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Beclin-1- mediated autophagy may be involved in the elderly cognitive and affective disorders in streptozotocininduced diabetic mice

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Translational Neurodegeneration 2016年第1期5卷 171-180页

作者： zhu-fei guan Xiu-Ling Zhou Xiao-Ming Zhang Yu Zhang Yan-Mei Wang Qi-Lin Guo Gang Ji Guo-Feng Wu Na-Na Wang Hao Yang Zhong-Yu Yu Hou-guang Zhou Jing-Chun Guo Ying-Chao Liu Department of Geriatric Neurology Huashan HospitalFudan UniversityNational Clinical Medicine Research Center for Age-related Diseases12 Middle WuLuMuQi RdShanghai 200040China National Clinical Medicine Research Center for Age-related Diseases 12 Middle WuLuMuQi RdShanghai 200040China Department of Ultrasonics Huashan HospitalFudan UniversityShanghai 200040China Department of Emergency Neurology Guiyang Medical UniversityGuiyang 550004China Department of Neurosurgery Shandong Provincial Hospital5 Latitude and 7 longitude RdJinan 250021China

Background:Diabetes is the most common metabolic disease with many chronic complications,and cognitive disorders are one of the common complications in patients with *** studies have showed that autophagy played important roles in the progression of metabolic syndrome,diabetes and other *** we investigated whether aged diabetic mice are prone to be associated with the cognitive and affective disorders and whether Beclin-1-mediated autophagy might be involved in thepahological ***:High-fat diet/streptozotocin(STZ)injection-induced diabetic C57 mice were adopted in this *** disorders were detected by Morris water maze and fear conditional *** disorders were detected by tail suspension test and forced swimming *** resonance imaging was applied to observe changes of morphology and metabolism in the *** 18 F-fluorodeoxyglucose positron emission tomography(FDG-PET)was used to assess metabolism changes in the brain of aged diabetic *** were evaluated by Beclin-1,LC3II/I and P62,which were detected by western blot analysis and observed by electron ***:*** with control group,diabetes mice showed significantly decreasing abilities in spatial memory and conditioned fear memory(all P<0.05),and increasing tendency of depression(P<0.05).*** showed that the majority of elderly diabetic mice were associated with multiple cerebral small vessel *** even showed hippocampal atrophy,ventricular dilatation and ***-PET-CT discovered that the glucose metabolism in the amygdala and hippocampus was significantly decreased compared with normal aged mice(P<0.05).*** microscopy found that,although autophagy bodies was not widespread,and there was no significant difference between the two groups,yet compared with normal aged mice,apparent cell edema,myelinated tow reduction and intracellular lipofuscin augmentation existed in elderly diabetic mice ***

关键词： Beclin1 metabolism diabetic

内镜下金属钛夹止血治疗上消化道出血的临床疗效及对患者凝血功能的影响

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医学信息 2024年第2期37卷 120-123页

作者：祝官飞黄家驷医院/玉山县人民医院消化内科

目的研究内镜下金属钛夹止血与注射止血药物治疗上消化道出血临床疗效及对凝血功能的影响。方法选取2019年10月-2022年10月在我院诊治的60例上消化道出血患者为研究对象，采用随机数字表法分为对照组（n=30）和观察组（n=30），对照... 详细信息

目的研究内镜下金属钛夹止血与注射止血药物治疗上消化道出血临床疗效及对凝血功能的影响。方法选取2019年10月-2022年10月在我院诊治的60例上消化道出血患者为研究对象，采用随机数字表法分为对照组（n=30）和观察组（n=30），对照组采用内镜下注射止血药物治疗，观察组采用内镜下金属钛夹止血治疗。比较两组临床疗效、凝血功能指标[凝血酶原时间（PT）、纤维蛋白原（Fbg）、血小板（PLT）]、血红蛋白（Hb）水平、红细胞计数（RBC）、便血消失时间、住院时间、再出血发生率以及并发症发生率。结果观察组治疗总有效率（93.33%）高于对照组（83.33%）(P0.05）。结论上消化道出血采用内镜下金属钛夹止血效果显著，可提高治疗效果，缩短恢复时间，预防再出血，改善凝血功能指标，减小对血红蛋白和红细胞的影响，值得临床应用。

关键词：内镜金属钛夹止血上消化道出血凝血功能

Effects of EGb761 on elderly diabetic mice with cerebral small vessel disease

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Effects of EGb761 on elderly diabetic mice with cerebral sma...

