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3D-printed Mg-1Ca/polycaprolactone composite scaffolds with promoted bone regeneration

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Journal of Magnesium and Alloys 2024年第3期12卷 966-979页

作者： Xiao Zhao Siyi wang Feilong wang Yuan {2. Ranli Gu Fan Yang Yongxiang xu Dandan Xia Yunsong Liu Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing 100081China National Center of Stomatology National Engineering Laboratory for Digital and Material Technology of StomatologyNational Clinical Research Center for Oral DiseasesBeijing Key Laboratory of Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing 100081China Department of Dental Materials Peking University School and Hospital of StomatologyBeijing 100081China

In bone tissue engineering,polycaprolactone(PCL)is a promising material with good biocompatibility,but its poor degradation rate,mechanical strength,and osteogenic properties limit its *** this study,we developed an Mg-1Ca/polycaprolactone(Mg-1Ca/PCL)composite scaffolds to overcome these *** used a melt blending method to prepare Mg-1Ca/PCL composites with Mg-1Ca alloy powder mass ratios of 5,10,and 2. wt%.Porous scaffolds with controlled macro-and microstructure were printed using the fused deposition modeling *** explored the mechanical strength,biocompatibility,osteogenesis performance,and molecular mechanism of the Mg-1Ca/PCL *** 5 and 10 wt%Mg-1Ca/PCL composites were found to have good ***,they promoted the mechanical strength,proliferation,adhesion,and osteogenic differentiation of human bone marrow stem cells(hBMSCs)of pure *** vitro degradation experiments revealed that the composite material stably released Mg_(2.+ions for a long period;it formed an apatite layer on the surface of the scaffold that facilitated cell adhesion and *** tomography and histological analysis showed that both 5 and 10 wt%Mg-1Ca/PCL composite scaffolds promoted bone regeneration bone *** results indicated that the Wnt/β-catenin pathway was involved in the osteogenic ***,Mg-1Ca/PCL composite scaffolds are expected to be a promising bone regeneration material for clinical *** of significance:Bone tissue engineering scaffolds have promising applications in the regeneration of critical-sized bone ***,there remain many limitations in the materials and manufacturing methods used to fabricate *** study shows that the developed Ma-1Ca/PCL composites provides scaffolds with suitable degradation rates and enhanced boneformation ***,the fused deposition modeling method allows precise control of the macroscopic morphology and microsc

关键词： 3D printing Bone tissue engineering Magnesium Osteogenic Polycaprolactone Scaffold.

Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women:a randomized,controlled trial

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Science china(Life Sciences) 2024年第1期67卷 113-121页

作者： Hui zhu Taishun Li Peizhen xu Lijun Ding Xianghong zhu Bin wang Xiaoqiu Tang Juan Li Pengfeng zhu Huiyan wang Chenyan Dai Haixiang Sun Jianwu Dai Yali Hu Department of Obstetrics and Gynecology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Biostatistics Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Gynecology Changzhou Maternal and Child Health Care HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China Clinical Center for Stem Cell Research Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Hematology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100190China

Intrauterine adhesion is a major cause of female reproductive *** we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe intrauterine adhesion obtain live birth,no large sample randomized controlled studies on this therapeutic strategy in such patients have been reported so *** verify if the therapy of autologous bone marrow stem cells-scaffold is superior to traditional treatment in moderate to severe intrauterine adhesion patients in increasing their ongoing pregnancy rate,we conducted this randomized controlled clinical *** 195 participants with moderate to severe intrauterine adhesion were screened and 152.of them were randomly assigned in a 1:1 ratio to either group with autologous bone marrow stem cells-scaffold plus Foley balloon catheter or group with only Foley balloon catheter(control group)from February 2.16 to January *** per-protocol analysis included 140 participants:72.in bone marrow stem cells-scaffold group and 68 in control *** ongoing pregnancy occurred in 45/72.62.5%)participants in the bone marrow stem cells-scaffold group which was significantly higher than that in the control group(2./68,41.2.)(RR=1.52.95%CI 1.08–2.12.P=0.012..The situation was similar in live birth rate(bone marrow stem cells-scaffold group 56.9%(41/72.*** group 38.2.(2./68),RR=1.49,95%CI 1.04–2.14,P=0.02.).Compared with control group,participants in bone marrow stem cells-scaffold group showed more menstrual blood volume in the 3rd and 6th cycles and maximal endometrial thickness in the 6th cycle after hysteroscopic *** incidence of mild placenta accrete was increased in bone marrow stem cells-scaffold group and no severe adverse effects were *** conclusion,transplantation of bone marrow stem cells-scaffold into uterine cavities of the participants with moderate to severe intrauterine adhesion increased their ongoing pregnancy and

