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Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng Zhou Wei Yang di zhu Bi-Fei Wu Hai-Bin Shi Sheng Liu Wei-Zhong Zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

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Flow field design and experimental investigation of electrochemical machining on blisk

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Chinese Journal of Aeronautics 2022年第8期35卷 295-303页

作者： Jianwei GUO Dong zhu di zhu College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Flow field is a crucial factor to influence the stability and surface quality in the electrochemical machining(ECM)of blisks.A four-way flow mode was proposed to eliminate mixing regions of electrolyte at the leading and tailing *** flow field models were described separately in this report:a W-shaped flow mode and a four-way flow *** flow field was analyzed through a finite element *** results showed that,in comparison with the W-shaped flow mode,the distribution of electrolyte flow was more uniformed and the mixed region in the flow channel was *** pressure of the leading and tailing edges inlets was optimized,and optimal pressure of 0.6 MPa was *** addition,verification experiments were performed,and the results showed that the stability,efficiency,and quality of the profiles of the blisk blade manufactured by ECM were enhanced in the new flow mode.

关键词： Blisk Electrochemical machining Electrolyte Flow field Surface quality

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Effects of process parameters on mechanical properties of abrasive-assisted electroformed nickel

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Chinese Journal of Aeronautics 2016年第4期29卷 1096-1102页

作者： Ren Jianhua zhu Zengwei zhu di College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

A cathode mandrel with translational and rotational motion, which was supposed to obtain uniform friction effect on surface, was employed in abrasive-assisted electroforming for revolving parts with complex profile. The effects of current density, translational speed and rotational speed on the deposit properties were studied by orthogonal test. The tensile strength, elongation and micro hardness value were measured to find out how the factors affected the properties. The optimized results show that changes of current density affect the tensile strength of nickel layer most, while translational speed has the most remarkable influences on both elongation and micro hardness. The low rotational speed affects the properties least. In this experiment, a smooth nickel layer with tensile strength 581 MPa, elongation 17% and micro hardness 248HV is obtained by the orthogonal test. (C) 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd.

关键词： Abrasive Cathode compound motion Electroforming Mechanical properties Nickel

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Single Emulsion Microfluidic Production of Janus and Core-Shell Particles via Off-chip Polymerization

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Chinese Journal of Polymer Science 2016年第3期34卷 367-377页

作者： ai-di zhu 郭明雨 Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of AdvancedFunctional Polymer Design and Application College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

In this work, we describe a straightforward approach to produce monodisperse Janus and core-shell particles by using organic solvent free single emulsion droplet-based microfluidic device combining with off-chip polymerization. To accomplish this, methyl methacrylate（MMA） was used as both the oil phase and solvent to dissolve a polymerizable PEGbased macromolecular surfactant, instead of traditional surfactant, and the photo-initiator. Janus particles can be easily obtained by off-chip UV polymerization due to polymerization induced phase separation between PEG and the formed poly（methyl methacrylate）. At the same time, core-shell particles can also be easily attained by inverting the original collecting tube several times and then exposing to UV light. These results may extend the scope of microfluidic technology and the studies on polymerization induced self-assembly/phase-separation into easy fabrication of various new functional materials.

关键词： Microfluidics Single emulsion Core-Shell spheres Janus particles Polymerization-induced phase-separation

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Improving profile accuracy and surface quality of blisk by electrochemical machining with a micro inter-electrode gap

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Chinese Journal of Aeronautics 2023年第4期36卷 523-537页

作者： Jingtao WANG Zhengyang XU di zhu College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Electrochemical machining(ECM)has emerged as an important option for manufacturing the *** inter-electrode gap(IEG)distribution is an essential parameter for the blisk precise shap-ing process in ECM,as it affects the process stability,profile accuracy and surface *** IEG leads to a poor localization effect and has an adverse influence on the machining accuracy and surface quality of *** achieve micro-IEG(ding/trailing edges was limited to within 91 ***-pared with the currently-established process,the profile accuracy of the blade’s concave and convex profiles was improved by 50.5%and 53.3%,*** surface quality was improved by 53.2%and 50.9%,***,the machined surface was covered with small corrosion pits and weak attacks of the grain boundary due to selective *** electrolytic products were dispersed on the machined surface,and their components were mainly composed of the carbide and oxide products of Ti and Nb *** results indicate that the variable-parameters strategy is effective for achieving a tiny IEG in blisk ECM,which can be used in engineering practice.

