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TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway

Current Medical Science 2024年第3期44卷 589-602页

作者： An-bang SUN Fang-hua LI Lin zhu Xi-xi ZENG min zhu Qing-hua LEI Yan-hong LIAO department of Anatomy School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China department of Transfusion Medicine Wuhan Hospital of Traditional Chinese and Western MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China department of Nephrology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China department of Thoracic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China National Basic Medical Teaching Demonstration Center Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Neurological Diseases of ministry of Education Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Renal fibrosis is the ultimate pathway of various forms of acute and chronic kidney ***,the knockout of transient receptor potential channel 6(TRPC6)has shown promise in alleviating renal ***,the regulatory impact of TRPC6 on renal fibrosis remains *** In vivo,TRPC6 knockout(TRPC6−/−)mice and age-matched 129 SvEv(WT)mice underwent unilateral renal ischemia-reperfusion(uIR)injury surgery on the left renal pedicle or sham *** and serum were collected on days 7,14,21,and 28 after *** vitro,primary tubular epithelial cells(PTECs)were isolated from TRPC6−/−and WT mice,followed by treatment with transforming growth factorβ1(TGFβ1)for 72 *** anti-fibrotic effect of TRPC6−/−and the underlying mechanisms were assessed through hematoxylin-eosin staining,Masson staining,immunostaining,qRT-PCR,and Western *** Increased TRPC6 expression was observed in uIR mice and PTECs treated with TGFβ***6−/−alleviated renal fibrosis by reducing the expression of fibrotic markers(Col-1,α-SMA,and vimentin),as well as decreasing the apoptosis and inflammation of PTECs during fibrotic progression both in vivo and in ***,we found that the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/glycogen synthase kinase 3 beta(GSK3β)signaling pathway,a pivotal player in renal fibrosis,was down-regulated following TRPC6 *** These results suggest that the ablation of TRPC6 may mitigate renal fibrosis by inhibiting the apoptosis and inflammation of PTECs through down-regulation of the PI3K/AKT/GSK3β*** TRPC6 could be a novel therapeutic strategy for preventing chronic kidney disease.

关键词： transient receptor potential channel 6 ischemia-reperfusion injury renal fibrosis renal tubular epithelial cells

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Unraveling the role of formate in improving nitrogen removal via coupled partial denitrification-anammox

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Frontiers of Environmental Science & Engineering 2024年第9期18卷 79-90页

作者： Wanlu zhu Rui Xiao min Xu Wenbo Chai Wenlong Liu Zhengyu Jin David Ikumi Huijie Lu Key Laboratory of Environmental Remediation and Ecological Health(ministry of Education) College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China China National Nuclear Corporation Beijing Research Institute of Chemical Engineering and MetallurgyBeijing 100029China College of Environment Zhejiang University of TechnologyHangzhou 310014China Key Laboratory of Ecology and Environment in minority Areas National Ethnic Affairs CommissionCollege of Life&Environmental SciencesMinzu University of ChinaBeijing 100081China Water Research Group Department of Civil EngineeringUniversity of Cape TownRondebosch 7700South Africa Key Laboratory of Water Pollution Control and Environmental Safety Hangzhou 310058China

The addition of traditional carbon sources(e.g.,acetate)could favor heterotrophic overgrowth in partial denitrification coupled with anammox(PD–A)systems,thus hindering the performance and stability of this novel wastewater nitrogen removal ***,it is necessary to develop an effective,environmentally friendly,and inexpensive *** study demonstrated the potential of formate to enhance the performance and community stability of PD–A under mainstream *** a laboratory-scale biofilm reactor,formate addition(COD/NO_(3)^(–)–N=1.75)improved nitrogen removal efficiency(from 72.1±3.5%to 81.7±2.7%),EPS content(from 106.3±8.1 to 163.0±15.5 mg/gVSS)and increased anammox bacteria growth(predominantly Candidatus Brocadia,from 29.5±0.7%to 34.5±5.4%)while maintaining stable heterotrophs dominated by methylotrophic ***–NanoSIMS revealed a formate uptake using *** and Desulfobacillus,with *** being the major contributor to partial nitrate reduction to *** can synthesize diverse hydrophobic amino acids and provide key nutrients for *** achieve comparable nitrogen removal,the cost of the formate-driven PD–A process should be 11.2%lower than that of *** results greatly enrich our understanding of C1 metabolism represented by formate in anammox communities and its application in the context of coupling partial denitrification–anammox toward enhanced nitrogen removal in global wastewater treatment systems.

