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鲁西临沂一带三山子组分布及熔剂用白云岩成矿特征

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山东国土资源 2024年第7期40卷 1-7页

作者：冯广王燕燕康鹏宇冯爱平陈保民张立朋祝丽媛山东省地矿建设有限公司山东济宁272100 山东省第七地质矿产勘查院山东临沂276006 山东省金刚石成矿机理与探测院士工作站山东临沂276006

奥陶纪三山子组是鲁西熔剂用白云岩产出的典型层位,而潍坊-临沂地层小区是三山子组最广泛发育区。本文在查明临沂地区三山子组呈“四个岩带”状分布的基础上,快速“锁定”熔剂用白云岩找矿区,于4个岩带中各选定典型矿区,以探矿工程和分... 详细信息

奥陶纪三山子组是鲁西熔剂用白云岩产出的典型层位,而潍坊-临沂地层小区是三山子组最广泛发育区。本文在查明临沂地区三山子组呈“四个岩带”状分布的基础上,快速“锁定”熔剂用白云岩找矿区,于4个岩带中各选定典型矿区,以探矿工程和分析测试数据为依据,总结临沂地区三山子组熔剂用白云岩成矿特征,为鲁西乃至华北地区熔剂用白云岩找矿提供参考。熔剂用白云岩矿体赋存于三山子组c段,矿体严格受地层控制,倾向NE、NW,倾角5°~40°。矿体厚度30.5~108.6 m,与三山子组c段厚度呈正相关,呈现自北向南厚度渐次变薄的规律。矿体中夹石不发育,矿体顶板为三山子组b段白云岩,直接底板为三山子组c段底部含燧石结核白云岩或薄层泥质白云岩。矿石质量稳定,MgO平均含量分别为20.23%~20.74%,夹石少,易于露天开采,具有良好的开发前景,预测远景资源量大于2亿t。

关键词：熔剂用白云岩成矿特征三山子组临沂一带鲁西

径向锻造加工率对TC4钛合金管材组织与性能的影响

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热加工工艺 2024年第13期53卷 134-137页

作者：陈胜川李建锋朱宝辉刘耀兵杨宝林曹立鹏王晓磊唐寿全宁夏中色金航钛业有限公司宁夏石嘴山753000

对TC4钛合金斜轧管坯分别进行23.4%、43.8%和52.8%三种加工率的无芯轴径向锻造,研究不同加工率对管材内壁质量、尺寸、显微组织和力学性能的影响。结果表明:随着径向锻造加工率的增加,内壁起皱量和壁厚增量随之增大,同时壁厚均匀性变差... 详细信息

对TC4钛合金斜轧管坯分别进行23.4%、43.8%和52.8%三种加工率的无芯轴径向锻造,研究不同加工率对管材内壁质量、尺寸、显微组织和力学性能的影响。结果表明:随着径向锻造加工率的增加,内壁起皱量和壁厚增量随之增大,同时壁厚均匀性变差;部分片状α发生球化,片状α和少量等轴α并存;抗拉强度和屈服强度随着加工率的增大而增加,塑性无明显变化。

关键词： TC4钛合金管材径向锻造壁厚均匀性

上海市浦东新区新型冠状病毒重复感染情况分析

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上海预防医学 2024年第2期36卷 117-122页

作者：张戈张安冉贾逸林张黎郝莉鹏徐红梅王远萍叶楚楚刘伯朱渭萍周一心大理大学公共卫生学院云南大理671003 上海市浦东新区疾病预防控制中心上海200136

【目的】掌握2022年春季上海新型冠状病毒(简称“新冠病毒”)感染疫情中既往感染者的重复感染发生水平、人群特征及疫苗接种史,基于浦东新区不同时期不同变异株感染者的重复感染水平及人群特征,为新冠病毒重复感染防控策略提供参考。【... 详细信息

【目的】掌握2022年春季上海新型冠状病毒(简称“新冠病毒”)感染疫情中既往感染者的重复感染发生水平、人群特征及疫苗接种史,基于浦东新区不同时期不同变异株感染者的重复感染水平及人群特征,为新冠病毒重复感染防控策略提供参考。【方法】从2022年3—5月上海市浦东新区报告的新冠病毒无症状感染者和确诊病例中随机抽取9250名调查对象,调查内容主要包括人口学特征、核酸或抗原检测情况、感染后的症状等。比较不同人群的重复感染率,采用logistic回归分析性别、年龄和疫苗接种情况对重复感染的影响。【结果】9250名调查对象中实际回收有效问卷7571份,应答率81.85%。男性4043人(53.40%),女性3528人(46.60%);年龄最小1个月,最大101岁,年龄中位数为34(P25,P75:7,61)岁;疫苗接种率为59.44%。调查对象中,2022年12月重复感染563例,重复感染率为7.44%,3~岁人群重复感染率最低(2.86%),30~岁组重复感染率最高(12.42%),不同年龄组间重复感染率差异有统计学意义。完成疫苗接种人群的重复感染率较低(6.57%),显著低于未完成疫苗接种人群(7.11%)。3~岁、60~岁以及完成全程疫苗接种和接种加强针是重复感染的保护因素。【结论】2022年春季上海疫情中的感染者在12月Omicron新亚型毒株流行中重复感染率整体较低,3~岁人群重复感染率显著低于其他人群,完成新冠疫苗全程接种显著降低重复感染风险。尽管接种加强针的重复感染率高,但是相对未接种人群是降低重复感染率的影响因素。建议仍持续关注重点人群重复感染情况,进一步加强人群免疫接种。

