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Biological scaffold as potential platforms for stem cells:Current development and applications in wound healing

World Journal of Stem Cells 2024年第4期16卷 334-352页

作者： Jie-Yu Xiang lin Kang Zi-Ming li Song-Lu Tseng li-Quan Wang Tian-Hao li zhu-jun li Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100021China

Wound repair is a complex challenge for both clinical practitioners and *** approaches for wound repair have several *** cell-based therapy has emerged as a novel strategy to address this issue,exhibiting significant potential for enhancing wound healing rates,improving wound quality,and promoting skin ***,the use of stem cells in skin regeneration presents several ***,stem cells and biomaterials have been identified as crucial components of the wound-healing *** therapy involving the development of biocompatible scaffolds,accompanying cells,multiple biological factors,and structures resembling the natural extracellular matrix(ECM)has gained considerable *** scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells,providing them with an environment conducive to growth,similar to that of the *** scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound *** article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing,emphasizing their capacity to facilitate stem cell adhesion,proliferation,differentiation,and paracrine ***,we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.

关键词： Stem-cell-based therapy Biological scaffolds Wound healing Extracellular matrix mimicry Cellular activities enhancement Scaffold characteristics

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Adipose-derived stem cells in diabetic foot care:Bridging clinical trials and practical application

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World Journal of Diabetes 2024年第6期15卷 1162-1177页

作者： Song-Lu Tseng lin Kang zhu-jun li li-Quan Wang Zi-Ming li Tian-Hao li Jie-Yu Xiang Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences BeijingBeijing 100021China

Diabetic foot ulcers(DFUs)pose a critical medical challenge,significantly impairing the quality of life of ***-derived stem cells(ADSCs)have been identified as a promising therapeutic approach for improving wound healing in *** extensive exploration of the mechanical aspects of ADSC therapy against DFU,its clinical applications remain *** this review,we aimed to bridge this gap by evaluating the use and advancements of ADSCs in the clinical management of *** review begins with a discussion of the classification and clinical management of diabetic foot *** then discusses the current landscape of clinical trials,focusing on their geographic distribution,reported efficacy,safety profiles,treatment timing,administration techniques,and dosing ***,the review discusses the preclinical strategies to enhance ADSC *** review shows that many trials exhibit biases in study design,unclear inclusion criteria,and intervention *** conclusion,this review underscores the potential of ADSCs in DFU treatment and emphasizes the critical need for further research and refinement of therapeutic approaches,with a focus on improving the quality of future clinical trials to enhance treatment outcomes and advance the field of diabetic wound care.

关键词： Adipose-derived stem cells Diabetic foot ulcers Wound healing Clinical

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钨丝增强非晶复合材料弹芯高速侵彻熔化快凝层研究

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塑性工程学报 2024年第1期31卷 240-246页

作者：祝理君杨少增赵洁浙江工商职业技术学院机电工程学院浙江宁波315012 中国兵器科学研究院宁波分院浙江宁波315103 浙江省模塑制品表面装饰与智能成型技术协同创新中心浙江宁波315699

对钨丝增强非晶复合材料弹芯高速侵彻靶板时产生的熔化快凝层进行了扫描电镜观察、能谱分析和X衍射分析,研究了弹靶作用下界面温升机理。结果表明,与传统钨合金相比,钨丝增强非晶复合材料具有更好的“自锐”效应,侵彻能力得到了有效提升... 详细信息

对钨丝增强非晶复合材料弹芯高速侵彻靶板时产生的熔化快凝层进行了扫描电镜观察、能谱分析和X衍射分析,研究了弹靶作用下界面温升机理。结果表明,与传统钨合金相比,钨丝增强非晶复合材料具有更好的“自锐”效应,侵彻能力得到了有效提升;熔化快凝层生成温度应高于1670℃,高温效应有助于提升其侵彻能力;熔化快凝层成分包含靶板材料(Fe、Cr、Mn)和弹芯材料(Zr、Ti、Cu、Ni、W)。其中W的原子分数仅有3.15%,且W元素主要以熔化或熔解方式存在于熔化快凝层中;非晶复合材料弹芯侵彻靶板时反喷物中存在TiW相。弹靶作用界面巨大的冲击导致弹靶材料受到冲击压缩并发生塑性变形、断裂等,引起弹靶作用界面温度急剧升高。

