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基于系统布置设计与混合算法的锻造厂车间布局优化

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科学技术与工程 2024年第1期24卷 170-176页

作者：张梦杨朱玉杰张许英龙东北林业大学机电工程学院哈尔滨150040 东北林业大学材料科学与工程学院哈尔滨150040

针对因车间布局不合理而导致物流量浪费的现象,对锻造厂进行研究,建立了物流量最小化的单目标优化函数,运用系统布置设计(systematic layout planning,SLP)方法对原始布局进行优化得到3种布局方案,采用层次分析法(analytic hierarchy pr... 详细信息

针对因车间布局不合理而导致物流量浪费的现象,对锻造厂进行研究,建立了物流量最小化的单目标优化函数,运用系统布置设计(systematic layout planning,SLP)方法对原始布局进行优化得到3种布局方案,采用层次分析法(analytic hierarchy process,AHP)与熵权法相结合的方法构建组合赋权模型,再通过逼近理想解排序法(technique for order preference by similarity to an ideal solution,TOPSIS)对3种方案进行排序优选,形成多指标决策评价模型。最后将遗传算法与和声搜索算法相结合,对锻造厂车间布局进行二次优化,获得最优布局方案。案例分析表明,此研究方法使物流量减少了28.82%,改进效果显著,同时也验证了该模型的优越性,对相关行业车间布局设计提供一定的参考价值。

关键词：系统布置设计组合赋权遗传算法和声搜索算法车间布局

In situ Synthesis of SAPO-34 Zeolites in Kaolin Microspheres for a Fluidized Methanol or Dimethyl Ether to Olefins Process

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Chinese Journal of Chemical Engineering 2010年第6期18卷 979-987页

作者： zhu jie CUI yu NAWAZ Zeeshan WANG Yao WEI Fei Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical Engineering Tsinghua University Beijing 100084 China

SAPO-34 zeolite is considered to be an effective catalyst for methanol or dimethyl ether conversion to olefins. In this study,we developed the in situ synthesis technology to prepare SAPO-34 zeolite in kaolin micro-spheres as a catalyst for fluidized methanol or dimethyl ether to olefins process. The silicoaluminophosphate zeolite was first time reported to be synthesized in kaolin microspheres. The SAPO-34 content of synthesized catalyst was about 22% as measured by three different quantitative methods(micropore area,X-ray fluorescence and energy dispersive spectroscopy element analysis) . Most of the SAPO-34 zeolites were in nanoscale size and distributed uniformly inside the spheres. The catalytic performance was evaluated in fixed bed and fluidized bed reactors. Compared with the conventional spray-dry catalyst,SAPO/kaolin catalyst showed superior catalytic activities,bet-ter olefin selectivities(up to 94%,exclusive coke) ,and very good hydrothermal stability. The in situ synthesis of SAPO-34 in kaolin microspheres is a facile and economically feasible way to prepare more effective catalyst for fluidized MTO/DTO(methanol to olefins/dimethyl ether to olefins) process.

关键词： SAPO-34 in situ synthesis kaolin fluidized bed methanol to olefins

基于公园城市理念的道路绿地公共空间活力营造策略

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建材技术与应用 2024年第3期 70-75页

作者：崔滋辰王夫帅朱婕妤中国城市建设研究院有限公司北京100010

公园绿地是实现公园城市建设目标的重要载体,道路绿地是绿色空间结构中重要的线性空间,能够发挥生态、游憩和景观风貌塑造等多重功能,对提升片区环境品质,激发公共空间活力具有重要意义。以开封市复兴大道绿地景观提升为例,结合片区发... 详细信息

