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Viability Property of Jump Diffusion Processes on Manifolds

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Acta Mathematicae Applicatae Sinica 2016年第2期32卷 349-354页

作者： Xue-hong zhu Guang-zu liu School of Science Nanjing University of Aeronautics and Astronautics School of Electronic and Optical Engineering Nanjing University of Science and Technology

In this note, we give a necessary and sufficient condition for viability property of diffusion processes with jumps on closed submanifolds of Rm. Our result is the system is viable in a closed submanifold K iff the coefficients are tangent to K along K if the equation is in the sense of stratonovich integral and the solution jumps from K to K.

关键词： viability property viscosity solution manifold

常山等中药浸提物复方对鸡柔嫩艾美耳球虫病的治疗试验

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中国兽医杂志 2016年第1期52卷 70-71,74页

作者：宋培勇曾燕玲任秘坊朱流红潘恒乙遵义师范学院生命科学学院贵州遵义563002

为了观察中药常山等浸提物与黄芪粗多糖组方对鸡球虫病的治疗效果,用广州大麻雏鸡对人工感染鸡柔嫩艾美耳球虫进行分组试验,结果显示,常山高(150mg)、中(100 mg)、低(50 mg)剂量组的抗球虫指数(ACI)分别为131.2、183.9、169.8,中剂量组... 详细信息

为了观察中药常山等浸提物与黄芪粗多糖组方对鸡球虫病的治疗效果,用广州大麻雏鸡对人工感染鸡柔嫩艾美耳球虫进行分组试验,结果显示,常山高(150mg)、中(100 mg)、低(50 mg)剂量组的抗球虫指数(ACI)分别为131.2、183.9、169.8,中剂量组和低剂量组分别达到了高效和中效;高剂量组可能由于常山浸提物过量产生了生长抑制等副作用致使ACI反而降低。试验表明,适量的中药常山等浸提物与黄芪粗多糖组方用于防治鸡球虫病是可行的,有望研发成一种新的抗球虫制剂。

关键词：常山浸提物黄芪粗多糖鸡人工感染柔嫩艾美耳球虫抗球虫指数

智慧医疗情境下四方主体隐私行为的交互机理及演化趋势研究

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现代情报 2025年第1期45卷 135-149页

作者：朱光吴晗逸刘雯南京信息工程大学风险治理与应急决策研究院江苏南京210044 南京信息工程大学管理工程学院江苏南京210044

[目的/意义]本文针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足,探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程]基于演化博弈理论,构建患者、医疗机构、智慧医疗平... 详细信息

[目的/意义]本文针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足,探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程]基于演化博弈理论,构建患者、医疗机构、智慧医疗平台和政府四方博弈模型。根据不同参数调节下各方行为策略的收益、成本、损失等计算收益矩阵,求解主体的演化稳定策略,并考虑不同因素对主体行为策略及系统稳定状态的影响。[结果/结论]患者的隐私披露行为与披露隐私后获得的服务收益密切相关,医疗机构的隐私保护投入成本和隐私泄露概率对其隐私保护行为有显著影响,智慧医疗平台的政府奖惩、罚款收益和投入成本是影响其严格管理行为的关键因素,政府的监管行为与奖惩机制等因素密切相关。通过应用本文模型和方法,可以动态调整隐私保护机制,明确各方职责,推动智慧医疗可持续健康发展。

关键词：智慧医疗演化博弈隐私行为患者医疗机构智慧医疗平台政府

Whole-genome RNAi screen identifies methylation-related genes influencing lipid metabolism in Caenorhabditis elegans

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Journal of Genetics and Genomics 2018年第5期45卷 259-272页

作者： Xiaotong zhu Yangli liu hong Zhang Pingsheng liu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Lipid droplets （LDs） are highly conserved multifunctional cellular organelles and aberrant lipid storage in LDs can lead to many metabolic diseases. However, the molecular mechanisms governing lipid dynamic changes remain elusive, and the high-throughput screen of genes influencing LD morphology was limited by lacking specific LD marker proteins in the powerful genetic tool Caenorhabditis elegons. In this study, we established a new method to conduct whole-genome RNAi screen using LD resident protein DHS-3 as a LD marker, and identified 78 genes involved in significant LD morphologic changes. Among them, mrhf-1, as well as a series of methylation-related genes, was found dramatically influencing lipid metabolism. SREBP-1 and SCD1 homologs in C. elegans were involved in the lipid metabolic change of rnthf-1（RNAi） worms, and the regulation of ATGL-1 also contributed to it by decreasing triacylglycerol （TAG） hydrolysis. Overall, this study not only identified important genes involved in LD dynamics, but also provided a new tool for LD study using C. elegans, with implications for the study of lipid metabolic diseases.