关键词：非晶复合材料熔化快凝层温升机理高速侵彻

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基于近红外光谱数据的一维卷积神经网络模型研究

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光谱学与光谱分析 2024年第3期44卷 731-736页

作者：唐杰罗彦波李翔宇陈云璨王鹏卢天纪晓波庞永强朱立军烟叶资源科学利用重庆市重点实验室重庆400060 国家烟草质量监督检验中心河南郑州450001 上海数之微信息科技有限公司上海200444 上海大学化学系上海200444

近红外光谱技术已被广泛应用于各种检测行业,但传统方法难以汇集光谱关键信息,导致模型预测误差较大。为减少误差,基于452个茄科植物,以化学成分为目标,探索了一维卷积神经网络(1DCNN)在近红外数据上的回归模型研究。经参数优化,总结了... 详细信息

近红外光谱技术已被广泛应用于各种检测行业,但传统方法难以汇集光谱关键信息,导致模型预测误差较大。为减少误差,基于452个茄科植物,以化学成分为目标,探索了一维卷积神经网络(1DCNN)在近红外数据上的回归模型研究。经参数优化,总结了一套兼顾精度与训练效率的1DCNN模型参数,为后续模型研究提供参考。模型测试集的均方根误差为0.02~0.49,平均相对误差为0.8%~1.7%,远小于历史文献。相比传统方法,1DCNN可充分利用全部近红外谱图数据,且建模简单,模型预测能力强。该工作能为近红外光谱相关研究提供新的数据处理思路,也能促进该技术的应用与发展。

关键词：一维卷积神经网络近红外光谱深度学习

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典型城市车用尿素质量状况评估及监管建议

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生态与农村环境学报 2024年第10期40卷 1328-1336页

作者：朱利军崔阳阳易华炜王春雨薛亦峰北京市生态环境保护科学研究院北京100037 国家城市环境污染控制工程技术研究中心北京100037 北京首创环境工程有限公司北京102199

作为柴油车选择性催化还原技术(SCR)系统还原剂,车用尿素溶液质量是柴油车NO_(x)达标排放的重要因素。为了解和评估典型城市车用尿素溶液质量状况,研究选取了45个销售端车用尿素溶液和50个使用端车用尿素溶液样品,按照标准方法检测分析... 详细信息

作为柴油车选择性催化还原技术(SCR)系统还原剂,车用尿素溶液质量是柴油车NO_(x)达标排放的重要因素。为了解和评估典型城市车用尿素溶液质量状况,研究选取了45个销售端车用尿素溶液和50个使用端车用尿素溶液样品,按照标准方法检测分析样品的尿素含量、密度、折光率、不溶物、缩二脲等19项指标,建立车用尿素溶液质量评价方法并对样品质量情况进行评估,提出相关监管保障建议。结果表明:(1)当前车用尿素溶液中尚存在一定的超标情况(不合格率为15%),其中销售端和使用端不合格率分别为2%和26%,需要重点关注使用端质量状况,表明当前市场尚存在一定量的以次充好或不达标的产品,部分车主未在规范的销售点购买或低价购置了不合格产品,或在加注使用环节混入杂质导致超标。(2)超标指标主要集中在缩二脲、不溶物和尿素含量,不合格样品分别有8、6和4个,这些指标会直接或间接影响SCR系统的NO_(x)的转化效率。(3)建立质量评价方法,考虑了超标情况以及不超标情况下结果接近最优值情况,重点评价尿素含量、密度、折光率、缩二脲、不溶物、钙、钠这7项尿素质量指标,其加权得分分别为83、91、84、66、84、97、97,密度以及钙、钠指标为优秀等级,尿素含量、折光率、不溶物为良好等级,缩二脲为合格等级,缩二脲整体质量相对较差。(4)后续监管中,一方面要确保生产销售端质量达标,加强抽检抽测力度,严厉打击超标行为;另一方面,使用端的车主或企业应选择正规的销售单位或供应商,检查产品相关证明文件,管理部门可根据使用端不合格情况进行跟踪、追溯生产销售源头。

