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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-qiang zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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Both self-assembly and aggregation-induced emission are photoswitchable

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Science China Chemistry 2018年第10期61卷 1201-1202页

作者： Ming-qiang zhu Wuhan National Laboratory of Optoelectronics(WNLO) Huazhong University of Science and Technology (HUST)

As a classical photochromic candidate, bisthienylethene(BTE) is a thermally irreversible photochromic compound and its photochromic behavior was firstly reported in *** to its thermal irreversibility and high fatigue resistance,its application has been widely studied for opto-electrical devices such as memories and switches. In general, the modification of fluorophore to the side of BTE is a simple method for constructing fluorescent photoswitches.

关键词：组装排放聚集光反应候选人变色混合物不可逆

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A generalized trajectory tracking controller for robot manipulators with bounded inputs

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第10期10卷 1500-1508页

作者： Hua-shan LIU Shi-qiang zhu State Key Lab of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

A generalized controller based on stability theory of singularly perturbed systems is proposed,to deal with the problem of bounded actuator inputs in robot trajectory tracking *** saturation function with error-gain matrix is applied in the torque control law,which ensures the upper bound of torque inputs in any given limited *** appropriately setting the entries of the error-gain matrix,the tracking performance can be ***,a pseudo signal is generated from a linear filter to substitute for the actual velocity error,eliminating the need for velocity ***,to verify the ef-fectiveness of the generalized controller,a new saturated controller with error-gain-contained arc tangent function is *** experiments show that the proposed controller can strictly guarantee the bound of the torque inputs in situations with non-zero initial tracking errors,and gives a better tracking result than other controllers.

关键词： Robot Tracking control Singular perturbation Bounded input

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New fast algorithm for hypercomplex decomposition and hypercomplex cross-correlation

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Journal of Systems Engineering and Electronics 2010年第3期21卷 514-519页

作者： Chunhui zhu Yi Shen qiang Wang School of Astronautics Harbin Institute of Technology Harbin 150001 E R. China

In order to calculate the cross-correlation of two color images treated as vector in a holistic manner,a rapid vertical/parallel decomposition algorithm for quaternion is *** calculation for decomposition is reduced from 21 times to 4 times real number multiplications with the same *** algorithm for cross-correlation of color images based on decomposition in time domain is put forward,in which some properties pointed out in this paper can be utilized to reduce the computational *** results show the effectiveness and superiority of the proposed method.

关键词： color image processing color image cross-correlation quaternion decomposition hypercomplex.

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Heat Transfer and Aerodynamics of Complex Shroud Leakage Flows in a Low-Pressure Turbine

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Journal of Thermal Science 2013年第5期22卷 447-458页

作者： Wang Pei Du qiang Yang Xiao Jie zhu Jun qiang Institute of Engineering Thermophysics Chinese Academy of Sciences University of Chinese Academy of Sciences

A numerical investigation on over-shroud & inter-shroud leakage flow has been carried out to explore the underneath flow physics at the stage of shrouded Low Pressure(LP) *** with the No inter-Shroud gap's Leakage flow Model(NSLM) and With inter-Shroud gap's Leakage flow Model(WSLM),the aerodynamic characteristics and the heat transfer performance have been *** the aerodynamic point of view,it is concluded that due to the pressure difference between the rotor's passage and the over-shroud cavity,in the stream-wise direction,flow structure has been modified,and the inter-shroud leakage flow may even cause flow separation in the vicinity of the blade passage's *** the circumferential direction,separation flows appear over the rotor's shroud surface(upper platform of the shroud).Meanwhile,from the point of view of heat transfer,further provision on contour maps of the non-dimensional Nusselt number reveals that the reattachment of leakage flow would enhance the heat transfer rates and endanger the rotor's labyrinth fins over the ***,due to the limited amount of inter-shroud leakage flow(current computational model),temperature distribution variation along the blade surface(near the rotor's tip section) seems to have only minor insignificant *** the end of the paper,the author puts forward some recommendations for the purpose of future successful turbine design.

关键词： over-shroud leakage flow inter-shroud leakage flow shrouded LP turbine

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Palladium-catalyzed intermolecular C–H amidation of indoles with sulfonyl azides

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Science China Chemistry 2015年第8期58卷 1349-1353页

作者： Ziwei Hu Shuang Luo qiang zhu State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences

A new kind of intermolecular indole C–H amidation reaction catalyzed by the most frequently used palladium catalyst has been *** azide was employed as an innovative nitrogen source and environmentally benign nitrogen... 详细信息

关键词： C-H amidation indole palladium sulfonyl azide

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Part-load Performance Characteristics of a Lean Burn Catalytic Combustion Gas Turbine System

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Journal of Thermal Science 2013年第2期22卷 159-167页

作者： Juan Yin Ming Li Jun-qiang zhu Institute of Engineering Thermophysics Chinese Academy of Sciences China Architecture and Building Press

