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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Effect of Optimum Plastic Depth on Stresses and Load-bearing Capacity of Autofrettaged Cylinder

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Chinese Journal of Mechanical Engineering 2013年第2期26卷 365-370页

作者： zhu Ruilin zhu Guolin Polytechnic College Hunan Normal University Basic Courses Department Jiangxi Police College

Autofrettage is an effective measure to even distribution of stresses and raise load-bearing capacity for （ultra-）high pressure apparatus. Currently, the research on autofrettage has focused mostly on specific engineering problems, while general theoretical study is rarely done. To discover the general law contained in autofrettage theory, by the aid of the authors’ previous work and according to the third strength theory, theoretical problems about autofrettage are studied including residual stresses and their equivalent stress, total stresses and their equivalent stress, etc. Because of the equation of optimum depth of plastic zone which is presented in the authors’ previous work, the equations for the residual stresses and their equivalent stress as well as the total stress and their equivalent stress are simplified greatly. Thus the law of distribution of the residual stresses and their equivalent stress as well as the total stress and their equivalent stress and the varying tendency of these stresses are discovered. The relation among various parameters are revealed. The safe and optimum load-bearing conditions for cylinders are obtained. According to the results obtained by theoretical analysis, it is shown that if the two parameters, namely ratio of outside to inside radius, k, and depth of plastic zone, kj, meet the equation of optimum depth of plastic zone, when the pressure contained in an autofrettaged cylinder is lower than two times the initial yield pressure of the unautofrettaged cylinder, the equivalent residual stress and the equivalent total stress at the inside surface as well as the elastic-plastic juncture of a cylinder are lower than yield strength. When an autofrettaged cylinder is subjected to just two times the initial yield pressure of the unautofrettaged cylinder, the equivalent total stress within the whole plastic zone is just identically equal to the yield strength, or it is a constant. The proposed research theoretically depicts the st

关键词： thick-wall cylinder autofrettage residual stress load-bearing capacity

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基于多尺度融合金字塔焦点网络的接触网零部件检测

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工程科学学报 2025年第2期47卷 315-327页

作者：朱新宇崔浩锐宋洋中国民用航空飞行学院航空电子电气学院广汉618307 西南交通大学利兹学院成都611756

作为高铁牵引供电系统的重要组成部分,接触网系统承担着向动车组传输电能的重要功能.实际工程运营表明,受弓网交互产生的持续冲击以及外部环境的影响,接触网支撑部件可能会出现“松、脱、断、裂”等缺陷,导致接触网结构可靠性下降,严重... 详细信息

作为高铁牵引供电系统的重要组成部分,接触网系统承担着向动车组传输电能的重要功能.实际工程运营表明,受弓网交互产生的持续冲击以及外部环境的影响,接触网支撑部件可能会出现“松、脱、断、裂”等缺陷,导致接触网结构可靠性下降,严重影响接触网系统稳定运行.因此,及时精确定位接触网支撑部件(CSCs),对保障高铁安全运行和完善接触网检修维护策略具有重大意义.然而,CSCs的检测通常面临着零部件种类多、尺度差异大、部分零部件微小的问题.针对以上问题,本文提出一种基于多尺度融合金字塔焦点网络的接触网零部件检测算法,将平衡模块和特征金字塔模块相结合,提高对小目标的检测性能.首先,设计了可分离残差金字塔聚合模块(SRPAM),用于优化模型多尺度特征提取能力、扩大感受野,缓解CSCs检测的多尺度问题;其次,设计了一种基于平衡特征金字塔的路径聚合网络(PA-BFPN),用于提升跨层特征融合效率和小目标检测性能.最后,通过对比试验、可视化实验和消融实验证明了所提方法的有效性和优越性.其中,所提的MFPFCOS在CSCs数据集上的检测精度(mAP)能够在达到48.6%的同时,实现30的FLOPs(Floating point operations per second),表明所提方法能够在检测精度和检测速度之间保持良好的平衡.

关键词：深度学习目标检测接触网支撑组件(CSCs) 路径聚合特征金字塔(PA-FPN) 空洞空间卷积池化金字塔(ASPP)

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基于双目视觉技术的茶叶嫩芽定位方法研究

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农机化研究 2025年第2期47卷 49-53页

作者：朱龙舜郑旻璐东南大学成贤学院南京210088 南京机电职业技术学院南京211306

进一步提升茶叶嫩芽定位的准确性及茶叶嫩芽采摘的作业效率,选取双目视觉技术作为切入点,针对其识别、定位、采摘等环节展开设计研究。考虑茶叶嫩芽采摘的基础特征和双目视觉技术的应用条件,合理搭建双目视觉模型,选用立体匹配的核心定... 详细信息