关键词：车用尿素质量评估监管建议柴油车典型城市

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Mechanism of brittle-ductile transition of a glass-ceramic rigid substrate

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International Journal of Minerals,Metallurgy and Materials 2011年第2期18卷 229-233页

作者： Yu-li Sun Dun-wen Zuo Hong-yu Wang Yong-wei zhu jun li Jiangsu Key Laboratory of Precision and Micro-manufacturing Technology College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The hardness, elastic modulus, and scratch resistance of a glass-ceramic rigid substrate were measured by nanoindentation and nanoscratch, and the fracture toughness was measured by indentation using a Vickers indenter. The results show that the hardness and elastic modulus at a peak indentation depth of 200 nm are 9.04 and 94.70 GPa, respectively. These values reflect the properties of the glass-ceramic rigid substrate. The fracture toughness value of the glass-ceramic rigid substrate is 2.63 MPa？m1/2. The material removal mechanisms are seen to be directly related to normal force on the tip. The critical load and scratch depth estimated from the scratch depth profile after scratching and the friction profile are 268.60 mN and 335.10 nm, respectively. If the load and scratch depth are under the critical values, the glass-ceramic rigid substrate will undergo plastic flow rather than fracture. The formula of critical depth of cut described by Bifnao et al. is modified based on the difference of critical scratch depth

关键词： brittle-ductile transition critical conditions glass ceramics nanoindentation nanoscratch

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Camera,liDAR,and IMU Based Multi-Sensor Fusion SLAM:A Survey

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Tsinghua Science and Technology 2024年第2期29卷 415-429页

作者： jun zhu Hongyi li Tao Zhang Department of Automation Tsinghua UniversityBeijing 100084China

In recent years,Simultaneous Localization And Mapping(SLAM)technology has prevailed in a wide range of applications,such as autonomous driving,intelligent robots,Augmented Reality(AR),and Virtual Reality(VR).Multi-sensor fusion using the most popular three types of sensors(e.g.,visual sensor,liDAR sensor,and IMU)is becoming ubiquitous in SLAM,in part because of the complementary sensing capabilities and the inevitable shortages(e.g.,low precision and long-term drift)of the stand-alone sensor in challenging *** this article,we survey thoroughly the research efforts taken in this field and strive to provide a concise but complete review of the related ***,a brief introduction of the state estimator formation in SLAM is ***,the state-of-the-art algorithms of different multi-sensor fusion algorithms are *** we analyze the deficiencies associated with the reviewed approaches and formulate some future research *** paper can be considered as a brief guide to newcomers and a comprehensive reference for experienced researchers and engineers to explore new interesting orientations.

关键词： multi-sensor fusion Simultaneous Localization And Mapping(SLAM) navigation localization

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Experimental Study of Hydrodynamic and Self-Buried Behavior of Submarine Pipeline with Perpendicular Spoilers

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China Ocean Engineering 2021年第2期35卷 250-261页

作者： FAN Hong-xia WANG Jian-zhong zhu li-jun WANG Nai-ru CHEN Huai State Key Laboratory of Hydrology Water Resources and Hydraulic EngineeringNanjing Hydraulic Research InstituteNanjing 210029China

