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Numerical Investigation on Dynamics of the Tendon System of A TLP by Applying Absolute Nodal Coordinate Formulation

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China Ocean Engineering 2021年第3期35卷 384-397页

作者： Luu Quang HUNG kang zhuang ZHANG Cheng JIE Li-shao College of Shipbuilding Engineering Harbin Engineering UniversityHarbin 150001China Office of Planning and Investment Saodo UniversityHai DuongVietnam

In the present study,the dynamics of the tendon system of a tension-leg platform(TLP)is investigated through the absolute nodal coordinate formulation(ANCF).Based on the energy conversion principle,the stiffness,generalized elastic force,external load and mass matrices of the element are deduced to perform the element assembling by using the finite element *** the motion equation of the tendon/riser is *** this study,the TLP in the International Ship Structures Committee(ISSC)model under the first and second wave forces is considered as the case *** simulation is performed in the MATLAB ***,the accuracy and reliability of the programs are verified for cases of beam model with theoretical *** is found that the motion response of tendons is affected by the TLP movement and environmental load,***,the motion response is calculated using the SESAM software and exported as the boundary of ANCF ***,the static and dynamic characteristics of the four tendons of ISSC TLP are analyzed systematically by the ANCF *** analysis proves the effectiveness and feasibility of the ANCF *** is concluded that the proposed method is a powerful scheme for calculating the dynamics of tendon/riser in the field of ocean engineering.

关键词： Absolute nodal coordinate formulation(ANCF) tendon/riser TLP platform large deformation top and middle nodes wave direction

Peridynamic Modeling and Simulation of Ice Craters By Impact

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Computer Modeling in Engineering & Sciences 2019年第11期121卷 465-492页

作者： Ying Song Jiale Yan Shaofan Li zhuang kang College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China Department of Civil and Environmental Engineering University of CaliforniaBerkeleyCAUSA

In the present work,a state-based peridynamics with adaptive particle refinement is proposed to simulate water ice crater formation due to impact loads.A modified Drucker-Prager constitutive model was adopted to model ice and was implemented in the state-based peridynamic equations to analyze the elastic-plastic deformation of *** simulations,we use the fracture toughness failure criterion in peridynamics to simulate the quasi-brittle failure of *** adaptive particle refinement method in peridynamics was proposed to improve computational *** results obtained using the peridynamic model were compared with the experiments in previous *** was found that the peridynamic simulation results and the experiments matched well except for some minor differences discussed,and the state-based peridynamic model has shown the specific predictive capacity to capture the detailed crater features of the ice.

关键词： Peridynamics ice constitutive model adaptive particle refinement ice craters impact

Two Improvements on Numerical Simulation of 2-DOF Vortex-Induced Vibration with Low Mass Ratio

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China Ocean Engineering 2017年第6期31卷 764-772页

作者： kang zhuang NI Wen-chi ZHANG Xu SUN Li-ping Deepwater Engineering Research Center Harbin Engineering University Harbin 150001 China

Till now, there have been lots of researches on numerical simulation of vortex-induced vibration. Acceptable results have been obtained for fixed cylinders with low Reynolds number. However, for responses of 2-DOF vortex-induced vibration with low mass ratio, the accuracy is not satisfactory, especially for the maximum amplitudes. In Jauvtis and Williamson＇s work, the maximum amplitude of the cylinder with low mass ratio m＊=2.6 can reach as large as 1.5D to be called as the ＂super-upper branch＂, but from current literatures, few simulation results can achieve such value, even fail to capture the upper branch. Besides, it is found that the amplitude decays too fast in the lower branch with the RANS-based turbulence model. The reason is likely to be the defects of the turbulence model itself in the prediction of unsteady separated flows as well as the unreasonable setting of the numerical simulation parameters. Aiming at above issues, a modified turbulence model is proposed in this paper, and the effect of the acceleration of flow field on the response of vortex-induced vibration is studied based on OpenFOAM. By analyzing the responses of amplitude, phase and trajectory, frequency and vortex mode, it is proved that the vortex-induced vibration can be predicted accurately with the modified turbulence model under appropriate flow field acceleration.