公园绿地是实现公园城市建设目标的重要载体,道路绿地是绿色空间结构中重要的线性空间,能够发挥生态、游憩和景观风貌塑造等多重功能,对提升片区环境品质,激发公共空间活力具有重要意义。以开封市复兴大道绿地景观提升为例,结合片区发展目标,针对现存在问题和居民休闲游憩等多元需求,改变传统填空式单一绿化的发展模式,通过生境营造、联通城市公共空间、营造多元场景和景观重塑等策略,构建生态资源融合、开放共享及绿色便捷的道路绿化空间,促进生态价值转化,激发片区活力。

关键词：公园城市道路绿地景观提升活力营造

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中枢神经系统相关水通道蛋白的研究进展

生理科学进展 2024年第1期55卷 34-42页

作者：郁凯琳朱宇杰吕叶辉奚盈盈陆怡颖杨明真童昉上海健康医学院基础医学院生理教研室上海201318 上海健康医学院基础医学院解剖与组胚教研室上海201318 上海健康医学院创面防治研究所上海201318 司法鉴定科学研究院上海市法医学重点实验室司法部司法鉴定重点实验室上海市司法鉴定专业技术服务平台上海200063 上海健康医学院附属周浦医院神经内科上海201318

水通道蛋白(aquaporins,AQPs)是一族表达于细胞膜上,对水分子高效通透的特异性孔道蛋白,其在全身广泛分布,与多个生物过程关系密切,同时也与较多神经系统疾病的发生发展存在联系。AQPs与中枢神经系统内的液体流动、能量代谢、神经修复... 详细信息

水通道蛋白(aquaporins,AQPs)是一族表达于细胞膜上,对水分子高效通透的特异性孔道蛋白,其在全身广泛分布,与多个生物过程关系密切,同时也与较多神经系统疾病的发生发展存在联系。AQPs与中枢神经系统内的液体流动、能量代谢、神经修复与发生、血脑屏障的发育与稳定、信号转导以及CSF的产生与循环密切相关。AQPs还与脑水肿、阿尔茨海默病、视神经脊髓炎、原发性颅内高压及帕金森病等中枢神经系统疾病的发生发展有关。在中枢神经系统中,虽然已经发现较多种类的AQPs存在,但研究成果主要集中于AQP1、AQP4及AQP9三个水通道蛋白上。对于AQPs的研究有助于加深中枢神经系统的认识,并提供疾病的潜在治疗靶点。本文综述了AQPs在中枢神经系统的表达分布、调节机制、生理功能及其与中枢神经系统疾病的关联,为相关神经科学研究提供新思路。

关键词：水通道蛋白中枢神经系统表达分布调节机制生理功能中枢神经系统疾病

Controllable Ring-opening Polymerization ofδ-Valerolactone Catalyzed by Quinolinyl-Urea/MTBD Systems

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Chinese Journal of Polymer Science 2024年第8期42卷 1103-1110页

作者： Xin-yu Liu Liang zhu Su-yun jie Bo-Geng Li State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

Due to their excellent biocompatibility and biodegradability,aliphatic polyesters are widely used in the biomedical,packaging and agricultural fields,which are usually accessed by the ring-opening polymerization(ROP)of lactones and the catalysts particularly play an important *** a series of quinolinyl-urea catalysts have been synthesized via the reaction between isocyanate and aminoquinoline with an amino group at different substitution positions and *** combination with 7-methyl-1,5,7-triazabicyclo[4,4,0]dec-5-ene(MTBD)as a cocatalyst and benzyl alcohol(BnOH)as an initiator,1-(3,5-bis(trifluoromethyl)phenyl)-3-(quinolin-3-yl)urea(3-QU)was observed to be most active for the ROP ofδ-valerolactone(δ-VL).The polymerization conditions were optimized by varying the type of organic base,catalyst concentration and reaction *** changing the ratio of[M]_0/[I],linear polyvalerolactones(PVLs)with different molecular weights and narrow molecular weight distribution were *** kinetic and chain extension experiments were carried out to prove the"living"/controllable *** the NMR experiments were used to support the proposal of possible mechanism.

