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Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng Xu Jing-Kai Wang Bo Chen Hao Xu Deng pan Yu-Yang Ma Kun pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

Optical metrology embraces deep learning:keeping an open mind

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Light(Science & Applications) 2022年第6期11卷 1023-1025页

作者： Bing pan School of Aeronautic Science and Engineering Beihang University100191 BeijingChina

Optical metrology practitioners ought to embrace deep learning with an open mind,while devote continuing efforts to look for its theoretical groundwork and maintain an awareness of its limits.

关键词： metrology while mind

3D Bioplotting of Gelatin/Alginate Scaffolds for Tissue Engineering:Influence of Crosslinking Degree and Pore Architecture on Physicochemical Properties

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Journal of Materials Science & Technology 2016年第9期32卷 889-900页

作者： Ting pan Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510641China National Engineering Research Center for Tissue Restoration and Reconstruction Guangzhou 5J0006China Guangdong Province Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006China

Gelatin/Alginate hydrogels were engineered for bioplotting in tissue engineering. One major drawback of hydrogel scaffolds is the lack of adequate mechanical properties. In this study, using a bioplotter, we constructed the scaffolds with different pore architectures by deposition of gelatin/alginate hydrogels layerby-layer. The scaffolds with different crosslinking degree were obtained by post-crosslinking methods. Their physicochemical properties, as well as cell viability, were assessed. Different crosslinking methods had little influence on scaffold architecture, porosity, pore size and distribution. By contrast, the water absorption ability, degradation rate and mechanical properties of the scaffolds were dramatically affected by treatment with various concentrations of crosslinking agent （glutaraldehyde）. The crosslinking process using glutaraldehyde markedly improved the stability and mechanical strength of the hydrogel scaf- folds. Besides the post-processing methods, the pore architecture can also evidently affect the mechanical properties of the scaffolds. The crosslinked gelatin/alginate scaffolds showed a good potential to encap-sulate cells or drugs.

关键词： Bioplotting Tissue engineering Scaffolds Gelatin Alginate

Analytical Solutions for an Isotropic Elastic Half-Plane with Complete Surface Effects Subjected to a Concentrated/Uniform Surface Load

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Acta Mechanica Solida Sinica 2024年第3期37卷 371-384页

作者： Xia-Hui pan School of Civil Engineering Henan Polytechnic UniversityJiaozuo454003China

Within the context of Gurtin-Murdoch surface elasticity theory,closed-form analytical solutions are derived for an isotropic elastic half-plane subjected to a concentrated/uniform surface *** the effects of residual surface stress and surface elasticity are *** stress function method and Fourier integral transform technique are *** solutions are provided in a compact manner that can easily reduce to special situations that take into account either one surface effect or none at *** results indicate that surface effects generally lower the stress levels and smooth the deformation profiles in the *** elasticity plays a dominant role in the in-plane elastic fields for a tangentially loaded half-plane,while the effect of residual surface stress is fundamentally crucial for the out-of-plane stress and displacement when the half-plane is normally *** the remaining situations,combined effects of surface elasticity and residual surface stress should be *** results for a concentrated surface force serve essentially as fundamental solutions of the Flamant and the half-plane Cerruti problems with surface *** solutions presented in this work may be helpful for understanding the contact behaviors between solids at the nanoscale.

关键词： Surface effects Residual surface stress Surface elasticity Half-plane Analytical solutions

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运动干预与细胞焦亡在骨关节炎中的作用

中国组织工程研究 2025年第8期29卷 1667-1675页

作者：王秋月靳攀蒲锐长江大学教育与体育学院湖北省荆州市434023 长江大学医学部湖北省荆州市434023 长江大学运动人体科学实验室湖北省荆州市434023

背景:细胞焦亡参与软骨细胞外基质降解、滑膜炎症以及疼痛,在骨关节炎防治中发挥重要作用。此外,运动可通过抑制细胞焦亡调控骨关节炎的发生,已成为防治骨关节炎的研究热点。目的:总结细胞焦亡在骨关节炎中的调控作用,以及运动介导细胞... 详细信息

