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Cancer Communications 2022年第11期42卷 1207-1211页

作者： Peipei Shan Feifei Yang Jie Yu Lirong Wang yuhua Qu Huiran Qiu Hua Zhang Sujie zhu Institute of Translational Medicine The Affiliated Hospital of Qingdao UniversityCollege of MedicineQingdao UniversityQingdaoShandong 266021P.R.China School of Biological Science and Technology University of JinanJinanShandong 250022P.R.China Qingdao Center Hospital:Qingdao Center Medical Group QingdaoShandong 266042P.R.China

Dear Editor,Breast cancer is one of the most lethal cancers in women,with many patients still succumbing to this dis-ease[1].Accumulating evidence demonstrates that histone deacetylase inhibitors(HDACIs)are a promising therapeu-tic intervention for breast cancer[2],and many of them have shown favorable anti-cancer activities in both pre-clinical and clinical settings[3].However,most current HDACIs only exhibit limited efficacy against solid tumors with toxic side effects and readily produce drug resistance[4].Therefore,it is necessary to develop new HDACIs with improved anti-tumor activities and decreased toxic-ities for breast cancer therapeutics and investigate their mechanism of action.

关键词： breast cancer clinical

临床护士心理韧性在结构性授权与工作投入间的中介效应

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中华现代护理杂志 2024年第7期30卷 926-931页

作者：刘智慧朱玉花李雪张全英杜迎杰新乡医学院第一附属医院护理部新乡453100

目的:探讨临床护士心理韧性在结构性授权与工作投入间的中介效应。方法:本研究为横断面研究。采用便利抽样法,于2023年3-5月选取河南省3所三级甲等医院的1 723名护士为研究对象。采用一般资料调查表、工作效能条件量表、护士心理韧性量... 详细信息

目的:探讨临床护士心理韧性在结构性授权与工作投入间的中介效应。方法:本研究为横断面研究。采用便利抽样法,于2023年3-5月选取河南省3所三级甲等医院的1 723名护士为研究对象。采用一般资料调查表、工作效能条件量表、护士心理韧性量表、工作投入量表对其进行调查。采用Pearson相关性分析探讨结构性授权、心理韧性与工作投入间的相关性;采用AMOS 24.0软件建立结构方程模型并分析中介效应。结果:本研究共发放问卷1 723份,回收有效问卷1 590份,问卷有效回收率为92.28%。1 590名临床护士的结构性授权、心理韧性、工作投入总分分别为(70.42±15.61)、(96.84±13.15)、(62.24±11.02)分。Pearson相关性分析结果显示,工作投入与结构性授权、心理韧性呈正相关( r值分别为0.637、0.670, P<0.01)。结构方程模型结果显示,心理韧性在结构性授权与工作投入间起部分中介效应,中介效应值为0.321,占总效应的48.86%。结论:本研究中临床护士结构性授权、心理韧性、工作投入均处于中等偏上水平,心理韧性在结构性授权与工作投入间起部分中介作用,护理管理者应从组织层面充分授权,采取针对性措施提高护士心理韧性,增强其工作投入水平。

关键词：护士心理韧性结构授权工作投入中介效应

A New Method for Converting T_(2) Spectrum into Pore Radius

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Journal of Earth Science 2023年第4期34卷 966-974页

作者： Fan Zhang Zhenxue Jiang Yuanhao Zhang Bin Hu Zaiquan Yang yuhua Yang Xianglu Tang Hanmin Xiao Lin zhu Yunhao Han CNOOC Energy Economics Institute Beijing 100013China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China Unconventional Oil and Gas Science and Technology Institute Beijing 102249China PetroChina Changqing Oilfield Company Xi􀆳an 710018China E&D Research Institute of Oilfield Company Ltd. Daqing 163412China Research Institute of Petroleum Exploration and Development Beijing 100083China

In this paper,a new method for converting the T_(2)(relaxation time) of NMR(nuclear magnetic resonance) into the pore radius is proposed.Combined with NMR and centrifugation experiments,the relationship between pore radius and T_(2) of the sample was established.The results show that the new method is more reasonable than the traditional method.When the sample was denser and the mercury saturation was lower,the pore distribution curve was obtained by traditional method had a worse agreement with mercury injection experiment,while pore distribution curve of the new method had a better agreement with the mercury injection curve,which reflected the greater advantage of the new method as the reservoir becomes denser.The new method can obtain all the pore information in the sample.The results show that the pores in tight sandstone are mainly consisted with mesopore and macropore,and the connectivity of macropore is better than that of mesopore.The new method can effectively characterize the full pore distribution and the seepage characteristics in different pores interval of tight reservoirs,which had a great significance to evaluate the recoverable resources of tight reservoir.