中国神经科学学会第十二届全国学术会议

作者： zhu-fei guan Zhong-Yu YU Xiao-Ming ZHANG Yan-Mei WANG Qian ZHANG Gang JI Qi-Lin GUO Xiao-Hong WEN Hou-guang ZHOU Jing-Chun GUO State Key Laboratory of Medical Neurobiology Institutes of Brain Science Fudan University Shanghai Medical college Department of Geriatrics Huashan Hospital Fudan University

Objective To observe whether ginkgo biloba extract 761（EGb761） could exert preventive interventions on elderly diabetic mice with cerebral small vessel disease and to explore the role of Beclin1 mediated autophagy in the above mechanisms. Methods 2-month-old male dbdb diabetic mice and WT mice were divided into six groups including dbdb group, dbdb-EGb761-50 mg group,dbdb-EGb761-100 mg group, WT group, WTEGb761-50 mg group and WT-EGb761-100 mg group, which firstly were given normal diets within four consecutive months, then given EGb-761 drops（50 mg/kg and 100 mg/kg） by gavage for one month from the age of six months. The cognitive abilities were examined when they were eight months old by using Y-maze（spatial learning and memory test） and Social Choice Test（non-spatial learning and memory test）. The blood pressure changes in caudal vein were measured by using the small animal blood pressure meter. Small animal MRI analysis was adopted to detect blood oxygen level dependent（f MRI-bold） change. The expression and distribution of Beclin1, LC3 and NF-κB were detected by using immunohistochemistry staining and Western-blot analysis. Results: 1. Compared with WT mice, the ability of learning and memory and overall cognitive function of dbdb mice decreased（P＜0.05）, and the EGb761 could improve obviously learning and memory function of dbdb mice（P＜0.05）. 2. EGb761 could improve slightly blood pressure in dbdb mice（P＜0.05）, but no dose-related. 3. Compared with the WT group, the result of f MRI-bold showed a decline in brain activity in the hippocampus in dbdb group which accompanied with decreasing connection with the surrounding brain regions. EGb761 could exert obvious improvement on the above changes. 4. Significant cell degeneration occurred in the brain of dbdb mice, e.g. brain cells decrease, nuclear condensation and cytoplasmic unevenness. 5. EGb761 could improve Beclin1 and LC3-I/II levels and reduce NF-κB. 6. Beclin1 protein levels in the brain of WT group and dbd

关键词： EGb761 Beclin 1 NF-κB autophagy cognitive function

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四氟菊酯的核磁共振法分析

分析测试学报 2003年第3期22卷 63-65页

作者：祝亚非关山越邵伟艳中山大学测试中心广东广州510275

采用 1HNMR、13CNMR、无畸变增强极化转移实验 (DEPT)、1H - 1H相关谱 (COSY)、1H检测异核多量子相关谱 (HMQC)、1H检测的异核多键相关谱 (HMBC)等方法 ,对四氟菊酯的 1H和 13CNMR谱信号进行了归属 ;并用奥氏核效应 (NOE)差谱法确定了... 详细信息

采用 1HNMR、13CNMR、无畸变增强极化转移实验 (DEPT)、1H - 1H相关谱 (COSY)、1H检测异核多量子相关谱 (HMQC)、1H检测的异核多键相关谱 (HMBC)等方法 ,对四氟菊酯的 1H和 13CNMR谱信号进行了归属 ;并用奥氏核效应 (NOE)差谱法确定了该化合物的立体结构。

关键词：四氟菊酯核磁共振法分析拟除虫菊酯杀虫剂质量控制结构鉴定

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie zhu Xiao-Jia Yang Qian-Ru He fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang Jia-zhu Wen Li-Kang Luo Jia-Cheng guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Digital CEOs in Digital Enterprises:Automating,Augmenting,and Parallel in Metaverse/CPSS/TAOs

