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Numerical analysis of an over-boarding operation for a subsea template

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Journal of Ocean Engineering and Science 2021年第2期6卷 146-159页

作者： Lin Li Adham M.Amer xinying zhu Department of Mechanical and Structural Engineering and Materials Science University of StavangerNorway Ocean Installer AS StavangerNorway

Subsea templates are normally transported to the installation site on the deck of a crane *** being lifted off from the deck,the template is 1)over-boarded from the initial location to the target position by the side of the vessel;2)lowered through the splash zone;3)further lowered down to the seabed and 4)finally positioned and *** the mentioned phases should be ***,the splash zone crossing phase is taken as the critical phase and analyzed to define the installation weather *** over-boarding phase has not been the focus of analysis due to a large involvement of human actions and little involvement of hydrodynamic *** offshore operations,the offshore manager may decide to decrease the defined installation weather criterion if the risk of the personnel safety on deck during over-boarding phase is considered ***,it is of great need to quantify the operational criterion for such *** objective of this paper is to perform numerical analyses and define the allowable sea states for a safe over-boarding *** numerical analyses using time-domain simulations have been performed in various sea *** lines have been modelled to control the motions of the template during the *** pendulum motions of the subsea template are considered as the critical responses for the assessment of the allowable sea states.

关键词： Over-boarding Subsea template installation Tugger lines Allowable sea states Pendulum motion

立德树人视域下脑血管病情景模拟案例教学效果评价问卷编制及信效度检验

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中国卒中杂志 2024年第8期19卷 978-982页

作者：吴春艳朱新颖于文轩高云彬季丽丽战同霞谢海山东第二医科大学附属医院神经内科潍坊261035 山东第二医科大学护理学院山东第二医科大学附属医院核医学科

目的在立德树人视域下,根据“价值塑造、能力培养、知识传授”三位一体学生培养目标和职业核心能力要求,编制以脑血管病情景模拟案例为载体的教学效果评价问卷,并评价其信效度。方法采用访谈、专家函询等方法构建脑血管病情景模拟案例... 详细信息

目的在立德树人视域下,根据“价值塑造、能力培养、知识传授”三位一体学生培养目标和职业核心能力要求,编制以脑血管病情景模拟案例为载体的教学效果评价问卷,并评价其信效度。方法采用访谈、专家函询等方法构建脑血管病情景模拟案例教学效果评价问卷。在山东第二医科大学2021级护理专业学生中随机抽取50名进行问卷填写和意见收集,进一步完善问卷。另外随机抽取130名学生进行正式问卷填写,并对问卷进行条目分析、效度和信度评价。结果本研究形成了脑血管病情景模拟案例教学效果评价问卷,该问卷包括能力培养、价值引领、案例编制3个维度,共25个条目。130份正式调查问卷中有125份为合格问卷,信效度检验显示:探索性因子分析提取3个公因子,累计方差贡献率为65.68%。问卷整体的Cronbach’α系数为0.914,能力培养、价值引领和案例编制维度的Cronbach’α系数分别为0.917、0.941和0.937。问卷具有良好的可靠性、稳定性。各维度得分与总分的相关系数r值在0.607~0.799之间。结论本研究形成的问卷具有良好的信效度,可以作为情景模拟案例教学效果的评价工具。

关键词：情景模拟案例教学脑血管病思政教育信度效度

Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4934-4944页

作者： Jia-Luo Huang Xue-Long Yan Dong Huang Lu Gan Huahua Gao Run-zhu Fan Shen Li Fang-Yu Yuan xinying zhu Gui-Hua Tang Hong-Wu Chen Junjian Wang Sheng Yin School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Guizhou Medical UniversityGuian New DistrictGuizhou 550025China School of Medicine University of California DavisSacramentoCA 95817USA

Nuclear transporter importin-β1 is emerging as an attractive target by virtue of its prevalence in many ***,the lack of druggable inhibitors restricts its therapeutic proof of *** the present work,we optimized a natural importin-β1 inhibitor DD1 to afford an improved analog DD1-Br with better tolerability(>25 folds)and oral ***1-Br inhibited the survival of castration-resistant prostate cancer(CRPC)cells with sub-nanomolar potency and completely prevented tumor growth in resistant CRPC models both in monotherapy(0.5 mg/kg)and in enzalutamidecombination *** study revealed that by targeting importin-β1,DD1-Br markedly inhibited the nuclear accumulation of multiple CRPC drivers,particularly AR-V7,a main contributor to enzalutamide resistance,leading to the integral suppression of downstream oncogenic *** study provides a promising lead for CRPC and demonstrates the potential of overcoming drug resistance in advanced CRPC via targeting importin-β1.