关键词： Electrochemical machining Blisk IEG Machining quality Surface quality

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Effects of Shielding Coatings on the Anode Shaping Process during Counter-rotating Electrochemical Machining

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Chinese Journal of Mechanical Engineering 2016年第5期29卷 971-976页

作者： WANG Dengyong zhu Zengwei WANG Ningfeng zhu di College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

Electrochemical machining （ECM） has been widely used in the aerospace, automotive, defense and medical industries for its many advantages over traditional machining methods. However, the machining accuracy in ECM is to a great extent limited by the stray corrosion of the unwanted material removal. Many attempts have been made to improve the ECM accuracy, such as the use of a pulse power, passivating electrolytes and auxiliary electrodes. However, they are sometimes insufficient for the reduction of the stray removal and have their limitations in many cases. To solve the stray corrosion problem in CRECM, insulating and conductive coatings are respectively used. The different implement processes of the two kinds of coatings are introduced. The effects of the two kinds of shielding coatings on the anode shaping process are investigated. Numerical simulations and experiments are conducted for the comparison of the two coatings. The simulation and experimental results show that both the two kinds of coatings are valid for the reduction of stray corrosion on the top surface of the convex structure. However, for insulating coating, the convex sidewall becomes concave when the height of the convex structure is over 1.26 ram. In addition, it is easy to peel off by the high-speed electrolyte. In contrast, the conductive coating has a strong adhesion, and can be well reserved during the whole machining process. The convex structure fabricated by using a conductive iron coating layer presents a favorable sidewall profile. It is concluded that the conductive coating is more effective for the improvement of the machining quality in CRECM. The proposed shielding coatings can also be employed to reduce the stray corrosion in other schemes of ECM.

关键词： counter-rotating electrochemical machining stray corrosion insulating coating conductive coating

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Trajectory control strategy of cathodes in blisk electrochemical machining

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Chinese Journal of Aeronautics 2013年第4期26卷 1064-1070页

作者： zhu Dong zhu di Xu Zhengyang Zhou Laishui College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University

A turbine blisk, which combines blades and a disk together, is one of the most important components of an aero engine. In the process of blisk electrochemical machining （ECM）, the sheet cathode, which is usually used as a tool electrode, has a complicated structure. In addition to that, the channel between the adjacent blades is narrow and twisted, so interference is apt to happen when the sheet cathode feeds into the channel. Therefore, it is important to choose suitable trajectory control strategy. In this paper, a new trajectory control strategy of the sheet cathode is presented and corresponding simulation analysis is conducted on the basis of an actual blisk model. The simulation results demonstrate that the sheet cathode can feed into the channel by a spatial line trajectory without interference. Moreover, the verification experiments are carried out according to the simulation. The experimental results show that the cathode can move into the channel without interference. It is verified that the new trajectory control strategy is correct and can be used in the blisk ECM process successfully.

