检索结果-南通市图书馆

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng Fu shining Ge Jiangwei shi Yanjun Zhang Pengwei zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

引用

Science China(Life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-Feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao Li Chang-Fa Fan Ke Song Yuan-Guo Li Run-Ze Ye Fang-Xu Li Dai-Yun Zhu Jie Zhang zhuang-zhuang shi Ming-Zhu Zhang Liang-Jing Li shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu Lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang Yan-Ling Hu Na Jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China Life Sciences Institute Guangxi Medical UniversityNanning 530020China College of Life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

结直肠癌进展与抑制的十字路口:间充质干细胞治疗干预效果及难题

引用

中国组织工程研究 2025年第23期29卷 5022-5030页

作者：郭昭庄浩岩史学文山东中医药大学第一临床医学院山东省济南市250000 山东中医药大学附属医院肛肠科山东省济南市250000

背景:结直肠癌早期的治疗方法包括内镜和手术切除,但是术后并发症多,晚期多采用化疗方法,然而化疗会引起胃肠功能紊乱、骨髓抑制、肝肾功能损伤等不良反应,导致大多数患者不主动、不配合治疗。目的:综述间充质干细胞治疗结直肠癌的作用... 详细信息

背景:结直肠癌早期的治疗方法包括内镜和手术切除,但是术后并发症多,晚期多采用化疗方法,然而化疗会引起胃肠功能紊乱、骨髓抑制、肝肾功能损伤等不良反应,导致大多数患者不主动、不配合治疗。目的:综述间充质干细胞治疗结直肠癌的作用机制、最新治疗进展及目前存在的问题,为将来临床应用提供依据。方法:计算机检索Pub Med数据库、中国知网、万方数据库收录的相关文献。英文检索词为“mesenchymal stem cells,colorectal cancer,cancer stem cell,tumor microenvironment”,中文检索词为“间充质干细胞,结直肠癌,癌症干细胞,肿瘤微环境”,最终纳入119篇文献进行分析。结果与结论:(1)间充质干细胞对于结直肠癌具有促进和抑制的双面作用;(2)间充质干细胞的肿瘤归巢特性使其能够准确迁移到肿瘤位置并释放药物,基于这一特性,增加了治疗结直肠癌的安全性和有效性;(3)间充质干细胞衍生的外泌体作为良好的药物载体,在结直肠癌靶向治疗中显示出良好的应用前景;(4)使用病毒载体、非病毒载体或其他转染工具将具有成熟抗肿瘤作用的药物加载到间充质干细胞中,共同治疗结直肠癌;(5)间充质干细胞与化疗药物联合使用可以提高化疗药物疗效并降低化疗药物不良反应;(6)间充质干细胞促进结直肠癌的发展机制主要与结直肠癌细胞中的信号转导、趋化因子的表达状态及间充质干细胞向癌症相关成纤维细胞转化有关;(7)间充质干细胞可能具有驱动癌症干细胞的特性,促进肿瘤起始并提高肿瘤侵袭性;(8)间充质干细胞治疗结直肠癌还存在着不可避免的问题:缺乏标准化治疗方案及疗效评价方法、治疗成本高昂、间充质干细胞的保存与运输问题、间充质干细胞与化疗药物共同使用的比例等。

关键词：结直肠癌间充质干细胞癌症干细胞肿瘤微环境化疗外泌体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polymer hydrogels with enhanced stability and heterogeneous Fenton activity in organic pollutant removal

引用

Journal of Environmental Sciences 2019年第11期31卷 147-155页

作者： Yuan zhuang Baoyou shi Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085 China University of Chinese Academy of Sciences Beijing 100049 China

Polymer hydrogel-based materials have been shown to act as novel Fenton catalysts for water treatment,but the rational design of hydrogel-based catalysts with good stability has been a great *** increase the stability and activity of polymer-based Fenton catalysts,uniform urchin-like α-Fe2O3 was grown in situ in a PVA carrier matrix *** molecules promoted the growth of urchin-like α-Fe2O3,and then the PVA hydrogel acted as a barrier and carrier to reduce *** coordination by hydroxyl groups,PVA had good combination with Fe ions and α-*** formation of Fe-O-C bonds between iron oxides and polymers was reported for the first time,enhancing the material stability during *** higher PVA concentrations,the resulting composite hydrogel could generate more OH due to the increase in the number of active sites because of the hairy urchin-like *** tetracycline degradation through a heterogeneous Fenton reaction,the resulting material had good catalytic activity from pH 2 to pH 10 with low iron leaching,good reusability and remained at a level of nearly 90% after five consecutive *** functional theory calculations were used to further prove the mechanism of structural change of the iron *** HOMO and LUMO energies of the iron oxides changed from 5.428 and 4.899 eV to 5.926 and 5.310 eV,indicating that the presence of PVA could influence the charge of the iron *** results provide new insights into the preparation of polymer hydrogel-based heterogeneous Fenton catalysts with enhanced stability for water treatment.

