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China CDC weekly 2023年第35期5卷 773-778,I0002-I0004页

作者： Zifan Zhang Weijie Ding Hui Wang Yangyang Cheng Yue Zhang xiaoqin zhu Xiaolin Xu School of Public Health The Second Affiliated HospitalZhejiang University School of MedicineHangzhou CityZhejiang ProvinceChina Health Care Department Affiliated Hospital of Yangzhou University Huai’an Maternal and Child Health Care CenterHuai’an CityJiangsu ProvinceChina School of Public Health Faculty of MedicineThe University of QueenslandBrisbaneAustralia.

Summary What is already known about this topic?Maintaining a healthy diet and appropriate weight during pregnancy is crucial for both the expectant mother and the *** eating behaviors(UEBs)such as eating out frequently are becoming increasingly prevalent across the ***,there is a dearth of research investigating the relationship between UEBs and gestational weight gain(GWG)specifically in the context of Chinese women.

关键词： becoming mother Jiangsu

Synthesis and characterization of 2,5-bis[4-(2-arylvinyl)phenyl]-1,3,4-oxadiazoles with two-photon fluorescence properties

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Frontiers of Chemical Science and Engineering 2007年第4期1卷 381-384页

作者： zhu xiaoqin QIAN Ying LU Zhifeng School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China

Four novel 2,5-bis[4-(2-arylvinyl)phenyl]-1,3,4-oxadiazoles that exhibit strong two-photon absorption and enhanced two-photon excited fluorescence were designed and synthesized based on“push-core-pull-core-push”molecules built from embedding electron-transporting 1,3,4-oxadiazole in aromatic conjugated system through Wittig-Horner *** chemical structures were determined to show trans-vinylene character according to infrared(IR)and 1H nuclear magnetic resonance(NMR)spectra.A very effective energy transfer from the excited units to the p-conjugated bridging unit can enhance the two-photon absorption and two-photon fluorescence.

关键词： 1,3,4-oxadiazole derivatives Wittig-Horner reaction two-photon fluorescence molecule

Angular-based spatially resolved laser-induced breakdown spectroscopy: a new technique for the effective enhancement of signals without an external time delay system

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Chinese Science Bulletin 2014年第27期59卷 3377-3384页

作者： Qingyu Lin Xu Wang Guanghui Niu Hongjun Lai xiaoqin zhu Kunping Liu Tao Xu Yixiang Duan Research Center of Analytical Instrumentation Analytical & Testing Centre Sichuan University College of Chemistry and Bioengineering Hezhou University

In this study, we developed a novel angularbased spatially resolved laser-induced breakdown spectroscopy(ABSR-LIBS) technique. This new method allows the spatially resolved spectroscopic properties of laserinduced plasma to be investigated using different angles and polar distances with a spatially adjustable fiber optics probe. The experimental evaluations suggested that the intensity of the Al signal distributions in the ‘‘side-view''depended greatly on the angle of the collection probe. The location of a collection probe at 50° would facilitate efficient spectral collection and minimize the disturbance of the plasma plume. The spectral signals in the plasma emissions had different distribution at various polar distances using the same collection angle, and the highest signal intensity was observed between 15 and 35 mm polar distances. This ABSR-LIBS technique improved both the LIBS signal and the maximum emission intensity of Al atoms by several times at the best spatial position in our experimental conditions. Furthermore, we successfully obtained well-resolved line emission spectroscopy signals without any external time delay using a nongated spectrometer based on the ABSR-LIBS system. We consider that the ABSR-LIBS technique has great potential for obtaining new insights with laser-induced plasma instruments and it could facilitate the development of a low-cost instrument.

关键词：激光诱导等离子体空间分辨光谱性质时滞系统信号分布技术击穿等离子发射

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点阵材料夹芯简支梁在冲击载荷下的动力响应

复合材料学报 2009年第1期26卷 162-167页

作者：朱小芹刘华北京航空航天大学航空科学与工程学院北京100083

首先给出了两端可移点阵材料夹芯简支梁受到均布冲击载荷时的刚塑性动力响应分析,然后将理论预测的夹芯梁中点的最大挠度和结构响应时间与有限元结果进行了比较,理论预测结果与有限元计算结果一致性较好。通过与质量和材料相同的单层实... 详细信息

首先给出了两端可移点阵材料夹芯简支梁受到均布冲击载荷时的刚塑性动力响应分析,然后将理论预测的夹芯梁中点的最大挠度和结构响应时间与有限元结果进行了比较,理论预测结果与有限元计算结果一致性较好。通过与质量和材料相同的单层实心梁进行对比分析,证实了点阵材料夹芯简支梁具有很好的抗冲击性能。通过对四棱锥夹芯简支梁进行拓扑构型设计,发现两端可移夹芯简支梁的最大挠度和结构响应时间对芯层的相对密度和相对厚度、面板与杆元的夹角十分敏感。随着夹芯梁所承受的单位面积冲量增大,夹芯梁中点的挠度增大。通过对由应变率敏感的304不锈钢制成的四棱锥桁架夹芯梁进行精细有限元分析,发现当考虑应变率效应时,梁的最大挠度小于不考虑应变率时的最大挠度。