关键词： 2-DOF vortex-induced vibration numerical simulation modified turbulence model acceleration

Imaging changes in neural circuits in patients with depression using 1 H-magnetic resonance spectroscopy and diffusion tensor imaging

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Neural Regeneration Research 2012年第24期7卷 1881-1888页

作者： Shaoqiong Chen Lisha Lai zhuang kang Xiao Luo Jiansheng Zhang Jianfang Li Department of Radiology the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Nuclear Medicine the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

1 H-magnetic resonance spectroscopy imaging and diffusion tensor imaging were performed in 19 patients with mild depression and in 13 *** mean age of the patients was 31 *** mean Hamilton depression score of the patients was 22.5±13.2.N-acetylaspartate,choline and creatine concentrations and the average diffusion coefficient and fractional anisotropy values were measured in the bilateral hippocampus,striatum,thalamus and prefrontal deep white matter. Compared with the control group,the mild depressed patients had：（1）a higher choline/creatine ratio and a negative correlation between the choline/creatine ratio and the average diffusion coefficient in the hippocampus;（2）a lower choline/creatine ratio and a higher fractional anisotropy in the striatum;（3）a lower fractional anisotropy and a positive correlation between the fractional anisotropy and the choline/creatine ratio in the prefrontal deep white matter;and（4）a higher average diffusion coefficient and a positive correlation between the choline/creatine ratio and the N-acetylaspartate/creatine ratio in the thalamus,as well as positive correlation between the choline/creatine ratio and Hamilton depression *** data suggest evidence of abnormal connectivity in neurofibrotic microstructures and abnormal metabolic alterations in the limbic-cortical-striatal-pallidal-thalamic neural circuit in patients with mild depression.

关键词： depression diffusion tensor imaging hippocampus magnetic resonance spectroscopy nerve fiber neural circuit neurotransmitter neural regeneration

PhaseⅠstudy of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up

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Cancer Biology & Medicine 2023年第6期20卷 465-476页

作者： zhuang kang Shan Li Xun kang Jing Deng Huarong Yang Feng Chen Jiandong Jiang Jie Zhang Wenbin Li Department of Neuro-oncology Cancer CenterBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Oncology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Sichuan Jiuzhang Biological Science and Technology Co.Ltd Chengdu 610095China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100070China

Objective:This study was aimed at analyzing the efficacy and safety of an injectable form of chlorogenic acid(CGA)in patients with recurrent high-grade glioma after standard of care treatments,through a first-in-human,open-label,dose-escalation phase I ***:A total of 26 eligible patients were enrolled,received intramuscular CGA injections at 5 dose levels,and were followed up for 5 *** was well tolerated,and the maximum tolerated dose was 5.5 mg/***:The most common treatment-related adverse events occurred at the sites of *** grade 3 or 4 adverse events(e.g.,drug allergy)were reported for these patients except for induration at the injection sites.A clinical pharmacokinetic study showed that CGA was rapidly eliminated from the plasma,with a t_(1/2)of 0.95–1.27 h on day 1 and 1.19–1.39 h on day 30,and no detectable CGA was observed on days 9,11,13,23,25,27,and 29 before CGA *** the first treatment cycle,52.2%of patients(12 of 23)achieved stable ***-term follow-up indicated an estimated median overall survival of 11.3 months for all 23 evaluable *** the 18 patients with grade 3 glioma,the median overall survival was 9.5 *** patients remained alive at the cutoff ***:This phase I study demonstrated that CGA has a favorable safety profile(with no severe toxicity),and provides preliminary clinical benefits for patients with high grade glioma relapsing after prior standard therapies,thus shedding light on the potential clinical application of CGA for recurrent grade 4 glioma.

关键词： injection glioma treatment

Drug clinical trials on high-grade gliomas: challenges and hopes

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Cancer Biology & Medicine 2023年第12期20卷 947-954页

作者： Mengqian Huang Shenglan Li Parker Li zhuang kang Botao Zhang Wenbin Li Cancer Center Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Clinical Medicine Shanghai Jiao Tong University School of MedicineShanghai 200025China

Gliomas are the most common group of malignant central nervous system tumors across all ages and have high *** to histopathologic criteria and molecular pathology,gliomas are classified as grades 1–***-grade gliomas(HGG),including the most aggressive subtype,glioblastoma(GBM),belong to grade 3 or *** a standard therapy comprising surgical resection,chemotherapy,and radiation is available,almost all patients with HGG experience recurrence within several months and a dismal prognosis1.