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 820-823页

作者： Juanjuan Li Rui Qin Sangtian guan Xiao Xue Peng zhu fei-Yue Wang with State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China the College of Intelligence and Computing Tianjin UniversityTianjin 300072China School of Economics and Management Nanjing University of Science and TechnologyNanjing 210094China the State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China

BIG models or foundation models are rapidly emerging as a key force in advancing intelligent societies[1]–[3]Their significance stems not only from their exceptional ability to process complex data and simulate advan... 详细信息

关键词： exceptional Auto advancing

Effect of Ce addition on hot corrosion behaviours of a cast γ'-strengthened Co–Al–W–Mo–Ta–B alloy at 800 ℃

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Progress in Natural Science:Materials International 2022年第4期32卷 463-471页

作者： Qi guan fei Zhong Jiangbo Sha School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics Key Laboratory of Aerospace Materials and Performance (Ministry of Education) College of Chemistry and Materials Science Hubei Engineering University

Hot corrosion behaviours of a novel Co–9Al-4.5W-4.5Mo–2Ta-0.02B alloy doped with 0.01, 0.05, 0.1 and 0.2 at%Ce exposed at 800℃ in a solution of 75%Na2SO4/25%Na Cl were investigated. The alloys comprised a coherentγ-CoSS/γ’-Co3(Al, W) microstructure(0.01Ce and 0.05Ce alloys) and κ-Co3(W, Mo) precipitates(0.1Ce and 0.2Ce alloys) at grain boundaries. Hot corrosion kinetics curves demonstrated the parabolic time dependency profile with two stages: the first parabolic stage is within the beginning ～50 h corrosion and follows by the second parabolic stage. With an increasing nominal Ce content the weight gain of the alloy significantly decreased from approximately 70.1 mg cm-2(0.01Ce) to 40.8 mg cm-2(0.2Ce) when exposed for 100 h. A two-layer corrosion scale formed, and the scale was composed of an outer layer of Co3O4oxide with spinel compounds of Co Al2O4,CoWO4and CoSO4, and an inner γ/needle-like Co3W/sulphide layer adhered to the substrate. Heavy spallation of the corrosion scale occurred in the 0.01Ce～0.1Ce alloys, however, spallation was slight in the 0.2Ce alloy. The excellent corrosion resistance of the 0.2Ce alloy could be attributed mainly to the formation of continuous Al2O3lines in the corrosion scale, as well as the prolongation of the incubation period of the corrosion product spallation.

关键词： Co–Al–W-Based alloys Doping Ce Microstructural evolution Kinetics curves Hot corrosion mechanisms

An efficient photocatalytic CO_(2) reduction system improved by emodin as a redox mediator

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Green Chemical Engineering 2023年第4期4卷 433-438页

作者： Hua Gao Guoquan Liu Yong zhu Zhibing Wen Xiao Liu guan Wang fei Li State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian116024China

Solar-driven photoreduction of CO_(2)to value-added fuels such as CO,CH_(4),and CH_(3)OH is a promising approach for alleviating the greenhouse ***-metal-complex molecular catalysts exhibit high catalytic performance for CO_(2)reduction owing to their tunable *** this study,we developed an efficient,inexpensive,and noble-metal-free photocatalytic CO_(2)reduction system containing an organic photosensitizer proflavine,a cobalt molecular catalyst,and an organic electron transfer relay emodin in DMF/H_(2)O(DMF:N,N-dimethylformamide)*** the presence of water,a turnover number(TON)of 1333 was achieved for CO_(2)-to-CO conversion under ambient conditions and visible light irradiation,which is a 1.7-fold improvement over the system without *** addition,a high selectivity of 90%was obtained for CO *** spectroscopy and cyclic voltammetry confirmed the crucial role of emodin in facilitating electron transfer between the photosensitizer and *** expect that our system will promote the development of an effective homogenous photocatalytic solar-fuel production technology.

关键词： Photocatalysis CO_(2)reduction Electron relay Organic dye