关键词： Quinolinyl-urea Ring-opening polymerization PVL

Parainfluenza Virus Types 1, 2, and 3 in Pediatric Patients with Acute Respiratory Infections in Beijing During 2004 to 2012

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Chinese Medical Journal 2015年第20期128卷 2726-2730页

作者： Fang Wang Lin-Qing Zhao Ru-Nan zhu jie Deng yu Sun Ya-Xin Ding Run Tian yuan Qian Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases Capital Institute of Pediatrics Beijing 100020 China

Background： Although human parainfluenza virus （HPIV） has been determined as an important viral cause of acute respiratory infections （ARIs） in infants and young children, data on long-term investigation are still lacking to disclose the infection pattern of HPIV in China. Methods： Nasopharyngeal aspirates were collected from 25,773 hospitalized pediatric patients with ARIs from January 2004 through December 2012 for respiratory virus screen by direct immuno-fluorescence assay. Results： Out of these specimens, 1675 （6.50%, 1675/25,773） showed HPIV positive, including 261 （1.01%, 261/25,773） for HPIVI, 28 （0.11%, 28/25,773） for HPIV2, and 1388 （5.39%, 1388/25373） for HPIV3, 2 of the samples were positive for both HPIV1 and HPIV3, and 36 were co-detected with other viruses. The positive rates of HPIVs were higher in those younger than 3 years old. HPIV3 was detected from all age groups, predominantly from patients under 3 years of age, and the highest frequency was found in those 6 months to 1-year old （352/4077, 8.63%）. HPlV3 was the dominant type in each of the years detected between May and July. HPIV1 showed a peak in every odd year, mainly in August or September. HPIV was detected most frequently from patients with upper respiratory infection （12.49%, 157/1257）, followed by bronchitis （ 11.13%, 176/2479）, asthma （9.31%, 43/462）, bronchiolitis （5.91%, 150/2536）, pneumonia （6.06%, 1034/17,068）, and those with underlying diseases （1.0%, 15/1506）. HPIV3 is the dominant type in these six disease groups referred above, especially in the asthma group. Conclusions： HPIV is one of the important viral causes of ARIs in infants and young children in Beijing based on the data from the hospitalized children covering a 9-year term. HPIV3 is the predominant type in all these years and in most of the disease groups. HPIVs with different types show different seasonality.

关键词： Acute Respiratory Infection China Human Parainfluenza Virus Infants and Young Children

Intelligent design and construction of novel APN-based theranostic probe driven by advanced computational methods

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Chinese Chemical Letters 2024年第2期35卷 352-357页

作者： Yingli zhu jie Qian Kunqian yu Jing Hou Yeshuo Ma Fei Chen jie Dong Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410083China National Engineering Research Center of Rice and Byproduct Deep Processing School of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha 410004China State Key Laboratory of Drug Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Geriatrics Third Xiangya HospitalCentral South UniversityChangsha 410013China

Multifunctional molecules with both optical signal and pharmacological activity play an important role in drug development,disease diagnosis,and basic theoretical *** N(APN),as a representative tumor biomarker with anti-tumor potential,still lacks a high-precision theranostic probe specifically targeting *** this study,a novel quaternity design strategy for APN theranostic probe was *** proposed strategy utilizes advanced machine learning and molecular dynamics simulations,and cleverly employs the strategy of conformation-induced fluorescence recovery to achieve multi-objective optimization and integration of functional *** this strategy,a unique“Off-On”theranostic probe,ABTP-DPTB,was ingeniously constructed to light up APN through fluorescence restoration,relying on conformation-induced effects and solvent *** from the common diagnostic probes,the intelligent design with non-substrated linkage makes ABTP-DPTB for long-term in-situ *** fabricated probe was used for detecting and inhibiting APN in various environments,with a better in vitro inhibitory than golden-standard drug bestatin.