关键词： Importin-β1 CRPC Drug discovery Enzalutamide-resistance Natural product Cancer Daphnane diterpenoid Nuclear transporter

Ancient mitochondrial genome depicts sheep maternal dispersal and migration in Eastern Asia

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Journal of Genetics and Genomics 2024年第1期51卷 87-95页

作者： Liu Yang Xing Zhang Yaning Hu Piao zhu Hua Li Zhenyu Peng Hai Xiang xinying Zhou Xingbo Zhao National Engineering Laboratory for Animal Breeding Key Laboratory of AnimalGeneticsBreeding and ReproductionMinistry of Agriculture and Rural AffairsCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding School of Life Science and EngineeringFoshan UniversityFoshanGuangdong 528225China State Key Laboratory of Agricultural Genomics BGI-ShenzhenShenzhenGuangdong 518083China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China

Sheep have been one of the most important groups of animals since ancient ***,the knowledge of their migration routes and genetic relationships is still poorly *** investigate sheep maternal migration histories alongside Eurasian communications routes,in this study,we obtain mitochondrial genomes(mitogenomes)from 17 sheep remains in 6 Chinese sites and 1 Uzbekistan site dated 4429–3100 years before present(BP).By obtaining the mitogenomes from the sheep(4429–3556 BP)found in the Tongtian Cave site in Xinjiang,Altai region of northwest China,our results support the emergence of haplogroup C sheep in Xinjiang as early as 4429–3556 *** combined phylogenetic analyses with extant ancient and modern sheep mitogenomes suggest that the Uzbekistan-Altai region may have been a migration hub for early sheep in eastern *** least two migration events have taken place for sheep crossing Eurasia to China,one passing by Uzbekistan and Northwest China to the middle and lower reaches of the Yellow River at approximately 4000 BP and another following the Altai region to middle Inner Mongolia from 4429 BP to 2500 ***,this study provides further evidence for early sheep utilization and migration patterns in Eastern Asia.

关键词： Sheep Ancient DNA Eastern Asia Mitochondrial genome Migration Altai

Actively contractible and antibacterial hydrogel for accelerated wound healing

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Nano Research 2024年第8期17卷 7394-7403页

作者： Zhaoxin Ji Ting Wei Jiafei zhu Jiaying Hu Zhisheng Xiao Boxiong Bai xinying Lv Yu Miao Muchao Chen Cheng Wang Feng Pan Yang Yang Meng Li Qian Chen Institute of Functional Nano and Soft Materials Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Central Laboratory Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China School of Materials Science and Engineering Tongji UniversityShanghai 201804China Department of dermatology Shanghai Children’s Medical Center School of MedicineShanghai Jiao Tong UniversityShanghai 200025China

Adhesive hydrogel has drawn great attention for wide applications in wound healing owing to its excellent biocompatibility and lasting ***,traditional adhesive hydrogels only keep the wound moist to promote wound *** is still imperative to fabricate adhesive hydrogels that exhibit efficient antibacterial ability,active driving dynamic wound closure,and reactive oxygen species(ROS)scavenging together with excellent mechanical ***,a novel hydrogel based on poly(N-isopropyl acrylamide)(PNIPAAm),a thermoresponsive polymer,and tannic acid(TA)-Ag nanoparticles(TA-Ag NPs)exhibiting active contraction,tissue adhesion,anti-inflammatory and antibacterial functions was ***-Ag dispersed in the hydrogel not only functioned as the catalyst to polymerize the reaction but also provided additional anti-inflammatory and antibacterial ***,tannic acid containing catechol groups endowed the hydrogel with adhesive *** interestingly,the obtained hydrogel exhibited the thermoresponsive shrinkage ability,which could mechanically drive wound closure due to the presence of PNIPAAm *** vivo mouse full-thickness skin defect model demonstrated that this actively contractible and antibacterial hydrogel is a promising dressing to improve wound healing process by accelerating tissue regeneration and preventing bacterial ***,this multi-functional adhesive hydrogel developed here may provide a new possibility for wound healing.