关键词：新型冠状病毒重复感染疫苗全程接种

Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury

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Bioactive Materials 2023年第5期23卷 328-342页

作者： Yuluo Rong zhuanghui Wang Pengyu Tang Jiaxing Wang Chengyue Ji Jie Chang Yufeng zhu Wu Ye Jianling Bai Wei Liu Guoyong Yin lipeng Yu Xuhui Zhou Weihua Cai Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029JiangsuChina Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjing210029JiangsuChina Department of Orthopedics Second Affiliated Hospital of Naval Medical UniversityShanghai200003China Department of Orthopedics Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong UniversityShanghai200003China

Spinal cord injury(SCI)is a severe disease of the nervous system that causes irreparable damage and loss of function,for which no effective treatments are available to *** extracellular vesicles(EVs)carrying therapeutic molecules hold promise as an alternative SCI therapy depending on the specific functionalized EVs and the appropriate engineering *** this study,we demonstrated the design of a drug delivery system of peptide CAQK-modified,siRNA-loaded EVs(C-EVs-siRNA)for SCI-targeted *** peptide CAQK was anchored through a chemical modification to the membranes of EVs isolated from induced neural stem cells(iNSCs).CCL2-siRNA was then loaded into the EVs through *** modified EVs still maintained the basic properties of EVs and showed favorable targeting and therapeutic effects in vitro and in vivo.C-EVs-siRNA specifically delivered siRNA to the SCI region and was taken up by target cells.C-EVs-siRNA used the inherent anti-inflammatory and neuroreparative functions of iNSCs-derived EVs in synergy with the loaded siRNA,thus enhancing the therapeutic effect against *** combination of targeted modified EVs and siRNA effectively regulated the microenvironmental disturbance after SCI,promoted the transformation of microglia/macrophages from M1 to M2 and limited the negative effects of the inflammatory response and neuronal injury on functional recovery in mice after ***,engineered EVs are a potentially feasible and efficacious treatment for SCI,and may also be used to develop targeted treatments for other diseases.

关键词： Extracellular vesicles Spinal cord injury siRNA Microglia/macrophages polarization Induced neural stem cells

Coat protein of rice stripe virus enhances autophagy activity through interaction with cytosolic glyceraldehyde-3-phosphate dehydrogenases,a negative regulator of plant autophagy

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Stress Biology 2023年第1期3卷 35-51页

作者： Wanying Zhao Li Wang lipeng Li Tong Zhou Fei Yan Heng Zhang Ying zhu Ida Bagus Andika Liying Sun State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiChina Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjing 210095China Institute of Plant Virology Ningbo UniversityNingbo 312362China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Institute of Virology and BiotechnologyZhejiang Academy of Agricultural SciencesHangzhou 310021China College of Plant Health and Medicine Qingdao Agricultural UniversityQingdao 266109China

Viral infection commonly induces autophagy,leading to antiviral responses or conversely,promoting viral infection or *** this study,using the experimental plant Nicotiana benthamiana,we demonstrated that the rice stripe virus(RSV)coat protein(CP)enhanced autophagic activity through interaction with cytosolic glyceraldehyde-3-phosphate dehydrogenase 2(GAPC2),a negative regulator of plant autophagy that binds to an autophagy key factor,autophagy-related protein 3(ATG3).Competitive pull-down and co-immunoprecipitation(Co-IP)assays showed that RSV CP activated autophagy by disrupting the interaction between GAPC2 and *** RSV CP mutant that was unable to bind GAPC2 failed to disrupt the interaction between GAPC2 and ATG3 and therefore lost its ability to induce *** CP enhanced the autophagic degradation of a viral movement protein(MP)encoded by a heterologous virus,citrus leaf blotch virus(CLBV).However,the autophagic degradation of RSV-encoded MP and RNA-silencing suppressor(NS3)proteins was inhibited in the presence of CP,suggesting that RSV CP can protect MP and NS3 against autophagic ***,in the presence of MP,RSV CP could induce the autophagic degradation of a remorin protein(NbREM1),which negatively regulates RSV infection through the inhibition of viral cell-to-cell ***,our results suggest that RSV CP induces a selective autophagy to suppress the antiviral factors while protecting RSV-encoded viral proteins against autophagic degradation through an as-yet-unknown *** study showed that RSV CP plays dual roles in the autophagy-related interaction between plants and viruses.