关键词：点阵材料夹芯梁动力响应有限元

The Effect and Nursing of Indwelling Nasal Jejunal Feeding Tube for Enteral Nutrition in Acute Severe Pancreatitis

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Journal of Clinical and Nursing Research 2021年第2期5卷 113-116页

作者： xiaoqin zhu Zhaolin Chen The First Affiliated Hospital of Jinnan University Guangzhou 510000Guangdong ProvinceChina

Objective:To analyze the effect of enteral nutrition and nursing intervention in patients with indwelling nasojejunal tube in acute severe ***:Sixty cases of patients with indwelt nasojejunal tubes treated in our hospital from August 2019 to August 2020 were divided into routine group and observation group as research *** in both groups received enteral nutrition,patients in the routine group received routine care,and patients in the observation group received quality *** recovery time of gastrointestinal function,length of hospital stay,hospitalization cost,nutritional indicators and incidence of complications in the two groups were ***:The recovery time of gastrointestinal function in observation group was lower than that in routine group,P<0.05;The length and cost of hospitalization in observation group were lower than those in routine group,P<0.05;The nutritional indexes in observation group were higher than those in routine group,P<0.05;The incidence of complications in observation group was lower than that in routine group,P<***:Quality nursing service improve the effect of enteral nutrition,so as to ensure that patients get sufficient nutritional *** effect is remarkable and it is worthy of widespread clinical application.

关键词： Acute severe pancreatitis To indwell the nasojejunal tube Enteral nutrition Effect Nursing

Monte Carlo Analysis of Different Administration Regiments for Isavuconazole against Candida spp.and Aspergillus spp.

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Pharmacology & Pharmacy 2021年第12期12卷 311-318页

作者： Jiuli Hu Chanchan Hu xiaoqin zhu Department of Clinic Pharmacy Affiliated of Chengde Medical College Chengde China Department of Oncology Department The Affiliated Hospital of Chengde Medical College Chengde China

In our study, we aimed to optimize the dosage regimen of Isavuconazole against Candida spp. and Aspergillus spp. by Monte Carlo simulation (MSC). Pharmacokinetic parameters and microbiological data of Isavuconazole were collected. Then we used MSC to simulate 10,000 patients analyzed by Crystal Ball to calculate probability of target attainment (PTA) and cumulative fraction of response (CFR). With dosages of 100 mg, 200 mg, and 400 mg in oral group and dosages of 100 mg, and 200 mg in intravenous administration, all have different degrees of antifungal effect. But when the dosage regimen was 50 mg IV, the therapeutic effect of Isavuconazole against Aspergillus spp. and Candida spp. were not good.

关键词： Monte Carlo Simulation (MSC) Isavuconazole Candida spp. Aspergillus spp.

Evaluation of Dosages Regimen of Fluconazole in Patients of Candidemia with Gender by PK/PD and Mote Carlo Simulation

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Open Journal of Blood Diseases 2022年第4期12卷 79-86页

作者： Jiuli Hu Xiaolei Yu Junhui Hu xiaoqin zhu Department of Clinic Pharmacy The Affiliated Hospital of Chengde Medical University Chengde China Department of Oncology Department The Affiliated Hospital of Chengde Medical University Chengde China

Candidemia is one of the four most common nosocomial blood infections and is the most common hospital-acquired fungemia in a recent multi-institutional study from the US. The mortality of Candidemia can be up to 50%. Fluconazole is a triazole derivative widely used for the treatment of invasive candidiasis. It was recommended as first-line drugs for the treatment and prevention of mycoses. In our study, we aimed to optimise the dosage of fluconazole with gender against Candida spp. based on pharmacokinetic/pharmacodynamics (PK/PD) analysis. We collected the published data about pharmacokinetic parameters of fluconazole and the MIC distribution of Candida spp. on fluconazole. We decided to evaluate the gender between males and females with the pharmacokinetics of fluconazole. Using probability of target attainment (PTA) and cumulative fraction of response (CFR) as indexes, crystal ball software 11.***.2.4 was used for Monte Carlo simulation of different dosage regimens of different males and females. For C. albicans, C. tropicalis and C. lusitaniae, when doses of regimen are 100 mg IV, 200 mg IV and MIC was lower than 1 g/ml, PTA was higher than 90%. For C. tropicalis, each dosing regimen and MIC was less than 2 g/ml. PTA was higher than 90%. As C. glabrata, C. parapsilosis, C. krusei, C. guilliermondii for PTA with more than 90%, MIC of fluconazole 200 mg were less than 32 g/ml, 64 g/ml and 64 g/ml, respectively. For the different dosage regimens 100 mg IV and 200 mg IV of fluconazole for Candida spp., it is desirable that fluconazole dosage regimens take into account both the gender of the patient.

