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Chinese Journal of Chemical Engineering 2016年第11期24卷 1533-1540页

作者： zhuan Yi Fa-dong Wu Yong Zhou Cong-jie Gao Department of Ocean Zhejiang University of Technology Hangzhou 310014 China Water Treatment Technology Development Center Hangzhou 310012 China

Microstructure in selective layer has played a decisive role in permselectivity of nanofiltration(NF) membranes,and nanomaterials were well-known additives that had been applied to mediate the microstructure and permeability of polyamide NF membranes. However, nanoadditives generally displayed a poor dispersion in membranes or in fabrication process. To solve this problem, we showed an interesting concept that novel NF membranes with hybrid selective layer consisting of flexible polyisobutylene(PIB) and rigid polyamide could be fabricated from well-defined interfacial polymerization. The hydrophobic polymer mediated phase separation and microdomains formation in polyamide layer were found. The immiscibility between the rigid polyamide and flexible PIB as well as the resultant interface effect was interpreted as the reason for the polymer enhanced permselectivity, which was similar with the well-known thin film nanocomposite(TFN) membranes that nanoparticles incorporated contributed significantly to membrane permeability and rejection *** results have demonstrated that novel NF membranes with enhanced performance can be prepared from immiscible polymers, which is a new area that has not been extensively studied before.

关键词： Nanofiltration membranes Interfacial polymerization Polymer additive Hydrophobicity Fabrication

课程思政优化大学生就业选择的内在逻辑和教改实践路径研究

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华北理工大学学报（社会科学版） 2024年第1期24卷 72-77页

作者：刘遵峰马新萌苏瑛转燕山大学马克思主义学院河北秦皇岛066004

新时代高校课程高质量建设对大学生就业选择具有重要影响。党的二十大提出要完善思想政治工作体系,落实立德树人根本任务,推动实现更加充分更高质量就业。深入学习贯彻党的二十大精神,从思想引领、目标导向、内容要求、预期效果四个层... 详细信息

新时代高校课程高质量建设对大学生就业选择具有重要影响。党的二十大提出要完善思想政治工作体系,落实立德树人根本任务,推动实现更加充分更高质量就业。深入学习贯彻党的二十大精神,从思想引领、目标导向、内容要求、预期效果四个层面探究课程思政优化大学生就业选择的内在逻辑关系,研究目的在于探索课程思政优化大学生就业选择的教改实践路径,探索实践育人方式,深化教育改革。

关键词：课程思政大学生就业教学改革实践路径

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渝东南红军文化资源在高校思政课教学中的运用

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长江师范学院学报 2024年第4期40卷 125-132页

作者：秦专松项福库姚茂华重庆资源与环境保护职业学院马克思主义学院重庆402360 长江师范学院马克思主义学院重庆408100

渝东南红军文化资源是社会主义先进文化的重要组成部分,蕴含着丰富的思政课教学资源,在立德树人方面发挥着不可替代的重要作用。寓渝东南红军文化资源于高校思政课教学中,不仅可以使红军革命精神得到赓续传承,还能充分发挥思政课育人的... 详细信息

渝东南红军文化资源是社会主义先进文化的重要组成部分,蕴含着丰富的思政课教学资源,在立德树人方面发挥着不可替代的重要作用。寓渝东南红军文化资源于高校思政课教学中,不仅可以使红军革命精神得到赓续传承,还能充分发挥思政课育人的主渠道作用,推进大学生的理想信念教育,帮助处在“拔节孕穗期”的青年大学生自觉抵御错误思潮的冲击,从而提升思政课育人效果。对此,各个高校可通过抓住课堂主渠道、占领网络新媒体、开展实践育人等方式将渝东南红军文化资源融入思政课教学,把思政育人道理讲深、讲透、讲活,使其成为改进高校思政课教学、实现铸魂育人的有效手段。