背景:细胞焦亡参与软骨细胞外基质降解、滑膜炎症以及疼痛,在骨关节炎防治中发挥重要作用。此外,运动可通过抑制细胞焦亡调控骨关节炎的发生,已成为防治骨关节炎的研究热点。目的:总结细胞焦亡在骨关节炎中的调控作用,以及运动介导细胞焦亡在改善骨关节炎中的机制。方法:以“pyroptosis,osteoarthritis,chondrocyte pyroptosis,synovial cell pyroptosis,exercise”和“细胞焦亡,骨关节炎,软骨细胞焦亡,滑膜细胞焦亡,运动”为关键词,检索PubMed与中国知网数据库1992-2024年间发表的相关文献,根据纳入及排除标准选择71篇文献进行综述。结果与结论:①骨关节炎是以软骨细胞外基质降解、滑膜炎症和软骨下骨重塑等为特点的慢性退行性关节疾病,易引起骨的器质性病变、疼痛并引发功能障碍。②细胞焦亡作为一种特殊的程序性死亡机制,其特征为细胞裂解死亡释放炎症因子引发强烈的炎症反应,与骨关节炎的发生发展关系密切。细胞焦亡可导致大量炎症因子释放,进而激活核因子κB转录,增加焦亡蛋白的产生,进而加剧骨关节炎的发生发展,因此细胞焦亡可作为骨关节炎防治的新方向。③运动可通过下调焦亡蛋白信号通路和抑制相关炎症因子表达等途径抑制软骨细胞和滑膜细胞的焦亡,从而在骨关节炎防治中发挥重要作用。有氧和无氧运动可通过抑制细胞焦亡的发生延缓骨关节炎的病理进程,中等强度的有氧运动通过抑制细胞焦亡信号通路改善骨关节炎的效果较好,无氧运动可通过提高肌肉质量进而对骨关节炎产生有益效应。

关键词：细胞焦亡骨关节炎运动运动调控信号通路综述

Experimental study of dual nano-network, high-temperature resistant aerogel material as an integration of thermal management functions

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Journal of Energy Chemistry 2025年第1期 157-170页

作者： Yueyue Xiao Tianke Mao Zun Zhao Yuelei pan Heping Zhang Xudong Cheng State Key Laboratory of Fire Science University of Science and Technology of China

Thermal management system is highly desirable to guarantee the performance and thermal safety of lithium-ion batteries,but it reduces the energy density of battery modules and even is unable to provide highly effective ***,a thermal management function integrated material is presented based on high-temperature resistant aerogel and phase change material and is applied at both charge–discharge process and thermal runaway *** this sandwich structure Paraffin@SiC nanowire/Aerogel sheet （denoted as PA@SAS） system,SiC nanowires endow the middle aerogel sheet （SAS） a dual nano-network *** enhanced mechanical properties of SAS were studied by compressive tests and dynamic mechanical ***,the thermal conductivity of SAS at 600°C is only 0.042 W/（m K）.The surface phase change material layers facilitate temperature uniformity of batteries （surface temperature difference less than 1.82°C） through latent ***,a large-format battery module with four 58 Ah LiNi0.5Co0.2Mn0.3O2LIBs was ***@SAS successfully prevents thermal runaway propagation,yielding a temperature gap of 602°C through the 2 mm-thick cross ***@SAS also exhibits excellent performance in other safety issues such as temperature rise rate,flame heat flux,*** lightweight property and effective insulation performance achieves significant safety enhancement with mass and volume energy density reduction of only 0.79%and 5.4%,*** originality of the present research stems from the micro and macro structure design of the proposed thermal management material and the combination of intrinsic advantages of every *** work provides a reliable design of achieving the integration of thermal management functions into an aerogel composite and improves the thermal safety of lithium-ion batteries.

关键词：

压应力激活SOST/Wnt/β-catenin 通路诱导软骨终板细胞退变

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中国组织工程研究 2025年第5期29卷 951-957页

作者：项攀车艳军罗宗平苏州大学附属第一医院骨科研究所江苏省苏州市215006 南京医科大学附属苏州医院骨科与运动医学中心江苏省苏州市215000

背景:在许多可以导致椎间盘退变的因素中(衰老、营养匮乏、机械因素等),力学负荷被认为是极其重要的因素,但其机制尚不清楚。目的:探讨硬骨素和Wnt/β-catenin信号通路在压应力诱导终板软骨退变中的作用。方法:提取4周龄雄性SD大鼠软骨... 详细信息

背景:在许多可以导致椎间盘退变的因素中(衰老、营养匮乏、机械因素等),力学负荷被认为是极其重要的因素,但其机制尚不清楚。目的:探讨硬骨素和Wnt/β-catenin信号通路在压应力诱导终板软骨退变中的作用。方法:提取4周龄雄性SD大鼠软骨终板细胞,体外利用力学加载仪器对终板软骨细胞施加压应力,于压缩细胞1,3,5,7 d,采用CCK-8法测定细胞活力;Western blot、RT-qPCR及细胞免疫荧光等检查终板软骨细胞内软骨标记物(聚集蛋白聚糖、Ⅱ型胶原)、钙化相关因子(Runx2、骨钙素)、细胞外基质降解酶及信号通路基因(硬骨素、β-catenin)等表达。结果与结论:①压应力作用下,终板软骨细胞活力会随着压应力时间、强度增加而降低;②终板软骨细胞的软骨标记物(聚集蛋白聚糖、Ⅱ型胶原)表达下降,而钙化相关因子(Runx2、骨钙素)表达上升;③压应力能促进终板软骨细胞的细胞外基质降解,基质金属蛋白酶3、基质金属蛋白酶13表达量增加;④细胞内Wnt/β-catenin信号通路表达出现异常,其特异性抑制因子硬骨素伴随着β-catenin的异常积累而表达下降。结果说明:在压应力作用下,终板软骨细胞内硬骨素的表达下降,导致Wnt/β-catenin信号通路激活,促进软骨终板的钙化、退变与细胞外基质的降解,进而促进椎间盘退变。

