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Science China Chemistry 2025年第1期 26-34页

作者： Yutao Zhang Juan Li Wei-hong zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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An institution theory of formal meta-modelling in graphically extended BNF

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Frontiers of Computer Science 2012年第1期6卷 40-56页

作者： hong zhu Department of Computing and Communication Technologies Oxford Brookes University Oxford UK

Meta-modelling plays an important role in model driven software development. In this paper, a graphic exten- sion of BNF （GEBNF） is proposed to define the abstract syn- tax of graphic modelling languages. From a GEBNF syntax definition, a formal predicate logic language can be induced so that meta-modelling can be performed formally by spec- ifying a predicate on the domain of syntactically valid mod- els. In this paper, we investigate the theoretical foundation of this meta-modelling approach. We formally define the se- mantics of GEBNF and its induced predicate logic languages, then apply Goguen and Burstall＇s institution theory to prove that they form a sound and valid formal specification lan- guage for meta-modelling.

关键词： meta-modelling modelling languages abstractsyntax semantics graphic extension of BNF (GEBNF) for-mal logic institution

A new strategy enabling intramolecular motion to obtain advanced photothermal materials

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Science China Chemistry 2019年第6期62卷 659-661页

作者： Wei-hong zhu Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology

Recently, considerable research interest has been focused on biomedical application of the photothermal materials, such as photoacoustic imaging (PAI) and photothermal therapy (PTT). PAI technique that roots in near-infrared (NIR) light excitation and ultrasonic detection has been extensively investigated in recent years since it surpasses the imaging depth limit of traditional optical imaging techniques, thereby providing deeper tissue penetration and higher spatial solution [1]. So far, several kinds of NIR-absorbing photothermal materials including gold nanorods/nanoshells, carbon nanotubes, 2D materials, semiconducting polymers and small-molecule organic dyes have been well studied for PAI and PTT.

关键词： Recently PAI PTT

Cosmic Wave Functions with the Brans-Dicke Theory

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Chinese Physics Letters 2000年第11期17卷 856-858页

作者： zhu Zong-hong Beijing Astronomical Observatory Chinese Academy of SciencesBeijing 100012 National Astronomical Observatories Chinese Academy of SciencesBeijing 100012 Institute of theoretical Physics Chinese Academy of SciencesBeijing 100080

Using the standard Wentzel-Kramers-Brillouin method,the Wheeler-DeWitt equation for the Brans-Dicke theory is solved under three kinds of boundary conditions(proposed by Hartle-Hawking,Vilenkin and Linde,respectively).It is found that,although the gravitational and cosmological“constants”are dynamical and time-dependent in the classical models,they will acquire constant values when the universe comes from the quantum creation,and that in particular,the amplitude of the resulting wave function under Linde or Vilenkin boundary conditions reaches its maximum if the cosmological constant is the minimum.

关键词： Dicke boundary constants

An extended stress-based method for orientation angle optimization of laminated composite structures

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Acta Mechanica Sinica 2011年第6期27卷 977-985页

作者： Jin Zhang Wei-hong Zhang Ji-hong zhu Engineering Simulation and Aerospace Computing （ESAC） The Key Laboratory of Contemporary Design ＆ Integrated Manufacturing Technology Northwestern Polytechnical University 710072 Xi＇ an China

Orientation optimization plays an important role in the lay-up design of composite *** orientation optimization methods face the main problem of huge number of design ***,a patch concept is proposed to reduce the number of design ***,the traditional stress-based method can not deal with patch orientation optimization of composite *** this paper,we propose an extended stress-based method to deal with such *** considered problems are to minimize the mean compliance under multiple load cases or to maximize the eigenvalues of a composite *** numerical examples are solved to demonstrate the efficiency of the new *** is shown that the new method has the ability to deal with constraints on orientation angle,such as symmetric,antisymmetric and discrete orientation angle *** iteration is less time-consuming because no sensitivity analysis is needed and a quick convergence rate can be achieved.

关键词： Structural optimization Composites Laminates Orientation angle optimization

Experimental Investigation of Vibration Response of A Free-Hanging Flexible Riser Induced by Internal Gas-Liquid Slug Flow

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China Ocean Engineering 2018年第6期32卷 633-645页

作者： zhu hong-jun ZHAO hong-lei GAO Yue State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University

The vibration response of a free-hanging flexible riser induced by internal gas-liquid slug flow was studied experimentally in a small-diameter tube model based on Froude number criterion. The flow regime in a curved riser model and the response displacements of the riser were simultaneously recorded by high speed cameras. The gas superficial velocity ranges from 0.1 m/s to 0.6 m/s while the liquid superficial velocity from 0.06 m/s to 0.3 m/*** slugging type 3, unstable oscillation flow and relatively stable slug flow were observed in the considered flow rates. Severe slugging type 3 characterized by premature gas penetration occurs at relatively low flow rates. Both the cycle time and slug length become shorter as the gas flow rate increases. The pressure at the riser base undergoes a longer period and larger amplitude of fluctuation as compared with the other two flow regimes. Additionally, severe slugging leads to the most vigorous in-plane vibration. However, the responses in the vertical and horizontal directions are not synchronized. The vertical vibration is dominated by the second mode while the horizontal vibration is dominated by the first mode. Similar to the vortex-induced vibration, three branches are identified as initial branch, build-up branch and descending branch for the response versus the mixture velocity of gas-liquid flow.