The spoiler is a kind of device to disturb current and promote *** present,all submarine pipeline spoilers at home and abroad are parallel spoilers,that is,the plane of the spoiler is parallel to the vertical plane of the pipeline *** to the results of indoor experiments,when the pipeline with the forward spoiler is installed perpendicular to the direction of water flow,the spoiler will accelerate the seabed erosion and cause the pipeline to endure downward pressure,which will eventually cause the pipeline self-buried to form a ***,when the pipeline direction is consistent with the flow direction,the self-buried behavior and protective effect is *** aiming at the defect that the forward spoiler cannot be self-buried when the direction of the pipeline and the flow are basically parallel,the spoiler burying aid device perpendicular to the pipeline axis has been innovatively developed,and the hydrodynamic changes and sediment erosion characteristics near the pipeline after the installation of the device were studied based on the *** reveal that although the perpendicular spoiler cannot generate downforce,it can greatly increase the turbulent kinetic energy of the flow and the rate of sediment *** larger the angle between the pipeline axis and the spoiler plane is,the larger the increase in turbulent energy will *** increase in turbulent energy near the bed surface can reach up about 70%when the angle is 90°,while serious sediment erosion mainly occurs along both sides of the pipeline with a distance of about 2−4 times the pipe *** the future,we can further explore the influence of the perpendicular spoiler size and installation position on the pipeline downforce and the effect of burying *** the same time,field tests on the perpendicular spoiler burying aid device currently developed will conduct to observe the actual effect of perpendicular spoiler promoting pipeline scouring and buryi

关键词： submarine pipeline spoiler self-burial turbulent kinetic energy sediment erosion

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High performance liquid chromatography with immobilized Ru(bpy)_3^(2+)-KMnO_4 chemiluminescence detection and its application in metabolism of repaglinide in pig liver microsomes

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Chinese Chemical Letters 2011年第10期22卷 1245-1248页

作者： Ai Hua Fu zhu jun Zhang li li Chen Xiao Ming Zhang Pan Xue Key Laboratory of Analytical Chemistry for life Science of Shaanxi Province School of Chemistry and Materials Science Shaanxi Normal University Xi＇ an 710062 China

A novel high performance liquid chromatography-chemiluminescence（HPLC-CL） method for investigation of in vitro metabolism of repaglinide in pig liver microsomes with microdialysis sampling technique was *** chromatographic separation was performed on a Hypersil BDS-C18 column with an isocratic mobile phase consisting of methanol and 0.01 mol/L KH_2PO_4（pH 3.0）（volume ratio 75：25） at a flow rate of 1.0 mL/*** detection was based on the chemiluminescence reaction of repaglinide with acidic potassium permanganate（KMnO_4） and tris（2,2＇-bipyridyl）ruthenium（Ⅲ）（Ru（bpy）_3^（3＋））,which was immobilized on the cationic ion-exchange resin for obtaining high sensitivity and reducing consumption of expensive reagent.

关键词： High performance liquid chromatography Chemiluminescence Microdialysis Repaglinide Immobilized Ru(bpy)_3^(2+)

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Application of adipose-derived stem cells in treating fibrosis

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World Journal of Stem Cells 2021年第11期13卷 1747-1761页

作者： zhu-jun li li-Quan Wang Yun-zhu li Chen-Yu Wang Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Fibrosis is the hyperactivation of fibroblasts that results in excessive accumulation of extracellular matrix,which is involved in numerous pathological changes and ***-derived stem cells(ASCs)are promising seed cells for regenerative medicine due to their bountiful source,low immunogenicity and lack of ethical *** anti-fibrosis,immunomodulation,angiogenesis and other therapeutic effects have made them suitable for treating fibrosis-related ***,we review the literature on ASCs treating fibrosis,elaborate and discuss their mechanisms of action,changes in disease environment,ways to enhance therapeutic effects,as well as current preclinical and clinical studies,in order to provide a general picture of ASCs treating fibrotic diseases.

关键词： Adipose-derived stem cells Fibrosis Immunomodulation Modification Therapeutic effect Clinical trials

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