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Blood glucose-lowering activity of protocatechuic acid is mediated by inhibiting a-glucosidase

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Food Science and Human Wellness 2024年第3期13卷 1212-1219页

作者： Huafang Ding Shouhe Huang Chui Yiu Chook Erika Kwek Chi Yan Kaying Ma Jianhui Liu Hanyue zhu Zhenyu Chen Food&Nutritional Sciences Programme School of Life SciencesThe Chinese University of Hong KongHong Kong 999077China

α-Glucosidase inhibitors are effective in controlling postprandial hyperglycemia,which play crucial roles in the management of type 2 *** acid(PCA)is one of phenolic acids existing not only in various plant foods but also as a major microbial metabolite of dietary anthocyanins in the large *** present study investigated the inhibitory mechanism of PCA on a-glucosidase in vitro and examined its effect on postprandial blood glucose levels in *** from in vitro experiments demonstrated that PCA was a mix-type inhibitor of *** by hydrogen bonds and van der Waals interactions,PCA reversibly bound withα-glucosidase to form a stable a-glucosidase-PCA complex in a spontaneous *** computational simulation found that PCA could insert into the active cavity of a-glucosidase and establish hydrogen bonds with catalytic amino acid *** binding aroused the steric hindrance for substrates to enter active sites and caused the structural changes of interacted catalytic amino acid *** also exhibited postprandial hypoglycemic capacity in diabetic *** study may provide the theoretical basis for the application of PCA as an active ingredient of functional foods in dietary management of diabetes.

关键词： Protocatechuic acid α-Glucosidase Postprandial hyperglycemia Inhibition mechanism

肿瘤相关成纤维细胞在乳腺癌中的作用研究进展

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解放军医学杂志 2024年第4期49卷 482-488页

作者：陈薏竹朱荔韦禹帆李席如解放军医学院北京100853 解放军总医院第一医学中心普通外科医学部北京100853 南开大学医学院天津300071

乳腺癌是全球发病率最高的恶性肿瘤之一。近年来肿瘤的各类研究均取得了诸多进展。随着对肿瘤认识的不断深入,肿瘤细胞生长的微环境对癌症发生发展的影响受到越来越多的关注。肿瘤相关成纤维细胞(CAFs)作为肿瘤微环境的重要成分,受肿瘤... 详细信息

乳腺癌是全球发病率最高的恶性肿瘤之一。近年来肿瘤的各类研究均取得了诸多进展。随着对肿瘤认识的不断深入,肿瘤细胞生长的微环境对癌症发生发展的影响受到越来越多的关注。肿瘤相关成纤维细胞(CAFs)作为肿瘤微环境的重要成分,受肿瘤调控的同时还可通过多种途径释放细胞因子、外泌体等参与调节免疫微环境、重塑细胞外基质,以及促进肿瘤发生、迁移、侵袭和耐药等过程。本文对CAFs在乳腺癌中作用的最新研究进展进行综述,阐述免疫微环境中CAFs与乳腺癌细胞的相互作用模式,以及CAFs促进乳腺癌细胞增殖、侵袭、转移、耐药等恶性生物学行为的多种途径,探讨以CAFs为靶点进行乳腺肿瘤早期筛查及治疗的潜在效能。

关键词：乳腺癌肿瘤微环境肿瘤相关成纤维细胞

状态权力感对亲社会行为的影响:一项三水平元分析

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心理科学进展 2024年第11期32卷 1786-1799,I0001-I0013页

作者：诸彦含贺彬孙蕾西南大学国家治理学院重庆400715

状态权力感是一种临时启动的外在权力感知,与亲社会行为关系的理论与实证研究结果均不一致。本研究采用三水平元分析技术,明确状态权力感与亲社会行为的整体关系,探索造成分歧的原因。通过文献检索和筛选,共计纳入48篇文献,106个效应量... 详细信息

状态权力感是一种临时启动的外在权力感知,与亲社会行为关系的理论与实证研究结果均不一致。本研究采用三水平元分析技术,明确状态权力感与亲社会行为的整体关系,探索造成分歧的原因。通过文献检索和筛选,共计纳入48篇文献,106个效应量,总样本量为14871人。主效应检验发现,状态权力感对亲社会行为的影响不显著。调节效应检验发现,状态权力感对亲社会行为的影响受到行为的社会可见性和诉求类型的调节,但不受年龄、性别、文化背景、状态权力感启动方式、状态权力感类型、亲社会行为的指标选取、数据来源以及出版状态的调节。本研究使用三水平元分析方法保证了纳入文献信息的完整性,从而就状态权力感对亲社会行为的影响及调节变量在两者关系中的作用得出更为全面可靠的研究结论,有助于拓展对状态权力感与亲社会行为关系及调节机制的认识。

关键词：权力感状态权力感亲社会行为三水平元分析

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THE ROLE FORE AIR FLOW IN SOIL SLOPE STABILITY ANALYSIS

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Journal of Hydrodynamics 2009年第5期21卷 640-646页