关键词：渝东南红军文化资源高校思政课

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A Comparative Toxicity Study of TiO2 Nanoparticles in Suspension and Adherent Culture Under the Dark Condition

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Chemical Research in Chinese Universities 2018年第1期34卷 44-50页

作者： CHEN Like LIU Miao LENG Su LI zhuan College of Environment and Resources Jilin University Changchun 130012 P. R. China College of Resources and Environment Jilin Agricultural University Changchun 130118 P. R. China

The present study focused on the different acute toxicity of TiO2 nanoparticles（TiO2 NPs） towards the bacteria in suspension culture and adherent culture under the dark conditions. The study investigated the bacteria toxicity with TiO2 NPs at different concentrations（1-2000 mg/L）, sizes（10 nm, 35 nm） and specific surface areas in unit volume solution（0-224 m^2/L） characterized by the cell viability, extracellular polymeric substances（EPS） release and biofilm formation. The bacteria in adherent culture was found to be more resistant against the toxicity of TiO2 NPs compared to that in suspension culture. An NP dose and surface area dependent（rather than the size） bacterial viability was observed in suspension culture, specifically the surface area positively correlated with the toxicity of TiO2 NPs. The size of TiO2 NPs, however, played a more critical role in toxicity of TiO2 NPs in adherent culture. Therefore, the surface area dependent toxicity of TiO2 NPs is a comprehensive parameter describing the dose and size dependent toxicity of TiO2 NPs. The electron microscopic（SEM, TEM, EDX） observations suggested the EPS release and biofilm formation, during aggregation of TiO2 NPs on the bacteria after 12 h cultivation in adherent culture under the dark condition. A possible toxic mechanism could be that ＂effective surface areas＂ that directly contact with the bacterial membrane greatly contributed to the toxicity of TiO2 NPs in both suspension culture and adherent culture. Therefore, as for the possible resistance mechanism, EPS secretion and subsequent biofilm formation may protect the bacteria against the toxicity of TiO2 NPs.

关键词： Toxicity of TiO2 nanoparticle Suspension culture Adherent culture Toxic mechanism

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药品生产远程检查案例分析与思考

中国药业 2024年第15期33卷 28-31页

作者：俞佳宁颛孙燕楼双凤上海药品审评核查中心上海201203

目的为药品监管部门开展药品生产远程检查工作提供参考。方法梳理国内药品生产远程检查相关制度和实践案例,从企业和检查机构两方面对远程检查相关案例的风险评估、实施情况进行分析,总结远程检查要点。结果与结论检查前,开展充分的... 详细信息

目的为药品监管部门开展药品生产远程检查工作提供参考。方法梳理国内药品生产远程检查相关制度和实践案例,从企业和检查机构两方面对远程检查相关案例的风险评估、实施情况进行分析,总结远程检查要点。结果与结论检查前,开展充分的风险评估;检查中,重视IT支持、有效沟通和风险控制;检查结束后,应保留现场检查的权利。

关键词：远程检查风险评估案例分析药品监管

乌司他丁联合奥曲肽治疗新生儿坏死性小肠结肠炎

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长春中医药大学学报 2024年第8期40卷 919-922页

作者：苗转何阿玲王导利西北妇女儿童医院新生儿科西安710061

目的探讨乌司他丁联合奥曲肽在新生儿坏死性小肠结肠炎(NEC)的临床疗效。方法纳入新生儿坏死性小肠结肠炎患儿89例,按随机数表法分为对照组与观察组。对照组45例予奥曲肽治疗,观察组44例予奥曲肽联合乌司他丁治疗。比较2组临床症状改善... 详细信息

