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Unraveling the role of formate in improving nitrogen removal via coupled partial denitrification-anammox

FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING 2024年第9期18卷 112-0页

作者： zhu, wanlu Xiao, Rui Xu, Min Chai, Wenbo Liu, Wenlong Jin, Zhengyu Ikumi, David Lu, Huijie Zhejiang Univ Coll Environm & Resource Sci Key Lab Environm Remediat & Ecol Hlth Minist Educ Hangzhou 310058 Peoples R China Key Lab Water Pollut Control & Environm Safety Hangzhou 310058 Peoples R China China Natl Nucl Corp Beijing Res Inst Chem Engn & Met Beijing 100029 Peoples R China Zhejiang Univ Technol Coll Environm Hangzhou 310014 Peoples R China Minzu Univ China Coll Life & Environm Sci Key Lab Ecol & Environm Minor Areas Natl Ethn Affairs Commiss Beijing 100081 Peoples R China Univ Cape Town Dept Civil Engn Water Res Grp ZA-7700 Rondebosch South Africa

The addition of traditional carbon sources (e.g., acetate) could favor heterotrophic overgrowth in partial denitrification coupled with anammox (PD-A) systems, thus hindering the performance and stability of this novel wastewater nitrogen removal technology. Therefore, it is necessary to develop an effective, environmentally friendly, and inexpensive alternative. This study demonstrated the potential of formate to enhance the performance and community stability of PD-A under mainstream conditions. In a laboratory-scale biofilm reactor, formate addition (COD/NO3--N = 1.75) improved nitrogen removal efficiency (from 72.1 +/- 3.5% to 81.7 +/- 2.7%), EPS content (from 106.3 +/- 8.1 to 163.0 +/- 15.5 mg/gVSS) and increased anammox bacteria growth (predominantly Candidatus Brocadia, from 29.5 +/- 0.7% to 34.5 +/- 5.4%) while maintaining stable heterotrophs dominated by methylotrophic Desulfobacillus. FISH-NanoSIMS revealed a formate uptake using Ca. Brocadia and Desulfobacillus, with Ca. Brocadia being the major contributor to partial nitrate reduction to nitrite. Desulfobacillus can synthesize diverse hydrophobic amino acids and provide key nutrients for Ca. Brocadia. To achieve comparable nitrogen removal, the cost of the formate-driven PD-A process should be 11.2% lower than that of acetate. These results greatly enrich our understanding of C1 metabolism represented by formate in anammox communities and its application in the context of coupling partial denitrification-anammox toward enhanced nitrogen removal in global wastewater treatment systems.

关键词： Formate Mixotrophic growth Partial denitrification-anammox Metabolic interaction FISH-NanoSIMS NITRITATION REACTOR

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一株降低了抗体依赖性增强效应的西尼罗病毒中和抗体的表达与体外活性研究

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中华微生物学和免疫学杂志 2024年第1期44卷 44-49页

作者：郝相君陈楠朱婉露王晶陈国江乔春霞李新颖沈倍奋冯健男柴立辉肖鹤军事科学院军事医学研究院毒物药物研究所北京100850 河南大学抗体药物开发技术国家地方联合工程实验室开封475004

目的建立降低抗体依赖性增强(antibody-dependent enhancement,ADE)效应的抗体表达系统,以期降低目标抗体的ADE效应。方法对哺乳细胞抗体表达载体Fc区进行L234A和L235A点突变,建立抗体表达载体pFRT-IgG1κ-FcM。选取前期工作中获得的1... 详细信息

