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Stroke & Vascular Neurology 2024年第4期9卷 351-359页

作者： Xiumei Xu Mingyu Chen dongya zhu School of Pharmacy Nanjing Medical UniversityNanjingJiangsuChina

Stroke is the second-leading cause of death and the leading cause of disability in much of the *** particular,China faces the greatest challenge from stroke,since the population is aged *** decades of clinical trials,no neuroprotectant has had reproducible efficacy on primary clinical end points,because reperfusion is probably a necessity for neuroprotection to be clinically ***,the success of thrombolysis and endovascular thrombectomy has taken us into a reperfusion era of acute ischaemic stroke(AIS)*** cytoprotective agents can prevent detrimental effects of ischaemia,and therefore‘freeze’ischaemic penumbra before reperfusion,extend the time window for reperfusion *** reperfusion often leads to reperfusion injury,including haemorrhagic transformation,brain oedema,infarct progression and neurological worsening,cytoprotective agents will enhance the efficacy and safety of reperfusion therapy by preventing or reducing reperfusion ***,reperfusion and cytoprotective agents are a mutually beneficial pair in AIS *** this review,we outline critical pathophysiological events causing cell death within the penumbra after ischaemia or ischaemia/reperfusion in the acute phase of AIS,focusing on excitotoxicity and free *** discuss key pharmacological targets for cytoprotective therapy and evaluate the recent advances of cytoprotective agents going through clinical trials,highlighting multitarget cytoprotective agents that intervene at multiple levels of the ischaemic and reperfusion cascade.

关键词： protective injuries drugs

Distributions and accumulation mechanisms of helium in petroliferous basins

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Science China Earth Sciences 2024年第10期67卷 3143-3168页

作者： Pengpeng LI Quanyou LIU dongya zhu Di zhu Zheng ZHOU Xiaoqi WU Qingqiang MENG Jiahao LV Yu GAO Institute of Energy Peking UniversityBeijing 100871China Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000China Petroleum Exploration&Production Research Institute SINOPECBeijing 102206China Energy Research Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan 250014China Lancaster Environment Centre Lancaster UniversityLA14YQUK Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

Helium is an irreplaceable strategic mineral resource, and commercial helium-rich gas fields(He>0.1%) worldwide are typically discovered serendipitously during hydrocarbon exploration efforts. According to an analysis of 75 helium-rich gas fields and 1048 natural gas samples worldwide, helium in natural gas generally exhibits “scarce”, “accompanying”, and“complex” properties, and helium-rich gas fields often occur at depths 1%). However, geological reserves in the former two types of gas fields are mainly in the range of 10^(7)–10^(11)m^(3), whereas in the latter, they are only in the range of 10^(5)–10^(7)m^(3). There are nevertheless notable disparities in the genesis and migration patterns between helium and gaseous hydrocarbons. Helium necessitates carriers(such as formation water, hydrocarbon fluids, N_(2), mantle-derived fluids, etc.) during both accumulation and long-distance migration processes, where migration conduits are not confined to sedimentary strata, and may extend to the basin's basement, lower crust, and even lithospheric mantle. However, the accumulation conditions of both helium and gaseous hydrocarbons are generally considered equivalent. The presence of gaseous hydrocarbons facilitates both the rapid exsolution of helium within helium-containing fluids and subsequent efficient aggregation in gaseous hydrocarbons, while both reduce helium diffusion and diminish escape flux. In terms of caprock, gypsum, salt, and thick shale as sealing layers contribute to the long-term preservation of helium over geological timescales. Large helium-rich gas fields, predominantly crust-derived gas fields, are primarily concentrated in uplifted zones of ancient cratonic basins and their peripheries. Based on a diagram of the He concentration versus He/N_(2) ratio, crust-derived helium fields can be categorized as basement, combined basement-s

关键词： Helium resource Geochemical characteristics Helium source rock Helium supply pattern Accumulation mechanism Determination of favorable zones