进一步提升茶叶嫩芽定位的准确性及茶叶嫩芽采摘的作业效率,选取双目视觉技术作为切入点,针对其识别、定位、采摘等环节展开设计研究。考虑茶叶嫩芽采摘的基础特征和双目视觉技术的应用条件,合理搭建双目视觉模型,选用立体匹配的核心定位算法,完成茶叶嫩芽的定位方法与采摘功能优化,并布置相应的试验机构,展开定位采摘验证试验。结果表明:基于双目视觉技术的茶叶嫩芽定位方法应用具有显著的优越性,较普通定位方法而言,识别误匹配率可降低至4.01%,平均漏采率为3.20%,嫩芽采摘完整率达93.40%,可以很好地促进茶叶嫩芽的后续处理加工,是采摘茶叶嫩芽的品质化的重要基础保障。

关键词：茶叶嫩芽定位双目视觉立体匹配采摘完整率品质化

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FDNet: Fourier transform guided dual-channel underwater image enhancement diffusion network

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Science China Technological Sciences 2025年第1期 62-78页

作者： Zhen zhu Xiaobo LI Qianwen MA Jingsheng ZHAI Haofeng HU School of Marine Science and Technology Tianjin University College of Mechanical Engineering and Automation Fuzhou University

Due to the scattering and absorption of light, underwater imaging yields suboptimal results characterized by low brightness, diminished image contrast, and the loss of details. Current learning-based underwater image enhancement(UIE)methods mainly focus on addressing these issues in the spatial domain, with limited attention to the Fourier frequency *** propose the Fourier transform guided dual-channel underwater image enhancement diffusion network(FDNet), aiming to fully leverage frequency domain information and the characteristics of a diffusion-based generation model. The amplitude-phase dualchannel not only effectively provides feedback on the energy distribution of the image but also incorporates crucial image structure and texture information. Capitalizing on these advantages, we first introduce a Fourier transform-based amplitude-phase dualchannel enhancement front-end network for UIE. This network significantly improves the quality of the network's image input,including brightness and contrast, by incorporating phase congruency edge enhancement and prior-driven amplitude mapping strategies. The preceding network mitigates the overall training challenges caused by poor input image quality. Simultaneously,the application of denoising networks based on lightweight transformers effectively improves the computational time required for each iteration during model training. The results indicate that FDNet outperforms many current learning-based UIE algorithms in restoring images across multiple real underwater image datasets, demonstrating more robust generalization capabilities in degraded underwater scenarios. The competitive performance advantage achieved in enhancing visual quality underscores the effectiveness of our method.

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Group Multi-Role Assignment With Conflicting Roles and Agents

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IEEE/CAA Journal of Automatica Sinica 2020年第6期7卷 1498-1510页

作者： Haibin zhu IEEE Department of Computer Science and Mathematics Nipissing UniversityNorth BayOntarioP1B 8L7Canada

Group role assignment(GRA)is originally a complex problem in role-based collaboration(RBC).The solution to GRA provides modelling techniques for more complex *** with constraints(GRA+)is categorized as a class of complex assignment *** present,there are few generally efficient solutions to this category of *** special problem case requires a specific *** multi-role assignment(GMRA)and GRA with conflicting agents on roles(GRACAR)are two problem cases in GRA+.The contributions of this paper include:1)The formalization of a new problem of GRA+,called group multi-role assignment with conflicting roles and agents(GMAC),which is an extension to the combination of GMRA and GRACAR;2)A practical solution based on an optimization platform;3)A sufficient condition,used in planning,for solving GMAC problems;and 4)A clear presentation of the benefits in avoiding conflicts when dealing with *** proposed methods are verified by experiments,simulations,proofs and analysis.

关键词： Group Multi-Role Assignment With Conflicting Roles and Agents

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Latent Variable Regression for Supervised Modeling and Monitoring

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IEEE/CAA Journal of Automatica Sinica 2020年第3期7卷 800-811页

作者： Qinqin zhu Department of Chemical Engineering University of WaterlooON N2L 3G1Canada

A latent variable regression algorithm with a regularization term(r LVR) is proposed in this paper to extract latent relations between process data X and quality data Y. In rLVR,the prediction error between X and Y is minimized, which is proved to be equivalent to maximizing the projection of quality variables in the latent space. The geometric properties and model relations of rLVR are analyzed, and the geometric and theoretical relations among r LVR, partial least squares, and canonical correlation analysis are also presented. The rLVR-based monitoring framework is developed to monitor process-relevant and quality-relevant variations simultaneously. The prediction and monitoring effectiveness of rLVR algorithm is demonstrated through both numerical simulations and the Tennessee Eastman(TE) process.

