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long-term potentiation-based screening identifies neuronal PYGM as a synaptic plasticity regulator participating in Alzheimer's disease

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Zoological Research 2023年第5期44卷 867-881页

作者： Ting Wang Yun-Qiang Zhou Yong Wang Liang Zhang Xiang zhu Xiu-Yan Wang Jing-Hui Wang Lin-Kun Han Jian meng Xian Zhang Hong Luo Qi-Lin Ma Zhan-Xiang Wang Yun-Wu Zhang Xiamen Key Laboratory of Brain Center The First Affiliated Hospital of Xiamen Universityand Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging ResearchInstitute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China Fujian Provincial Clinical Research Center for Brain Diseases The First Affiliated Hospital of Xiamen UniversityXiamenFujian 361003China

Synaptic dysfunction is an important pathological hallmark and cause of Alzheimer's disease(AD).High-frequency stimulation(HFS)-induced long-term potentiation(LTP)has been widely used to study synaptic plasticity,with impaired LTP found to be associated with ***,the exact molecular mechanism underlying synaptic plasticity has yet to be completely *** genes regulating synaptic plasticity are altered in AD and contribute to disease onset also remains ***,we induced LTP in the hippocampal CA1 region of wildtype(WT)and AD model mice by administering HFS to the CA3 region and then studied transcriptome changes in the CA1 *** identified 89 genes that may participate in normal synaptic plasticity by screening HFS-induced differentially expressed genes(DEGs)in mice with normal LTP,and 43 genes that may contribute to synaptic dysfunction in AD by comparing HFS-induced DEGs in mice with normal LTP and AD mice with impaired *** further refined the 43 genes down to 14 by screening for genes with altered expression in pathological-stage AD mice without HFS *** them,we found that the expression of Pygm,which catabolizes glycogen,was also decreased in AD *** further demonstrated that down-regulation of PYGM in neurons impaired synaptic plasticity and cognition in WT mice,while its overexpression attenuated synaptic dysfunction and cognitive deficits in AD ***,we showed that PYGM directly regulated energy generation in *** study not only indicates that PYGM-mediated energy production in neurons plays an important role in synaptic function,but also provides a novel LTP-based strategy to systematically identify genes regulating synaptic plasticity under physiological and pathological conditions.

关键词： Alzheimer's disease High-frequency stimulation long-term potentiation PYGM Synaptic plasticity Transcriptome

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Application of Helical Strakes for Suppressing the Flow-Induced Vibration of Two Side-by-Side long Flexible Cylinders

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China Ocean Engineering 2020年第2期34卷 172-184页

作者： XU Wan-hai YANG meng AI Hua-nan HE Ming LI Mu-han State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of Hydro Science&Engineering Taiyuan University of TechnologyTaiyuan 030024China

Helical strakes have been widely applied for suppressing the vibration of flexible cylinders undergoing vortexshedding in offshore ***,most research works have concerned on the application of helical strakes for the isolated flexible cylinder subjected to vortex-induced vibration(VIV).The effectiveness of helical strakes attached to side-by-side flexible cylinders in vibration reduction is still *** this paper,the response characteristics of two side-by-side flexible cylinders with and without helical strakes were experimentally investigated in a towing *** configuration of the helical strakes used in the experiment had a pitch of 17.5D and a height of 0.25D(where D is the cylinder diameter),which is usually considered the most effective for VIV suppression of isolated marine risers and *** center-to-center distance of the two cylinders was *** uniform flow with a velocity ranging from 0.05 m/s to 1.0 m/s was generated by towing the cylinder models along the *** results,including the displacement amplitude,the dominant frequency,the dominant mode,and the mean drag force coefficient,were summarized and *** the case where only one cylinder in the two-cylinder system had helical strakes,the experimental results indicated that helical strakes can remarkably reduce the flow-induced vibration(FIV)of the staked *** the case of two straked cylinders in a side-by-side arrangement,it was found that the performance of helical strakes in suppressing the FIV is as good as that for the isolated cylinder.

