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Near-perfect replication on amorphous alloy. through active force modulation based on machine learning/neural network parameter prediction

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Science China(Phy.ics,Mechanics & Astronomy. 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan Meng Zheng Wang Ruisong zhu Ruijie Liu Jiang Ma Lina Hu Weihua Wang Key.Laboratory.for Liquid-Solid Structural Evolution and Processing of Materials (Ministry.of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and Control Engineering Shenzhen University Songshan Lake Materials Laboratory Institute of Phy.ics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remarkable superplasticity.in the supercooled liquid region, amorphous alloy. or metallic glasses(MGs) are regarded as ideal materials for miniature fabrication. However, due to the intrinsic metastable nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely.relied on trial-and-error *** this work, a low-frequency.active force modulation sy.tem is employ.d to apply.a stable, precise, and real-time feedback stress field for imprinting of MG samples. Low-frequency.vibrations can facilitate the filling of microstructures on the template surface by.reducing the effective viscosity.of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy.based on back-propagation(BP) neural networks was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal combination of imprinting process parameters was identified, and its filling ratio was experimentally.validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority.of the active force modulation sy.tem and the data-driven strategy.of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy.cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

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A Cross Attention Transformer-Mixed Feedback Video Recommendation Algorithm Based on DIEN

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Computers, Materials & Continua 2025年第1期82卷 977-996页

作者： Jianwei Zhang Zhishang Zhao Zengy. Cai y.an Feng Liang zhu y.hui Sun College of Software Engineering Zhengzhou University of Light IndustryZhengzhou450000China Faculty.of Information Engineering Xuchang Vocational Technical CollegeXuchang461000China College of Computer Science and Technology Zhengzhou University of Light IndustryZhengzhou450000China College of Electronics and Information Zhengzhou University of Light IndustryZhengzhou450000China

The rapid development of short video platforms poses new challenges for traditional recommendation *** sy.tems ty.ically.depend on two ty.es of user behavior feedback to construct user interest profiles:explicit feedback(interactive behavior),which significantly.influences users’short-term interests,and implicit feedback(viewing time),which substantially.affects their long-term ***,the previous model fails to distinguish between these two feedback methods,leading it to predict only.the overall preferences of users based on extensive historical behavior ***,it cannot differentiate between users’long-term and shortterm interests,resulting in low accuracy.in describing users’interest states and predicting the evolution of their *** paper introduces a video recommendationmodel calledCAT-MFRec(CrossAttention Transformer-Mixed Feedback Recommendation)designed to differentiate between explicit and implicit user feedback within the DIEN(Deep Interest Evolution Network)*** study.emphasizes the separate learning of the two ty.es of behavioral feedback,effectively.integrating them through the cross-attention ***,it leverages the long sequence dependence capabilities of Transformer technology.to accurately.construct user interest profiles and predict the evolution of user *** results indicate that CAT-MF Rec significantly.outperforms existing recommendation methods across various performance *** advancement offers new theoretical and practical insights for the development of video recommendations,particularly.in addressing complex and dy.amic user behavior patterns.

关键词： Video recommendation user interest cross-attention transformer

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The emerging role of nitric oxide in the sy.aptic dy.function of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiy.ng Chen y.ny. Xiong Qin Zhou Ling-Qiang zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary.Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophy.iology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by.cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely.related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly.improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,sy.aptic dy.function is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple phy.iological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating sy.aptic plasticity.and play. an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in phy.iological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of sy.aptic dy.function,neuroinflammation,oxidative stress,and blood-brain barrier dy.function that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway.using certain specific approaches may.provide a novel therapeutic strategy.for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide sy.thase gene therapy nitric oxide NO-sGC-cGMP pathway sy.aptic dy.function vascular dementia

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Molecule‑Level Multiscale Design of Nonflammable Gel Poly.er Electroly.e to Build Stable SEI/CEI for Lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi Sun Zelong Gong Tao Zhang Jiafeng Li Xianli zhu Ruixiao zhu Lingxu Wang Ley.an Ma Xuehui Li Miaofa y.an Zhiwei Zhang Luy.an Zhang Zhao Qian Longwei y.n Rajeev Ahuja Chengxiang Wang Key.Laboratory.for Liquid‑Solid Structural Evolution and Processing of Materials(Ministry.of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability.is an unavoidable issue for gel poly.er electroly.es(GPEs).Usually.flameretardant solvents are necessary.to be used,but most of them would react with anode/cathode easily.and cause serious interfacial instability.which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by.in situ poly.erizing trifluoroethy. methacry.ate(TFMA)monomers with flame-retardant triethy. phosphate(TEP)solvents and LiTFSI–LiDFOB dual lithium *** is strongly.anchored to PTFMA matrix via polarity.interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously.mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of Li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electroly.e interface/cathode electroly.e interface *** coordination structure changes Li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity.to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The Li|SGPE|Li cell presents highly.reversible Li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V LiCoO_(2)|SGPE|Li battery.delivers high average specific capacity.120 mAh g^(−1) over 200 *** study.paves a new way.to make nonflammable GPE that is compatible with Li metal anode.

