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A Tool for the Treatment of Gastrointestinal Tumors: Micro- Ecological Immunotherapy

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Journal of Nutritional Oncology 2019年第4期4卷 151-160页

作者： Zhu Jiang Dai Qi Wu Jing Qiu Zhang Jia Ming Xu Han Jian Zhu Jin Gao zhuang zhuang liu Dong Tang Dao Rong Wang Clinical Medical College Yangzhou UniversityYangzhouJiangsu 225000China Department of General Surgery Institute of General SurgeryClinical Medical CollegeYangzhou UniversityNorthern Jiangsu People’s HospitalYangzhouJiangsu 225000China

It has been proposed that the intestinal microbiota and gastrointestinal tumors are *** in the microbiota can cause dysfunction of the gastrointestinal tract,thereby promoting carcinogenic changes,leading to the occurrence of gastrointestinal *** studies on intestinal microbiota have opened up a new area in intestinal micro-ecological *** intestinal microbiota is a double-edged *** microbes participate in carcinogenesis,but can also be used for *** intestinal microbiota is also regulated by the daily *** micro-ecological immunotherapy combines intestinal immune nutrition and intestinal ecological nutrition to make full use of the intestinal microbiota to strengthen nutritional ***-ecological immunotherapy enhances the body’s immune function by providing energy,improving the functional state of tissues and organs,protecting the intestinal mucosal barrier and maintaining normal intestinal microbiota *** involves,to some extent,PD-1 and *** microbiota is beneficial to improve the clinical efficacy of conventional anti-cancer therapy and to reduce the incidence of *** the same time,micro-ecological immunotherapy is itself active and effective in the perioperative treatment of tumors,which is of great significance for the prognosis of the *** tumors are increasingly linked to intestinal microbiota,and various microbiota-related technologies and drugs have been *** the future,the intestinal microbiota may represent a screening marker for gastrointestinal *** addition,clinicians may be able to prevent and treat cancers by changing the gene expression levels of certain microbiota,or by regulating the types of microbes present.

关键词： Micro-ecological immunotherapy Immune nutrition Ecological nutrition Gastrointestinal tumors Microbiota

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua zhuang Yan liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

The Mechanism of CagA and VacA in Gastric Cancer under the Tumor Microenvironment and Vitro Factors

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Journal of Nutritional Oncology 2020年第2期5卷 59-70页

作者： Zhu Jiang Dai Hui Wen Fang Jing Qiu Zhang Qi Wu Jia Ming Xu Han Jian Zhu Jin Gao zhuang zhuang liu Dong Tang Dao Rong Wang Clinical Medical college Yangzhou UniversityYangzhou 225001JiangsuChina Department of General Surgery Institute of General SurgeryClinical Medical CollegeYangzhou UniversityYangzhou 225001JiangsuChina

Gastric cancer is closely related to the stomach microbiota,especially Helicobacter *** reports and clinical studies have shown that microbial behavior in the stomach may lead to pathological changes in the gastrointestinal tract of the host,which ultimately leads to the production and development of gastric *** review outlines the major pathogenic processes of Helicobacter pylori in the stomach,specifically focusing on Cag A,Vac A,inflammatory pathways and oxidative *** addition,we describe the effects of some non-Helicobacter pylori factors,such as other microbiota,alcohol,and tobacco,on the carcinogenesis induced by Helicobacter *** effects of family history are also taken into *** hope that understanding the stomach microbiota will make it possible to more easily prevent,detect and treat gastric cancer.

关键词： Microbiota Gastric cancer Helicobacter pylori CagA VacA Inflammatory pathway

ICA-Net: improving class activation for weakly supervised semantic segmentation via joint contrastive and simulation learning

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Optoelectronics Letters 2025年第3期21卷 188-192页

作者： YE zhuang liu Ruyu SUN Bo School of Information Engineering Chengdu Aviation Vocational and Technical College School of Computer Science and Engineering Hangzhou Normal University Quanzhou Institute of Equipment Manufacturing Haixi Institutes Chinese Academy of Sciences

In the field of optoelectronics, certain types of data may be difficult to accurately annotate, such as high-resolution optoelectronic imaging or imaging in certain special spectral ranges. Weakly supervised learning can provide a more reliable approach in these situations. Current popular approaches mainly adopt the classification-based class activation maps (CAM) as initial pseudo labels to solve the task.