关键词：软骨终板软骨细胞 SOST Wnt/β-catenin 压应力椎间盘退变

Unveiling the promotion role of ZnO on Zn-Al spinel oxide for CO2 hydrogenation

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Journal of Energy Chemistry 2025年第1期 18-25页

作者： Tongyao Wang Xinlong Yao Lixin Liang Hongyu Chen pan Gao Guangjin Hou State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The Zn-Al spinel oxide stands out as one of the most active catalysts for high-temperature methanol synthesis from CO2hydrogenation. However, the structure–activity relationship of the reaction remains poorly understood due to challenges in atomic-level structural characterizations and analysis of reaction intermediates. In this study, we prepared two Zn-Al spinel oxide catalysts via coprecipitation（ZnAl-C）and hydrothermal（ZnAl-H） methods, and conducted a comparative investigation in the CO2hydrogenation reaction. Surprisingly, under similar conditions, ZnAl-C exhibited significantly higher selectivity towards methanol and DME compared to ZnAl-H. Comprehensive characterizations using X-ray diffraction（XRD）, Raman spectroscopy and electron paramagnetic resonance（EPR） unveiled that ZnAl-C catalyst had abundant ZnO species on its surface, and the interaction between the ZnO species and its ZnAl spinel oxide matrix led to the formation of oxygen vacancies, which are crucial for CO2adsorption and activation. Additionally, state-of-the-art solid-state nuclear magnetic resonance（NMR） techniques,including ex-situ and in-situ NMR analyses, confirmed that the surface ZnO facilitates the formation of unique highly reactive interfacial formate species, which was readily hydrogenated to methanol and DME. These insights elucidate the promotion effects of ZnO on the ZnAl spinel oxide in regulating active sites and reactive intermediates for CO2-to-methanol hydrogenation reaction, which is further evidenced by the significant enhancement in methanol and DME selectivity observed upon loading ZnO onto the ZnAl-H catalyst. These molecular-level mechanism understandings reinforce the idea of optimizing the ZnO-ZnAl interface through tailored synthesis methods to achieve activity-selectivity balance.

关键词：

Decoupling effect and driving factors of carbon footprint in megacity Wuhan,Central China

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Ecological Processes 2023年第1期12卷 330-343页

作者： Gao pan Xinhang Li Deng pan Wensheng Liu College of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004People’s Republic of China Central South Academy of Inventory and Planning of NFGA Changsha 410014People’s Republic of China

Background China’s 35 largest cities,including Wuhan,are inhabited by approximately 18%of the Chinese popula-tion,and account for 40%energy consumption and greenhouse gas *** is the only sub-provincial city in Central China and,as the eighth largest economy nationwide,has experienced a notable increase in energy ***,major knowledge gaps exist in understanding the nexus of economic development and carbon footprint and their drivers in *** We studied Wuhan for the evolutionary characteristics of its carbon footprint(CF),the decoupling relation-ship between economic development and CF,and the essential drivers of *** on the CF model,we quantified the dynamic trends of CF,carbon carrying capacity,carbon deficit,and carbon deficit pressure index from 2001 to *** also adopted a decoupling model to clarify the coupled dynamics among total CF,its accounts,and eco-nomic *** used the partial least squares method to analyze the influencing factors of Wuhan’s CF and determine the main *** The CF of Wuhan increased from 36.01 million t CO_(2)eq in 2001 to 70.07 million t CO_(2)eq in 2020,a growth rate of 94.61%,which was much faster than that of the carbon carrying *** energy consumption account(84.15%)far exceeded other accounts,and was mostly contributed by raw coal,coke,and crude *** carbon deficit pressure index fluctuated in the range of 8.44-6.74%,indicating that Wuhan was in the relief zone and the mild enhancement zone during *** the same time,Wuhan was in a transition stage between weak and strong CF decoupling and economic *** main driving factor of CF growth was the urban per capita residen-tial building area,while energy consumption per unit of GDP was responsible for the CF *** Our research highlights the interaction of urban ecological and economic systems,and that Wuhan’s CF changes were mainly affected by four factors:city size,economic developm

关键词： Carbon footprint Economic development Decoupling analysis Partial least squares analysis Megacity

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