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天然氢气:一种潜在的零碳能源

科学通报 2024年第17期69卷 2344-2350页

作者：刘全有吴小奇孟庆强朱地黄晓伟朱东亚李朋朋金之钧北京大学能源研究院北京100871 中国石油化工股份有限公司石油勘探开发研究院北京102260 页岩油气富集机理与高效开发全国重点实验室北京102260 齐鲁工业大学(山东省科学院)能源研究所济南250014

2023年2月17日,Hand[1]在Science上发表了“Hidden hydrogen:Does Earth hold vast stores of a renewable,carbonfree fuel?”一文,对地球上是否存在巨量的天然氢(H_(2))进行了探讨,引发了全球能源界和科技界对这一可再生零碳能源的热议,“寻找天然氢源的热潮”也入选了Science“2023年度十大科学突破”.H2燃烧产物只有水,不释放CO_(2),因而被认为是最环保的绿色能源.天然H2作为能源转型背景下不可忽视的新能源之一[2],除了在未来一次能源需求中扮演重要角色外,甚至还可能成为气候问题的“解药”[1],同时其在原始有机质分子[3]和地球早期生命形成[4,5]中可能扮演了重要角色,因而得到了国际社会越来越多的关注.

关键词：绿色能源燃烧产物零碳新能源科学突破

Hydrothermal recrystallization of the Lower Ordovician dolomite and its significance to reservoir in northern Tarim Basin

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Science China Earth Sciences 2010年第3期53卷 368-381页

作者： zhu dongya JIN ZhiJun HU WenXuan Petroleum Production and Exploration Institute of China Petroleum and Chemical Corporation Beijing 100083China Department of Earth Sciences Nanjing UniversityNanjing 210093China

Discovered in S15 and some other wells, the Lower Ordovician in the northern Tarim Basin consists mainly of brown gray-dark gray very fine-fine crystalline dolomite, with a minor portion of locally light gray-white medium-coarse crystalline dolomite. Silicification can be observed in the medium-coarse dolomite, and some euhedral drusy quartz can also be found in pores and fractures of the dolomite. The homogenization temperature of the fluid inclusions in the medium-coarse dolomite is between 110 and 200°C with maximum between 140 and 190°C, and the salinity is between 10.7 and 18.5 wt.% NaCl Eq. The homogenization temperature and salinity of the fluid inclusions in the medium-coarse dolomite are similar to those in the drusy quartz. Compared with the very fine-fine dolomite, the medium-coarse phase contains relatively high Fe and Mn. The average concentration of FeO and MnO in the medium-coarse dolomite is 1.917% and 0.323%, respectively. The medium-coarse dolomite has a remarkable negative Eu anomaly, consistent with the REE pattern of the intermediate-felsic igneous rocks in the Tarim Basin. The oxygen isotopic composition of the medium-coarse dolomite is relatively lighter than that of the very fine-fine dolomite. The δ18OPDB values of the medium-coarse dolomite are between -10.35‰ and -7.31‰. The δ18OSMOW values of the fluid associated with the medium-coarse dolomite can be calculated according to homogenization temperature and oxygen isotope fractionation factor between dolomite and fluid, and the calculated values are between +4‰ and +10‰, consistent with those of the hydrothermal fluid. The medium-coarse dolomite has relatively high 87Sr/86Sr ratios as well, indi- cating an origin associated with intermediate-felsic igneous rock. The homogenization temperature, element composition, REE pattern, oxygen and strontium isotopes demonstrate that the medium-coarse dolomite is the result of recrystallization of very fine-fine dolomite under hydrothermal environment

关键词： Tarim hydrothermal dolomite recrystallization reservoir

nNOS-mediated protein-protein interactions:promising targets for treating neurological and neuropsychiatric disorders

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The Journal of Biomedical Research 2021年第1期35卷 1-10页

作者： Yuanyuan Gu dongya zhu Department of Pharmacology School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Institution of Stem Cell and Neuroregeneration School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China