关键词： glioma chemotherapy pathology

Extracranial metastasis of anaplastic oligoastrocytoma

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Cancer Biology & Medicine 2018年第3期15卷 311-313页

作者： zhuang kang Shoubo Yang Hongmei Zhang Quan Zhou Jianxin Chen Yan Li Xun kang Shan Li Wenbin Li Department of Glioma Beijing Shijitan Hospital Capital Medical University Department of Pathology Beijing Shijitan Hospital Capital Medical University

Extracranial metastasis(ECM) of glioma is a rare condition that occurs in the internal nervous axis. A 23-year-old woman presented with anaplastic oligoastrocytoma(WHO III) in a left temporal tumor. The patient received chemoradiotherapy after surgery in our center. Three years after treatment, the patient experienced multiple ECMs in the right lung, left iliac bone, and multiple swollen subcutaneous nodules including the right clavicle, back of the neck, left forearm, right upper arm, and right clavicle. The patient died of cerebral herniation at the age of 27 due to recurrent intracranial glioma. Treatment of ECM of glioma remains very challenging, and further investigations are needed.

关键词： Extracranial metastasis(ECM) glioma anaplastic oligoastrocytoma chemoradiotherapy

Diffusion tensor imaging of the brain in patients with Alzheimer's disease and cerebrovascular lesions

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第4期8卷 242-247页

作者： CHEN Shao-qiong kang zhuang HU Xi-quan HU Bing ZOU Yan Department of Radiology the Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China Department of Rehabilitation the Third Affiliated Hospital Sun Yat-Sen University Guangzhou 5 10630 China

Background:Recent autopsy study showed a high incidence of cerebrovascular lesions in Alzheimer's disease(AD).To assess the impact of cerebrovascular pathology in AD,we used diffusion tensor imaging(DTI) to study AD patients with and without cerebrovascular *** and Methods:Conventional and DTI scans were obtained from 10 patients with probable AD,10 AD/V patients(probable AD with cerebrovascular lesions) and ten normal *** diffusivity(D) and fractional anisotropy(FA) values of some structures involved with AD pathology were ***:D value was higher in AD patients than in controls in hippocampus and the cingulate *** AD/V patients,increased D value was found in the same structures and also in the thalamus and basal ganglia compared to *** was a significant difference of D value between AD and AD/V *** value reduced in the white matter of left inferior temporal gyrus and in the bilateral middle cingulate gyrus in patients with AD/V compared with *** MMSE(mini-mental state examination) score significantly correlated with FA value in the right hippocampus(r=0.639,P<0.019),in the right anterior cingulate gyrus(r=0.587,P<0.035) and in left parahippocampal gyrus(r=0.559,P<0.047).Conclusion:Cerebrovascular pathology had stronger impact on the D value than the AD pathology alone *** D value in thalamic and basal ganglia may contribute to cognitive decline in AD/V *** FA values in AD/V patients may indicate that cerebrovascular pathology induced more severe white matter damage than the AD pathology alone did.

关键词： Diffusion tensor imaging (DTI) Alzheimer's disease (AD) Cerebrovascular Magnetic resonance imaging (MRI)

Signaling pathways in brain tumors and therapeutic interventions

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Signal Transduction and Targeted Therapy 2023年第2期8卷 423-445页

作者： Shenglan Li Can Wang Jinyi Chen Yanjie Lan Weichunbai Zhang zhuang kang Yi Zheng Rong Zhang Jianyu Yu Wenbin Li Department of Neuro-Oncology Cancer CenterBeijing Tiantan HospitalCapital Medical UniversityBeijingChina

Brain tumors,although rare,contribute to distinct mortality and morbidity at all *** there are few therapeutic options for brain tumors,enhanced biological understanding and unexampled innovations in targeted therapies and immunotherapies have considerably improved patients’***,the reduced response rates and unavoidable drug resistance of currently available treatment approaches have become a barrier to further improvement in brain tumor(glioma,meningioma,CNS germ cell tumors,and CNS lymphoma)*** literature data revealed that several different signaling pathways are dysregulated in brain ***,a better understanding of targeting signaling pathways that influences malignant behavior of brain tumor cells might open the way for the development of novel targeted ***,there is an urgent need for a more comprehensive understanding of the pathogenesis of these brain tumors,which might result in greater progress in therapeutic *** paper began with a brief description of the epidemiology,incidence,risk factors,as well as survival of brain ***,the major signaling pathways underlying these brain tumors’pathogenesis and current progress in therapies,including clinical trials,targeted therapies,immunotherapies,and system therapies,have been systemically reviewed and ***,future perspective and challenges of development of novel therapeutic strategies in brain tumor were emphasized.

关键词： therapeutic epidemiology mortality