目的探讨乌司他丁联合奥曲肽在新生儿坏死性小肠结肠炎(NEC)的临床疗效。方法纳入新生儿坏死性小肠结肠炎患儿89例,按随机数表法分为对照组与观察组。对照组45例予奥曲肽治疗,观察组44例予奥曲肽联合乌司他丁治疗。比较2组临床症状改善情况,检测2组肠道菌群指标以及炎性因子指标C反应蛋白(CRP)、白介素-6(IL-6)、白介素-8(IL-8),测定2组细胞免疫功能指标抗原分化簇4受体(CD4^(+))、抗原分化簇8受体(CD8^(+))、CD4^(+)/CD8^(+),比较2组不良反应发生情况。结果观察组临床症状改善优于对照组(P0.05)。结论乌司他丁联合奥曲肽治疗新生儿坏死性小肠结肠炎,能改善患儿临床症状、肠道菌群失调、炎性因子水平与免疫功能,安全性良好。

关键词：乌司他丁奥曲肽新生儿坏死性小肠结肠炎免疫功能炎性因子

2-D/2-D heterostructured biomimetic enzyme by interfacial assembling Mn_(3)(PO_(4))_(2) and MXene as a flexible platform for realtime sensitive sensing cell superoxide

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Nano Research 2021年第3期14卷 879-886页

作者： Shen Fei Zhao Fang Xin Hu zhuan zhuan Shi Jing Jing Fu Yue Chen Fang Yin Dai Chun Xian Guo Chang Ming Li Institute of Materials Science and Devices Suzhou University of Science and TechnologySuzhou215009China Institute for Clean Energy and Advanced Materials Southwest UniversityChongqing400715China State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqing400715China Institute for Advanced Cross-field Science&College of Life Science Qingdao UniversityQingdao200671China

It is critical for fabricating flexible biosensors with both high sensitivity and good selectivity to realize real-time monitoring superoxide anion(O_(2)^(·−)),a specific reactive oxygen species that plays critical roles in various biological *** work delicately designs a Mn_(3)(PO_(4))_(2)/MXene heterostructured biomimetic enzyme by assembling two-dimensional(2-D)Mn_(3)(PO_(4))_(2) nanosheets with biomimetic activity and 2-D MXene nanosheets with high conductivity and abundant functional *** 2-D nature of the two components with strong interfacial interaction synergistically enables the heterostructure an excellent flexibility with retained 100%of the response when to reach a bending angle up to 180°,and 96%of the response after 100 bending/relaxing *** is found that the surface charge state of the heterostructure promotes the adsorption of O_(2)^(·−),while the high-energy active site improves electrochemical oxidation of O_(2)^(·−).The Mn_(3)(PO_(4))_(2)/MXene as a sensing platform towards O2•−achieves a high sensitivity of 64.93µA·µM^(−1)·cm^(−2),a wide detection range of 5.75 nM to 25.93µM,and a low detection limit of 1.63 ***,the flexible heterostructured sensing platform realizes real-time monitoring of O_(2)^(·−)in live cell assays,offering a promising flexible biosensor towards exploring various biological processes.

关键词： two-dimensional(2-D)nanosheets assembled heterostructure interface flexible biosensor real-time monitoring

Studies of GnRH-A Active Immunization Effects on LH and FSH Secretion and Histostructure of the Ovary and Uterus in Rabbits

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Agricultural Sciences in China 2011年第10期10卷 1630-1637页

作者： WEI Suo-cheng GONG zhuan-di WEI Min Life Science and Engineering College Northwest University for Nationalities Lanzhou 730030 P.R.China Medicine Faculty Northwest University for Nationalities Lanzhou 730030 P.R.China