Neurological and neuropsychiatric disorders are one of the leading causes of disability worldwide and affect the health of billions of *** oxide(NO),a free gas with multitudinous bioactivities,is mainly produced from the oxidation of L-arginine by neuronal nitric oxide synthase(nNOS)in the *** nNOS benefits a variety of neurological and neuropsychiatric disorders,including stroke,depression and anxiety disorders,posttraumatic stress disorder,Parkinson’s disease,Alzheimer’s disease,chronic pain,and drug *** to critical roles of nNOS in learning and memory and synaptic plasticity,direct inhibition of nNOS may cause severe side ***,interactions of several proteins,including post-synaptic density 95(PSD-95),carboxyterminal PDZ ligand of nNOS(CAPON)and serotonin transporter(SERT),with the PSD/Disc-large/ZO-1 homologous(PDZ)domain of nNOS have been demonstrated to influence the subcellular distribution and activity of the enzyme in the ***,it will be a preferable means to interfere with nNOS-mediated proteinprotein interactions(PPIs),which do not lead to undesirable ***,we summarize the current literatures on nNOS-mediated PPIs involved in neurological and neuropsychiatric disorders,and the discovery of drugs targeting the PPIs,which is expected to provide potential targets for developing novel drugs and new strategy for the treatment of neurological and neuropsychiatric disorders.

关键词： nNOS PSD-95 CAPON SERT protein-protein interaction neurological and neuropsychiatric disorder

氦气资源的盖层特征探究--以塔里木盆地为例

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地质论评 2024年第3期70卷 1192-1204页

作者：张朝鲲弓明月田伟何衍鑫朱东亚王磊北京大学地球与空间科学学院北京100871 中国石化石油勘探开发研究院北京100083

良好的盖层封盖条件是氦气资源得到保护的关键,在氦气资源潜力评估中有着重要的意义。目前对于氦气资源盖层特征的研究仍处于空白阶段,笔者等对盖层的封盖机理及宏观-微观特征与氦气封盖效果之间的关系进行了探究,认为氦气在地层中保存... 详细信息

良好的盖层封盖条件是氦气资源得到保护的关键,在氦气资源潜力评估中有着重要的意义。目前对于氦气资源盖层特征的研究仍处于空白阶段,笔者等对盖层的封盖机理及宏观-微观特征与氦气封盖效果之间的关系进行了探究,认为氦气在地层中保存的封盖机理主要包括物性、压力、浓度三重封闭。盖层对于氦气的封盖效果受一系列微观特征(孔隙度、渗透率、突破压力、中值半径)与宏观特征(岩性、厚度、成岩作用、连续性、构造作用)影响,含氦气藏载体气类型的不同也会使盖层对于氦气的封闭能力产生差异。基于笔者等归纳出的盖层特征与氦气封盖效果的关系,对塔里木盆地内具有一定的生氦潜力的和田河区块、雅克拉区块、古城区块的氦气资源盖层条件进行评估,评估结果对应实际勘探中含氦气藏的分布情况。综合分析塔里木盆地含氦气藏盖层特征,发现常规评价油气藏封盖条件的方法并不完全适用于氦气资源盖层条件的评估,精准化分析含氦气藏盖层条件的方法仍需进一步探索。

关键词：氦气盖层封盖效能含氦气藏塔里木盆地

Effects of Deep Fluids on Hydrocarbon Generation and Accumulation in Chinese Petroliferous Basins

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Acta Geologica Sinica(English Edition) 2017年第1期91卷 301-319页

作者： zhu dongya LIU Quanyou JIN Zhijun MENG Qingqiang HU Wenxuan State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing 100083 China Petroleum Exploration and Production Research Institute of SINOPEC Beijing 100083 China Department of Earth Sciences Nanjing University Nanjing 210093 Jiangsu China