关键词： Data analytics inferential monitoring latent variable regression regularization

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水力循环高架设施栽培装置优化设计及试验分析

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农机化研究 2025年第2期47卷 165-170,185页

作者：朱庆松严露露李玉斌白东方朱赞彬信阳农林学院河南信阳464000

高架设施栽培模式提升了温室作物的产量和质量。为此,针对固定式高架设施遮荫问题,通过测定30°、40°、50°、60°等不同角度栽培装置的光照遮阴变化情况,确定了基于光照因素的最优高架栽培架式角度为50°。为了解决固定式高架设施角... 详细信息

高架设施栽培模式提升了温室作物的产量和质量。为此,针对固定式高架设施遮荫问题,通过测定30°、40°、50°、60°等不同角度栽培装置的光照遮阴变化情况,确定了基于光照因素的最优高架栽培架式角度为50°。为了解决固定式高架设施角度过大、底层作物光照不足等问题,利用温室控温管路系统中水的压力,创新设计了一种以水轮机为动力的自动循环高架装置,分析了结构组成及工作原理,采用SolidWorks软件设计了三维模型。同时,通过Fluent模拟分析不同型号叶轮作用下的水力压力和速度变化,确定了双列直线型六叶轮为最优叶轮选型。装置是以水力产生动力使栽培槽围绕支架匀速转动,为高架设施架式设计提供一种新思路,在创造良好光照条件的同时减少能源的消耗,具有较高的经济效益,在实际生产中具有一定的推广应用价值。

关键词：高架设施栽培装置水力循环优化设计

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Incorporating truncated fractal distribution into Maxwell model to quantify thermal conductivity and its uncertainty in heterogeneous multiparticle systems

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Particuology 2023年第9期80卷 81-89页

作者： Jianting zhu Department of Civil and Architectural Engineering and Construction Management University of WyomingLaramieWY82071USA

An approach is developed to examine the mean and uncertainty of thermal conductivity of a heterogeneous multiparticle system,where the particle concentration or void fraction is treated as a truncated fractal *** truncated fractal distribution is then integrated into the Maxwell model,which is equivalent to a cell model in which the multiparticle system is conceptualized as a spherical fluid cell that envelopes a solid *** developed mean thermal conductivity is compared with four experimental data sets of liquid-saturated media from the *** effect of fractal characteristics is quantified and *** particle concentration or void fraction truncated fractal distribution can better capture scatters in the experimental *** thermal conductivity and its standard deviation decrease with increasing fractal *** the void fraction is truncated fractal,the uncertainty increases mostly in the low mean void fraction range and drops more quickly with the increasing mean void fraction compared to the case where the particle concentration is truncated *** a typical case of multiparticle system when the solid particles are more conductive than the fluid,the faster increase rate of standard deviation with the ratio of solid over fluid conductivities occurs when the mean void fraction is smaller.

关键词： Thermal conductivity Heterogeneous multiparticle system Truncated fractal distribution Particle concentration Void fraction

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使用合规农药能确保农产品“地头”质量安全吗?——基于豇豆农户的扎根理论分析

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海南大学学报（人文社会科学版） 2025年第1期43卷 119-128页

作者：樊孝凤张娇朱月季海南大学国际商学院海南海口570228

新的农产品质量安全法首次将小农户施药行为纳入监管范围,进一步厘清农户施药行为的影响机理与因素,有助于政府精准施策。通过对海南3个村32户农民豇豆种植过程的全程蹲点跟踪,对豇豆施药环节的参与式观察与深度访谈,运用扎根理论分析... 详细信息

新的农产品质量安全法首次将小农户施药行为纳入监管范围,进一步厘清农户施药行为的影响机理与因素,有助于政府精准施策。通过对海南3个村32户农民豇豆种植过程的全程蹲点跟踪,对豇豆施药环节的参与式观察与深度访谈,运用扎根理论分析了访谈资料。研究发现:农户施药环节是一个复杂的行为选择过程,即使施用合规农药也不能确保农产品在产地的质量安全。在合规农药视角下影响农户施药行为选择的最重要因素是信息渠道,其次是农产品质量安全管理的政策强度、农产品市场价格和农村劳动用工成本。同时,邻里效应在农户施药行为选择中的作用越来越弱。在此基础上提出,要增加农户用药信息的有效供给渠道,加强农产品质量安全的全面检测,坚持为农户提供形式多样的有针对性的有效培训,增加重要食用农产品质量安全关键技术供给与推广,加强农产品“优质优价”市场建设的政策建议,并进一步指出海南自贸港建设和RECP协议实施背景下提升海南农产品质量安全水平的紧迫性。

关键词：合规农药施药行为农产品质量安全扎根理论

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