卷 499-507页

作者： TAO He JI Chengshan ZHANG jian YIN yuanyuan jia Wenwen jiaNG Xin XU Jie YANG Yulin MIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001P.R.China

The abuse of tetracycline antibiotics has caused great harm to human health and *** inexpensive,convenient and sensitive methods for the detection of tetracycline antibiotics is highly ***,based on the H_(4)ddp ligand[H_(4)ddp=3-(3,5-dicarboxyphenyl)pyridine-2,6-dicarboxylic acid],two novel zinc-based metal-organic frameworks(MOFs){[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn1-ddp)and{[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn2-ddp)were successfully designed by delicate structural *** Zn1-ddp and Zn2-ddp exhibited excellent water and chemical stability and showed excellent fluorescence quenching performance for tetracycline ***,the more advanced framework structure and better fluorescent performance make Zn1-ddp more sensitive than Zn2-ddp in fluorescent detection with a detection limit of 0.29µmol/L for tetracycline(TC),0.09µmol/L for doxycycline(DOX),0.10µmol/L for minocycline(min)and metacycline(MEL),0.19µmol/L for chlortetracycline(CTC),and 0.67µmol/L for oxytetracycline(OTC)among tetracycline *** fluorescence quenching mechanism of Zn1-ddp and Zn2-ddp for tetracycline antibiotics detection was deeply *** reasons for the superior detection performance of Zn1-ddp over Zn2-ddp were also analyzed in depth through Fourier transform infrared spectrophotometry(FTIR),X-ray photoelectron spectroscopy(XPS)analysis and framework structure *** developed method opens up a new perspective for antibiotics detection based on zinc-based MOFs.

关键词： Water system Metal-organic framework Fluorescent detection Tetracycline antibiotic

挤压316H奥氏体不锈钢大口径管材的晶粒度控制

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金属热处理 2024年第4期49卷 168-174页

作者：贾晓斌秦瑞廷涂明金李媛媛胡永平周仲成北京科技大学新金属材料国家重点实验室北京100083 内蒙古北方重工业集团有限公司内蒙古包头014030 北京科技大学材料科学与工程学院北京100083

系统研究了不同变形量、变形速率、冷却方式、固溶处理温度对316H奥氏体不锈钢晶粒度的影响,并开展了挤压大口径316H奥氏体不锈钢工程化试制。结果表明,变形量越大,晶粒越细小,挤压变形量为80%时,挤压后的晶粒度可达4级以上;在相同变形... 详细信息

系统研究了不同变形量、变形速率、冷却方式、固溶处理温度对316H奥氏体不锈钢晶粒度的影响,并开展了挤压大口径316H奥氏体不锈钢工程化试制。结果表明,变形量越大,晶粒越细小,挤压变形量为80%时,挤压后的晶粒度可达4级以上;在相同变形速率情况下,试样的晶粒尺寸与冷却方式关系明显,水冷、空冷和3 min保温再空冷方式的晶粒尺寸依次增大;在相同的冷却速度条件下,变形速率越快,晶粒尺寸越细小,但随着冷却力度的减弱,晶粒尺寸差距逐渐减少。固溶处理温度对晶粒尺寸长大的作用远大于固溶时间的作用,成形后固溶处理对晶粒的均匀化起到一定的作用,但固溶温度过高会使晶粒迅速长大,固溶处理温度和保温时间应该控制在1050℃和40 min内。

关键词： 316H不锈钢晶粒度挤压温度变形量固溶温度

Impact of National Centralized Drug Procurement Policy on Antiviral Utilization and Expenditure for Hepatitis B in China

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 420-428页

作者： Xinyu Zhao min Li Hao Wang Xiaoqian Xu Xiaoning Wu Yameng Sun Canjian Ning Bingqiong Wang Shuyan Chen Hong You Jidong jia.yuanyuan Kong Clinical Epidemiology and EBM Unit Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseasesBeijingChina Liver Research Center Beijing Friendship HospitalCapital Medical UniversityBeijing Key Laboratory of Translational Medicine on Liver CirrhosisNational Clinical Research Center of Digestive DiseasesBeijingChina Human resources and Social Security Bureau of jiangsu Taizhou Medical High-tech Zone(Gaogang District)Management Committee TaizhouJiangsuChina Liver Research Center Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseasesBeijingChina

Background and Aims:The National Centralized Drug Procurement(NCDP)policy was launched in China's Mainland in April 2019,with entecavir(ETV)and tenofovir disoproxil fumarate(TDF)being included in the procurement *** conducted the current study to investigate the impact of the NCDP policy on the utilization and expenditures of antiviral therapy for chronic hepatitis B(CHB)in ***:Procurement records,including monthly purchase volume,expenditure,and price of nucleos(t)ide analogs(NAs),were derived from the National Healthcare Security Administration from April 2018 to March *** changes in volumes and expenditures of the first-line NAs and bid-winning products were *** effects of price,volume,and structure related to drug expenditure were calculated by the Addis and Magrini(AM)Index System ***:The purchase volume of NAs significantly increased from 134.3 to 318.3 million DDDs,whereas the expenditure sharply decreased from 1,623.41 to 490.43 million renminbi(RMB)or 241.94 to 73.09 million US dollars(USD).The proportions of firstline NAs rose from 72.51%(ETV:69.00%,TDF:3.51%)to 94.97%(ETV:77.42%,TDF:17.55%).AM analysis showed that the NCDP policy decreased the expenditure of all NAs(S=0.91)but increased that of the first-line NAs in the bidwinning list(S=1.13).Assuming the population size of CHB patients remains stable and a compliance rate of≥75%,the proportion of CHB patients receiving first-line antiviral therapy would increase from 6.36–8.48%to 11.56–15.41%.Conclusions:The implementation of the NCDP policy significantly increased the utilization of first-line NAs for CHB patients at a lower *** findings provided evidence for optimizing antiviral therapy strategy and allocating medical resources in China.

关键词： National centralized drug procurement Drug utilization Drug expenditures Antiviral therapy Chronic hepatitis B

The brassinosteroid signaling component SlBZR1 promotes tomato fruit ripening and carotenoid accumulation

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Journal of Integrative Plant Biology 2023年第7期65卷 1794-1813页

作者： Fanliang Meng Haoran Liu Songshen Hu Chengguo jia min Zhang Songwen Li yuanyuan Li jiayao Lin Yue jian Mengyu Wang Zhiyong Shao Yuanyu Mao Lihong Liu Qiaomei Wang Key Laboratory of Horticultural Plant Growth and Development Ministry of AgricultureDepartment of HorticultureZhejiang UniversityHangzhou 310058China College of Plant Science Jilin UniversityChangchun 130062China

The plant hormone ethylene is essential for climacteric fruit ripening, although it is unclear how other phytohormones and their interactions with ethylene might affect fruit ripening. Here, we explored how brassinosteroids(BRs) regulate fruit ripening in tomato(Solanum lycopersicum) and how they interact with ethylene. Exogenous BR treatment and increased endogenous BR contents in tomato plants overexpressing the BR biosynthetic gene SlCYP90B3promoted ethylene production and fruit *** analysis indicated that the BR signaling regulators Brassinazole-resistant1(SlBZR1) and BRI1-EMS-suppressor1(SlBES1) act redundantly in fruit softening. Knocking out Sl BZR1 inhibited ripening through transcriptome reprogramming at the onset of ripening. Combined transcriptome deep sequencing and chromatin immunoprecipitation followed by sequencing identified 73 Sl BZR1-repressed targets and 203 Sl BZR1-induced targets involving major ripening-related genes, suggesting that Sl BZR1 positively regulates tomato fruit *** BZR1 directly targeted several ethylene and carotenoid biosynthetic genes to contribute to the ethylene burst and carotenoid accumulation to ensure normal ripening and quality formation. Furthermore,knock-out of Brassinosteroid-insensitive2(Sl BIN2),a negative regulator of BR signaling upstream of Sl BZR1, promoted fruit ripening and carotenoid accumulation. Taken together, our results highlight the role of Sl BZR1 as a master regulator of tomato fruit ripening with potential for tomato quality improvement and carotenoid biofortification.