关键词： intrauterine adhesion Asherman’s syndrome uterine infertility autologous bone marrow stem cells transplantation endometrial regeneration ongoing pregnancy rate

Formation of Intragranular Ferrite During Isothermal/Thermomechanical Processes in a Medium Carbon V-Ti-N Microalloyed Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 350-354页

作者： xu Lei 1,LIU Guo-quan 2.NIE Yu-zhu 1,{2. xue-hui 1,MA E 1 (1.Hebei Iron and Steel technology Research Institute,Shi Jiazhuang 05002.,Hebei,china 2.school of Materials Science and Engineering /State Key Laboratory for Advanced Metals and Materials,university of Science and technology beijing,beijing 100083,china) Hebei Iron & Steel Technol Res Inst Shijiazhuang 050021 Hebei Peoples R China Univ Sci & Technol beijing Sch Mat Sci & Engn State Key Lab Adv Met & Mat Beijing 100083 Peoples R China

For a V-Ti-N microalloyed steel with 0.34%C-1.54%Mn,intragranular ferrite (IGF) was obtained in both isothermal austenite decomposition processes and thermomechanical processes simulating the industrial seamless tubing manufacture *** show that with decrease of the isothermal temperature in range of 600℃ down to 450℃,not only the morphology of IGF changed from equiaxed to acicular,but also the equiaxed IGF and the acicular IGF were *** importantly,it is found that the amount of equiaxed ferrite increased significantly in the thermomechanical process sample water quenched from 550℃ after 800℃ deformation than that in the isothermally treated sample at 550℃ sample without hot *** implies that appropriate controlled deformation with controlled cooling can significantly promote equiaxed IGF formation,and not solely rely on nucleation mechanisms related with *** deformation of austenite without dynamic and complete static recrystallization causes high energy regions,therefore further promotes the nucleation potency of IGF.

关键词： V-Ti-N microalloyed steel intragranular ferrite (IGF) isothermal treatment thermomechanical processes controlled cooling

LiOH-mediated crystallization regulating strategy enhancing electrochemical performance and structural stability of SiO anodes for lithium-ion batteries

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Nano Research 2024年第9期17卷 8174-8183页

作者： Zhengqiu He Zewen xu Yu Long Jiexin zhu Hao Yang Kuo Chen Qiang Zhou Ning Cao Xiaobo {2. Juan {2. Xiaojie Tan Litao {2. Luhai {2. Shengbao He Mengdi Zhang Han Hu Mingbo Wu State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore school of Chemical Sciences University of AucklandAuckland 1010New Zealand Petrochemical Research Institute Petro China Company Ltd.Beijing 102206China