关键词： Formate Mixotrophic growth Partial denitrification-anammox Metabolic interaction FISH-NanoSIMS

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Identification of LRG1 targeting peptide and its application in targeted imaging for breast cancer

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Nano Research 2024年第10期17卷 9044-9051页

作者： Mengdie Chen Anying zhu Furong zhu Ziwen Lei Tao Huang Shengnan Du Dongdong Wang Xiaoyu Zhang Huan min Yingqiu Qi Guangjun Nie department of Pharmacology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450008China department of General Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China department of Breast Disease The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450003China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China

Breast cancer remains a leading cause of morbidity and mortality among women worldwide,emphasizing the urgent need for enhanced diagnostic and therapeutic ***-rich-alpha-2-glycoprotein 1(LRG1)has emerged as a notable target due to its markedly elevated expression in breast tumors,suggesting the viability of LRG1 as a theranostic *** our study,we employed phage display technology to identify a peptide,termed ET,that binds to LRG1 with a dissociation constant of 48.4μ*** modified with fluorescent cyanine dye,the ET peptide showcased effective tumor-targeting imaging across three different primary breast tumor models and a metastatic breast tumor *** also undertook a comprehensive safety evaluation,which verified the good biosafety credentials of ET *** summary,the ET peptide identified in this study shows effective LRG1-targeting ability both in vitro and in vivo,thus exhibiting immense potential for clinical translation.

关键词： breast cancer leucine-rich-alpha-2-glycoprotein 1(LRG1) phage display peptide tumor targeting

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Association of daily sitting time and leisure-time physical activity with body fat among ***

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Journal of Sport and Health Science 2024年第2期13卷 195-203页

作者： Jingwen Liao min Hu Kellie Imm Clifton J.Holmes Jie zhu Chao Cao Lin Yang Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion Guangzhou Sport UniversityGuangzhou 510500China Scientific Research Center Guangzhou Sport UniversityGuangzhou 510500China Division of Epidemiology&Genetics Department of Population and Public Health SciencesKeck School of Medicine of the University of Southern CaliforniaLos AngelesCA 90033USA Program in Physical Therapy Washington University School of MedicineSt.LouisMO 63110USA Center for Human Nutrition Washington University School of MedicineSt.LouisMO 63110USA department of Plastic and Reconstructive Surgery Shanghai East HospitalTongji UniversityShanghai 200070China department of Cancer Epidemiology and Prevention Research Alberta Health ServicesCalgary T2S 3C3Canada department of Oncology and Community Health Sciences University of CalgaryCalgary T2N 1N4Canada

Background:Prolonged sitting and reduced physical activity lead to low energy ***,little is known about the joint impact of daily sitting time and physical activity on body fat *** investigated the independent and joint associations of daily sitting time and physical activity with body fat among ***:This was a cross-sectional analysis of *** representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged 20 years or *** sitting time and leisure-time physical activity(LTPA)were self-reported using the Global Physical Activity *** fat(total and trunk fat percentage)was determined via dual X-ray ***:Among 10,808 adults,about 54.6%spent 6 h/day or more sitting;more than one-half reported no LTPA(inactive)or less than 150 min/week LTPA(insufficiently active)with only 43.3%reported 150 min/week or more LTPA(active)in the past *** fully adjusting for sociodemographic data,lifestyle behaviors,and chronic conditions,prolonged sitting time and low levels of LTPA were associated with higher total and trunk fat percentages in both *** stratifying by LTPA,the association between daily sitting time and body fat appeared to be stronger in those who were inactive/insuufficiently *** the joint analyses,inactive/insuufficiently active adults who reported sitting more than 8 h/day had the highest total(female:3.99%(95%confidence interval(95%CI):3.09%-4.88%);male:3.79%(95%CI:2.75%-4.82%))and trunk body fat percentages(female:4.21%(95%CI:3.09%-5.32%);male:4.07%(95%CI:2.95%-5.19%))when compared with those who were active and sitting less than 4 h/***:Prolonged daily sitting time was associated with increased body fat among *** higher body fat associated with 6 h/day sitting may not be offset by achieving recommended levels of physical activity.