Deep fluids in a petroliferous basin generally come from the deep crust or mantle beneath the basin basement, and they transport deep substances（gases and aqueous solutions） as well as heat to sedimentary strata through deep faults. These deep fluids not only lead to large-scale accumulations of CO2, CH4, H2, He and other gases, but also significantly impact hydrocarbon generation and accumulation through organic-inorganic interactions. With the development of deep faults and magmatic-volcanic activities in different periods, most Chinese petroliferous basins have experienced strong impacts associated with deep fluid activity. In the Songliao, Bohai Bay, Northern Jiangsu, Sanshui, Yinggehai and Pearl Mouth Basins in China, a series of CO2 reservoirs have been discovered. The CO2 content is up to 99%, with δ-（13）C（CO2） values ranging from-4.1‰ to-0.37‰ and -3He/-4He ratios of up to 5.5 Ra. The abiogenic hydrocarbon gas reservoirs with commercial reserves, such as the Changde, Wanjinta, Zhaozhou, and Chaoyanggou reservoirs, are mainly distributed in the Xujiaweizi faulted depression of the Songliao Basin. The δ-（13）CCH4 values of the abiogenic alkane gases are generally -30‰ and exhibit an inverse carbon isotope sequence of δ-（13）C（CH4）δ-（13）C（C2H6）δ-（13）C（C3H8）δ-（13）C（C4H10）. According to laboratory experiments, introducing external H2 can improve the rate of hydrocarbon generation by up to 147% through the kerogen hydrogenation process. During the migration from deep to shallow depth, CO2 can significantly alter reservoir rocks. In clastic reservoirs, feldspar is easily altered by CO2-rich fluids, leading to the formation of dawsonite, a typical mineral in high CO2 partial pressure environments, as well as the creation of secondary porosity. In carbonate reservoirs, CO2-rich fluids predominately cause dissolution or precipitation of carbonate minerals. The minerals, e.g., calcite and dolomite, show some typical features, such as higher homogenization temperatures th

关键词： petroliferous basin deep fluids organic-inorganic interaction hydrogenation reservoir rock alteration hydrocarbon migration

Organic-Inorganic Interaction Recorded by Polycyclic Aromatic Steranes in Continental Epithermal Ore Deposits

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Acta Geologica Sinica(English Edition) 2023年第1期97卷 327-336页

作者： XU Huiyuan LIU Quanyou JIN Zhijun zhu dongya MENG Qingqiang LI Pengpeng zhu Biqing State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing 100083China Petroleum Exploration&Production Research Institute SINOPECBeijing 100083China Institute of Energy School of Earth cand Space SciencesPeking UniversityBeijing 100871China

Continental epithermal ore deposits are commonly associated with sedimentary organic matter,oils or solid *** organics embedded in mineral deposits can convey valuable information of the ore ***,the extent to which the formation of ore minerals was recorded by organic compounds remains largely unknown,as also is how metal-rich ores interfere with the molecular proxies in the temperature regime envisaged for hydrothermal *** molecular compositional changes of various polycyclic aromatic steranes and polycyclic aromatic hydrocarbons and compounds derived from the Jinding Pb/Zn deposit,SW China provide new *** regular steranes are present as *** transformation from polycyclic aromatic steranes to unsubstituted polycyclic aromatic hydrocarbons is observed to show an increased trend with increasing hydrothermal alteration levels;this is consistent with the transformation from unsubstituted polycyclic aromatic hydrocarbons to heterocyclic ***(aromatization)of polycyclic biological compounds and hydrodecyclization(dearomatization)of polycyclic aromatic compounds are two important reaction pathways in hydrothermal systems with moderate *** detailed investigation of organicinorganic interactions of two groups of polycyclic compounds with metal-rich ores provides insights into the questions on how and to what extent the formation of Pb/Zn deposits can be recorded by *** work will improve our understanding of carbon reduction,oxidation or condensation in the deep Earth and the carbon exchange between the Earth's crust and mantle,and may shed light on the processes for ultra-deep hydrocarbon exploration.

关键词： petroleum resources organic-inorganic interaction biomarker polycyclic compounds hydrothermal environment

Activity of Silica-Rich Hydrothermal Fluid and Its Impact on Deep Dolomite Reservoirs in the Sichuan Basin, Southern China

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Acta Geologica Sinica(English Edition) 2017年第6期91卷 2214-2229页

作者： zhu dongya ZHANG Dianwei LIU Quanyou JIN Zhijun HE Zhiliang State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Petroleum Exploration and Production Research Institute of SINOPEC Laboratory of Structural and Sedimentological Reservoir Geology