Silicon monoxide(SiO)is widely recognized as a promising anode material for next-generation lithium-ion *** to its metastable amorphous structure,SiO exhibits a highly complex degree of crystallization at the microscopic level,which significantly influences its electrochemical *** a consequence,accurately regulating the crystallization of SiO,and further establishing the relationship between crystallinity and electrochemical performance are very critical for SiO *** this article,carbon-coated SiO materials with different crystallinity degrees were synthesized using lithium hydroxide monohydrate(LiOH·H_(2.O)as a structural modifier to reveal this ***,moderate amount of LiOH·H_(2.O addition results in the forming of an oxygen-rich shell,which effectively inhibits the inward migration of oxygen atoms on the SiO surface and suppresses volume ***,the crystallinity of SiO will gradually enhance and the crystalline phase appears with increasing the amount of LiOH·H_(2.O,which will generate a deteriorative Li+diffusion *** balancing the above two contradictions,a mass fraction of 1%LiOH·H_(2.O for the additive yielded SiO@C-1,characterized by optimal ***@C-1 demonstrates exceptional long-cycle stability with 74.8%capacity retention after 500 cycles at 1 A·g^(-1).Furthermore,it achieves a capacity retention of 52.2.even at a high density of 5 A·g^(-1).This study first reveals the relationship between SiO crystallinity and electrochemical performance,which efficiently guides the design of high-performance SiO anodes.

关键词： lithium-ion batteries SiO anodes crystallinity regulation high rate long life

Neglected Mendelian causes of stroke in adult Chinese patients who had an ischaemic stroke or transient ischaemic attack

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Stroke & Vascular Neurology 2024年第3期9卷 194-201,I0001-I0103页

作者： Wei Li Hao Li Chaoxia Lu Jialu Zhao Huichun xu Zhe xu Braxton Mitchell Yong Jiang Hong-Qiu Gu Qin xu Anxin wang Xia Meng Jinxi Lin Jing Jing Zixiao Li Wanlin zhu Zhigang Liang Mengxing wang Yongjun wang china National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Division of Endocrinology Diabetes and NutritionDepartment of MedicineUniversity of Maryland School of MedicineBaltimoreMarylandUSA Department of Neurology Qindao University Medical College Affiliated Yantai Yuhuangding HospitalYantaiShandongChina Clinical Center for Precision Medicine in Stroke Capital Medical UniversityBeijingChina

Background and purpose Multiple factors play important roles in the occurrence and prognosis of ***,the roles of monogenic variants in all-cause ischaemic stroke have not been systematically *** aim to identify underdiagnosed monogenic stroke in an adult ischaemic stroke/transient ischaemic attack(TIA)cohort(the Third china National Stroke Registry,CNSR-III).Methods Targeted next-generation sequencing for 181 genes associated with stroke was conducted on DNA samples from 1042. patients recruited through *** genetic and clinical data from electronic health records(EHRs)were reviewed for completion of the diagnostic *** assessed the percentages of individuals with pathogenic or likely pathogenic(P/LP)variants,and the diagnostic yield of pathogenic variants in known monogenic disease genes with associated *** In total,1953 individuals harboured at least one P/LP variant out of 1042. ***,792.7.6%)individuals(comprising 759 individuals harbouring one P/LP variant in one gene,2. individuals harbouring two or more P/LP variants in different genes and 4 individuals with two P/LP variants in ABCC6)were predicted to be at risk for one or more monogenic diseases based on the inheritance ***,2.0 of 792.individuals manifested a clinical phenotype in the EHR data to support the diagnosis of stroke with a monogenic *** most diagnosed Mendelian cause of stroke in the cohort was cerebral autosomal dominant arteriopathy with subcortical infarcts and *** were no relationships between age or family history and the incidence of first symptomatic monogenic stroke in *** The rate of monogenic cause of stroke was 2.2.after reviewing the clinical *** reasons that Mendelian causes of stroke may be missed in adult patients who had an ischaemic stroke/TIA include a late onset of stroke symptoms,combination with common vascular risks and the absence of a promine

关键词： patients transient likely

Fabricating bio-inspired high impact resistance carbon nanotube network films for multi-protection under an extreme environment

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Nano Research 2024年第9期17卷 7793-7802页