关键词： side-by-side FIV reduction helical strakes flexible cylinder center-to-center distance

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Analysis of the Distribution,Rotation and Scale Characteristics of Solar Wind Switchbacks:Comparison between the First and Second Encounters of Parker Solar Probe

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Research in Astronomy and Astrophysics 2022年第3期22卷 178-185页

作者： Ming-Ming meng Ying D.Liu Chong Chen Rui Wang State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The S-shaped magnetic structure in the solar wind formed by the twisting of magnetic field lines is called a switchback,whose main characteristics are the reversal of the magnetic field and the significant increase in the solar wind radial *** identify 242 switchbacks during the first two encounters of Parker Solar *** methods are applied to analyze the distribution and the rotation angle and direction of the magnetic field rotation of the *** diameter of switchbacks is estimated with a minimum variance analysis(MVA)method based on the assumption of a cylindrical magnetic *** also make a comparison between switchbacks from inside and the boundary of coronal *** main conclusions are as follows:(1)the rotation angles of switchbacks observed during the first encounter seem larger than those of the switchbacks observed during the second encounter in general;(2)the tangential component of the velocity inside the switchbacks tends to be more positive(westward)than in the ambient solar wind;(3)switchbacks are more likely to rotate clockwise than counterclockwise,and the number of switchbacks with clockwise rotation is 1.48 and 2.65 times those with counterclockwise rotation during the first and second encounters,respectively;(4)the diameter of switchbacks is about 10;km on average and across five orders of magnitude(10^(3)–10^(7)km).

关键词： ISM:magnetic fields methods:statistical (Sun:)solar wind

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Fast removal of Pb^(2+) from water using new chelating fiber modified with acylamino and amino groups

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Chinese Chemical Letters 2012年第4期23卷 496-499页

作者： Ying meng Jin Nan Wang Li Xu Ai Min Li State Key Laboratory of Pollution Control and Resource Reuse&School of the Environment Nanjing UniversityNanjing 210046China

The graft copolymerization of acrylic acid（AA） onto polyethylene glycol terephthalate（PET） fiber initiated by benzoy peroxide （BPO） was carried out in heterogeneous ***,modification of the grafted PET fiber（PET-AA） was done by changing the carboxyl group into acylamino and amino groups through the reaction with *** new modified chelating fiber （NDWJN6） was characterized using elementary analysis,SEM and FT-IR *** kinetic curve indicated that NDWJN6 could fastly remove Pb^（2＋） from water,and adsorption isotherm also indicated that NDWJN6 had high equilibrium adsorption capacity for Pb^（2＋）.

关键词： Removal Pb2+ Chelating fiber Acylamino groups Amino groups

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Recent Development of Bio-inspired Porous Materials for Catalytic Applications

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Chemical Research in Chinese Universities 2023年第1期39卷 13-18页

作者： TANG Yongquan QI Ganggang WANG Sai meng Xiangju XIAO Feng-Shou Department of Chemistry Zhejiang UniversityHangzhou310028P.R.China Stomatology Hospital School of StomatologyZhejiang UniversityHangzhou310006P.R.China Key Lab of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310028P.R.China Department of Chemistry Zhengzhou UniversityZhengzhou450001P.R.China

Nature has served as a source of inspiration for chemists to design the catalysts with superior performance via mimicking their characteristics,such as active sites,reaction microenvironment and electron transfer *** a few decades,many different types of materials have been widely used to construct the biomimetic *** these materials,the porous materials have been demonstrated to be powerful platforms for constructing the biomimetic catalysts owing to their high surface area,controllable composition and easy *** this review,we briefly showed recent advances in the construction of various biomimetic porous catalysts using porous materials for the design of excellent *** addition,we also present the challenge and opportunities in this emerging field.