目的建立降低抗体依赖性增强(antibody-dependent enhancement,ADE)效应的抗体表达系统,以期降低目标抗体的ADE效应。方法对哺乳细胞抗体表达载体Fc区进行L234A和L235A点突变,建立抗体表达载体pFRT-IgG1κ-FcM。选取前期工作中获得的1株具有显著ADE效应的抗体Wt-WNV利用pFRT-IgG1κ-FcM系统进行表达,获得突变后抗体FcM-WNV。ELISA检测FcM-WNV与靶抗原西尼罗病毒包膜蛋白DⅢ(West Nile virus envelope protein-DⅢ,WNV E-DⅢ)的结合,流式细胞术分析FcM-WNV与人高亲和力IgG Fc受体hFcγRⅠ(hCD64)的结合。假病毒感染宿主细胞(BHK21和K562)试验检测FcM-WNV的体外中和活性。结果FcM-WNV与Wt-WNV表达水平相当,能识别结合WNV E-DⅢ,且呈浓度依赖效应;与Wt-WNV相比,FcM-WNV与hCD64的结合力明显减弱,表现为荧光强度明显降低;与前期实验结果一致,Wt-WNV在5μg/ml的浓度下具有明显增强WNV假病毒感染K562细胞的作用,而FcM-WNV在5μg/ml浓度下,能有效阻断假病毒感染K562和BHK21细胞。结论本研究建立的抗体表达系统可有效降低目标抗体的ADE效应。

关键词：中和抗体西尼罗病毒抗体依赖性增强效应

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Therapeutic cancer vaccines:advancements,challenges,and prospects

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Signal Transduction and Targeted Therapy 2024年第1期9卷 150-172页

作者： Ting Fan Mingna Zhang Jingxian Yang Zhounan zhu wanlu Cao Chunyan Dong Department of Oncology East Hospital Affiliated to Tongji UniversityTongji University School of MedicineShanghaiChina Postgraduate Training Base Shanghai East HospitalJinzhou Medical UniversityShanghai 200120China

With the development and regulatory approval of immune checkpoint inhibitors and adoptive cell therapies,cancer immunotherapy has undergone a profound transformation over the past ***,therapeutic cancer vaccines have shown promise by eliciting de novo T cell responses targeting tumor antigens,including tumor-associated antigens and tumor-specific *** objective was to amplify and diversify the intrinsic repertoire of tumor-specific T ***,the complete realization of these capabilities remains an ongoing ***,we provide an overview of the current landscape of cancer vaccines in this *** range of antigen selection,antigen delivery systems development the strategic nuances underlying effective antigen presentation have pioneered cancer vaccine ***,this review addresses the current status of clinical trials and discusses their strategies,focusing on tumor-specific immunogenicity and anti-tumor efficacy ***,current clinical attempts toward developing cancer vaccines have not yielded breakthrough clinical outcomes due to significant challenges,including tumor immune microenvironment suppression,optimal candidate identification,immune response evaluation,and vaccine manufacturing ***,the field is poised to overcome hurdles and improve patient outcomes in the future by acknowledging these clinical complexities and persistently striving to surmount inherent constraints.

关键词： breakthrough approval overcome

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A MHMM risk prediction assessment method for the ship micro-grid

A MHMM risk prediction assessment method for the ship micro-...

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第37届中国控制会议

作者： Zhi Pengfei zhu Zhiyu zhu wanlu Jiangsu University of Science and Technology

A new risk prediction assessment method of the ship micro-grid is proposed in the article. Firstly, the paper puts forward the MHMM（Multi Hidden Markov Model） algorithm to predict the state probabilities of components in the continuous time points in the future. Secondly, according to the influence of external environment, the working states of the components of micro-grid are predicted by using the MHMM algorithm. Thirdly, the risk assessment model of network topology of the micro-grid is built, and power flow analysis under the abnormal condition are repeatedly calculated by using the Monte Carlo simulation. Finally the risk prediction assessment results is given. The article also takes a ship micro-grid as an example and the risk prediction assessment method is verified.