关键词： tight reservoir nuclear magnetic resonance(NMR) pore radius T_(2)spectrum.

Review of the Relocation of General Zhang Fei’s Temple in View of the Three Gorges Dam Project

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Journal of World Architecture 2023年第6期7卷 19-29页

作者： yuhua zhu Fuhan Liu Beijing University of Civil Engineering and Architecture Beijing 100044China

As a national cultural property,General Zhang Fei’s Temple is the largest ancient architectural complex in the Three Gorges of the Yangtze River.It was built in the Han Dynasty and has a long history of nearly 2,000 years.In 1994,the Chinese government launched the Three Gorges Dam project at the Yangtze River and implemented the largest relocation project for the General Zhang Fei Temple to prevent it from being submerged.The temple was relocated 32 kilometers upstream along with the local people of Yunyang County,and the historic environment was rebuilt on the opposite side of the migrant city of New Yunyang County.The temple was restored successfully and the tradition of offering sacrifices to General Zhang Fei continued in the local community.The relocation project lasted for 8 years and became the largest cultural heritage conservation project of the People’s Republic of China at the end of the 20th century.This paper comprehensively summarizes and reviews the project goals,implementation process,and project highlights of this relocation,so as to provide an important case reference for heritage conservation projects in the future.

关键词： General Zhang Fei’s Temple Relocation project Three Gorges Dam project Heritage conservation

A Review on the Post-Earthquake Emergency Conservation Project of Fulong Taoist Temple

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Journal of World Architecture 2022年第3期6卷 19-30页

作者： yuhua zhu Bowen Li Beijing University of Civil Engineering and Architecture Beijing 100044China

The 2008 Wenchuan earthquake in Sichuan Province caused significant damage to Dujiangyan irrigation system,which is one of the world's cultural heritages.After the earthquake,the Chinese government launched the post-earthquake emergency conservation project for cultural heritages.The Fulong Taoist Temple in Dujiangyan was the first to adopt the conservation project.The earthquake-damaged Fulong Taoist Temple was restored in just 18 months.This article reviews the entire emergency conservation project of Fulong Taoist Temple in Dujiangyan after the earthquake,discusses the restoration principles and technical methods used in this project,and uses the comments of the Asia-Pacific Heritage Protection Award to expound the historical significance of this protection project.

关键词： Post-earthquake emergency Heritage conservation project Fulong Taoist Temple

基于生物信息学和网络药理学探讨补肾健脾方改善2型糖尿病作用机制

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中国中医药图书情报杂志 2024年第4期48卷 95-101页

作者：邓钰骅封杰妮朱娴琼徐颖黄宇轩刘继洪广州中医药大学广东广州511000 广东药科大学广东广州511400 佛山市中医院广东佛山528000

目的基于生物信息学和网络药理学探讨补肾健脾方治疗2型糖尿病(T2DM)的作用机制。方法通过TCMSP、BATMAN-TCM数据库筛选补肾健脾方活性成分及作用靶点,通过GEO数据库获取T2DM相关数据集GSE18732和GSE19420,通过Mfuzz分析筛选与糖尿病... 详细信息

目的基于生物信息学和网络药理学探讨补肾健脾方治疗2型糖尿病(T2DM)的作用机制。方法通过TCMSP、BATMAN-TCM数据库筛选补肾健脾方活性成分及作用靶点,通过GEO数据库获取T2DM相关数据集GSE18732和GSE19420,通过Mfuzz分析筛选与糖尿病同步变化的基因,作为T2DM疾病靶点。获取补肾健脾方与T2DM疾病靶点交集靶点,作为补肾健脾方治疗T2DM的作用靶点,通过STRING数据库构建靶点蛋白相互作用网络,筛选网络中的关键靶点,通过GO功能和KEGG通路富集分析其生物功能,对关键靶点进行单因素Logistic回归,筛选Hub基因,基于Hub基因构建T2DM预测模型。结果获取补肾健脾方药物靶点1 837个,T2DM疾病靶点983个,药物-疾病交集靶点115个,主要富集于内分泌抵抗、胰岛素抵抗、胰岛素信号通路、非酒精性脂肪性肝病、细胞凋亡、细胞衰老、AMPK信号通路、糖尿病并发症中的AGE-RAGE信号通路和HIF-1信号通路。Hub基因有NFKB1和SREBF1,预测模型曲线下面积=0.829,具有良好的预测性能。结论本研究综合生物信息学和网络药理学研究发现,补肾健脾方可能通过调控AMPK通路和AGE-RAGE等通路,发挥延缓T2DM进展作用,但仍需进一步实验验证。