关键词： anti-inflammatory antibacterial active contraction hydrogel patch wound healing

2018年英国胃肠病学会《成人慢性腹泻的调查指南》解读

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中国全科医学 2021年第7期24卷 780-783页

作者：朱新影赵东强河北医科大学第二医院消化内科河北省石家庄市050050

2018年4月英国胃肠病学会(BSG)在Gut上发表了第3版《成人慢性腹泻的调查指南》,对2003年第2版指南进行了更新,新版指南对慢性腹泻的临床评估流程、肿瘤和炎症评估、吸收不良的检测,以及常见病因、结构性/手术病因、少见病因的管理等方... 详细信息

2018年4月英国胃肠病学会(BSG)在Gut上发表了第3版《成人慢性腹泻的调查指南》,对2003年第2版指南进行了更新,新版指南对慢性腹泻的临床评估流程、肿瘤和炎症评估、吸收不良的检测,以及常见病因、结构性/手术病因、少见病因的管理等方面进行阐述。本文结合此指南更新内容探讨成人慢性腹泻诊疗中的常见误区,包括:病史采集不全面,病因诊断困难;未把胆汁酸性腹泻作为慢性腹泻的常见病因考虑;乳糜泻诊治延迟;结肠镜检查不取活检;年轻慢性腹泻患者中漏诊结直肠癌;对老年人溢出性腹泻不识别;对小肠细菌过度生长检测方法的临床意义认知不足,针对这些误区给出相应的应对策略。

关键词：腹泻成年人指南解读

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云数据中心的多维资源调度策略探析

智能计算机与应用 2015年第5期5卷 74-76页

作者：朱欣颖周口师范学院物理与机电工程学院河南周口466001

资源调度问题是数据提高运行效率的关键。然而目前大部分任务调度算法都聚焦于单一维度的资源,忽略了多维资源(CPU、Memory、Disk、Storage)同时消耗的实际情况。本文将此多维资源调度问题归纳为多维背包问题,并且提出了相应的MS调度算... 详细信息

资源调度问题是数据提高运行效率的关键。然而目前大部分任务调度算法都聚焦于单一维度的资源,忽略了多维资源(CPU、Memory、Disk、Storage)同时消耗的实际情况。本文将此多维资源调度问题归纳为多维背包问题,并且提出了相应的MS调度算法。为了展示MS的优势,在WMware平台做了仿真实验,实验结果表明:MS算法能取得较高的服务器综合资源利用率。

关键词：数据中心多维资源资源调度

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钢桁架运输栈桥销钉式支座设计与施工

施工技术 2008年第11期37卷 54-55,114页

作者：陶红林朱新颖徐州建筑职业技术学院江苏徐州221116 徐州中煤钢结构建设有限公司江苏徐州221004

销钉式支座可以防止支撑主桁架的支座因地基的不均匀沉降或地震作用引起主桁架在支座处滑落事故的发生。基于此,介绍销钉式支座的构造、设计和计算。并阐述了销钉式支座的制作与安装,包括放样与切割、焊接、制孔等。研究结果表明,销钉... 详细信息

销钉式支座可以防止支撑主桁架的支座因地基的不均匀沉降或地震作用引起主桁架在支座处滑落事故的发生。基于此,介绍销钉式支座的构造、设计和计算。并阐述了销钉式支座的制作与安装,包括放样与切割、焊接、制孔等。研究结果表明,销钉式支座与传统支座相比,构造简单、结构可靠、安装方便、节省钢材,且工艺上无特殊要求,便于推广到其它梁式结构中。

关键词：销钉式支座制作安装钢结构

基于改进双中心粒子群算法的电动公交车运营数量优化策略研究

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电力系统保护与控制 2017年第8期45卷 126-131页

作者：朱鹰屏韩新莹刘世立王轶群广东技术师范学院自动化学院广东广州510665 国家电网许继集团市场部河南许昌461000 武汉理工大学国际教育学院湖北武汉430070

针对电动公交车在一定容量约束的馈线充电的情况,采用了一种改进的双中心粒子群算法对电动公交车充电进行优化调度,以获得最大的电动公交车运营数量。首先,建立公交车充电后馈线负荷曲线峰谷差最小的模型,设公交车运营初始数量,利用改... 详细信息

针对电动公交车在一定容量约束的馈线充电的情况,采用了一种改进的双中心粒子群算法对电动公交车充电进行优化调度,以获得最大的电动公交车运营数量。首先,建立公交车充电后馈线负荷曲线峰谷差最小的模型,设公交车运营初始数量,利用改进的双中心粒子群算法进行优化。然后,根据优化结果对比该馈线容量约束修改电动公交车运营数量,重新优化,逐步逼近并最终找到最优的运营数量。改进的双中心粒子群优化算法是在原算法的基础上,增加了5条粒子运动路线,扩大了搜索精度,抑制了粒子群的早熟。同时,为了提高寻优速度,粒子的初始化是根据日负荷曲线距离馈线约束容量的远近来确定。最后以南方某城市典型的馈电线路为例进行仿真计算,结果表明,该方法具有更优的调度效果。

关键词：容量约束电动公交车双中心粒子群初始化优化