作者： ZHANG Xiao-yue zhu Yue-ming FANG Chun-hui College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China

In order to investigate the effect of the pore air flow in the soil slope stability analysis, a water-air two-phase flow model, based on the multi-phase flow theory, is proposed and with the model, the water-phase and air-phase seepages of the soil slope in the stable seepage and rainfall situations are simulated. The soil slope safety coefficients are obtained according to the simulated pore air pressure and pore water pressure. The calculation results show that in the stable seepage situation, the influence of the pore air pressure on the soil slope stability can be neglected, while in the rainfall situation, the pore air pressure generated in the unsaturated zone will reduce the safety coefficient, and the larger the distance between the slip surface and the underground water level is, the greater the influence of the pore air pressure on the soil slope stability will be.

关键词： unsaturated soil water-air two-phase flow rainfall slope stability

Effects of Adalimumab Entering National Reimbursement on Medical Costs for Patients With Psoriasis:A 4-Year Single-Center Retrospective Study in China

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International Journal of Dermatology and Venereology 2024年第2期7卷 84-88页

作者： Yu Li Bo-Kun zhu Qing-Sheng Min Mei Ju Min Li Department of Medical Affairs Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Hospital Network Information Center Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Physiotherapy Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Objective:Adalimumab(ADA)is expensive and rarely used among ***,its cost for moderate to severe chronic plaque psoriasis can now be reimbursed since its addition to the National Reimbursement Drug List(NRDL)in January ***,we conducted this study to estimate the medical cost of ADA and its influencing factors in patients with psoriasis using ADA and thus gain a better understanding of the effect of the NRDL adjustment in ***:This retrospective study evaluated the medical cost of ADA before and after the addition of ADA to the NRDL(2018—2022)among 320 patients in a large professional dermatology specialty *** analysis,Welch’s analysis of variance,and multiple regression analysis were used to evaluate the medical cost and influencing ***:Before ADA was added to the NRDL,patients’mean total cost and ADA cost were¥24,243.56±16,346.53 and¥20,391.11±14,440.69,*** ADA became covered by the NRDL,the above 2 expenses decreased to¥10,461.19±7,554.66 and¥8,775.27±7,092.16,*** significant decrease in the cost of ADA resulted in a significant 110.5-times increase in ADA *** significant differences were found in the total cost,patient type(outpatient/inpatient),insurance status(yes/no),reimbursement status(before/after),and *** insurance reimbursement(P<0.001,β=-0.468,before reimbursement=1,after reimbursement=2)was the most significant influencing factor,followed by patient type(P=0.018,β=-0.215,outpatient=1,inpatient=2)and age(P=0.0046,β=-0.174).Conclusion:Medical insurance reimbursement is the most important factor affecting patients’total cost of ADA by reducing the economic burden,enhancing the availability of ADA,and stimulating the need for treatment.

关键词： adalimumab biological agent psoriasis medical cost medical insurance

Effects of different processing methods on the quality of Polygonatum cyrtonema Hua

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TMR Modern Herbal Medicine 2024年第2期7卷 28-34页

作者： Xin-Ning Zhang Shuang-Hui Shi Jun-Li Zhang Fan-Miao Kong Hai-Ting zhu Si-Yuan Ma Yu-Feng Hu ming-Rui Jiang Hui-Nan Wang Meng-Lin Wang Xiao-Tong Wei Jing-Qiu Zhang Nan Sun Meng-Yu Chen Qian-Qian Liu Ying-Zi Wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China

Background:In this study,we explored the effects of different processing methods on the quality of Polygonatum cyrtonema Hua(PC),and the role of Huangjiu in the processing ***:The sensory characteristics of the crude product,steamed product,and wine-processed product of PC were *** colorimeter was used to analyze the chromatic values of three different processed products on *** the same time,the contents of the water extract and alcohol extract were measured *** content of three different processing Polygonatum Polysaccharide(PCP)was determined using 0.2%anthrone-sulfuric *** correlation difference between the chromatic values and chemical composition of different PC products was analyzed using various analytical ***:The surface colors gradually deepened,the sweetness increased,the viscosity strengthened,and the tongue-numbing sensation disappeared after PC *** contents of extract and L^(*) gradually decreased from the crude to the steamed to the wine-processed product,consistent with the pattern of surface color ***,E^(*)ab gradually *** content of PCP was crude product>wine-processed product>steamed *** results of multivariate statistical analysis showed that the samples processed for crude,steamed,and wine-processed product were clustered into three *** correlation analysis showed that L^(*)and E^(*)ab were highly significant positively correlated with the content of PCP,and a*was significantly negatively correlated with the content of ***:The results showed that the wine-processed product had the best *** internal quality of the PC was correlated with its characteristics and chromatic *** this study,we investigated the internal and external quality of three different products of PC in order to provide a reference for further research on the impact of different processing methods on PC quality,the standardization of PC processing,and the