关键词： 2型糖尿病补肾健脾方网络药理学生物信息学

日粮中添加厚朴提取物对产蛋后期蛋鸡产蛋性能、蛋品质、抗氧化功能及肠道微生物的影响

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黑龙江畜牧兽医 2024年第2期 88-92,98页

作者：朱瑞娟郎元君王玉华杨文文张庆莉魏培孙新堂王成森山东畜牧兽医职业学院潍坊市兽用微生物发酵重点实验室山东潍坊261061

为了研究日粮中添加厚朴提取物对产蛋后期蛋鸡产蛋性能、蛋品质、抗氧化功能及肠道微生物的影响,试验将400只65周龄健康的海兰褐商品蛋鸡随机分为4组(每组4个重复,每个重复25只),对照组仅饲喂基础日粮,低、中、高剂量组分别在基础日粮... 详细信息

为了研究日粮中添加厚朴提取物对产蛋后期蛋鸡产蛋性能、蛋品质、抗氧化功能及肠道微生物的影响,试验将400只65周龄健康的海兰褐商品蛋鸡随机分为4组(每组4个重复,每个重复25只),对照组仅饲喂基础日粮,低、中、高剂量组分别在基础日粮中添加250,500,750 mg/kg厚朴提取物,预试期3 d,正试期42 d。试验结束后统计生产性能指标,检测蛋品质、血清抗氧化及肠道微生物指标。结果表明:与对照组相比,中、高剂量组产蛋率、平均合格蛋重显著提高(P<0.05),料蛋比显著降低(P<0.05);低、中、高剂量组哈氏单位和蛋壳强度显著提高(P<0.05);中、高剂量组谷胱甘肽过氧化氢酶(GSH-Px)、总超氧化物歧化酶(T-SOD)活性显著提高(P<0.05),丙二醛(MDA)浓度显著降低(P<0.05);低、中、高剂量组蛋鸡肠道内的大肠杆菌、沙门氏菌数量均显著降低(P<0.05),乳酸菌数量显著升高(P<0.05)。说明在蛋鸡产蛋后期日粮中添加厚朴提取物可以提高其产蛋性能、蛋品质、抗氧化功能并调节肠道菌群结构,建议添加量为500 mg/kg。

关键词：厚朴提取物产蛋后期蛋鸡产蛋性能蛋品质抗氧化肠道微生物

TPO、CD56、Galectin-3辅助诊断甲状腺乳头状癌的价值分析

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中国社区医师 2024年第14期40卷 106-108页

作者：朱彦刘莹马玉花刁兆杰梁飞何丽任丽娟新疆第二医学院基础医学院病理生理学教研室新疆维吾尔自治区克拉玛依834000 克拉玛依市中心医院病理科新疆维吾尔自治区克拉玛依834000 新疆第二医学院公共卫生学院社会医学与卫生事业管理教研室新疆维吾尔自治区克拉玛依834000

目的:分析甲状腺过氧化物酶(TPO)、神经细胞黏附分子56(CD56)和β-半乳糖凝集素-3(Galectin-3)辅助诊断甲状腺乳头状癌的价值。方法:选取2018年3月—2020年12月于克拉玛依市中心医院接受手术切除的PTC患者104例作为研究对象,分析患者PT... 详细信息

目的:分析甲状腺过氧化物酶(TPO)、神经细胞黏附分子56(CD56)和β-半乳糖凝集素-3(Galectin-3)辅助诊断甲状腺乳头状癌的价值。方法:选取2018年3月—2020年12月于克拉玛依市中心医院接受手术切除的PTC患者104例作为研究对象,分析患者PTC癌变组织及距离癌灶>2 cm的癌旁组织TPO、CD56、Galectin-3表达情况,评估TPO、CD56、Galectin-3单项及联合检测辅助诊断PTC的效能。结果:TPO、CD56、Galectin-3单项及联合诊断PTC的特异度比较,差异无统计学意义(P>0.05);三项联合诊断PTC的准确度高于TPO、CD56,Galectin-3及TPO均高于CD56,差异有统计学意义(P<0.05);Galectin-3、三项联合诊断PTC的灵敏度高于TPO、CD56,TPO高于CD56,差异有统计学意义(P<0.05)。结论:TPO、CD56、Galectin-3三项联合检测可用于辅助诊断PTC。

