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A new method for identifying flow pattern of spouted fluidized bed by coupling Hilbert-Huang transform characteristics of differential pressure signals in different zones

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Particuology 2024年第6期89卷 67-78页

作者： Yongzhi Mei Yang Wang lihui Zhang Feng Duan School of Energy and Environment Anhui University of TechnologyMaanshan243002China Wuhu Technology and Innovation Research Institute Wuhu241000China Wuhu Cigarette Factory of China Tobacco Anhui Industrial Co. Ldt.Wuhu241002China

On a cold spouted fluidized bed,this study compares the characteristic differences in intrinsic mode function(IMF)energy and Hilbert–Huang spectrum between the spout zone and annulus zone under different combinations of spouted gas and fluidized gas flow rates for five typical flow *** energy distribution characteristics under different flow patterns are also *** Hilbert–Huang spectrum and IMF energy of pressure difference signals exhibit distinct variations in different zones as the flow pattern ***,there exists a correlation between the energy in the middle-frequency range and the flow *** the K-means algorithm,the middle-frequency range energy of IMFs in the spout zone and annulus zone is subjected to clustering analysis,leading to the identification of partition boundaries for each flow *** on this,a flow pattern identification method of spouted fluidized bed coupled with middle-frequency range energy in spout zone and annulus zone is proposed,which has very high identification accuracy.

关键词： Spouted fluidized bed Flow pattern Zoning signal Flow pattern transition Hilbert-Huang transform

A 21-bp InDel in the promoter of STP1 selected during tomato improvement accounts for soluble solid content in fruits

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Horticulture Research 2023年第3期10卷 176-188页

作者： Ying Wang Chunmei Shi Pingfei Ge Fangman Li lihui zhu Yaru Wang Jinbao Tao Xingyu Zhang Haiqiang Dong Wenxian Gai Fei Wang Zhibiao Ye Donald Grierson Wei Xu Yuyang Zhang National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops College of Horticulture and Forestry ScienceHuazhong Agricultural UniversityWuhan 430070China Plant Sciences Division School of BiosciencesUniversity of NottinghamSutton Bonington CampusLoughborough LE125RDUK Key Laboratory of Special Fruits and Vegetables Cultivation Physiology and Germplasm Resources Utilization(Xinjiang Production and Construction Crops) College of AgricultureShihezi UniversityShihezi 832003XinjiangChina Hubei Hongshan Laboratory Wuhan 430070China

Domestication and improvement are important processes that generate the variation in genome and phonotypes underlying crop ***,during selection for certain attributes,other valuable traits may be inadvertently *** example is the decline in fruit soluble solids content(SSC)during tomato *** genetic loci for SSC have been identified,but few reports on the underlying mechanisms are *** this study we performed a genome-wide association study(GWAS)for SSC of the red-ripe fruits in a population consisting of 481 tomato accessions with large natural variations and found a new quantitative trait locus,STP1,encoding a sugar transporter *** causal variation of STP1,a 21-bp InDel located in the promoter region 1124 bp upstream of the start codon,alters its ***1 Insertion accessions with an 21-bp insertion have higher SSC than STP1Deletion accessions with the 21-bp *** of STP1 in TS-23 with high SSC using CRISPR/Cas9 greatly decreased SSC in *** vivo and in vitro assays demonstrated that ZAT10-LIKE,a zinc finger protein transcription factor(ZFP TF),can specifically bind to the promoter of STP1Insertion to enhance STP1 expression,but not to the promoter of STP1Deletion,leading to lower fruit SSC in modern *** analysis revealed that STP1 was selected during tomato *** these results together,we identified a naturally occurring causal variation underlying SSC in tomato,and a new role for ZFP TFs in regulating sugar *** findings enrich our understanding of tomato evolution and domestication,and provide a genetic basis for genome design for improving fruit taste.