关键词： Ship micro-grid Risk prediction assessment MHMM Monte Carlo simulation

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高质量发展背景下公立医院职工满意度调查分析

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现代医药卫生 2024年第15期40卷 2608-2612页

作者：陆琳琳刘海军左姣朱婉露鲍敦鹏杨柳丰江王国平皖南医学院附属弋矶山医院安徽芜湖241001 皖南医学院人文与管理学院安徽芜湖241002

目的了解高质量发展背景下某公立医院职工满意度现状。方法2022年3月23日至2022年4月22日采取“国家卫生健康委员会职工满意度调查表”对安徽省某地级市某三级甲等综合医院在职职工进行整群抽样调查。结果职工满意度总分为(72.14±10.59... 详细信息

目的了解高质量发展背景下某公立医院职工满意度现状。方法2022年3月23日至2022年4月22日采取“国家卫生健康委员会职工满意度调查表”对安徽省某地级市某三级甲等综合医院在职职工进行整群抽样调查。结果职工满意度总分为(72.14±10.59)分。薪酬福利、发展晋升、工作内容与环境、上下级关系、同级关系5个维度得分分别为(16.14±4.18)、(13.10±3.45)、(17.29±2.38)、(10.40±1.50)、(15.20±1.83)分。不同工作年限、工作岗位、职称职工满意度得分比较,差异均有统计学意义(P<0.05)。不同性别职工薪酬福利、工作内容与环境维度得分比较,差异均有统计学意义(P<0.05)。不同工作年限职工满意度各维度得分比较,差异均有统计学意义(P<0.05)。不同工作岗位职工满意度各维度得分比较,差异有统计学意义(P<0.05)。不同职称职工薪酬福利、发展晋升、上下级关系、同级关系维度得分比较,差异有统计学意义(P<0.05)。结论该医院职工满意度总体向好,为促进医院高质量发展,应关注满意度较低的职工及得分较低维度。

关键词：公立医院职工满意度调查

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Research on Lifetime Optimization of Unmanned Ship Lithium Battery Pack Power Supply System Based on Artificial Fish Swarm Algorithm

Research on Lifetime Optimization of Unmanned Ship Lithium B...

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第三十九届中国控制会议

作者： Yongshuang QI Pengfei ZHI Hui YE wanlu zhu Jiangsu University of Science and Technology Jiangsu Zhenjiang Shipyard(Group) Co.LTD

New energy is an important direction for the development of unmanned ships. The intermittent and random characteristics of new energy have seriously affected the support of new energy to the load. The access of energy storage devices effectively solves the instability of new energy. This article uses the three lithium battery power supply system as an example to explore the relationship between the service life of the unmanned ship’s lithium battery pack power supply system and the battery capacity, charging current, and discharge current. At the same time, the artificial fish swarm algorithm is used to optimize the battery capacity, charging current, and discharge current of the three-lithium battery-powered system to extend the life of the three-lithium battery-powered system.

关键词： Unmanned Ship lithium battery power supply system three lithium battery power supply system artificial fish swarm algorithm service life new energy

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Superwettable interface towards biodetection in confined space

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Nano Research 2024年第2期17卷 602-617页

作者： Zexu Pang Zhikang Cao wanlu Li Wenxia Xu Yingying Zhang Qitao Zhou Jing Pan Fan Xia State Key Laboratory of Biogeology and Environmental Geology Engineering Research Center of Nano-Geomaterials of the Ministry of EducationFaculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074China

The detection of biomarkers with both high sensitivity and specificity is crucial for the diagnosis and treatment of related ***,many current detections employ ex-situ detection method and non-confined condition,thus have many problems,which may eventually lead to inaccurate detection *** to detection in non-confined space,detection in confined space can better reflect the real in-vivo ***,the construction of detection for target molecules in confined space has great significance for both theoretical research and practical *** realize the detection of target molecules in confined space,the probes should accurately enter the confined space where the target molecules reside and interact with the ***,how to explore and utilize the properties of the interface(for example,bioinspired superwettability)has always been a hot and difficult topic in this ***,the recent advances and our efforts in recent 10 years on detection of bio-target molecules in confined space with superwettable interface have been introduced from the perspective of the detection *** suitable and most widely employed detection methods for target molecules in confined spaces are introduced ***,recent progresses for related detections based on visual,optical,and electrochemical detection methods are presented ***,the perspective for detection in confined space is discussed for the future development of biochemical detection.