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Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin Qi Huixian Zhu Kangli Shen Ruiqi liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin Cao Liang Chen Qianxing zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

层状Ti-Al复合材料界面约束导致的晶内变形不均匀性

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Transactions of Nonferrous Metals Society of China 2023年第3期33卷 789-801页

作者：倪新波刘壮壮缪克松冷金凤范国华滕新营吴昊济南大学材料科学与工程学院济南250022 南京工业大学先进轻质高性能材料研究中心南京211816 哈尔滨工业大学材料科学与工程学院哈尔滨150001

以纯钛箔和纯铝箔为原料,通过热压和热轧制制备层状Ti-Al复合材料。使用原位电子背散射衍射技术,研究层状复合材料拉伸过程中的取向演化和形变微结构特征。结果表明,Ti晶粒内部塑性变形存在不均匀性,即越靠近晶界或Ti/Al层状界面,Ti晶... 详细信息

以纯钛箔和纯铝箔为原料,通过热压和热轧制制备层状Ti-Al复合材料。使用原位电子背散射衍射技术,研究层状复合材料拉伸过程中的取向演化和形变微结构特征。结果表明,Ti晶粒内部塑性变形存在不均匀性,即越靠近晶界或Ti/Al层状界面,Ti晶粒的塑性变形越困难。这种晶内变形不均匀性主要来自于晶界和Ti/Al相界的协同约束效应。因此,本研究提供了一种通过充分利用界面约束效应来调控塑性变形行为从而实现性能优化的新策略。

关键词：层状复合材料塑性变形电子背散射衍射界面约束

PSC-induced Galectin-1 Promotes the Malignant Behavior of Pancreatic Ductal Adenocarcinoma

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Journal of Nutritional Oncology 2019年第3期4卷 121-131页

作者： Dong Tang Qi Wu Hong Peng Zhang Zhong Xu Yuan Jia Ming Xu Han Jian Zhu Jin Gao zhuang zhuang liu Zhu Jiang Dai Xiao Ming Sun Meng Yue Xu Hui Wen Fang Zhen Li Chao Biao Lin Chun Feng Shi Dao Rong Wang Department of General Surgery Institute of General SurgeryClinical Medical CollegeYangzhou University(Northern Jiangsu People’s Hospital)YangzhouJiangsu 225001China Department of Clinical Medicine Medical College of Yangzhou UniversityYangzhouJiangsu 225001China Department of General Surgery Anhui No.2 Provincial People’s HospitalHefeiAnhui 230041China

Background Galectin-1 is aβ-galactoside-binding protein overexpressed in the pancreatic stellate cells(PSCs)of pancreatic ductal adenocarcinoma(PDAC),while its expression is typically low in pancreatic cancer cells(PCCs).The point at which galectin-1 expression in PCCs increases,and its association with PDAC progression,have been *** Galectin-1 expression in PDAC and metastatic lymph nodes was investigated using an immunohistochemical ***-1 PCC cells were co-cultured with PSCs expressing different levels of ***,galectin-1 was overexpressed in PANC-1 cells using recombinant lentiviruses,and their proliferation,invasion,anchorage-independent growth,and in vivo tumorigenicity were *** There was intermediate galectin-1 expression in PCCs,and it was positively associated with galectin-1 expression in PSCs in the PDAC ***-1 was strongly expressed in the metastatic lymph *** the co-culture,high galectin-1 expression in the PSCs increased the galectin-1 expression in the PANC-1 *** galectin-1 overexpression in the PANC-1 cells enhanced their clone formation ability,proliferation,and invasion,increased the expression of proliferating cell nuclear antigen(PCNA)and BCL-2,and decreased Bax expression,promoting the establishment and growth of *** High galectin-1 expression in PSCs induces galectin-1 expression in PCCs and subsequently promotes the malignant biological behavior of PDAC.

关键词： Pancreatic ductal adenocarcinoma Pancreatic stellate cells Galectin-1 Invasion Metastasis

Conductive MOFs with Photophysical Properties:Applications and Thin-Film Fabrication

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Nano-Micro Letters 2020年第10期12卷 132-163页

作者： Zeyu zhuang Dingxin liu Skate Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterSchool of Materials Science and EngineeringSun Yat-Sen UniversityGuangzhou 510275People’s Republic of China

Metal-organic frameworks(MOFs)are a class of hybrid materials with many promising *** recent years,lots of investigations have been oriented toward applications of MOFs in electronic and photoelectronic *** many high-quality reviews have focused on synthesis and mechanisms of electrically conductive MOFs,few of them focus on their photophysical ***,we provide an in-depth review on photoconductive and photoluminescent properties of conductive MOFs together with their corresponding applications in solar cells,luminescent sensing,light emitting,and so *** integration of MOFs with practical devices,recent advances in fabrication of photoactive MOF thin films are also summarized.

关键词： Metal-organic frameworks Photoconductivity Photoluminescence Thin films