关键词： CRISPR/Cas9 content sugar

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阿甘本的生命政治思想研究

世界哲学 2019年第1期 41-49页

作者：朱丽卉兰州财经大学马克思主义学院中国社会科学院马克思主义学院

阿甘本的生命政治所要讨论的核心思想就是例外状态中赤裸生命的救赎。主权者通过悬置法律,制造出一个无法的例外状态。在例外状态中,任何人都是不被法律保护的神圣人。正是因为例外状态根植于西方的政治历史之中,才会导致20世纪现代民... 详细信息

阿甘本的生命政治所要讨论的核心思想就是例外状态中赤裸生命的救赎。主权者通过悬置法律,制造出一个无法的例外状态。在例外状态中,任何人都是不被法律保护的神圣人。正是因为例外状态根植于西方的政治历史之中,才会导致20世纪现代民主政治爆发了极权主义和集中营这种例外状态和生命政治的典范。但是阿甘本强调,集中营并没有随着第二次世界大战的结束而消逝,而是以看不见的形式散落在当代社会,其中的赤裸的生命正是人民。

关键词：例外状态主权生命政治神圣人人民

基于Web of Science数据库的新生儿安宁疗护的可视化分析

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中华现代护理杂志 2024年第4期30卷 487-494页

作者：蒋思珊罗听薇张娜向玉琼夏青青张智强朱丽辉湖南中医药大学护理学院长沙410208 湖南省肿瘤医院院办长沙410013

目的基于Web of Science数据库, 对新生儿安宁疗护进行可视化分析, 探讨研究热点与前沿, 为我国新生儿安宁疗护的发展提供参考。方法检索并筛选1991—2023年Web of Science核心合集收录的与新生儿安宁疗护相关的文献, 采用CiteSpace 6.1... 详细信息

目的基于Web of Science数据库, 对新生儿安宁疗护进行可视化分析, 探讨研究热点与前沿, 为我国新生儿安宁疗护的发展提供参考。方法检索并筛选1991—2023年Web of Science核心合集收录的与新生儿安宁疗护相关的文献, 采用CiteSpace 6.1.R6软件从作者、国家/地区、机构、期刊共被引频次、关键词知识图谱等方面进行可视化分析。结果共纳入文献1 452篇, 发文量整体呈上升趋势, 美国、英国、加拿大占据新生儿安宁疗护相关研究的核心地位。研究热点包括不同阶段和不同疾病种类的安宁疗护、新生儿重症监护病房安宁疗护的关键环节、新生儿安宁疗护服务模式的创新、家属和医护人员的需求及心理支持策略。研究前沿集中在医护人员在安宁疗护中的作用和挑战、疾病诊断、与决策制定相关的道德困扰。结论我国可借鉴国际研究热点及前沿探索不同安宁疗护服务模式的可适性, 丰富研究类型, 加强法律政策层面的引领, 完善教育培训系统, 构建符合我国国情和文化的新生儿安宁疗护服务体系。

关键词：新生儿安宁疗护可视化分析文献计量学

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载阿霉素聚乳酸多孔微球的表征及释药性能

化工进展 2018年第3期37卷 1130-1136页

作者：洪雅真朱利会华侨大学化工学院福建厦门361021 华侨大学生物材料与组织工程研究所福建厦门361021

以阿霉素(DOX)为小分子化学药物模型,采用吸附法对聚乳酸(poly-L-lactide,PLLA)多孔微球进行载药,采用场发射扫描电子显微镜(FE-SEM)、傅里叶变换红外光谱(FTIR)、X射线衍射(XRPD)及差示扫描量热(DSC)对DOX-PLLA复合微球的形貌粒径及空... 详细信息

以阿霉素(DOX)为小分子化学药物模型,采用吸附法对聚乳酸(poly-L-lactide,PLLA)多孔微球进行载药,采用场发射扫描电子显微镜(FE-SEM)、傅里叶变换红外光谱(FTIR)、X射线衍射(XRPD)及差示扫描量热(DSC)对DOX-PLLA复合微球的形貌粒径及空气动力学性能、药物及材料的理化性能、载药性能进行表征,并且研究了其载药量、包封率和体外释放性能。结果表明,不同载药量之间的PLLA多孔微球粒径并无显著差异,均具有良好的空气动力学性能,适合肺部可吸入给药的条件;化学组成未见明显改变,物理结构由结晶态变为无定形态;随载药量的增加(2.9%,4.0%,4.6%),包封率逐渐降低(56%,51%,44%);药物的体外释放与原料药相比具有一定的缓释效果,最长释放时间可达5天,表明DOX-PLLA复合微球有望作为缓释制剂用于肺部给药。

关键词：阿霉素多孔微球聚乳酸体外释放肺部给药

Primary Amine Catalyzed Remote Stereocenter Formation Through Oxidative C-H Bond Cleavage

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Primary Amine Catalyzed Remote Stereocenter Formation Throug...

