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Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues

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Chinese Journal of Chemistry 2024年第11期42卷 1209-1216页

作者： ning Li Shanshan Xiao Xiaoxiong Jin Ziyuan Song Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhouJiangsu215123 China

The structural and surface properties of nanomedicines play an important role in determining their biological fate. Surface chemistry of nanomedicines is one of the key parameters, where researchers used various strategies such as PEGylation to avoid the undesired clearance of nanoparticles (NPs) for enhanced targeting effect. Nevertheless, the fine-tuning of surface chemistry through polymer functionalization remains largely unexplored. In this concise report, we find that the incorporation of only 10 mol% valine residues into the surface-anchored poly(L-glutamic acid) significantly lowered the macrophage uptake of NPs. The introduction of other hydrophobic amino acid residues, however, increased the NPs internalization instead. The chirality and the side-chain structure of valine played an important role in the unexpected uptake behavior. We believe this work highlights the impact of slight changes of the surface-anchored polymer structure on the behavior of NPs, drawing people's attention to the careful design of surface chemistry to optimize the nanomedicine design.

关键词： Nanoparticles Copolymers Structure-activity relationships Surface chemistry Polypeptide Macrophage uptake

A New High-Precision and Lightweight Detection Model for Illegal Construction Objects Based on Deep Learning

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Tsinghua Science and Technology 2024年第4期29卷 1002-1022页

作者： Wenjin Liu Lijuan Zhou Shudong Zhang ning Luo Min Xu School of Cyberspace Security(School of Cryptology) Hainan UniversityHaikou 570228China School of Information Engineering Capital Normal UniversityBeijing 100048China

Illegal construction has caused serious harm around the world. However, current methods are difficult to detect illegal construction activities in time, and the calculation complexity and the parameters of them are large. To solve these challenges, a new and unique detection method is proposed, which detects objects related to illegal buildings in time to discover illegal construction activities. Meanwhile, a new dataset and a high-precision and lightweight detector are proposed. The proposed detector is based on the algorithm You Only Look Once (YOLOv4). The use of DenseNet as the backbone of YDHNet enables better feature transfer and reuse, improves detection accuracy, and reduces computational costs. Meanwhile, depthwise separable convolution is employed to lightweight the neck and head to further reduce computational costs. Furthermore, H-swish is utilized to enhance non-linear feature extraction and improve detection accuracy. Experimental results illustrate that YDHNet realizes a mean average precision of 89.60% on the proposed dataset, which is 3.78% higher than YOLOv4. The computational cost and parameter count of YDHNet are 26.22 GFLOPs and 16.18 MB, respectively. Compared to YOLOv4 and other detectors, YDHNet not only has lower computational costs and higher detection accuracy, but also timely identifies illegal construction objects and automatically detects illegal construction activities.

关键词： object detection lightweight illegal buildings illegal construction objects high-precision

Health-oriented strategies are needed to optimize China’s 2025 clean air action plan

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Science Bulletin 2024年第13期69卷 2007-2008页

作者： Tao Xue ning Kang Wei Wan Tong Zhu Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health and Department of Epidemiology and Biostatistics/Ministry of Education Key Laboratory of Epidemiology of Major Diseases(PKU) School of Public HealthPeking University Health Science CentreBeijing 100191China State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management Center for Environment and HealthPeking UniversityBeijing 100871China Advanced Institute of Information Technology Peking UniversityHangzhou 311215China Clean Air Asia Beijing 100600China College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China

Recently,China’s State Council issued the Continuous Improvement of Air Quality Action Plan(hereafter,the third action plan),which follows the Air Pollution Prevention and Control Action Plan(2013–2017)(hereafter,the first action plan)and the Three-Year Action Plan for Winning the Blue Sky Defense Battle(2018–2020)(hereafter the second action plan).The first two action plans yielded nationwide health benefits[1–3],from improving lung function[4]to saving medical expenditures[5].Based on our previous estimates[6],due to reductions in the fine particulate matter(PM2.5)level,implementation of the first and second action plans was expected to increase life expectancy by 2.11 and 3.68 months.

关键词： action hereafter nationwide

Robotic liver resection for hepatocellular carcinoma:a new dawn?

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 845-846页

作者： Charing Ching-ning Chong Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina

I read the article titled“Safety and Efficacy of Robotic vs Open Liver Resection for Hepatocellular Carcinoma”,published in JAMA Surgery with great interest(1).This study marks an important milestone in the field of... 详细信息

关键词： Robotic liver resection(RLR) robotic hepatectomy hepatocellular carcinoma(HCC)

Triboelectric nanogenerator hybrid array driven by multiform natural energies and its applications in self-powered cathodic protection

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Science China(Technological Sciences) 2024年第3期67卷 878-890页

作者： SUN Weixiang YANG Di LUO ning LI Hao WANG DaoAi School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China State Key Laboratoryof Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Qingdao Center of Resource Chemistry and New Materials Qingdao 266100China

In view of the increasing energy shortage and environmental pollution, the collection of friction charges to achieve the conversion of various natural energies and provide in-situ cathodic protection for metals is a significant challenge. Here, we designed a dual device-structure TENG composite array with the triboelectric layer of linear siloxane-modified polyurethane(PU) coating. This array could achieve a comprehensive collection for multiple forms of nature energy and cathodic protection of metals in multi-weather conditions. For one thing, the wave-mode TENG based on tanker structure could collect wave energy and showed the output performance with a short-circuit current of 15.5 μA. For another thing, the droplet-mode TENG based on arc-shaped surface structure could collect raindrop kinetic energy and showed the output performance with a short-circuit current of 16.3 μA. Notably, the parallel array of wave-mode TENG(W-TENG) and droplet-mode TENG(D-TENG) could simultaneously collect wave energy and raindrop kinetic energy, which showed a short-circuit current of 30.7 μA. Besides, a selfpowered a cathodic protection system powered by the dual structure TENG array is assembled and the open-circuit potential drop of the carbon steel connected with the TENG array is about 450 mV. Compared with cathodic protection system powered by single structure TENG, the composite array could provide more effective corrosion resistance for marine equipment in rainy weather. Due to the characteristic for comprehensive collection of nature energy, the anti-corrosion system supplied by TENG parallel array possesses great application potential in the all-weather corrosion protection of metal machinery under complex marine conditions.