The purpose of this study is to compare the part-load performance of a lean burn catalytic combustion gas turbine (LBCCGT) system in three different control modes: varying fuel, bleeding off the fuel mixture flow after the compressor and varying rotational speed. The conversions of methane species for chemical process are considered. A 1D heterogeneous plug flow model was utilized to analyze the system performance. The actual turbomachinery components were designed and predicted performance maps were applied to system performance research. The part-load characteristics under three control strategies were numerically investigated. The main results show that: the combustor inlet temperature is a significant factor that can significantly affect the part-load characteristics of the LBCCGT system; the rotational speed control mode can provide the best performance characteristics for part-load operations; the operation range of the bleed off mode is narrower than that of the speed control mode and wider than that of the fuel only mode; with reduced power, methane does not achieve full conversion over the reactor at the fuel only control mode, which will not warrant stable operation of the turbine system; the thermal efficiency of the LBCCGT system at fuel only control strategy is higher than that at bleed off control strategy within the operation range.

关键词： Lean burn catalytic combustion gas turbine part-load characteristics control mode

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Enhanced drug loading efficiency of contact lenses via salt-induced modulation

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Asian Journal of Pharmaceutical Sciences 2019年第2期14卷 204-215页

作者： qiang zhu Shirui Mao School of Pharmacy Shenyang Pharmaceutical University

Low drug loading efficiency is one of the main obstacles hindering the application of contact lenses(CLs) as the carrier for extended ocular drug delivery. Here in this study, a simple and effective drug loading method based on salt induced modulation was proposed and demonstrated with mechanism elucidation. First of all, using poly(2-hydroxyethyl methacrylate)(p-HEMA) as the contact lens material, betaxolol hydrochloride, Diclofenac Sodium and Betaxolol Base as the model drugs with different solubility, influence of salt concentration,salt type(sodium salts of sulfate, chloride, and sulfocyanate) and drug properties in the loading solution on drug loading efficiency was investigated. Mechanism of enhanced drug loading in contact lens was further explored via studying the influence of salt on the absorption isotherm, drug solubility and water content of CLs. Applicability of this method to other CLs materials was also investigated. It was demonstrated that adjusting the ionic strength of loading solutions resulted in significant increase of drug loading in CLs. Type and concentration of the salts and solubility of the drug were the main factors influencing enhancement ratio of drug loading. The mechanism for improved drug loading was related to the reduced drug solubility in loading solutions and the reduced bound water content in contact lenses. Modulation of drug loading by adjusting ionic strength was also applicable to other CLs and the light transmittance was not affected. This method was more suitable for salt-form drugs with high solubility. In summary, adjusting ionic strength of loading solution is an economical and effective way to improve drug loading in CLs, and this simple method may also find application in other hydrogel based drug delivery systems.

关键词： Contact lenses Drug loading Ionic strength Absorption isotherms Drug solubility Bound water content

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Fractal-like Kinetic Characteristics of Coalbed Methane Hydrate Dissociation at Normal Pressure

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Chinese Journal of Chemistry 2011年第1期29卷 21-26页

作者： Xu, Feng Wu, qiang zhu, Lihua School of Safety Engineering & Technology Heilongjiang Institute of Science & Technology Harbin Heilongjiang 150027 China

Surface modality of coalbed methane hydrate and fractal-like kinetic characteristics of the hydrate dissociation at normal pressure have been studied by using fractal geometry theory. The results show that the surface modality of coalbed methane hydrate has fractal characteristic, and the dissociation kinetics of coalbed methane hydrate is fractal-like. Moreover, a new kinetic model for coalbed methane hydrate dissociation was proposed, and its reliability was validated.

关键词： coalbed methane hydrate dissociation kinetic normal pressure fractal

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EXPERIMENTAL INVESTIGATION OF TIP CLEARANCE FLOW FOR AN AXIAL FLOW FAN ROTOR

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Chinese Journal of Mechanical Engineering 2006年第3期19卷 376-382页

作者： GUO qiang zhu Xiaocheng DU Zhaohui School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030 China

The flow field in the tip region of an axial ventilation fan is investigated with a particle image velocimeter （PIV） system at the design condition. Flow fields with three different tip clearances are surveyed on three different circumferential planes, respectively. The phase-locked average method is used to investigate the generation and the development of a tip leakage vortex. The result from PIV system is compared with that from a particle dynamics anemometer（PDA） system. Both data are in good agreement and the structure of the tip leakage vortex for the rotor is illustrated. The characteristic of a leakage vortex is described in both velocity vectors and vortical contours. The unsteadiness of the leakage vortex and the position of the vortex are surveyed in detail, which interprets the discrepancy between the numerical simulation and PDA experimental results to a certain extent. The center loci of tip leakage vortex at different times and the mean center loci of the leakage vortex are displayed particularly. Finally, the trajectories of the tip leakage vortex by the experimental measurement are compared with predictions from the existing models for high speed and high-pressure compressors and turbines when appropriately interpreted. A good agreement is obtained.

关键词： Axial ventilation fan Tip leakage vortex Particle image velocimetry (PIV) Vortex center trajectory

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