An mmWave Dual-Band Integrated Substrate Gap Waveguide Single Cavity Filter with Frequency Selectivity

中国化学会第十二届全国物理有机化学学术会议

作者： lihui zhu Long Zhang Sanzhong Luo CAS Key Laboratory of Molecular Recognition and Function Institute of ChemistryChinese Academy of Sciences

＜正＞Within the realm of organic synthesis,the carbonyl moiety represents one of the most prevalent functional groups that has been widely used in organic *** α-C-H and ipsofunctionalizations are standard text-book ...

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China Communications 2024年第1期21卷 188-199页

作者： Qiuhua Lin Dongya Shen lihui Wang Zhiyong Luo School of Electronics and Communication Engineering Sun Yat-sen UniversityShenzhen 518107China School of Information Science and Engineering Yunnan UniversityKunming 650091China Pengcheng Laboratory Shenzhen 518107China Shenzhen Key Laboratory of Navigation and Communication Integration Shenzhen 518107China

A novel dual-band ISGW cavity filter with enhanced frequency selectivity is proposed in this paper by utilizing a multi-mode coupling *** cavity is designed to control the number of modes,and then the ports are determined by analyzing the coupling relationship between these selected *** synthesizing the coupling matrix of the filter,a nonresonating node(NRN)structure is introduced to flexibly tune the frequency of modes,which gets a dualband and quad-band filtering response from a tri-band filter no the ***,a frequency selective surface(FSS)has been newly designed as the upper surface of the cavity,which significantly improves the bad out-of-band suppression and frequency selectivity that often exists in most traditional cavity filter designs and *** results show that its two center frequencies are f01=27.50 GHz and f02=32.92GHz,*** with the dual-band filter that there is no the FSS metasurface,the out-of-band suppression level is improved from measured 5 dB to18 dB,and its finite transmission zero(FTZ)numbers is increased from measured 1 to 4 between the two designed *** with the tri-band and quadband filter,its passband bandwidth is expanded from measured 1.17%,1.14%,and 1.13% or 1.31%,1.50%,0.56%,and 0.57% to 1.71% and 1.87%.In addition,the filter has compact,small,and lightweight characteristics.

关键词： coupling topology frequency selectivity non-resonating node(NRN) out-of-band suppression single ISGW cavity filter

NOD2 suppresses hepatocarcinoma via inhibiting glycolysis of tumor cells through activating AMPK signaling pathway

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NOD2 suppresses hepatocarcinoma via inhibiting glycolysis of...

TRIM50 suppressed hepatocarcinoma progression through directly targeting SNAIL for ubiquitous degradation

第十二届全国免疫学学术大会

作者： Ma xiaomin Qiu Yumin zhu lihui Ma Xiaoxiao Lin Yueke Han lihui Department of Immunology Shandong University School of Basic Medical Sciences

Objective:To explore the role of NOD2(Nucleotide-Binding Oligomerization Domain Containing 2) in the development of hepatocellular carcinoma(HCC).Methods:Immunohistochemical staining,western blot and qRT-PCR were performed to detect the relative expression of NOD2 in liver cancer tissues and corresponding non-cancerous liver tissues from HCC ***/CCL4 induced HCC mice model and xenograft tumor model were constructed to define the function of NOD2 in HCC *** effect of NOD2 on malignant behaviors of HCC cells were investigated in NOD2 overexpressed HCC cells and NOD2 knockdown *** of AMPK pathway and its downstream signaling was detected by western ***-Immunoprecipitation(Co-IP) and immunofluorescence(IF) were performed to verify the binding between NOD2 and AMPKLKB1 *** status of glycolysis was represented by detection of lactic acid(LD).AnnexinV-PI staining was used to examine cell ***:NOD2 expression was significantly decreased in liver cancer tissues compared with non-cancerous liver *** expression of NOD2 promotes HCC progression in DEN/CCL4 induced HCC mice model,and xenograft tumor model further verified the anti-tumor effect of *** model data showed that NOD2 significantly inhibited the proliferation,colony formation and invasion capability of HCC *** investigation showed that NOD2 inhibited HCC malignant behavior through activating AMPK signaling pathway by directly binding with AMPK-LKB1 *** was intracellular energy sensor and our data further verified that NOD2 exert its anti-tumor effect through AMPK pathway mediated energy switch from glycolysis to oxidative ***:NOD2 negatively regulates glycolysis via activating AMPK pathway in HCC cells,and further acts as a tumor suppressor to inhibit HCC progression.

关键词： NOD2 AMPK glycolysis HCC progression

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TRIM50 suppressed hepatocarcinoma progression through direct...