关键词： Polygonatum cyrtonema Hua different products chemical composition chromatic value characteristics

Shear-thinning behavior of the CaO–SiO2–CaF2–Si3N4 system mold flux and its practical application

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International Journal of Minerals,Metallurgy and Materials 2017年第10期24卷 1096-1103页

作者： Ying Xu Zhi-peng Yuan Li-guang zhu Yi-hua Han xing-juan Wang Hebei Provincial Key Laboratory of Inorganic Nonmetallic Materials College of Materials Science and Engineering North China University of Science and Technology Tangshan 063009 China Key Laboratory for Advanced Metallurgy Technology Hebei Provincial High-Quality Steel Continuous Casting Engineering Technology Research Center College of Metallurgy & Energy North China University of Science and Technology Tangshan 063009 China

Satisfying the mold-flux performance requirements for high-speed continuous casting necessitates the development of a new non-Newtonian-fluid mold flux with shear-thinning behavior, i.e., a mold flux whose viscosity is relatively high under lower shear rates and relatively low under higher shear rates. In this work, a mold flux that exhibits shear-thinning behavior was developed by adding different amounts of Si_3N_4 to the CaO–SiO_2–CaF_2 mold flux. The shear-thinning behavior was investigated using a rotational viscometer. In addition, the microstructure of the newly prepared slags was studied by high-temperature Raman spectroscopy and X-ray photoelectron spectroscopy. The results showed that the mechanism of shear-thinning was attributable to a temporary viscosity loss caused by the one-way shear stress, whereas the corresponding magnitude of shear-thinning was closely related to the degree of polymerization(DP). Finally, the non-Newtonian fluid mold flux was used for laboratory casting tests, which revealed that the mold flux could reduce slag entrapment and positively affect the continuous casting optimization.

关键词： mold flux viscosity shear-thinning behavior non-Newtonian fluid degree of polymerization

基于最小二乘法的振动监测系统测量噪声现场标定

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噪声与振动控制 2024年第4期44卷 110-117页

作者：李宾宾朱伟谢炎龙朱作浙江大学浙江大学伊利诺伊大学厄巴纳香槟校区联合学院浙江海宁314400 浙江大学建筑工程学院杭州310058 深圳大学土木与交通工程学院广东深圳518060 南洋理工大学土木与环境工程学院新加坡639798

分析振动监测系统的测量噪声水平是结构健康监测设计的重要步骤,有利于优化测试方案和后期模态参数识别。本文从数据采集全过程入手分析测量噪声的主要来源和统计特性,基于最小二乘法原理,提出标定硬件噪声水平的“n信道”方法和估计多... 详细信息

分析振动监测系统的测量噪声水平是结构健康监测设计的重要步骤,有利于优化测试方案和后期模态参数识别。本文从数据采集全过程入手分析测量噪声的主要来源和统计特性,基于最小二乘法原理,提出标定硬件噪声水平的“n信道”方法和估计多信道同步误差的方法。前者允许以任意数量的信道组合进行噪声估计,能够充分利用所有信道的信息,增强结果的稳定性;后者运用时滞测量信号的频域特性,通过互功率谱密度的比值实现信道间亚毫秒级同步误差估计。所提方法的正确性、鲁棒性和实用性通过某桥梁振动监测系统的测量数据得到验证。

关键词：振动与波结构健康监测拾振器测量噪声同步误差最小二乘法

考虑换乘通道利用的地铁换乘站行人疏散引导策略研究

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安全与环境学报 2024年第9期24卷 3548-3555页

作者：朱孔金朱军王小艳梅鹏合肥工业大学汽车与交通工程学院合肥230009 合肥泽众城市智能科技有限公司合肥230601

换乘地铁站的安全管理因其结构更为复杂、客流交织更为严重而备受关注。以某T形换乘地铁站为例,基于元胞自动机场域模型构建了考虑换乘通道利用程度的行人紧急疏散模型,并分别设计了面向站台层和站厅层的行人引导策略,对比分析了不同疏... 详细信息

换乘地铁站的安全管理因其结构更为复杂、客流交织更为严重而备受关注。以某T形换乘地铁站为例,基于元胞自动机场域模型构建了考虑换乘通道利用程度的行人紧急疏散模型,并分别设计了面向站台层和站厅层的行人引导策略,对比分析了不同疏散策略组合对换乘地铁站行人疏散的影响。结果表明:T形换乘地铁站中等规模(约3000人)疏散场景下,与无引导策略相比,同时考虑站台引导和站厅引导的疏散用时更短,且疏散人员分布更均衡;针对换乘通道利用程度调配的疏散分区设计,存在最优分隔间距,总疏散人数的变化对最优分隔间距没有影响,但疏散人员在各个站台的分布比例对最优分隔间距有一定的影响。研究有助于T形换乘地铁站内的密集人群安全管理。

关键词：公共安全行人疏散疏散引导地铁换乘站场域模型