关键词： Heterogeneous Fenton Tetracycline Polymer Stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical study on indoor environment and thermal comfort in train station waiting hall with two different air-conditioning modes

引用

Building Simulation 2021年第2期14卷 337-349页

作者： Biyao zhuang Juan shi Zhenqian Chen Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education of China School of Energy and EnvironmentSoutheast UniversityNanjing210096China

With the increasing size of the waiting hall,the large-area use of transparent envelope materials makes the interior surface temperature of the envelope too high,which puts forward higher requirements for the control of environment and thermal comfort *** this paper,the characteristics of indoor temperature distribution,relative humidity distribution and thermal comfort under the all air system(AAs)and the radiant floor cooling and wall cooling combined with air supply system(RC/ASs)were investigated in the large *** computational fluid dynamics(CFD)method was used,and the performance of the CFD model was validated by comparing the measured results with CFD simulation results in the *** numerical results clearly showed that the temperature and relative humidity indoors could satisfy the design requirement both in the AAs and RC/*** indoor air distribution in most areas under the RC/ASs was more uniform based on the indoor heat and humidity requirements under the cooling load of measured *** the AAs,the total cooling capacity of air conditioning unit was the highest when indoor thermal comfort was the best,that meant that to achieve the best working condition,the air-conditioning system need high energy ***,the RC/ASs addressed the problem that the temperature around the seated passengers in the waiting area was relatively high in the *** paper will provide reference for the air conditioning system design in the similar large spaces in the future.

关键词： radiant floor cooling radiant wall cooling large spaces thermal comfort

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A high‐voltage solid‐state Marx generator with adjustable pulse edges

引用

High Voltage 2023年第5期8卷 878-888页

作者： Junfeng Rao Rui Zhang Fukun shi Longyu zhuang Zhenyu Ji Jie zhuang Chinese Academy of Sciences Suzhou Institute of Biomedical Engineering and TechnologySuzhouChina University of Shanghai for Science and Technology School of Mechanical EngineeringShanghaiChina Air Force Military Medical University Faculty of Biomedical EngineeringXi'anChina

Most reactors for non‐thermal plasma excitation are capacitive to pulse *** density and temperature of electrons in plasma are dominated by the discharging currents which are proportional to the pulse ***,adjusting the pulse edges is quite challenging since the switching speed and the inductance and capacitance in the discharging loops dominate *** study proposes a drive circuit for solid‐state Marx generators with adjustable *** drive circuit controls the Miller plateau by adjusting the gate voltage amplitude to adjust both the rise time and fall time of pulses continuously and *** influence of the gate voltage on the Miller plateau and the rise time is *** feasibility is verified by both simulating and experimental *** 8‐stage solid‐state Marx generator prototype was built,and 4.8‐kV pulses with a rise time in the range of 79 ns‐22.21μs were obtained over capacitive *** pulse edges can control the current amplitudes in dielectric barrier discharge loads.

关键词： pulse generator state

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical characteristics and mortality risk prediction model in children with acute myocarditis

引用

World Journal of Pediatrics 2023年第2期19卷 180-188页

作者： shi-Xin zhuang Peng shi Han Gao Quan-Nan zhuang Guo-Ying Huang Children’s Hospital of Fudan University 399 Wan Yuan RoadShanghai201102China Pediatric Clinical Research Unit Department of Research ManagementChildren’s Hospital of Fudan UniversityShanghaiChina

Background Acute myocarditis(AMC)can cause poor outcomes or even death in *** aimed to identify AMC risk factors and create a mortality prediction model for AMC in children at hospital *** This was a single-center retrospective cohort study of AMC children hospitalized between January 2016 and January *** demographics,clinical examinations,types of AMC,and laboratory results were collected at hospital ***-hospital survival or death was *** characteristics associated with death were *** Among 67 children,51 survived,and 16 *** most common symptom was digestive disorder(67.2%).Based on the Bayesian model averaging and Hosmer–Lemeshow test,we created a final best mortality prediction model(acute myocarditis death risk score,AMCDRS)that included ten variables(male sex,fever,congestive heart failure,left-ventricular ejection fraction4,fulminant myocarditis,abnormal creatine kinase-MB,and hypotension).Despite differences in the characteristics of the validation cohort,the model discrimination was only marginally lower,with an AUC of 0.781(95%confidence interval=0.675–0.852)compared with the derivation *** calibration likewise indicated acceptable fit(Hosmer‒Lemeshow goodness-of-fit,P¼=0.10).Conclusions Multiple factors were associated with increased mortality in children with *** prediction model AMCDRS might be used at hospital admission to accurately identify AMC in children who are at an increased risk of death.