关键词： Theranostic probe Artificial intelligence Conformational restriction Fluorescence restoration Design strategy

Taiji-TianQin-LISA network:Precisely measuring the Hubble constant using both bright and dark sirens

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 59-77页

作者： Shang-jie Jin Ye-zhu Zhang Ji-yu Song Jing-Fei Zhang Xin Zhang Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China

In the coming decades,the space-based gravitational-wave(GW)detectors such as Taiji,TianQin,and LISA are expected to form a network capable of detecting millihertz GWs emitted by the mergers of massive black hole binaries(MBHBs).In this work,we investigate the potential of GW standard sirens from the Taiji-TianQin-LISA network in constraining cosmological *** the optimistic scenario in which electromagnetic(EM)counterparts can be detected,we predict the number of detectable bright sirens based on three different MBHB population models,i.e.,popⅢ,Q3d,and *** results show that the TaijiTianQin-LISA network alone could achieve a constraint precision of 0.9%for the Hubble constant,meeting the standard of precision ***,the Taiji-TianQin-LISA network could effectively break the cosmological parameter degeneracies generated by the CMB data,particularly in the dynamical dark energy *** combined with the CMB data,the joint CMB+Taiji-TianQin-LISA data offerσ(w)=0.036 in the wCDM model,which is close to the latest constraint result obtained from the CMB+SN *** also consider a conservative scenario in which EM counterparts are not *** to the precise sky localizations of MBHBs by the Taiji-TianQin-LISA network,the constraint precision of the Hubble constant is expected to reach 1.2%.In conclusion,the GW standard sirens from the Taiji-TianQin-LISA network will play a critical role in helping solve the Hubble tension and shedding light on the nature of dark energy.

关键词： space-based gravitational wave detection standard sirens the Taiji-TianQin-LISA network the Hubble constant dark energy

Spray pyrolysis-derived W-doped MoSe_(2)/rGO paper-like microspheres:optimization of microstructure and mesostructure for enhanced lithium storage

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Rare Metals 2024年第7期43卷 3019-3031页

作者： Wei Wang Jun-yu Chen jie Ouyang Hong Yin Ao-jie Li Liang Chen Jun-Lin Huang yu-Can zhu Gang-Yong Li Zhao-Hui Hou Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and TechnologyYueyang 414006China School of Chemistry and Chemical Engineering Hunan Institute of Science and TechnologyYueyang414006China Hunan Province Key Laboratory of Materials Surface&Interface Science and Technology Material Science and Engineering SchoolCentral South University of Forestry and TechnologyChangsha 410004China International Iberian Nanotechnology Laboratory(INL) AvMestre Jose Veiga4715-330 BragaPortuga

Two-dimensional MoSe_(2) is a promising candidate for lithium-ion battery ***,its conductivity and lithium storage volumetric effect still need to be *** this work,W-doped MoSe_(2)/rGO paper-like microspheres are successfully prepared through ultrasonic spray pyrolysis,achieving optimization at both the microstructure and mesostructure to enhance the lithium storage performance of the ***,by utilizing the similar two-dimensional structure between MoSe_(2) and rGO,self-assembly is achieved through spray pyrolysis,resulting in a well-defined van der Waals heterostructure at the interface on the microscale,enhancing the electron and ion transfer capability of the ***,the mesoscale paper-like microsphere morphology provides additional volume expansion buffering ***,W-doping not only increases the interlayer spacing of MoSe_(2)(0.73 nm),thereby reducing the diffusion resistance of Li+,but also allow for the modulation of the energy band structure of the *** functional theory(DFT)calculations confirm that W-doped MoSe_(2)/rGO exhibits the narrowest bandgap(0.892 eV).Therefore,the composite demonstrates excellent lithium storage performance,maintaining a specific capacity of 732.9 mAh·g^(-1)after 300 cycles at a current density of 1 A·g^(-1).

关键词： Molybdenum selenide Heterostructure Microspheres Li-ion batteries Kinetics