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不同术式治疗内侧间室膝骨关节炎的疗效比较

临床医学研究与实践 2018年第26期3卷 69-70页

作者：朱冬朱梦龙姚舒馨富平县朱老二骨伤医院陕西渭南711700 西安交通大学附属西安市红会医院陕西西安710054

目的研究不同术式治疗内侧间室膝骨关节炎(KOA)的效果和对膝关节评分(KSS)、人工关节被遗忘指数(FJS)及膝关节活动度(ROM)的影响。方法将我院收治的69例内侧间室KOA患者根据手术方式不同分为观察组(32例)和对照组(37例)。观察组接受单... 详细信息

目的研究不同术式治疗内侧间室膝骨关节炎(KOA)的效果和对膝关节评分(KSS)、人工关节被遗忘指数(FJS)及膝关节活动度(ROM)的影响。方法将我院收治的69例内侧间室KOA患者根据手术方式不同分为观察组(32例)和对照组(37例)。观察组接受单髁关节置换术(UKA),对照组接受全膝关节置换术(TKA)。比较两组患者的治疗效果。结果观察组患者手术时间、下床活动时间、首次直腿抬高时间及住院时间明显短于对照组(P<0.05)。术后1个月,观察组KSS及ROM评分明显高于对照组(P<0.05)。术后1、6、12、24个月,观察组FJS评分均明显高于对照组(P<0.05)。结论相比于TKA,UKA治疗内侧间室KOA的膝关节功能恢复更快更好,假体自感性更明显,手术时间短,创伤更小,值得临床推广。

关键词：内侧间室膝骨关节炎(KOA) 单髁关节置换(UKA) 全膝关节置换(TKA)

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冯学功辨治颈性眩晕方药规律数据挖掘分析

中华中医药杂志 2019年第10期34卷 4929-4932页

作者：郝文杰冯学功武晓磊朱梦龙北京市中西医结合医院

目的:分析冯学功教授治疗颈性眩晕的用药规律,为该病治疗提供新的思路。方法:将冯学功教授治疗颈性眩晕门诊处方录入中医传承辅助系统(V2.5),建立相关数据库,挖掘冯学功教授治疗颈性眩晕用药规律。结果:筛选治疗颈性眩晕的处方172首,其... 详细信息

目的:分析冯学功教授治疗颈性眩晕的用药规律,为该病治疗提供新的思路。方法:将冯学功教授治疗颈性眩晕门诊处方录入中医传承辅助系统(V2.5),建立相关数据库,挖掘冯学功教授治疗颈性眩晕用药规律。结果:筛选治疗颈性眩晕的处方172首,其中,中药使用频次较高的药物17味,基本为经验方柴胡晕痛汤、四逆晕痛汤所用药物。结论:冯学功教授治疗颈性眩晕多从太阳少阳合病入手,柴胡晕痛汤、四逆晕痛汤为其常用效方,临床具体治疗与理论认识具备良好的一致性。

关键词：颈性眩晕太少合病中医传承辅助系统方药规律

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan meng Kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

基于现场实测的绢云母片岩隧道变形与受力特征

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科学技术与工程 2019年第29期19卷 312-318页

作者：朱孟龙张庆文徐国林蒋锐刘欢西南林业大学土木工程学院

绢云母片岩是西南地区普遍存在的复杂地质软岩,遇水易软化、泥化,在该中地层条件下施工的隧道普遍出现软岩大变形问题,处理不当还会造成塌方,极易造成严重后果。以实际工程为载体,通过现场试验,研究绢云母片岩隧道的变形与受力特征。研... 详细信息

绢云母片岩是西南地区普遍存在的复杂地质软岩,遇水易软化、泥化,在该中地层条件下施工的隧道普遍出现软岩大变形问题,处理不当还会造成塌方,极易造成严重后果。以实际工程为载体,通过现场试验,研究绢云母片岩隧道的变形与受力特征。研究结果表明:三台阶开挖造成围岩压力的多级释放,每台阶开挖后围岩压力均经历快速增长与缓慢增加两个阶段,围岩压力总体呈现出“右上、左下大,右下、左上小”的非对称分布;初期支护钢架以受压为主,应力“上大下小”分布,右拱腰处钢架压应力最大237. 4 MPa,大于钢架抗压强度设计值;围岩整体向内挤压,隧道呈现“上大下小”不对称变形,右拱腰处最大变形量325 mm,大于预留变形。研究指出了施工过程中的安全隐患,并为绢云母片岩隧道的设计、施工提供了数据参考。