关键词： Adults Body fat distribution Physical activity Sitting time

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A transferrin receptor targeting dual-modal MR/NIR fluorescent imaging probe for glioblastoma diagnosis

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Regenerative Biomaterials 2024年第3期3卷 122-133页

作者： Jiaqi Hao Huawei Cai Lei Gu Yiqi Ma Yan Li Beibei Liu Hongyan zhu Fanxin Zeng min Wu department of Radiology and Huaxi MR Research Center(HMRRC) Functional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduSichuan 610041China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610041China department of Nuclear Medicine&Laboratory of Clinical Nuclear Medicine West China HospitalSichuan UniversityChengduSichuan 610041China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China department of Clinical Research Center Dazhou Central HospitalDazhouSichuan 635000China

The prognosis of glioblastoma(GBM)remains challenging,primarily due to the lack of a precise,effective imaging technique for comprehensively *** GBM diagnostic challenges,our study introduces an innovative dual-modal imaging that merges near-infrared(NIR)fluorescent imaging with magnetic resonance imaging(MR).This method employs superparamagnetic iron oxide nanoparticies coated with NIR fluorescent dyes,specifically Cyanine 7,and targeted *** synthetic probe facilitates MRI functionality through superparamagnetic iron oxide nanoparticles,provides NIR imaging capability via Cyanine 7 and enhances tumor targeting trough peptide interactions,offering a comprehensive diagnostic tool for ***,the probe traverses the blood-brain barrier,targeting GBM in vivo via peptides,producing clear and discermible images in both *** and histopathology assessments confirm the probe's favorable safet *** findings suggest that the dual-modal MRINIR fluorescent imaging probe could revolutionize GBM prognosis and survival rate which can also be extended to other tumors type.

关键词： glioblastoma magnetic resonance imaging dual-modal probes near-infrared fluorescent targeting peptides

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Discharge and mass transfer characteristics of atmospheric pressure gas-solid two-phase gliding arc

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Plasma Science and Technology 2024年第9期26卷 88-96页

作者： min zhu Yuchen PING Yinghao ZHANG Chaohai ZHANG Shuqun WU department of Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106People’s Republic of China

In this work,a gas-solid two-phase gliding arc discharge(GS-GAD)reactor was *** arc was formed in the gap between the blade electrodes,and solid powder was deposited on the sieve plate positioned beneath the blade electrodes.A range of experimental parameters,including the inter-electrode spacing,gas flow rate,applied voltage,and the type of the powder,were systematically varied to elucidate the influence of solid powder matter on the dynamics of gliding arc discharge(GAD).The discharge images were captured by ICCD and digital camera to investigate the mass transfer characteristics of GS-GAD,and the electrical parameters,such as the effective values of voltage,current,and discharge power were record to reveal the discharge characteristics of *** results demonstrate that powder undergoes spontaneous movement towards the upper region of the gliding arc due to the influence of electric field *** the discharge voltage,decreasing relative dielectric constant of the powder and reducing the electrode-to-sieve-plate distance all contribute to a greater involvement of powder in the GAD process,subsequently resulting in an enhanced powder concentration within the GAD ***,powder located beneath the gliding arc experiences downward resistance caused by the opposing gas flow and *** gas flow rate notably hampers the powder concentration within the discharge region,and the velocity of powder motion in the upper part of the GAD region is *** the condition of electrode-to-sieve-plate distance of 30 mm,gas flow rate of 1.5 L/min,and peak-to-peak voltage of 31 kV,the best combination of arc gliding and powder spark discharge phenomena can be achieved with the addition of Al_(2)O_(3) powder.

关键词： gliding arc discharge atmospheric pressure plasma multiphase discharge mass transfer

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Research advances in the function and anti-aging effects of nicotinamide mononucleotide

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第9期25卷 723-735页

作者： min WANG Yuan CAO Yun LI Lu WANG Yuyan LIU Zihui DENG Lianrong zhu Hongjun KANG Chinese PLA Medical School Beijing100853China department of Critical Care Medicine the First Medical CentreChinese PLA General HospitalBeijing100853China department of Emergency The Second Hospital of Hebei Medical UniversityShijiazhuang050004China department of Biochemistry Chinese PLA Medical SchoolBeijing100853China department of Clinical Nutrition the First Medical CentreChinese PLA General HospitalBeijing100853China Nephrology Institute of the Chinese People’s Liberation Army State Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchDepartment of Nephrologythe First Medical CenterChinese PLA General HospitalBeijing100853China

Aging and age-related ailments have emerged as critical challenges and great burdens within the global contemporary *** these concerns is an imperative task,with the aims of postponing the aging process and finding effective treatments for age-related degenerative *** investigations have highlighted the significant roles of nicotinamide adenine dinucleotide(NAD+)in the realm of *** has been empirically evidenced that supplementation with nicotinamide mononucleotide(NMN)can elevate NAD+levels in the body,thereby ameliorating certain age-related degenerative *** principal anti-aging mechanisms of NMN essentially lie in its impact on cellular energy metabolism,inhibition of cell apoptosis,modulation of immune function,and preservation of genomic stability,which collectively contribute to the deferral of the aging *** paper critically reviews and evaluates existing research on the anti-aging mechanisms of NMN,elucidates the inherent limitations of current research,and proposes novel avenues for anti-aging investigations.