关键词： Blisk Cathodes Electrochemical machining Feed Trajectory control

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Convex shaping process simulation during counter-rotating electrochemical machining by using the finite element method

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Chinese Journal of Aeronautics 2016年第2期29卷 534-541页

作者： Wang Dengyong zhu Zengwei Wang Hongrui zhu di Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Nanjing Institute of Technology Nanjing 211167 China

In counter-rotating electrochemical machining （CRECM）, a revolving cathode tool with hollow windows of various shapes is used to fabricate convex structures on a revolving part. During this process, the anode workpiece and the cathode tool rotate relative to each other at the same rotation speed. In contrast to the conventional schemes of ECM machining with linear motion of a block tool electrode, this scheme of ECM is unique, and has not been adequately studied yet. In this paper, the finite element method （FEM） is used to simulate the anode shaping process during CRECM, and the simulation process which involves a meshing model, a moving boundary, and a simulation algorithm is described. The simulated anode profiles of the convex structure at different processing times show that the CRECM process can be used to fabricate convex structures of various shapes with different heights. Besides, the variation of the inter-electrode gap indicates that this process can also reach a relative equilibrium state like that in conventional ECM. A rectangular convex and a circular convex are successfully fabricated on revolving parts. The experimental results indicate relatively good agreement with the simulation results. The proposed simulation process is valid for convex shaping prediction and feasibility studies as well.

关键词： Counter-rotating Convex shaping process Electrochemical machining Finite element method Inter-electrode gap

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Machining of a film-cooling hole in a single-crystal superalloy by high-speed electrochemical discharge drilling

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Chinese Journal of Aeronautics 2016年第2期29卷 560-570页

作者： Zhang Yan Xu Zhengyang zhu Yun zhu di College of Mechanical and Electrical Engineering Nanjing University of Aeronautics & Astronautics

Single-crystal superalloys are typical advanced materials used for manufacturing aero- engine turbine blades. Their unique characteristics of high hardness and strength make them exceedingly difficult to machine. However, a key structure of a turbine blade, the film-cooling hole, needs to be machined in a single-crystal superalloy; such machining is challenging, especially considering the increasing levels of machining efficiency and quality demanded by the aeroengine industry. Tube electrode high-speed electrochemical discharge drilling （TSECDD）, a hybrid technique of high-speed electrical discharge drilling and electrochemical machining, provides high machining efficiency and accuracy, as well as eliminating the recast layer. In this study, TSECDD is used to machine a film-cooling hole in a nickel-based single-crystal superalloy （DD6）. The Tagu- chi methods of experiment are used to optimise the machining parameters. Experimental results show that TSECDD can effectively drill the film-cooling hole; the optimum parameters that give the best performance are as follows： pulse duration： 12μs, pulse interval： 30 gs, peak current： 6 A, and salt solution conductivity： 3 mS/cm. Finally, a hole is machined by TSECDD, and the results are compared with those obtained by electrical discharge machining. TSECDD is found to be promising for improving the surface quality and eliminating the recast layer.

关键词： Electrical discharge machin-ing (EDM) Electrochemical machining(ECM) Film-cooling hole Hybrid technique Single crystal Taguchi methods

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Mechanical electrodeposition of bright nanocrystalline nickel

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Science China(Technological Sciences) 2008年第7期51卷 911-920页

作者： zhu ZengWei zhu di QU NingSong College of Mechanical and Electrical Engineering Nanjing University of Aeronautics&AstronauticsNanjing 210016China

A new mechanical electrodeposition technology was proposed, and nanocrystalline nickel deposit with bright and smooth surface was prepared in the bath without any additive agents. Unlike traditional methods, the novel technology employed dynamical hard particles to continuously polish the cathode surface and disturb the nearby solution during electrodepositing. Experimental results showed that the polishing effect of hard particles can effectively prevent the hydrogen bubbles and impurities from adhering on the deposit surface and avoid the production of pits, pinholes and nodules. Furthermore, comparing with the deposit prepared by traditional methods, the one prepared by the novel technology was substantially refined with grain size ranging from 30 to 80 nm. Every diffraction peak's intensity of the deposit was reduced, the preferential orientation degree of (200) decreased and those of (111) and (220) increased. The microhardness notably increased. The magnetic properties were also changed with decreased saturation magnetization and increased coercive force. It was also found that variation of current density and cathode rotational speed could affect the structure and properties of the nickel deposits prepared by this technology.

关键词： electrodeposition electroforming hard particle nanocrystalline bright nickel

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