关键词： Monte Carlo Simulation (MSC) Fluconazole Candidemia Gender

Based on PK/PD and Monte Carlo Simulation Analysis of the Dosing Regimens of Micafungin in Children with Febrile Neutropenic

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Open Journal of Pediatrics 2022年第4期12卷 711-717页

作者： Jiuli Hu Ying Wang Junhui Hu Xiaolei Yu xiaoqin zhu Department of Clinic Pharmacy Affiliated of Chengde Medical College Chengde China Oncology Department The Affiliated Hospital of Chengde Medical College Chengde China

Neutropenia with fever is a special group of patients. Due to low immune function, inflammation-related clinical symptoms and signs are often not obvious, and pathogenic bacteria and infection focus are not clear. Fever may be the only sign of infection. If appropriate antimicrobial treatment is not given in time, infection-related mortality is high. In our study, we aimed to optimize the dosage regimen of Micafungin in children with febrile neutropenic against Candida spp. by Mote Carlo Simulation (MCS). Pharmacokinetic parameters and microbiological data of Micafungin were collected. Then we used MCS to calculate Probability of Target Attainment (PTA) and Cumulative Fraction of Response (CFR). With dosages of 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg, 2 mg/kg, 3 mg/kg, and 4 mg/kg in oral group and dosages of 100 mg, and 200 mg in intravenous administration, all have different degree of antifungal effect. But when the dosage regimen was 50 mg IV, the therapeutic effect of Micafungin against Candida spp. was not good.

关键词： PK/PD Model Mote Carlo Simulation Micafungin Febrile Neutropenic

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高质量发展引领下ESG信息披露的规制优化

厦门大学学报（哲学社会科学版） 2024年第3期74卷 58-67页

作者：朱晓勤厦门大学法学院福建厦门361005

ESG理念与高质量发展的内涵高度契合。当前,我国ESG信息披露规制领域存在一些问题,包括政出多门不成体系、披露比率偏低、披露标准不统一、披露内容不全面、“漂绿”现象比较严重等。从ESG信息披露规制的发展趋势及特点来看,各国(地区)... 详细信息

ESG理念与高质量发展的内涵高度契合。当前,我国ESG信息披露规制领域存在一些问题,包括政出多门不成体系、披露比率偏低、披露标准不统一、披露内容不全面、“漂绿”现象比较严重等。从ESG信息披露规制的发展趋势及特点来看,各国(地区)对ESG信息披露的规制趋向严格,规制方式多以硬法为主、软法为辅,比例原则得到重视和适用,全球可持续披露准则加速统一。为解决实践中出现的突出问题,与国际标准相接轨,新形势下我国监管机构应当软硬兼施优化ESG信息披露的规制方式、明确ESG信息披露规则的实体内容、采取多元化的监管方式以及引入第三方强制鉴证机制。

关键词：高质量发展 ESG信息披露监管机构规制方式强制鉴证

Correlation between a Change of Drug Resistance of Klebsiella pneumoniaand Defined Daily Doses of Antimicrobial Agents from 2014 to 2018

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Pharmacology & Pharmacy 2020年第11期11卷 299-305页

作者： Jiuli Hu Xu Xiao Chanchan Hu Rui Wang Yanwu Zhao xiaoqin zhu Affiliated Hospital of ChengdeMedical University Chegnde Hebei China

Introduction: The prevalence of Klebsiella pneumoniae has rapidly increased in recent years and the distribution differed greatly by region, We aimed to study the relationship between antibiotic resistance and K. pneumoniae, especially carbapenem-resistant Klebsiella pneumoniae (CRKP) in our tertiary hospitals from 2014 to 2018. Methodology: The antibiotic consumption data of K. pneumoniae were expressed as the defined daily dose (DDD) per 100 inpatient days (DDDs). K. pneumoniae which isolated from clinical samples in hospital between January 2014 and December 2018 were retrospectively analyzed, and the correlation between antibiotic resistance rate and antibiotic frequency was analyzed. Results: From 2014 to 2018, a total of 2295 strains of K. pneumoniae were isolated, with the detection rates of 8.2%, 9.2%, 11.9%, 13.4% and 14.0%. There were 423 strains of CRKP, with the detection rates of 7.5%, 5.8%, 17.8% 24.2% and 25.2% respectively.

关键词： Klebsiella pneumonia Antibiotic Consumption Resistance Correlation Analysis Defined Daily Doses