关键词： Nicotinamide mononucleotide(NMN) Anti-aging Energy metabolism Apoptosis DNA repair

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3D Road Network Modeling and Road Structure Recognition in Internet of Vehicles

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1365-1384页

作者： Dun Cao Jia Ru Jian Qin Amr Tolba Jin Wang min zhu College of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha410114China department of Computer Science Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia College of Information Science and Technology Zhejiang Shuren UniversityHangzhou310015China

Internet of Vehicles (IoV) is a new system that enables individual vehicles to connect with nearby vehicles,people, transportation infrastructure, and networks, thereby realizing amore intelligent and efficient transportationsystem. The movement of vehicles and the three-dimensional (3D) nature of the road network cause the topologicalstructure of IoV to have the high space and time *** modeling and structure recognition for 3Droads can benefit the description of topological changes for IoV. This paper proposes a 3Dgeneral roadmodel basedon discrete points of roads obtained from GIS. First, the constraints imposed by 3D roads on moving vehicles areanalyzed. Then the effects of road curvature radius (Ra), longitudinal slope (Slo), and length (Len) on speed andacceleration are studied. Finally, a general 3D road network model based on road section features is *** paper also presents intersection and road section recognition methods based on the structural features ofthe 3D road network model and the road features. Real GIS data from a specific region of Beijing is adopted tocreate the simulation scenario, and the simulation results validate the general 3D road network model and therecognitionmethod. Therefore, thiswork makes contributions to the field of intelligent transportation by providinga comprehensive approach tomodeling the 3Droad network and its topological changes in achieving efficient trafficflowand improved road safety.

关键词： Internet of vehicles road networks 3D road model structure recognition GIS

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Recent advances in glycerol valorization through electrocatalytic methods

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Tungsten 2024年第4期6卷 696-710页

作者： Hao-Hai Dong Yu-Xin zhu Yi-Gu Li Jia-Yan Liang Ya Tan Xin-Yue Zhang Hao-min Jiang Liu Lin Ze-min Sun Center for Advanced Materials Research & College of Arts and Sciences Beijing Normal University department of Chemistry University College London

The recent tremendous growth of biodiesel production from vegetable oils or waste fats has led to increased glycerol accumulation as a by-product of this *** sparked attention towards glycerol use and valorization of this largely available and cheap *** several methods for glycerol valorization,electrochemical glycerol oxidation reaction(EGOR)is an attractive alternative anodic reaction to oxygen evolution reaction for a variety of electrolytic synthesis,due to the low thermodynamic ***,the EGOR at the anode can be coupled with a cathodic hydrogen evolution reaction to achieve efficient energy conversion in an aqueous electrolytic *** review provides a comprehensive summary and critical analysis of glycerol electrochemical oxidation research during the last 5 *** review focuses on the recent development and prospects of electrochemical pathways(indirect or direct routes) for application in the *** particular,the recent development and prospects of using noble and non-noble group metal catalysts for glycerol electro-oxidation are ***,reaction product selectivity analysis and conversion efficiency are also highlighted.

关键词： Active oxygen species Electrocatalytic methods Glycerol Noble metal catalysts Non-noble metal catalysts

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CRISPR/Cas9 system and its applications in nervous system diseases

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Genes & Diseases 2024年第2期11卷 675-686页

作者： Haibin Jiang Mengyan Tang Zidi Xu Yanan Wang Mopu Li Shuyin Zheng Jianghu zhu Zhenlang Lin min Zhang The Second School of Medicine Wenzhou Medical UniversityWenzhouZhejiang 325035China The First School of Medicine Wenzhou Medical UniversityWenzhouZhejiang 325035China department of Pediatrics The Second School of MedicineThe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China Key Laboratory of Perinatal Medicine of Wenzhou WenzhouZhejiang 325027China Key Laboratory of Structural Malformations in Children of Zhejiang Province WenzhouZhejiang 325000China Zhejiang Provincial Clinical Research Center for Pediatric Disease WenzhouZhejiang 325027China

The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system is an acquired immune system of many bacteria and archaea,comprising CRISPR loci,Cas genes,and its associated *** system can recognize exogenous DNA and utilize the Cas9 protein's nuclease activity to break DNA double-strand and to achieve base insertion or deletion by subsequent DNA *** recent years,multiple laboratory and clinical studies have revealed the therapeutic role of the CRISPR/Cas9 system in neurological *** article reviews the CRISPR/Cas9-mediated gene editing technology and its potential for clinical application against neurological diseases.

关键词： CRISPR/Cas9 Gene editing Mutation Neurological diseases Therapeutics

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