关键词： RSV Coat protein Autophagy GAPC ATG3

Identification of a SARS-CoV-2 virus-encoded small non-coding RNA in association with the neurological disorders in COVID-19 patients

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Signal Transduction and Targeted Therapy 2022年第4期7卷 981-983页

作者： Qian Zhao Qiong Wang Bing Zhao Yixing Wang Jinhui Lü Yuefan Guo Xiaoping zhu Lu Qian Shanshan Yu lipeng Hao Zhongmin Liu Zuoren Yu Key Laboratory of Arrhythmias of the Ministry of Education Research Center for Translational MedicineHeart Failure InstituteShanghai East HospitalTongji University School of MedicineShanghaiChina Shanghai Pudong Center for Disease Control&Prevention Pudong New AreaShanghaiChina Department of Internal Medicine of Traditional Chinese Medicine Tongji University School of MedicineShanghai East HospitalShanghaiChina

Dear Editor,Coronavirus disease 2019(covid-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has led to 460 million cases confirmed and 6.1 million deaths across almost 200 countries until March *** addition to the vaccine-based protection against viral infection,it is urgently needed to accurately diagnose covid-19 patients as early as possible after infection.

关键词： patients acute vaccine

基于智能眼镜与情景模拟教学法的放射科住院医师医患沟通培训课程构建与实施

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中国毕业后医学教育 2024年第6期8卷 440-444页

作者：连耿鹏肖育斌王焕鹏黄立鹏杨宏武朱春敏梅维黄瑞滨汕头大学医学院第一附属医院放射科广东汕头515041

该文采用问卷调查放射科住院医师在医患沟通认知、态度和培训需求等方面需求,基于此开发了联合智能眼镜与情景模拟教学法的医患沟通培训课程。理论课程包括医学伦理学、思想政治教育、医德医风和医患沟通技巧4次课,每次2学时,共8学时;... 详细信息

该文采用问卷调查放射科住院医师在医患沟通认知、态度和培训需求等方面需求,基于此开发了联合智能眼镜与情景模拟教学法的医患沟通培训课程。理论课程包括医学伦理学、思想政治教育、医德医风和医患沟通技巧4次课,每次2学时,共8学时;实践阶段为联合智能眼镜与情景模拟的教学实施,内容包括告知坏消息、拒绝异性医师检查等12个典型案例,共12次课,每次2学时,共24个学时。结果显示,89.47%(17/19)的住院医师认为该教学模式更有趣味性,94.74%(18/19)住院医师认为培训有助于提高医患沟通能力。

关键词：住院医师医患沟通放射科情景教学法智能眼镜

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基于实际行为策略的飞行员着舰模型

华中科技大学学报（自然科学版） 2015年第7期43卷 98-103页

作者：朱齐丹王立鹏张智哈尔滨工程大学自动化学院黑龙江哈尔滨150001

从飞行员人工下滑进场着舰过程中操纵舰载机的行为机理出发,建立了基于实际行为策略的飞行员着舰模型.最终动作采用离散动作序列的方式,基于一系列可分割的动作集合对飞行员操纵过程进行描述.在不同着舰环境下,飞行员模型在纵向、横向... 详细信息

从飞行员人工下滑进场着舰过程中操纵舰载机的行为机理出发,建立了基于实际行为策略的飞行员着舰模型.最终动作采用离散动作序列的方式,基于一系列可分割的动作集合对飞行员操纵过程进行描述.在不同着舰环境下,飞行员模型在纵向、横向和油门操纵回路上动态切换操作策略和注意力.采用变分辨率离散化、专注模式协调策略以及误差叠加模型等方法对相应子模块进行建模.此外,模型含有设置不同能力指标和着舰指挥官的接口,用于模拟不同飞行员的行为动作.通过仿真平台对不同等级的飞行员模拟可知,建立的飞行员模型符合实际飞行员的动作机理和特性,能区别不同飞行员在表现水平上的综合差异.

关键词：舰载机飞行员行为机理操纵策略着舰模型着舰指挥官

A panel of monoclonal antibodies against the prion protein proves that there is no prion protein in human pancreatic ductal epithelial cells

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Virologica Sinica 2014年第4期29卷 228-236页

作者： Liheng Yang Yan Zhang lipeng Hu Ying zhu Man-Sun Sy Chaoyang Li State Key Laboratory of Virology and Department of Molecular Virology Wuhan Institute of Virology Chinese Academy of Sciences Department of Virology School of Life Sciences Wuhan University Department of Molecular Endocrinology Institute of Hydrobiology Chinese Academy of Sciences Department of Pathology Case Western Reserve University

Prion diseases are a group of neurodegenerative diseases that are fatal. The study of these unique diseases in China is hampered by a lack of resources. Amongst the most important resources for biological study are monoclonal antibodies. Here, we characterize a panel of monoclonal antibodies specific for cellular prion protein by enzyme-linked immunosorbent assay(ELISA), immunofluorescent staining, flow cytometry, and western blotting. We identify several antibodies that can be used for specific applications and we demonstrate that there is no prion protein expression in human pancreatic ductal epithelial cells(HPDC).

关键词： prion protein monoclonal antibody human pancreatic ductal epithelial cells