关键词： brassinosteroids carotenoids ethylene fruit ripening quality improvement SlBIN2 SlBZR1 tomato

A heavy metal transporter gene ZmHMA3a promises safe agricultural production on cadmium-polluted arable land

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Journal of Genetics and Genomics 2023年第2期50卷 130-134页

作者： yuanyuan Chen Zhen-Fei Chao min Jin Ya-Ling Wang Yaoyao Li jia-Chen Wu Yingjie Xiao Yong Peng Qiao-Yan Lv Songtao Gui Xiaqing Wang Mei-Ling Han Alisdair R.Fernie Dai-Yin Chao jianbing Yan National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhanHubei 430070China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China School of Life Sciences State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesSouth China Agricultural UniversityGuangzhouGuangdong 510642China Hubei Hongshan Laboratory WuhanHubei 430070China Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding Maize Research CenterBeijing Academy of Agriculture&Forestry Sciences(BAAFS)Beijing 100097China Department of Molecular Physiology Max-Planck-Institute of Molecular Plant PhysiologyAm Mühlenberg 114476 Potsdam-GolmGermany National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan LaboratoryWuhanHubei 430070China

In China,19%of agricultural soils contain harmful heavy metal pollutants at levels exceeding environmentally recommended standards,whilst around 3 million hectares of arable land are too polluted to grow crops on(Zhao et al.,2015;Hu et al.,2016).Among the deleterious heavy metals,cadmium(Cd)is the most bioavailable toxic metallic pollutant and is rapidly transferable through the food chain(Wang et al.,2019).Concerning the current dilemma of the enhanced food demands of a rising population and decreasing availability of arable land,it is promising to cultivate field crops that produce enough safe foods for human consumption and simultaneously remove the pollutants from contaminated arable lands.

关键词： arable crops cadmium

副猪嗜血杆菌AfuA-ELISA抗体检测方法的建立与应用

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中国动物检疫 2024年第2期41卷 65-71页

作者：李真亚赵晓康杨红玉李允孔嫄嫄贾荣玲李生涛南阳农业职业学院河南南阳473000

为建立一种特异性强、灵敏度高的副猪嗜血杆菌(Haemophilus parasuis,HPS)ELISA抗体检测方法,为副猪嗜血杆菌病的诊断及免疫抗体检测提供技术支撑,首先重组表达了HPS 2个具有免疫原性的蛋白(HbpA、AfuA),随后对HbpA、AfuA进行初筛,选择A... 详细信息

为建立一种特异性强、灵敏度高的副猪嗜血杆菌(Haemophilus parasuis,HPS)ELISA抗体检测方法,为副猪嗜血杆菌病的诊断及免疫抗体检测提供技术支撑,首先重组表达了HPS 2个具有免疫原性的蛋白(HbpA、AfuA),随后对HbpA、AfuA进行初筛,选择AfuA作为最佳包被蛋白。通过优化AfuA-ELISA反应条件,确定了最佳抗原包被质量浓度为5μg/mL,最佳封闭液为5%脱脂乳溶液,最佳样品稀释液为2%BSA溶液,最佳样品孵育时间为30 min,最佳样品稀释度为1:25,最佳酶标二抗稀释度为1:20000,最佳酶标二抗孵育时间为30 min,最佳底物孵育时间为10 min。特异性试验显示,建立的AfuA-ELISA方法对猪其他常见病原阳性血清的检测结果均为阴性,表明其具有良较好的特异性。对300份临床样品进行检测,AfuA-ELISA方法分别检出阳性、阴性血清177、123份,与商业化试剂盒的阳性、阴性符合率分别为90.0%、87.5%,总体符合率为89.0%。结果表明,本研究建立的AfuA-ELISA方法具有特异性强、灵敏度高,与商业化试剂盒符合率高的优点,可以用于临床HPS抗体检测。

关键词：副猪嗜血杆菌间接ELISA HbpA AfuA

DBLiPro:A Database for Lipids and Proteins in Human Lipid Metabolism

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Phenomics 2023年第4期3卷 350-359页

作者： Qian Wu yuanyuan Huang Xiangya Kong Ben jia Xiaoting Lu Yunqin Chen Zechi Huang Yuan‑Yuan Li Wentao Dai NHC Key Laboratory of Reproduction Regulation&Shanghai‑MOST Key Laboratory of Health and Disease Genomics Shanghai Institute for Biomedical and Pharmaceutical Technologies(SIBPT)Fudan UniversityNo.779Old Hu Min RoadShanghai 200237China Beijing Cloudna Technology Co. Ltd.No.53Yanqi StreetBeijing 100101China Shanghai Key Laboratory of Gastric Neoplasms Department of General SurgeryShanghai Institute of Digestive SurgeryRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Engineering Research Center of Pharmaceutical Translation Shanghai 201203China