关键词：绢云母片岩隧道试验监测变形受力

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非饱和绢云母片岩残积土一维压缩变形规律

科学技术与工程 2021年第3期21卷 1131-1137页

作者：刘欢张庆文连晓兰朱孟龙聂广影云南省建筑工程设计院有限公司昆明650501 西南林业大学土木工程学院昆明650224 云南建投中航建设有限公司昆明650217

绢云母片岩残积土遇水软化疏松,易发生湿化破坏,变形受水影响明显。为研究其土水特性及压缩变形规律,开展了基质吸力测定试验及在不同条件下的一维侧限压缩试验。结果表明:非饱和绢云母片岩残积土的土水特征曲线呈非典型"S"形,非饱和残... 详细信息

绢云母片岩残积土遇水软化疏松,易发生湿化破坏,变形受水影响明显。为研究其土水特性及压缩变形规律,开展了基质吸力测定试验及在不同条件下的一维侧限压缩试验。结果表明:非饱和绢云母片岩残积土的土水特征曲线呈非典型"S"形,非饱和残余段段特征不明显;净竖向压力相同时,孔隙比随着基质吸力的增大而逐渐增大,得到其屈服吸力为200 kPa;基质吸力相同时,孔隙比随着净竖向压力的的增大逐渐减小,密度较大的试样产生的压缩变形量小,说明基质吸力和干密度能增强其抗压性。在实际工程中应充分考虑这些因素。

关键词：非饱和土基质吸力干密度一维侧限压缩

2,7-二辛基[1]苯并噻吩并[3,2-b]苯并噻吩在Cu(100)上的吸附生长以及能级结构演化

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物理学报 2016年第15期65卷 235-243页

作者：张宇河牛冬梅吕路谢海鹏朱孟龙张红刘鹏曹宁通高永立中南大学先进材料超微结构与超快过程研究所长沙410083 Department of Physics and Astronomy University of Rochester

结合紫外光电子能谱(UPS),X射线光电子能谱(XPS),原子力显微镜(AFM)和掠入射X射线衍射谱(GIXRD)等实验手段,系统研究了2,7-二辛基[1]苯并噻吩并[3,2-b]苯并噻吩在Cu(100)基底上的吸附、生长过程以及界面能级结构.发现第一层的分子平躺... 详细信息

结合紫外光电子能谱(UPS),X射线光电子能谱(XPS),原子力显微镜(AFM)和掠入射X射线衍射谱(GIXRD)等实验手段,系统研究了2,7-二辛基[1]苯并噻吩并[3,2-b]苯并噻吩在Cu(100)基底上的吸附、生长过程以及界面能级结构.发现第一层的分子平躺吸附于Cu(100)上形成稳定的物理吸附.随膜厚增加,分子取向转为直立于薄膜平面,生长模式转为岛状生长模式.分子取向的变化导致膜厚大于16A的薄膜的能级结构发生变化.直立取向的分子在表面形成由内向外的电偶极层,引起真空能级下降,功函数降低;而轨道电离的各向异性使得分子从平躺到直立时UPS得到的分子最高占据轨道(HOMO)峰型发生变化,且HOMO起始边向深结合能端移动整体上随着膜厚的增加,真空能级向下弯曲,HOMO下移,电离能则先减小后增大下移的能带结构利于电子从界面向表面的迁移以及空穴从表面向界面的迁移.

关键词：光电子能谱能级结构分子取向薄膜生长

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan Wen Zhigang Tao Hai Pu Tianci Deng Yaoyao meng Qingbin meng Hongwen Jing Bo meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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干式变压器风冷系统在线监测与温控保护装置

仪表技术与传感器 2020年第4期 31-34页

作者：尹春杰王亚男宋彦螟朱孟隆吴边山东建筑大学信息与电气工程学院山东济南250101

针对传统干式变压器温控保护装置对风机运行状态缺乏有效监测的不足,设计实现了以STM32F103为控制器核心的新型干式变压器温控保护装置。提出基于离散傅里叶变换实现对风机运行状态参数在线监测,阐明实现风冷系统故障诊断的判据与温控... 详细信息

针对传统干式变压器温控保护装置对风机运行状态缺乏有效监测的不足,设计实现了以STM32F103为控制器核心的新型干式变压器温控保护装置。提出基于离散傅里叶变换实现对风机运行状态参数在线监测,阐明实现风冷系统故障诊断的判据与温控保护策略,并给出电压电流采样电路、三线桥式温度采样电路及相应的信号调理电路设计。该装置具有风机电源电压、电流等全电量参数及温度监测、系统控制、状态诊断、保护预警、数据存储、远程通讯等功能。

关键词：风冷系统在线诊断温控保护离散傅里叶变换 STM32 干式变压器