关键词： Acute myocarditis Bayesian model averaging Fulminant myocarditis Hosmer–Lemeshow test Mortality risk prediction model Pediatrics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification and analysis of the inlet vortex of an axial-flow pump

引用

Journal of Hydrodynamics 2022年第2期34卷 234-243页

作者： Wen-peng Zhang Li-jian shi Fang-ping Tang zhuang-zhuang Sun Ye Zhang College of Hydraulic Science and Engineering Yangzhou UniversityYangzhou225009China

Axial-flow pumps are widely employed in urban flood control and drainage pumping *** inlet vortex is one factor that seriously threaten the safe,stable and efficient operation of axial-flow pump *** this paper,the vortex recognition performances of two vortex identification methods,the Q—criterion and Liutex methods,are compared based on an axial-flow pump,and the interactions between the impeller and vortex are explored.A flat plate vortex generator is installed in front of the impeller to continuously induce a stable *** numerical simulation results show that the Liutex method can not only simultaneously identify strong and weak vortices but also reduce the influence of shear force at the *** vortex and the impeller influence each *** the influence of rotating blades,the vortex changes from a low frequency to the blade frequency,and the vortex significantly changes the tangential velocity inside the *** accuracy of the numerical simulation results is verified by experiments on the external and internal characteristics.

关键词： Axial-flow pump inlet vortex vortex identification vortex generator numerical simulation experiment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Performance evaluation of multi-GNSSs navigation in super synchronous transfer orbit and geostationary earth orbit

引用

Satellite Navigation 2021年第1期2卷 58-70页

作者： Tao shi Xuebin zhuang Liwei Xie School of System Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China

The autonomous navigation of the spacecrafts in High Elliptic Orbit (HEO), Geostationary Earth Orbit (GEO) and Geostationary Transfer Orbit (GTO) based on Global Navigation Satellite System (GNSS) are considered feasible in many studies. With the completion of BeiDou Navigation Satellite System with Global Coverage (BDS-3) in 2020, there are at least 130 satellites providing Position, Navigation, and Timing (PNT) services. In this paper, considering the latest CZ-5(Y3) launch scenario of shijian-20 GEO spacecraft via Super-Synchronous Transfer Orbit (SSTO) in December 2019, the navigation performance based on the latest BeiDou Navigation Satellite System (BDS), Global Positioning System (GPS), Galileo Navigation Satellite System (Galileo) and GLObal NAvigation Satellite System (GLONASS) satellites in 2020 is evaluated, including the number of visible satellites, carrier to noise ratio, Doppler, and Position Dilution of Precision (PDOP). The simulation results show that the GEO/Inclined Geo-Synchronous Orbit (IGSO) navigation satellites of BDS-3 can effectively increase the number of visible satellites and improve the PDOP in the whole launch process of a typical GEO spacecraft, including SSTO and GEO, especially for the GEO spacecraft on the opposite side of Asia-Pacific region. The navigation performance of high orbit spacecrafts based on multi-GNSSs can be significantly improved by the employment of BDS-3. This provides a feasible solution for autonomous navigation of various high orbit spacecrafts, such as SSTO, MEO, GEO, and even Lunar Transfer Orbit (LTO) for the lunar exploration mission.

关键词： GNSS BDS Navigation PDOP SSTO

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

shift current response in elemental two-dimensional ferroelectrics

引用

npj Computational Materials 2023年第1期9卷 1675-1685页

作者： zhuang Qian Jian Zhou Hua Wang shi Liu Zhejiang University HangzhouZhejiang 310058China Key Laboratory for Quantum Materials of Zhejiang Province Department of PhysicsSchool of Science and Research Center for Industries of the FutureHangzhouZhejiang 310030China Center for Alloy Innovation and Design State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhouZhejiang 310024China

A bulk material without inversion symmetry can generate a direct current under *** interface-free current generation mechanism,referred to as the bulk photovoltaic effect(BPVE),does not rely on p-n ***,we explore the shift current generation,a major mechanism responsible for the BPVE,in single-element two-dimensional(2D)ferroelectrics represented by phosphorene-like monolayers of As,Sb,and *** strong covalency,small band gap,and large joint density of states afforded by these elemental 2D materials give rise to large shift currents,outperforming many state-of-the-art *** find that the shift current,due to its topological nature,depends sensitively on the details of the Bloch wave *** is crucial to consider the electronic exchange-correlation potential beyond the generalized gradient approximation as well as the spin-orbit interaction in density functional theory calculations to obtain reliable frequency-dependent shift current responses.

关键词： functions materials details

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：