关键词： Lipid droplet C.elegans RNAi screen Lipid metabolism One-carbon metabolism

Densities and viscosities for ionic liquids [BMIM][BF4] and [BMIM][Cl] and their binary mixtures at various temperatures and atmospheric pressure

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Chinese Journal of Chemical Engineering 2019年第12期27卷 2994-2999页

作者： Jinlong Li hong zhu Changjun Peng honglai liu Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology and School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China State Key Laboratory of Chemical Engineering and Department of Chemistry East China University of Science and TechnologyShanghai 200237China

The density and viscosity of 1-butyl-3-methylimidazolium tetrafluoroborate[BMIM][BF4]and 1-butyl-3-methylimidazolium chloride[BMIM][Cl]and their binary mixtures within the temperatures from 303.15 K to323.15 K and at ambient pressure were determined in this *** temperature dependences of density and viscosity were satisfactorily described with the linear model and the Vogel-Tammann-Fulcher type equation,*** molar volume and viscosity of binary IL mixtures were predicted through ideal mixing rules showing that almost null deviations for IL mixtures were observed and their mixing was remarkably close to linear ideal behavior in the molar volumes,while comparatively large errors in viscosity ***,the molar volume of the investigated pure ILs and their mixtures could well be predicted by a predictive model presented by Valderrama et al.(Fluid Phase Equilib.,275(2009)145).

关键词： Ionic liquid mixture Density Viscosity Excess property

Sub-micron Co-Al_(2)O_(3) composite powders prepared by room-temperature ultrasonic-assisted electroless plating

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Rare Metals 2022年第6期41卷 1968-1971页

作者： liu zhu hong-Bo Guo Sheng-Kai Gong School of Materials Science and Engincering Beihang UniversityBeijing 100191China Department of Mechanical Engineering Taizhou UniversityTaizhou 318000China

Sub-micron Co-Al_(2)O_(3)composite powders were synthesized by ultrasonic-assisted electroless plating process at room temperature with a one-step activating method *** effect of process parameters on plating rate,Co content,and the uniformity of cobalt layer was analyzed by transmission electron microscopy(TEM).The results show that as the initial pH values of plating bath increase,the plating rate *** plating rate declines as the load increases when the load of powders is less than 12 g·L^(-1),but increases when the load is greater than 12 g·L^(-1).The relative Co content of the Co-Al_(2)O_(3) powder declines with the powder load increasing.

关键词： Ultrasonic-assisted electroless plating Co-Al_(2)O_(3)compositepowders Load

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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黄淮海夏大豆新品系鉴定

安徽农业科学 2018年第13期46卷 41-43页

作者：朱虹润刘永德冷国友安徽丰和农业有限公司安徽淮北235000

[目的]筛选适合黄淮海地区大面积推广种植的高产、优质、成熟期适宜的大豆新品种。[方法]采用同一播期,进行随机区组设计,以中黄13为对照,对9个夏大豆新品系进行鉴定试验。[结果]郑1427产量为3 316.95 kg/hm^2,居第1位,比对照增产23.98%... 详细信息

[目的]筛选适合黄淮海地区大面积推广种植的高产、优质、成熟期适宜的大豆新品种。[方法]采用同一播期,进行随机区组设计,以中黄13为对照,对9个夏大豆新品系进行鉴定试验。[结果]郑1427产量为3 316.95 kg/hm^2,居第1位,比对照增产23.98%;皖豆905产量为3 125.25 kg/hm^2,居第2位,比对照增产16.82%;圣豆24产量为2 941.95 kg/hm^2,居第3位,比对照增产9.96%;周豆26号产量为2 908.5 kg/hm^2,居第4位,比对照增产8.72%;圣豆22产量为2 875.2 kg/hm^2,居第5位,比对照增产7.47%。这5个品种与对照熟期相近,生育期日数均低于101 d。[结论]郑1427、皖豆905、圣豆24、周豆26号、圣豆22适宜在淮北地区作夏播种。

关键词：夏大豆新品系鉴定产量

Trapping endoplasmic reticulum with amphiphilic AIE-active sensor via specific interaction of ATP-sensitive potassium(KATP)

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National Science Review 2021年第6期8卷 34-45页

作者： Zhirong zhu Qi Wang hongze Liao Ming liu Zhenxing liu Youheng Zhang Wei-hong zhu Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and Technology Research Center for Marine Drugs State Key Laboratory of Oncogene and Related GenesDepartment of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong University

The current aggregation-induced emission luminogens(AIEgens) sometimes suffer from poor targeting selectivity due to undesirable aggregation in the hydrophilic biosystem with ‘always-on’ fluorescence or unspecific aggregation in the lipophilic organelle with prematurely activated fluorescence. Herein, we report an unprecedented ‘amphiphilic AIEgen’ sensor QM-SO3-ER based on the AIE building block of quinoline-malononitrile(QM). The introduced hydrophilic sulfonate group can well control the specific solubility in a hydrophilic system with desirable initial ‘fluorescence-off’ state. Moreover, the incorporated p-toluenesulfonamide group plays two roles: enhancing the lipophilic dispersity, and behaving as binding receptor to the adenosine triphosphate(ATP)-sensitive potassium(KATP) on the endoplasmic reticulum(ER) membrane to generate the docking assay confinement effect with targetable AIE signal. The amphiphilic AIEgen has for the first time settled down the predicament of unexpected ‘always-on’fluorescence in the aqueous system and the untargetable aggregation signal in the lipophilic organelle before binding to ER, thus successfully overcoming the bottleneck of AIEgens’ targetability.

关键词： aggregation-induced emission amphiphilic AIEgens endoplasmic reticulum targeting specificity high-fidelity tracking