作者： Mingquan zhu Kailu Xiao Wei Zhang xudong Lei Yunxiang Bai Shijun {2. Peng Zhang Feng Gao Congying {2. Wenqiang xu Huiyong Li Xianqian Wu Chao {2. Hui Zhang Luqi Liu Zhong Zhang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China university of Chinese Academy of Sciences Beijing 100049China Department of Materials Science and Engineering Texas A&M UniversityCollege StationTexas 77840USA Institute of Mechanics Chinese Academy of SciencesBeijing 100190China school of Astronautics Harbin Institute of TechnologyHarbin150001China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China

The fabrication of light-weight,highly impact-resistant,and energy-absorbent materials is urgently demanded in many facets of the society from body armor to aerospace engineering,especially under an extreme *** nanotubes(CNTs),one of the strongest and toughest materials ever found,also have good conductivity,chemical stability,and thermal stability,etc,making them a competitive candidate as building blocks to help achieve the above *** this work,a kind of CNT network was prepared by using chlorosulfonic acid(CSA)to release the internal stress of super-aligned carbon nanotube films(SA-CNTF)and dendritic polyamide amine(PAMAM)to further introduce multiple hydrogen bonds and interlocking *** fabricated bioinspired carbon nanotube network films(PAMAM@C-CNTF)have a high toughness of 45.97 MJ/m3,showing an increase of 42.%compared to neat *** importantly,the anti-impact performance of the films(e.g.,with a maximum specific energy absorption of 1.40 MJ/kg under 80-100 m/s projectile impact)is superior to that of conventional protective materials from steel and Kevlar fiber,and also exceeds that of any other reported carbon-based *** hierarchical energy dissipation mechanism was further revealed through experiment and *** functions including intelligent heating/anti-icing,ultraviolet protection,as well as electromagnetic interference shielding properties make these network films have great potential in practical multi-protection applications,especially under an extreme environment.

关键词： carbon nanotubes composites mechanical properties multi-function

Ultramafic xenoliths in Mesozoic diorite in west Shandong Province

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Science china Earth Sciences 2004年第6期47卷 489-499页

作者： CHEN Lihui1,2.& ZHOU Xinhua2.1.The Key Laboratory of Orogenic Belts and Crustal Evolution,Ministry of Education,china and school of Earth and Space Sciences,Peking {2.,beijing 100871,china 2.Institute of Geology and Geophysics,Chinese Academy of Sciences,beijing 10002.,china Correspondence should be addressed to Chen Lihui(email: lihui_chen@***) 1. The Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education China and School of Earth and Space Science Peking University 100871 Beijing China 2. Institute of Geology and Geophysics Chinese Academy of Sciences 100029 Beijing China

Ultramafic xenoliths are common in Tietonggou intrusion, Laiwu, Shandong Prov-ince. Peridotite xenoliths develop two-stage metasomatism popularly: (i) The early metasoma-tism is characterized by intergranular clinopyroxene and phlogopite; (ii) The later metasomatism is characterized by orthopyroxene veins with a few plagioclases and amphiboles. These ul-tramafic xenoliths are thought to be mostly from the crust-mantle transitional zone on the basis of their combination, mineral chemistry, equilibrium temperature, and metasomatic characteristics. Major elements, rare earth elements, and Sr-Nd isotopic composition of the ultramafic xenoliths indicate that there is a petrogenetic relationship between the silica-enriched xenoliths and their host diorites. We propose that such silica enrichment might be an indicator of melt-rock interac-tions in the Mesozoic lithosphere beneath western Shandong.

关键词： ultramafic xenoliths, crust-mantle transitional zone,metasomatism, Tietonggou intrusion, Laiwu.