关键词： gas-liquid two-phase flow severe slugging liquid slug flexible riser flow-induced vibration

A fine-grained access control model for relational databases

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第8期11卷 575-586页

作者： Jie SHI hong zhu College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

Fine-grained access control (FGAC) must be supported by relational databases to satisfy the requirements of privacy preserving and Internet-based *** much work on FGAC models has been conducted,there are still a number of ongoing *** propose a new FGAC model which supports the specification of open access control policies as well as closed access control policies in relational *** negative authorization is supported,which allows the security administrator to specify what data should not be accessed by certain ***,multiple policies defined to regulate user access together are also *** definition and combination algorithm of multiple policies are thus ***,we implement the proposed FGAC model as a component of the database management system (DBMS) and evaluate its *** performance results show that the proposed model is feasible.

关键词： Fine-grained access control Database security Prohibition Multiple policies

Biomimetic Cationic Cyclization toward ent-Kaurene-type Diterpenoids

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Chinese Journal of Chemistry 2013年第1期31卷 111-118页

作者： Lili zhu Ran hong CAS Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic Chemistry Chi- nese Academy of Sciences Shanghai 200032 China

Terpenoids comprise the largest family of natural products and include various structurally different genus which play important roles in living organisms. Biosynthetically, diterpenoids are derived from （E,E,E）-geranylgeranyl diphosphate （GGPP）. From GGPP, diterpene cyclase catalyzes a sequence of carbocation- mediated cyclizations, rearrangements, and further oxidations, leading to a class of structurally unique ent-kaurenes, such as cafestol, gibberellin A3 and oridonin. According to the biosynthesis pathway of ent-kaurene, we designed a chiral acetal-enabled and SnCln-promoted biomimetic polyene cationic cyclization. With a following Birch reduc- tiort/alkylation cascade, a core skeleton of representative ent-kaurenes diterpenoids was completed.

关键词： diterpenoid ent-kaurene biomimetic synthesis carbocation cyclization Birch reduction/alkylationcascade

Chinese Continental Blocks in Global Paleocontinental Reconstruction during Paleozoic and Mesozoic

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Acta Geologica Sinica(English Edition) 2011年第3期85卷 581-597页

作者： WAN Tianfeng zhu hong School of Earth Sciences and Resources China University of Geosciences Beijing 100083 China

The Cambrian to Cretaceous paleomagnetic data from Chinese continental and adjacent blocks were collected using principles to obtain reliable and high-precision paleomagnetic data and to pay attention to the similarity of paleobiogeography and the coordination of tectonic *** Chinese continental blocks were laid up on the reconstruction of proposed global paleocontinents with almost the same ***,it can be clearly recognized that the global continents,including Chinese continental blocks,range along latitudes on the southern side of the equator during the Early Paleozoic. In the Paleozoic,Chinese continental blocks were still located among the Laurentia,Siberia and Gondwana plates,following the fast moving of the Siberia Plate northwards,the amalgamation in a north-south direction at the western parts of the Laurentia and Gondwana plates,and the Iapetus and Rheic Oceans were subducted,eventually to form a uniform Pangea in the Late *** Australian and Indian plates of Eastern Gondwana moved and dispersed gradually southwards, continued to extend the Paleo-Tethys *** Chinese continental and adjacent blocks were still located in the Paleo-Tethys Ocean,preserved the status of dispersion,gradually moving northwards, showing characteristics of ranging along a north-south orientation until the *** addition,a series of local collisions happened during the Triassic,and consequently most of the Chinese continental blocks were amalgamated into the Pangea,except for the Gangdise and Himalayan blocks. There was a counter-clockwise rotation of the Eastern Asian continent in the Jurassic and northwards migration of the Chinese continent in varying degrees during the Cretaceous,but the Himalayan and Indian plates did not collide into the Chinese continent during this period.

关键词： paleomagnetism paleogeographic reconstruction Paleozoic Mesozoic China

Numerical Simulation of the Vortex-Induced Vibration of A Curved Flexible Riser in Shear Flow

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China Ocean Engineering 2018年第3期32卷 301-311页

作者： zhu hong-jun LIN Peng-zhi State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

A series of fully three-dimensional(3 D) numerical simulations of flow past a free-to-oscillate curved flexible riser in shear flow were conducted at Reynolds number of 185–1015. The numerical results obtained by the two-way fluid–structure interaction(FSI) simulations are in good agreement with the experimental results reported in the earlier study. It is further found that the frequency transition is out of phase not only in the inline(IL) and crossflow(CF) directions but also along the span direction. The mode competition leads to the non-zero nodes of the rootmean-square(RMS) amplitude and the relatively chaotic trajectories. The fluid–structure interaction is to some extent reflected by the transverse velocity of the ambient fluid, which reaches the maximum value when the riser reaches the equilibrium position. Moreover, the local maximum transverse velocities occur at the peak CF amplitudes, and the values are relatively large when the vibration is in the resonance regions. The 3 D vortex columns are shed nearly parallel to the axis of the curved flexible riser. As the local Reynolds number increases from 0 at the bottom of the riser to the maximum value at the top, the wake undergoes a transition from a two-dimensional structure to a 3 D one. More irregular small-scale vortices appeared at the wake region of the riser, undergoing large amplitude responses.

关键词： vortex-induced vibration flexible riser shear flow fluid–structure interaction computational fluid dynamics