Well-developed dissolution pores occur in the dolomites of the Sinian Dengying Formation, which is an important oil and gas reservoir layer in the Sichuan Basin and adjacent areas in southern China. The pores are often filled with quartz, and some dolomites have been metasomatically altered to siliceous chert. Few studies have documented the characteristics, source or origin of silica-rich fluids and their effects on the dolomite reservoir. The peak homogenisation temperatures （Th） of fluid inclusions in pore-filling quartz are between 150~C and 190~C, with an average of 173.7~C. Gases in the inclusions are mainly composed of CO2, CH4 and N2. Compared with host dolomite, pore-filling quartz and metasomatic chert contain higher amounts of Cr, Co, Mo, W and Fe, with average concentrations of 461.58, 3.99, 5.05, 31.43 and 6666.83 ppm in quartz and 308.98, 0.99, 1.04, 13.81 and 4703.50 ppm in chert, respectively. Strontium levels are lower than that in the host dolomite, with average concentrations in quartz and chert of 4.81 and 11.06 ppm, respectively. Rare earth element compositions in quartz and chert display positive Eu anomalies with a maximum δEu of 5.72. The δDsMow values of hydrogen isotopes in water from quartz inclusions vary from -85.1‰ to -53.1‰ with an average of-64.3‰, whereas the δ18OsMow values range from 7.2‰ to 8.5‰ with an average of 8.2‰. The average 87Sr/86Sr ratios in quartz and chert are 0.711586 and 0.709917, respectively, which are higher than that in the host dolomite. The fluid inclusions, elemental and isotopic compositions demonstrate that the formation of quartz and chert was related to silica-rich hydrothermal fluid and that the fluid was the deep circulation of meteoric water along basement faults. Interactions with silica-rich hydrothermal fluids resulted in densification of dolomite reservoirs in the Dengying Formation through quartz precipitation and siliceous metasomatism. However, it increased the resistance of the host dolomite to

关键词： Dengying Formation dolomite silica-rich hydrothermal fluid quartz rare earth element,Sichuan Basin

Distribution and Geochemical Characteristics of Hydrogen in Natural Gas from the Jiyang Depression, Eastern China

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Acta Geologica Sinica(English Edition) 2015年第5期89卷 1616-1624页

作者： MENG Qingqiang SUN Yuhua TONG Jianyu FU Qi zhu Jun zhu dongya JIN Zhijun Petroleum Exploration and Production Research Institute Sinopec Laboratory of sedimentary-tectonic reservoir PEPRIS Key Laboratory of Tectonics and Petroleum Resources (China University of Geosciences) Ministry of Education Geological Scientific Research Institute Shengli Oilfield Sinopec Jidong Branch Petrochina Department of Earth and Atmospheric Sciences University of Houston Bin’nan Oil Production Plant Shengli Oilfield

Hydrogen gas accelerates hydrocarbon generation, but little is known about its distribution and origin in petroliferous basins, which has hindered the further *** the Jiyang Depression in eastern China as an example, this study collected natural gas from different tectonic units, and analyzed various geochemical characters including gas contents, and carbon and hydrogen isotopic *** result shows that：（1） hydrogen gas is widespread distributed, but its content is very low, which typically ranges from 0.01% to 0.1% in this region;（2） the ratios of H2/3He, indicative of the origins of hydrogen gas, suggest that mantle-derived hydrogen is *** in tectonically stable areas absent with deep fluid activities, there is also mantle-derived;（3） the isotopic composition of hydrogen falls in the range of –798‰ to –628‰（relative to VSMOW standard）.In areas with deep-derived fluids, the hydrogen gas has a similar isotopic composition with the previously documented deep-sourced gas, with lighter isotopic *** contrast, hydrogen gas has a heavier isotopic composition in relatively stable *** isotopic signatures suggest that there is a mixture of mantle- and crust-derived hydrogen gas in the relatively stable area, which is consistent with the H2/3He ***, it is clear that the hydrogen gas has a much wider distribution than found in the deep-derived fluid area, resulting in a much broader area with hydrogenating effect for resource *** understanding will provide new insights for hydrocarbon generation research and resource assessment in petroliferous basins.

关键词： isotope genesis hydrogen gas deep fluid Jiyang Depression