关键词：甲状腺乳头状癌甲状腺过氧化物酶神经细胞黏附分子56 β-半乳糖凝集素-3

^(18)F-FET PET/CT双模态影像组学特征对成人胶质瘤病理学分级的非侵入性预测分析

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肿瘤影像学 2024年第2期33卷 127-135页

作者：华涛周维燕周支瑞黄琪李明朱毓华管一晖复旦大学附属华山医院核医学科/PET中心上海200235 复旦大学附属华山医院放射治疗中心上海200040

目的:基于^(18)F-FET正电子发射体层成像(positron emission tomography,PET)/计算机体层成像(computed tomography,CT)双模态影像组学特征构建模型,并对成人胶质瘤的病理学分级进行非侵入性预测分析。方法:回顾并分析58例经组织病理学... 详细信息

目的:基于^(18)F-FET正电子发射体层成像(positron emission tomography,PET)/计算机体层成像(computed tomography,CT)双模态影像组学特征构建模型,并对成人胶质瘤的病理学分级进行非侵入性预测分析。方法:回顾并分析58例经组织病理学检查证实的未治疗成年胶质瘤患者的^(18)F-FET PET/CT影像学数据,根据病理学分级将患者分成低级别胶质瘤组[世界卫生组织(World Health Organization,WHO)Ⅱ级,共计32例]和高级别胶质瘤组(WHOⅢ级13例、WHOⅣ级13例,共计26例)。在PET、CT影像模态中分别提取105个影像组学特征参数进行分析,采用基于R语言机器学习算法的5折交叉验证最小绝对收缩与选择算子(least absolute shrinkage and selection operator,LASSO)回归分析方法,构建成人胶质瘤病理学分级的3个独立的影像组学预测模型(PET-Rad模型、CT-Rad模型和PET/CT-Rad模型),然后再采用全子集回归对影像组学预测模型进行校正。采用受试者工作特征曲线的曲线下面积(area under curve,AUC)对预测模型进行评价。结果:基于4个^(18)F-FET PET影像组学参数建立PET-Rad模型的AUC为0.845(95%CI 0.726~0.927);基于3个CT影像组学参数构建的CT-Rad模型的AUC为0.802(95%CI 0.676~0.895);而联合3个CT和2个PET影像组学特征的^(18)F-FET PET/CT-Rad模型的AUC为0.901(95%CI 0.794~0.964),准确度为86.21%。DeLong检验结果显示PET/CT-Rad模型优于CT-Rad模型(P=0.032)。尽管PET/CT-Rad模型效能优于PET-Rad模型,但差异无统计学意义(P=0.146)。构建胶质瘤病理学级别预测的PET/CT-Rad模型中,3个CT影像组学参数分别为firstorder_10Percentile、glrlm_LowGrayLevelRunEmphasis、ngtdm_Busyness,其中glrlm_LowGrayLevelRunEmphasis是最重要的预测变量,其相对重要性为30.97%;2个PET组学特征为firstorder_Maximum和ngtdm_Contrast,其相对重要性分别为21.99%、21.01%。结论:基于^(18)F-FET PET与CT双模态影像组学特征相结合的预测模型能够有效地预测未经治疗成人胶质瘤的病理学分级,可为临床诊治决策提供依据和重要参考。

关键词：胶质瘤正电子发射体层成像/计算机体层成像 ^(18)F-FET 影像组学病理学分级

Studies of benzyl hydroxamic acid/calcium lignosulphonate addition order in the flotation separation of smithsonite from calcite

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International Journal of Mining Science and Technology 2021年第6期31卷 1153-1158页

作者： Cheng Liu yuhua zhu Kaihua Huang Siyuan Yang Zhian Liang School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhou 510530China State Key Laboratory of Mineral Processing BGRIMM Technology GroupBeijing 102600China State Key Laboratory of Comprehensive Utilization of Low-Grade Refractory Gold Ores Xiamen 361101China

Flotation separation of smithsonite from calcite is difficult due to their similar surface properties.In the present study,a reagent scheme of depressant calcium lignosulphonate(CLS) and collector benzyl hydroxamic acid(BHA) was introduced in the flotation of smithsonite from calcite.Microflotation tests revealed that the efficient flotation of smithsonite from calcite could only be obtained with the addition order of BHA before CLS,which was opposite to the widely-used order that adding depressant prior to the collector.The zeta potential measurements indicated that BHA selectively adsorbed onto smithsonite surface,then not allowed the CLS adsorption onto the smithsonite surface rather than calcite surface because of the steric hindrance,thereby the smithsonite surface remained hydrophobic while calcite surface became more hydrophilic after the addition of CLS.As a result,the calcite flotation was completely depressed while the smithsonite flotation recovery was still in high value,leading to the optimal flotation separation performance.

关键词： Smithsonite Calcite Benzyl hydroxamic acid Calcium lignosulphonate Flotation separation