To help researchers in the field of biology,medicine,chemistry,and materials science to use lipidomic data conveniently,there is an urgent need to develop a platform that provides a systematic knowledgebase of human lipid metabolism and lipidome-centric omics analysis *** is a user-friendly webserver allowing for access to human metabolism-related lipids and proteins knowledge database and an interactive bioinformatics integrative analysis workflow for lipidomics,transcriptomics,and proteomics *** DBLiPro,there are 3109 lipid-associated proteins(LAPs)and 2098 lipid metabolites in the knowledge base section,which were obtained from Uniprot,Kyoto Encyclopedia of Genes and Genomes(KEGG)and were further annotated by information from other public resources in the knowledge base section,such as RaftProt and *** offers a step-by-step interactive analysis workflow for lipidomics,transcriptomics,proteomics,and their integrating multi-omics analysis focusing on the human lipid *** summary,DBLiPro is capable of helping users discover key molecules(lipids and proteins)in human lipid metabolism and investigate lipid–protein functions underlying mechanisms based on their own omics *** DBLiPro is freely available at http://*** ***/home.

关键词： Lipid-associated proteins Lipid Human lipid metabolism Database Omics

度普利尤单抗治疗中重度老年特应性皮炎临床疗效观察

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中华皮肤科杂志 2023年第2期56卷 125-129页

作者：贾元源毛秋雨杨婧怡闵玮苏州大学附属第一医院皮肤科苏州215006

目的观察度普利尤单抗治疗中重度老年特应性皮炎(AD)的临床疗效及安全性。方法本研究为观察性研究,纳入2021年9月至2022年6月于苏州大学附属第一医院皮肤科就诊的中重度老年AD患者42例,均予度普利尤单抗首次皮下注射600 mg,随后300 mg/2... 详细信息

目的观察度普利尤单抗治疗中重度老年特应性皮炎(AD)的临床疗效及安全性。方法本研究为观察性研究,纳入2021年9月至2022年6月于苏州大学附属第一医院皮肤科就诊的中重度老年AD患者42例,均予度普利尤单抗首次皮下注射600 mg,随后300 mg/2周,总疗程为16周。于第0、4、8、12、16周记录患者临床指标,包括湿疹面积与严重程度指数(EASI)、瘙痒数值评分量表(NRS)、皮肤病生活质量指数(DLQI)、研究者整体评分(IGA),并统计EASI改善超过50%(EASI-50)和75%(EASI-75)的患者比例;于第0、4、16周检测患者血清总IgE水平和嗜酸性粒细胞计数,观察患者不良事件发生情况。使用SPSS27、GraphPad Prism 9.0软件,通过χ2检验、单因素ANOVA检验、t检验进行统计学分析。结果42例患者中,男25例(59.5%),女17例(40.5%),年龄(71.82±16.81)岁。其中,泛发性湿疹表型17例(40.5%),屈侧湿疹表型15例(35.7%),结节性痒疹表型10例(23.8%)。经治后,第4和16周时患者EASI评分分别降低38.4%和73.3%,NRS评分分别降低53.0%和77.4%,DLQI评分分别降低58.2%和93.8%,治疗前后比较,差异均有统计学意义(P<0.05或0.001)。第4和16周时,IGA评分降至0或1的比例分别为11.9%和61.9%,EASI-50分别为11.9%和76.2%,EASI-75分别为2.4%和57.1%。实验室指标方面,与基线相比,第4及16周时血清总IgE分别降低23.1%(P=0.274)和38.2%(P=0.395),嗜酸性粒细胞计数分别下降24.4%(P=0.059)和37.5%(P=0.735),差异均无统计学意义。治疗期间6例(14.3%)患者发生不良事件,程度均轻微,分别为结膜炎(3例)、头面部真菌感染(2例)、银屑病样皮炎(1例),予对症治疗后消退。结论度普利尤单抗治疗中重度老年AD起效迅速,疗效显著,不良事件较少且轻微;但部分患者16周时仍未实现EASI-50或EASI-75缓解,需维持用药。

关键词：皮炎,特应性老年人治疗生物制剂度普利尤单抗