关键词： Bio-inspired Porous material Biomimetic catalyst

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万古霉素在肥胖人群与正常人群中药动学参数的系统评价

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重庆医科大学学报 2015年第2期40卷 309-313页

作者：蒙龙李娟龙锐贾运涛重庆医科大学附属第一医院药学部重庆400016 重庆医科大学附属儿童医院药剂科重庆400014

目的:通过Meta分析比较万古霉素在肥胖人群和非肥胖正常人群中的药代动力学特点。方法:在Medline、Sciencedirect、Cochrane、CEPS、CETD、CNKI、万方数据库系统搜索相关文献。采用Rev Man4.2软件对其统计分析。结果:总计5篇研究被纳入... 详细信息

目的:通过Meta分析比较万古霉素在肥胖人群和非肥胖正常人群中的药代动力学特点。方法:在Medline、Sciencedirect、Cochrane、CEPS、CETD、CNKI、万方数据库系统搜索相关文献。采用Rev Man4.2软件对其统计分析。结果:总计5篇研究被纳入分析。Meta结果表明:肥胖人群的万古霉素清除率(clearance,CL),稳态表观分布容积(volume of distribution at steady state,Vdss)比正常人群更高。清除率与理想体质量的比值(clearance/ideal body weight,CL/IBW)以及分布容积与理想体质量的比值(volume of distribution/ideal body weight,Vd/IBW)在肥胖人群中更高。但是,清除率与总体质量的比值(clearance/total body weight,CL/TBW)在2组中没有差异。结论:虽然肥胖人群的万古霉素CL和Vdss比正常人群更高,但是2组中的CL/TBW没有差异。

关键词：肥胖万古霉素 Meta分析药动学

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The First Fengyun Satellite International User Conference

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Advances in Atmospheric Sciences 2021年第8期38卷 1429-1432页

作者： Di XIAN Peng ZHANG meng FANG Chang LIU Xu JIA National Satellite Meteorological Center China Meteorological AdministrationBeijing 100081China

*** The First Fengyun Satellite International User Conference,sponsored by the China Meteorological Administration(CMA)and China National Space Administration(CNSA),took place during 15-17 November 2019 in Haikou,Hainan Province,*** purpose of this initial conference was to develop a comprehensive mechanism for Fengyun satellite international users to exchange their applications,discuss an integrated approach to promote global applications of FY satel-lite data,and to better serve countries and users along the“Belt and Road”.Experts from over 30 countries,the World Meteor-ological Organization(WMO),the Asia-Pacific Space Cooperation Organization(APSCO),the National Oceanic and Atmo-spheric Administration(NOAA),the European Organization for the Exploitation of Meteorological Satellites(EUMET-SAT),and the Sixth International Strategic Consultative Committee on Chinese Meteorological Satellite Programmes(ISCC),attended this conference(Fig.1).

关键词： users Strategic attended

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H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak

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World Journal of Gastroenterology 2000年第6期6卷 829-832页

作者： Yu Liang Zhao Zong Da meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin zhu Department of Virology Hebei Provincial Sanitary and Antiepidemic StationBaoding 071000Hebei ProvinceChina Department of Epidemiology Shanghai Medical University.Shanghai 200032China Fucheng County Sanitary and Anti-epidemic Station Zhejiang Academy of Medical Sciences Hangzhou

AIM:To investigate the protective efficacy of H2 strain attenuated live hepatitis A vaccines (H2-strain vaccines) in hepatitis A (HA) ***:With the permission of their parents, 5551 pre-school and grade 1-3 primary school children were inoculated with 1 dose (10(6.5) TCID(50)) of H2 strain vaccines in a nonrandomized, controlled trial conducted in Fucheng County, Hebei Province in May *** 6485 children in the same grades and compatible in gender and age were enrolled as controls. Epidemiological and serological survey was conducted to evaluate the protective efficacy of the vaccines. ELISA was used to detect serum IgM ***:HA outbreak started in early May 1998, peaked in the middle of the same month, and lasted about 80 days. Overall 302 HA cases were found, 192(63.58%) were 5-9 years old. One vaccinee and 25 control cases were found to have hepatitis A, which account for 0.28% (1/356) and 5.92% (25/422) of all vaccinees and controls in the 14 villages, respectively. The protective efficacy of vaccines was 95.27% (95% CI: 85.83%-104.72%). In subjects tested for anti-HAV IgM from 13 villages, 1(0.40%) overt and 11(4.06%) asymptomatic HAV cases were found in 271 vaccinees but 21(6.69%) of overt and asymptomatic ones were found in 314 ***:H2 strain vaccines were excellent in preventing overt hepatitis A,but not so effective in preventing asymptomatic hepatitis A virus infection.A booster dose might be needed to get permanent reliable immunity.