The objective of the study is to investigate the effects of active immunization against gonadotropin releasing hormone agonist （GnRH-A） on secretion of luteinizing hormone （LH） and follicle-stimulating hormone （FSH） in the pituitary, and to observe the histological structures and development about ovaries and uteri in female rabbits. 24 female rabbits （Oryctolagus cuniculus） were divided randomly into 4 groups （n=6）, namely, experimental group I （EG-I）, experimental II （EG-II）, experimental III （EG-III）, and control group （CG）. Rabbits were subcutaneously injected with 1.0 mL GnRH-A （alarelin） antigen respectively at concentrations of 100, 100 and 50 μg mL-1 respectively, in EG-I, EG-II and EG-III. Alarelin antigen was re-injected in EG-II and EG-III with the same dosage on 20 d. CG was a blank. The ovarian and uterine samples were collected aseptically at the end of the experiment of 70 d. The tissue slices were observed under light and electron microscopes. Serum concentrations of LH and FSH were measured with ELISA. The results showed that serum LH concentrations in EG-II and EG-III reached the peak levels on 50 and 40 d respectively, and LH level in EG-II exceeded other 3 groups on 50 d （P0.05）. FSH level in EG-II was higher than those in EG-I, CG （P0.01） and EG-III （P0.05） on 40 d. GnRH-A could increase the number of primary follicles, enlarge the primary follicle vertical diameter （PFV） and primary follicle transverse diameter （PFT）, and promote growth and maturation of follicles. The endometrial epithelium thickness （EET） and uterine wall thickness （UWT） in three EGs were less than that in CG （P0.05）. GnRH-A can increase the quantities of mitochondrial cristaes, cortex granules in cytoplasm, broaden and lengthen zona pellucidas and microvilli of oocytes. It also enlarged nuclei of ooxytes and mitochondria, thereby it promoted the development of oocytes. Re-injection of 100 μg alarelin antigen enhanced the secretion of LH and FSH. GnRH-A promoted the growth an

关键词： gonadotropin releasing hormone agonist (GnRH-A) luteinizing hormone follicle-stimulating hormone ovary uterus histostructure female rabbit

Preparation of Cu/ZrO2 catalysts for methanol synthesis from CO2/H2

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Frontiers of Chemical Science and Engineering 2012年第1期6卷 47-52页

作者： Xinmei LIU Shaofen Bai Huidong zhuan Zifeng YAN State Key Laboratory for Heavy Oil Processing Key Laboratory of Catalysis(China National Petroleum Corporation)Chiina University of PetroleumQingdao 266555China

Cu/ZrO2 catalysts for methanol synthesis from CO2/H2 were respectively prepared by deposition coprecipitation （DP） and solid state reaction （SR） methods. There is an intimate interaction between copper and zirconia, which strongly affects the reduction property and catalytic performance of the catalysts. The stronger the interaction, the lower the reduction temperature and the better the performance of the catalysts. Surface area, pore structure and crystal structure of the catalysts are mainly controlled by preparation methods and alkalinity of synthesis system. The conversion of CO2 and selectivity of methanol are higher for DP catalysts than for SP catalysts.

关键词： Cu/ZrO2 methanol synthesis depositioncoprecipitation solid state reaction C02/H2

Sawdust discharge rate from aerated hoppers

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Particuology 2011年第3期9卷 306-313页

作者： Pan Chen Zhulin Yuan Chien-Song Chyang Fu-Xiong zhuan School of Energy and Environment Southeast UniversityNanjing 210096JiangsuChina Department of Chemical Engineering Chung Yuan Christian UniversityChungli 32023TaiwanChina

This paper presents a numerical and experimental study of the discharge rate of sawdust from an aerated hopper as an important parameter in many industrial processes involving the handling of other granular materials. Numerical experiments are conducted by means of an Eulerian-Eulerian approach coupled with the kinetic theory of granular flow （KTGF）. Emphasis is given to the effects of particle size, hopper outlet width, hopper half angle, aeration height and air flow rate. The results show that the discharge rate is significantly affected by hopper outlet width, particle size and air flow rate, but is not sensitive to the hopper half angle and aeration height： increasing hopper outlet width or air flow rate increases discharge rate, while increasing particle size decreases discharge rate. Close agreement between numerical predictions and experimental results is obtained.

关键词： Granular flow Aeration Hopper Flow rate GranuLar kinetic theory Sawdust