关键词： biodetection superwettability confined space interface

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综合电力推进系统风险预测评估方法

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哈尔滨工程大学学报 2019年第5期40卷 953-959页

作者：智鹏飞刘胜朱琬璐叶辉江苏科技大学电子信息学院江苏镇江212003 哈尔滨工程大学自动化学院黑龙江哈尔滨150001

为了解决综合电力推进系统在复杂环境下的风险评估延时性高和应对策略难以实时制定的问题,本文提出了一种综合电力推进系统风险预测评估方法。将传统HMM算法、Viterbi算法与统计学理论相结合,对未来连续时间点所处的工作状态进行预测分... 详细信息

为了解决综合电力推进系统在复杂环境下的风险评估延时性高和应对策略难以实时制定的问题,本文提出了一种综合电力推进系统风险预测评估方法。将传统HMM算法、Viterbi算法与统计学理论相结合,对未来连续时间点所处的工作状态进行预测分析,然后采用MHMM-Viterbi算法根据系统运行状态和外界因素影响,预测分析系统内各单元子系统在未来一段时间的工作状态,建立系统的网络拓扑风险评估模型,采用蒙特卡洛模拟系统失效状态,得到风险预测评估结果,最后以船舶综合电力推进系统为例,对本文提出的方法进行了验证。实验表明:系统风险发生概率等参数随海况等级变化而时序波动,与系统在海上航行时记录的实际风险情况相符合。

关键词：综合电力推进系统风险预测风险评估 Viterbi算法马尔可夫模型蒙特卡洛模拟网络拓扑

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Path Planning of Shallow Submersible Unmanned Ship Based on MSFA Method

Path Planning of Shallow Submersible Unmanned Ship Based on ...

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第32届中国过程控制会议(CPCC2021)

作者： Lei Zhao Pengfei Zhi wanlu zhu Haiyang Qiu Hui Wang Weiran Wang School of Electronic and Information Engineering Jiangsu University of Science and Technology

In order to enable the shallow submersible unmanned ship to quickly and accurately collect water area information when working in unknown waters,carry out real-time path planning,shorten the planned path,and solve the limitations of traditional unmanned ship path *** paper proposes a shallow submersible unmanned ship path planning method based on multi-sensor information fusion and firefly optimization algorithm(MSFA).First of all,real-time information of the water area is acquired through the sensors mounted on the shallow-submersible unmanned ship,information fusion is carried out,and real-time modeling of the water area ***,the Firefly algorithm is optimized to increase the computing speed to meet the needs of real-time path ***,the real-time model of the water environment based on multi-sensor information fusion is combined with the Firefly optimization algorithm to form a shallow submersible unmanned ship path planning based on MSFA ***,the method proposed by me was verified by simulation analysis.

关键词： shallow submersible unmanned ship data fusion firefly optimization algorithm route plan

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Nickel catalysts with asymmetric steric hindrance for ethylene polymerization

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中国科学技术大学学报 2024年第6期54卷 48-52,59,I0010,I0011页

作者： wanlu Tian Fuzhou Wang Chen Zou Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China

α-Diimide catalysts have attracted widespread attention due to their unique chain walking characteristics.A series ofα-diimide nickel/palladium catalysts with different electronic effects and steric hindrances were designed and synthesized for olefin *** this work,we synthesized a series of asymmetricα-diimide nickel complexes with different steric hindrances and used them for ethylene *** nickel catalysts have high ethylene polymerization activity,up to 6.51×10^(6)g·mol^(−1)·h^(−1),and the prepared polyethylene has a moderate melting point and high molecular weight(up to 38.2×10^(4)g·mol^(−1)),with a branching density distribution between 7 and 94 branches per 1000 *** importantly,the polyethylene prepared by these catalysts exhibits excellent tensile properties,with strain and stress reaching 800%and 30 MPa,respectively.

关键词： α-diimine nickel complex polyethylene polymerization asymmetric steric hindrance

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