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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong qin Zhou Ling-Qiang zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan qin Lin zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang qin Wenzhen zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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乙亚胺致急性白血病1例

中国新药与临床杂志 2003年第3期22卷 189-190页

作者：卢庆忠栗竹琴檀济平杨帆平山县医院内科河北平山050400

乙亚胺作为一种抗代谢药,临床上常用于银屑病的治疗.但在治疗过程中我们发现1例病人引起急性粒-单核细胞白血病,作者未见国内文献报道,现报告如下.

关键词：白血病粒-单核细胞急性银屑病乙亚胺药物不良反应

Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期 350-359页

作者： Can zhu Yiyang Wang Lei Meng Beibei Qiu Jing Li Shucheng qin Ke Hu Xin Jiang Wenbin Lai Minchao Liu Zhe Liu Chenxing Lu Jinyuan Zhang Yongfang Li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

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带式输送机智能化发展现状研究

煤矿机械 2025年第1期46卷 73-76页

作者：秦翥中煤科工集团上海有限公司上海200030

带式输送机作为煤矿运输的关键装备,通过与智能化技术深度融合,成为智慧矿山建设的重要组成部分。从安全生产、可靠运行、高效运输、无人化作业4个智能化应用场景目标出发,列举了视觉分析、全生命周期监测、智控调速、巡检集控平台等带... 详细信息

带式输送机作为煤矿运输的关键装备,通过与智能化技术深度融合,成为智慧矿山建设的重要组成部分。从安全生产、可靠运行、高效运输、无人化作业4个智能化应用场景目标出发,列举了视觉分析、全生命周期监测、智控调速、巡检集控平台等带式输送机智能化关键技术应用现状,结合现场反馈,明确在安全预警、专家库模型、输送带精准调控、无人巡检作业等方面尚存在问题。结合技术发展趋势,给出了以大数据技术与带式输送机远程运维控制中心为基础、以透明化感知应用与全矿井智能运输体系为依托、通过工业级信息交互与数据挖掘手段、实现带式输送机安全可靠高效无人化的目标,为推动智能矿山新质生产力提供支撑。

关键词：带式输送机智能装备安全生产远程运维无人化

DVCast:denoising and variable dct for analog visual communications

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Digital Communications and Networks 2020年第4期6卷 471-479页

作者： Min Wang Bin tan Dongmei zhu qin Zou The School of Mathematics and Computer Science Gannan Normal UniversityGanzhou341000China College of Electronics and Information Engineering Jinggangshan UniversityJi’an343009China Key Laboratory of Jiangxi Province for Numerical Simulation and Emulation Techniques Ganzhou341000China

Recently,analog visual transmission has attracted considerable attention owing to its graceful performance degradation for various wireless *** this study,we propose a novel analog visual communications system,named DVCast,in which an image denoising algorithm is used to fully utilize spatial correlation;moreover,the variable block size Discrete Cosine Transform(DCT)is used to preserve more correlation information in an ***,there is a tradeoff between system performance and computing ***,to improve the real-time performance of the proposed system,implementation of Block Matching with 3D filtering(BM3D)and DCT by Graphics Processing Units(GPUs)is *** to DCT block size,i.e.,88,1616,and 3232,the schemes DVCast8,DVCast16,and DVCast32,respectively,are designed and *** show that DVCast with larger block size achieves better gain and visual quality than reference ***,it requires less computing ***32 outperforms conventional digital schemes by approximately 3.51 dB and achieves a 1.12 dB gain over state-of-the-art reference ***,the analysis shows that DVCast can reduce overhead by at least 75%.

关键词： Analog visual communications Image de-noising DCT Graphics processing units

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红豆杉细胞悬浮培养生产紫杉醇研究进展

天然产物研究与开发 2003年第5期15卷 471-475页

作者：胡凯何颖祝顺琴谈锋唐克轩西南师范大学生命科学学院重庆400715 复旦大学遗传工程国家重点实验室上海200433

介绍了近年来由红豆杉细胞培养生产紫杉醇领域取得的进展,其中特别介绍了由紫杉醇生物合成途径及其代谢酶类的研究发展而来的用基因工程方法改良细胞系,为提高紫杉醇产量而采取添加前体物质,诱导子,抑制子等方面的研究。

关键词：红豆杉细胞悬浮培养紫杉醇产量生物合成

Evolution of fermion resonance in thick brane

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Communications in Theoretical Physics 2024年第12期76卷 129-139页

作者： Chun-Chun zhu qin tan Yu-Peng Zhang Yu-Xiao Liu Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University Key Laboratory of Quantum Theory and Applications of Mo E Lanzhou University Lanzhou Center for Theoretical Physics & Key Laboratory of Theoretical Physics of Gansu Province Lanzhou University

In this work, we investigate the numerical evolution of massive Kaluza–Klein(KK) modes of a Dirac field on a thick brane. We deduce the Dirac equation in five-dimensional spacetime, and obtain the time-dependent evolution equation and Schr?dinger-like equation of the extradimensional component. We use the Dirac KK resonances as the initial data and study the corresponding dynamics. By monitoring the decay law of the left-and right-chiral KK resonances, we compute the corresponding lifetimes and find that there could exist long-lived KK modes on the brane. Especially, for the lightest KK resonance with a large coupling parameter and a large three momentum, it will have an extremely long lifetime.

关键词： braneworld dynamic evolution fermion resonance