关键词： Anchoring effect Nonflammable gel electroly.e In situ cross-linked Electrode-electroly.e interface Li metal battery

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Inhibition of Forkhead Box 01 Protects Pancreatic beta-Cells against Dexamethasone- Induced Dy.function

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南京医科大学学报（自然科学版） 2009年第11期29卷 1618-1618页

作者： Zhang, X. F. y.ng, W. Lv, J.H. zhu, y. X. Zhang, J. J. Chen, F. Zhang, R. H. y.ng, T. Sun,y.J. Han, X. Nanjing Med Univ Affiliated Hosp 1 Key Lab Human Funct Genom Jiangsu ProvNanjing 210029 Peoples R China. Nanjing Med Univ Affiliated Hosp 1 Dept Endocrinol Jiangsu Diabet Ctr Nanjing 210029 Peoples R China Nanjing Med Univ Affiliated Hosp 1 Dept Gen Surg Nanjing 210029 Peoples R Chin

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Observation of acoustic hy.rid topological phases induced by.the p-d orbital interactions

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Science China(Phy.ics,Mechanics & Astronomy. 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao y.-Gui Peng Peng Wu Zong-Lin Li Xue-Feng zhu School of Phy.ics and Innovation Institute Huazhong University of Science and Technology

In spinless sy.tems,growing attention has recently.been attracted to sy.thetic gauge fields,which redefine the fundamental cry.tal sy.metries by.utilizing the projective algebraic ***,sy.thetic gauge fields have been commonly.investigated in single orbital sy.tems,and explorations on hy.rid orbitals remain elusive in ***,we report the experimental observation of hy.rid topological phases induced by.hy.rid sy.thetic gauge flux,which is formed by.the interaction between p and d orbitals embedded in acoustic *** breaking the translation sy.metries of Lxand/or Ly.we unambiguously.demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by.hy.rid-orbitals interactions and initializing the framework of hy.rid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality.sensing and robust wave trapping due to the stepwise energy.distribution of the hy.rid topological phase.

关键词： topological insulator sy.thetic gauge field projective sy.metry corner states

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Constructing Donor–Acceptor‑Linked COFs Electroly.es to Regulate Electron Density.and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang Ma Conghui Zhang y.ngxin y.ng Shuy.an y. Haiy. zhu y.ngjiang Sun Hong Guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China y.nnan y.ntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density.of solid-state electroly.e by.donor–acceptor(D–A)sy.tem can achieve highly.selective Li^(+)transportation and conduction in solid-state Li metal *** study.reports a high-performance solid-state electroly.e thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electroly.e,the developed concept with D–A-linked COFs not only.achieves electronic modulation to promote highly.selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity.to understand the role of electronic density.in solid-state Li metal *** introduced strong electronegativity.F-based ligand in COF electroly.e results in highly.elective Li^(+)(transference number 0.83),high ionic conductivity.6.7×10^(-4)S cm^(−1)),excellent cy.lic ability.1000 h)in Li metal sy.metric cell and high-capacity.retention in Li/LiFePO_(4)cell(90.8%for 300 cy.les at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphy.in and acceptor F atoms,which effectively.expedites electron transferring from porphy.in to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy.for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A sy.tem.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

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Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei zhu Zhey. Zhang Min y. Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy.of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only.affects the brain,but also induces metabolic dy.function in peripheral organs and alters the gut *** aim of this study.was to investigate sy.temic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analy.ed peripheral organ metabolism and the gut microbiota in amy.oid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by.untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with y.unger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney.metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely.related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney.axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amy.oid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu y.qing Liu Hongli Li Lemei zhu Lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina y.ngsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary.cause of dementia,is characterized by.neuropathologies,such as amy.oid plaques,sy.aptic and neuronal degeneration,and neurofibrillary.*** amy.oid plaques are the primary.characteristic of Alzheimer's disease in the central nervous sy.tem and peripheral organs,targeting amy.oid-beta clearance in the central nervous sy.tem has shown limited clinical efficacy.in Alzheimer's disease *** abnormalities are commonly.observed in patients with Alzheimer's *** liver is the primary.peripheral organ involved in amy.oid-beta metabolism,play.ng a crucial role in the pathophy.iology.of Alzheimer's ***,impaired cholesterol metabolism in the liver may.exacerbate the development of Alzheimer's *** this review,we explore the underly.ng causes of Alzheimer's disease and elucidate the role of the liver in amy.oid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy.for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amy.oid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density.lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxy.holic acid

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Dip2a regulates stress susceptibility.in the basolateral amy.dala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai Meng Tian Huali y. Xiaoxiao He Xiaojuan zhu Key.Laboratory.of Molecular Epigenetics Ministry.of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dy.regulation of neurotransmitter metabolism in the central nervous sy.tem contributes to mood disorders such as depression, anxiety. and post–traumatic stress disorder. Monoamines and amino acids are important ty.es of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analy.is and found that Dip2a deficiency.caused abnormal metabolism of try.tophan and thy.oxine in the basolateral amy.dala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hy.roxy.ry.tamine in the basolateral amy.dala. Additionally. Dip2a was abundantly.expressed in excitatory.neurons of the basolateral amy.dala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amy.dala may.be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hy.roxy.ry.tamine acute restraint stress basolateral amy.dala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analy.is stress susceptibility try.tophan

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