Proactive Caching at the Wireless Edge:A Novel Predictive User Popularity-Aware Approach

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1997-2017页

作者： Yunye Wan Peng Chen Yunni Xia Yong Ma Dongge zhu xu {2. Hui Liu Weiling Li Xianhua Niu Lei xu Yumin Dong College of Computer Science Chongqing UniversityChongqing400044China school of Computer and Software Engineering Xihua UniversityChengdu610039China school of Computer and Information Engineering Jiangxi Normal UniversityNanchang330022China Electric Power Research Institute of State Grid Ningxia Electric Power Co. Ltd.Yinchuan750002China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400030China school of Computer Science and technology Beijing Institute of TechnologyBeijing100083China school of Computer Science and technology Dongguan University of TechnologyDongguan523808China school of Emergency Management Xihua UniversityChengdu610039China College of Computer and Information Science Chongqing Normal UniversityChongqing401331China

Mobile Edge Computing(MEC)is a promising technology that provides on-demand computing and efficient storage services as close to end users as *** an MEC environment,servers are deployed closer to mobile terminals to exploit storage infrastructure,improve content delivery efficiency,and enhance user ***,due to the limited capacity of edge servers,it remains a significant challenge to meet the changing,time-varying,and customized needs for highly diversified content of ***,techniques for caching content at the edge are becoming popular for addressing the above *** is capable of filling the communication gap between the users and content providers while relieving pressure on remote cloud ***,existing static caching strategies are still inefficient in handling the dynamics of the time-varying popularity of content and meeting users’demands for highly diversified entity *** address this challenge,we introduce a novel method for content caching over MEC,i.e.,*** synthesizes a content popularity prediction model,which takes users’stay time and their request traces as inputs,and a deep reinforcement learning model for yielding dynamic caching *** results demonstrate that PRIME,when tested upon the MovieLens 1M dataset for user request patterns and the Shanghai Telecom dataset for user mobility,outperforms its peers in terms of cache hit rates,transmission latency,and system cost.

关键词： Mobile edge computing content caching system average cost deep reinforcement learning collaborative mechanism

Relationships between blood chromium exposure and liver injury:Exploring the mediating role of systemic inflammation in a chromate-exposed population

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Journal of Environmental Sciences 2024年第9期143卷 224-234页

作者： Zekang Su Yali Zhang Shiyi Hong Qiaojian Zhang Jiayu xu Guiping Hu Xiaojun zhu Fang Yuan Shanfa Yu Tianchen {2. Guang Jia Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China school of Engineering Medicine and beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing 100191China National Center for Occupational Safety and Health Beijing 102308China Department of Occupational Health and Radiological Health Chongqing Centers for Disease Control and PreventionChongqing 400042China Henan Institute for Occupational Medicine Zhengzhou 450052China Department of Clinical Laboratory Third Hospital of Peking UniversityBeijing 100191China

Hexavalent chromium and its compounds are prevalent pollutants,especially in the work environment,pose a significant risk for multisystem toxicity and *** it is known that chromium accumulation in the liver can cause damage,the dose-response relationship between blood chromium(Cr)and liver injury,as well as the possible potential toxic mechanisms involved,remains poorly *** address this,we conducted a follow-up study of 590 visits from 305 participants to investigate the associations of blood Cr with biomarkers for liver injury,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),and direct bilirubin(DBIL),and to evaluate the mediating effects of systemic ***(PLT)and the platelet-to-lymphocyte ratio(PLR)were utilized as biomarkers of systemic *** the linear mixed-effects analyses,each 1-unit increase in blood Cr level was associated with estimated effect percentage increases of 0.82.(0.11%,1.53%)in TBIL,1.67%(0.06%,3.2.%)in DBIL,0.73%(0.04%,1.43%)in ALT and 2.08%(0.2.%,3.87%)in AST,***,PLT mediated 10.04%,11.35%,and 10.77%increases in TBIL,DBIL,and ALT levels induced by chromate,*** addition,PLR mediated 8.2.%and 15.58%of the association between blood Cr and TBIL or *** findings shed light on the mechanisms underlying blood Cr-induced liver injury,which is partly due to worsening systemic inflammation.

关键词： Blood chromate Liver injury Systemic inflammation Mediation analysis