关键词： triboelectric nanogenerator hybrid structure array siloxane-modified polyurethane cathodic protection

Sustainable production of high-energy-density jet fuel via cycloaddition reactions

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Journal of Energy Chemistry 2024年第8期95卷 712-722,I0016页

作者： Yan-Cheng Hu Yingying Zhao ning Li Jing-Pei Cao School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou 221116JiangsuChina School of Education Science Jiangsu Normal UniversityXuzhou 221116JiangsuChina CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Developing an energy supply-chain based on renewable biomass holds great potential to build a low carbon ***-energy-density(HED)jet fuel,featuring unique fused/strained cycloalkanes,is of great significance for volume-limited military aircrafts,as their high density and combustion heat can extend flight duration and increase the ***,the exploration of biomass-based routes towards HED fuel has drawn much attention over the past *** reaction features rapid construction of various carbocycles in an atom-and step-economical *** elegant strategy has been widely applied in the manufacture of sustainable HED *** we carefully summarize the progress achieved in this fascinating area and the review is categorized by the cycloaddition patterns including[4+2],[2+2],[4+4],and[2+1]***,the energy densities of the as-prepared biofuels and petroleumbased fuels(conventional Jet-A and advanced JP-10)are also *** review will provide important insights into rational design of new HED fuel with different ring-types/sizes and inspire the chemists to turn those literature studies into practical applications in military field.

关键词： High-energy-density fuel Biomass-based chemicals Cycloaddition Cycloalkanes Catalysis

Glaucoma surgery experiments using digital microscope-integrated optical coherence tomography and OCT-compatible instruments

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 105-113页

作者： Tianliang Jiang Jinyu Fan ning Tang Yi He Guohua Shi School of Biomedical Engineering(Suzhou)Division of Life Sciences and Medicine University of Science and Technology of China Hefei 230026 P.R.China Jiangsu Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Science Suzhou 215163P.R.China

There is a certain failure rate in traditional glaucoma surgery because of the lack of depth information in microscope *** this work,we present a digital microscope-integrated optical coherence tomography(MIOCT)system and several custom-made OCT-compatible instruments for glaucoma *** ophthalmologists were asked to perform trabeculectomy and canaloplasty on live porcine eyes using the system and *** surgery,a subjective feedback survey about the user experience was *** experiment results showed that our system can help surgeons easily locate important tissue structures during *** custom-made instruments also solved the shadowing problem in OCT *** preferred to use the system in their future practice.

关键词： Microscope-integrated optical coherence tomography OCT-compatible instruments glaucoma surgery trabeculectomy canaloplasty

Embracing digital mindsets to ensure a sustainable future

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 177-179页

作者： Chengjun Li Riqing Yu Wenjing ning Huan Zhong Christian Sonne Institute of Environmental Research at Greater Bay Area Guangzhou UniversityGuangzhou 510000China Department of Biology Center for EnvironmentBiodiversity and ConservationThe University of Texas at TylerTylerTX 75701USA School of Environment Nanjing UniversityNanjing 210000China Environmental and Life Science Program Trent UniversityPeterboroughOntarioK9H 0A1Canada Faculty of Science and Technology Aarhus UniversityRoskildeDenmark 4000The Kingdom of Denmark Sustainability Cluster School of EngineeringUniversity of Petroleum&Energy StudiesDehradunUttarakhand 248001India

The 19th Asian Games astounded global audiences with an opening spectacle that showcased stunning digital fireworks(International Olympic Committee,2021;Zhe,2023).The groundbreaking display was brought to life through virtual reality(VR)and augmented reality(AR)*** sets a pioneering example to replace conventional fireworks in major international events as well as in other large-scale entertainment activities,marking a historic milestone in the pursuit of a sustainable and healthy future.

关键词： Wildlife Climate Change Heavy metals Noise LAN Light pollution

Hydrodynamic Performance of An Integrated System of Breakwater and A Multi-Chamber OWC Wave Energy Converter

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China Ocean Engineering 2024年第4期38卷 543-556页

作者： ning De-zhi ZHANG Xiang-yu WANG Rong-quan ZHAO Ming State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Dalian Key Laboratory of Offshore Renewable Energy Dalian University of TechnologyDalian 116024China School of Computing Engineering and MathematicsUniversity of Western SydneyPenrith NSW 2751Australia

A multi-chamber oscillating water column wave energy converter(OWC-WEC)integrated to a breakwater is *** hydrodynamic characteristics of the device are analyzed using an analytical model based on the linear potential flow theory.A pneumatic model is employed to investigate the relationship between the air mass flux in the chamber and the turbine *** effects of chamber width,wall draft and wall thickness on the hydrodynamic performance of a dual-chamber OWC-WEC are *** results demonstrate that the device,with a smaller front wall draft and a wider rear chamber exhibits a broader effective frequency *** device with a chamber-width-ratio of 1:3 performs better in terms of power ***,results from the analysis of a triplechamber OWC-WEC demonstrate that reducing the front chamber width and increasing the rearward chamber width can improve the total performance of the *** the number of chambers from 1 to 2 or 3 can widen the effective frequency bandwidth.

关键词： oscillating water column power extraction efficiency potential flow theory wave energy converter multi-chamber