关键词： hepatitis A/prevention and control vaccines, attenuated vaccines, inactivated viral hepatitis vaccines disease outbreaks protective efficacy

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Recent progress in silk fibroin-based flexible electronics

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Microsystems & Nanoengineering 2021年第3期7卷 1-25页

作者： Dan-Liang Wen De-Heng Sun Peng Huang Wen Huang meng Su Ya Wang meng-Di Han Beomjoon Kim Juergen Brugger Hai-Xia Zhang Xiao-Sheng Zhang School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China CIRMM Institute of Industrial ScienceThe University of TokyoTokyo 153-8505Japan Microsystems Laboratory Ecole Polytechnique Federale de Lausanne(EPFL)1015 LausanneSwitzerland Institute of Microelectronics Peking University100087 BeijingChina

With the rapid development of the Internet of Things(loT)and the emergence of 5G,traditional silicon-based electronics no Ion ger fully meet market dema nds such as nonplanar application scenarios due to mechanical *** provides unprecedented opportunities for flexible electronics that bypass the physical rigidity through the introduction of flexible *** recent decades,biological materials with outstanding biocompatibility and biodegradability,which are considered some of the most promising candidates for next-generation flexible electronics,have received increasing attention,e.g.,silk fibroin,cellulose,pectin,chitosan,and *** them,silk fibroin presents greater superiorities in biocompatibility and biodegradability,and moreover,it also possesses a variety of attractive properties,such as adjustable water solubility,remarkable optical transmittance,high mechanical robustness,light weight,and ease of processing,which are partially or even completely lacking in other biological ***,silk fibroin has been widely used as fundamental components for the construction of biocompatible flexible electronics,particularly for wearable and implantable ***,in recent years,more attention has been paid to the investigation of the functional characteristics of silk fibroin;such as the dielectric properties,piezoelectric properties,strong ability to lose electrons,and sensitivity to environmental ***,this paper not only reviews the preparation technologies for various forms of silk fibroin and the recent progress in the use of silk fibroin as a fundamental material but also focuses on the recent advaneed works in which silk fibroin serves as functional *** on ally,the challenges and future development of silk fibroin-based flexible electronics are summarized.

关键词： fibroin silk attractive

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Denoising Stochastic Progressive Photon Mapping Renderings Using a Multi-Residual Network

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Journal of Computer Science & Technology 2020年第3期35卷 506-521页

作者： Zheng Zeng Lu Wang Bei-Bei Wang Chun-meng Kang Yan-Ning Xu School of Software Shandong UniversityJinan 250101China School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Information Science and Engineering Shandong Normal UniversityJinan 250358China

Stochastic progressive photon mapping(SPPM)is one of the important global illumination methods in computer *** can simulate caustics and specular-diffuse-specular lighting effects ***,as a biased method,it always suffers from both bias and variance with limited iterations,and the bias and the variance bring multi-scale noises into SPPM *** learning-based methods have shown great advantages on denoising unbiased Monte Carlo(MC)methods,but have not been leveraged for biased *** this paper,we present the first learning-based method specially designed for denoising-biased SPPM ***,to avoid conflicting denoising constraints,the radiance of final images is decomposed into two components:caustic and *** two components are then denoised separately via a two-network *** each network,we employ a novel multi-residual block with two sizes of filters,which significantly improves the model’s capabilities,and makes it more suitable for multi-scale noises on both low-frequency and high-frequency *** also present a series of photon-related auxiliary features,to better handle noises while preserving illumination details,especially *** with other state-of-the-art learning-based denoising methods that we apply to this problem,our method shows a higher denoising quality,which could efficiently denoise multi-scale noises while keeping sharp illuminations.

关键词： denoising stochastic progressive photon mapping(SPPM) deep learning residual neural network

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