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Protective Effect and Mechanism of n-butanol Extract from Diploclisia glaucescens(B1.)Diels on Rats with Adjuvant Arthritis

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Medicinal Plant 2023年第5期14卷 45-48页

作者： Chuhui ZHOU zhouyan huang Fengxian ZHAO Yong CHEN Xianxian LIU Xiaolian LIANG Wenli LI Guangxi University of Chinese Medicine Nanning 530200China

[Objectives]To study the protective effect and mechanism of n-butanol extract of Diploclisia glaucescens(B1.)Diels on rats with adjuvant arthritis.[Methods]A rat adjuvant arthritis(AA)model with similarities to a clinical RA(rheumatoid arthritis)patient was used,and the model was made by injection of Complete Freund s adjuvant(CFA).Body mass and joint swelling degree were used as indicators,and the organ index was calculated and the synovial tissue of rats was examined under microscope to evaluate the protective effect of n-butanol extract on *** effects of n-butanol extract on TNF-α,IL-1βand PGE_(2)contents in rat serum were detected by ELISA kit.[Results]Arthritic rats experienced significant weight loss;the n-butanol extract reduced the joint swelling in *** exerted an effect on rat organs and reduced the contents of TNF-α,IL-1βand PGE_(2) in rat serum,and also reduced synovial inflammation in rats.[Conclusions]The n-butanol extract of *** can protect rats with adjuvant arthritis by reducing the content of inflammatory factors.

关键词： Diploclisia glaucescens(B1.)Diels n-butanol extract Rats with adjuvant arthritis

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民族药苍白秤钩风的初步质量研究

壮瑶药研究 2022年第1期 115-124,236页

作者：周楚惠黄周艳陈勇刘纤纤李文莉梁晓莲赵凤仙广西中医药大学科学实验中心南宁530200

目的:研究苍白秤钩风药材的初步质量分析。方法:采用性状鉴别、显微鉴别、薄层鉴别进行定性鉴别,按2020年《中国药典》附录中的方法对水分、总灰分和浸出物进行检查。结果:药材性状、显微鉴别特征明显;14批样品的薄层色谱斑点清晰;水分... 详细信息

目的:研究苍白秤钩风药材的初步质量分析。方法:采用性状鉴别、显微鉴别、薄层鉴别进行定性鉴别,按2020年《中国药典》附录中的方法对水分、总灰分和浸出物进行检查。结果:药材性状、显微鉴别特征明显;14批样品的薄层色谱斑点清晰;水分,总灰分,浸出物。结论:该方法准确稳定,重复性好,可为苍白秤钩风质量标准的制定提供依据。

关键词：苍白秤钩风质量分析民族药

Effects of Different Processed Products of Ilex hainanensis Merr on Rats with Hyperlipidemia

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Medicinal Plant 2019年第2期10卷 42-46页

作者： Jiangcun WEI Zujie QIN Zhen XIE Yong CHEN Long ZHANG Qian HAN zhouyan huang Guangxi International Zhuang Medicine Hospital Guangxi University of Chinese Medicine

[Objectives] This study aimed to investigate the hypolipidemic effects of different processed products of Ilex hainanensis Merr to provide experimental basis for the research on the hypolipidemic mechanism of I. hainanensis Merr. [Methods] SD rats were fed high-fat diet to establish hyperlipidemia rat models. The hyperlipidemia rats were administered with different processed products of I. hainanensis Merr by gavage to investigate the preventive and therapeutic effects of the medicinal material. [Results] The levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C) in the rats fed high-fat diet were significantly higher than those in of the control group(Pdrying in shade. Among different baking times, the hypolipidemic effects ranked as 180 ℃>200 ℃=220 ℃. Among different baking times, the hypolipidemic effects ranked as 20 min=40 min>30 min. The hypolipidemic effects of processed product of I. hainanensis Merr with different amounts of active ingredients were different. [Conclusions] The processed products of I. hainanensis Merr all had hypolipidemic effects, but the effects were different. This study will provide a scientific basis for expanding the resources of I. hainanensis Merr.

关键词： Ilex hainanensis Merr Hypolipidemic effect Processed products Processing technology

Simultaneous Determination of Gallic Acid and Cinnamic Acid Content in Rhubarb by HPLC

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Plant Diseases and Pests 2020年第3期11卷 31-34页

作者： Han Qian Wei Jiangcun Chen Yong Shi Xianyi Wu Yuyan Fu Zhenying huang zhouyan Liu Wenjun Guangxi University of Traditional Chinese Medicine Nanning 530200China Guangxi International Zhuang Medicine Hospital Nanning 530201China

[Objective]The paper was to determine the contents of gallic acid and cinnamic acid in Chinese herb rhubarb by HPLC.[Method]High performance liquid chromatography(HPLC)was established with the following conditions:Thermo SCIENTIFIC Hypersil GOLD Dim column(4.6 mm×250 mm,5μm),mobile phase methanol-0.1%phosphoric acid solution,gradient elution,detection wavelength 278 nm,flow rate 1.0 mL/min,column temperature 30℃,injection volume 10 pL.[Result]The content of gallic acid and cinnamic acid in rhubarb was determined by HPLC,and they showed good linear relationship in the linear ranges of 0.125-1.250 pg(E2=0.9998)and 0.0382-0.3820μg(E2=0.9994),respectively.[Conclusion]A HPLC method is established to determine gallic acid and cinnamic acid content in *** method will provide a scientific basis for quality control of rhubarb and its traditional Chinese medicine.

关键词： Rhubarb Gallic acid Cinnamic acid HPLC

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三七叶总皂苷对中枢神经系统的作用研究进展

壮瑶药研究季刊 2019年第1期 88-92,107页

作者：陈良妮陈勇刘玟君黄周艳韩倩广西中医药大学药学院

三七茎叶的资源丰富,价廉,且尚未得到充分利用,研究发现三七茎叶富含糖类、黄酮类、三七叶总皂昔等化合物。其中三七叶总皂昔是三七茎叶的提取物,三七叶总皂昔毒性低,其功效日益受到瞩目,对心血管系统、对中枢神经系统、免疫功能、抗肿... 详细信息

三七茎叶的资源丰富,价廉,且尚未得到充分利用,研究发现三七茎叶富含糖类、黄酮类、三七叶总皂昔等化合物。其中三七叶总皂昔是三七茎叶的提取物,三七叶总皂昔毒性低,其功效日益受到瞩目,对心血管系统、对中枢神经系统、免疫功能、抗肿瘤及改善微循环等方面有良好的作用,临床应用越来越广泛。三七叶总皂昔中是人参皂昔Rbi、Rc、Rb2,Rbs对中枢神经系统有药理活性,其对中枢神经系统的作用包括抗抑郁、改善睡眠、镇痛及镇静这几个作用。本文从三七叶总皂昔抗抑郁、改善睡眠、镇痛及镇静这几方面综述其对中枢神经系统的作用的研究进展。

关键词：三七叶抗抑郁人参皂昔镇静镇痛

新型冠状病毒肺炎疫情常态化防控期间综合医院口腔门诊预检分诊管理

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中西医结合护理 2022年第11期8卷 60-66页

作者：熊雁洁刘芳黄周燕王超中国人民解放军总医院第七医学中心口腔科北京100700

目的探讨新型冠状病毒肺炎疫情常态化防控期间综合医院口腔科门诊预检分诊管理方案实施效果。方法根据国家及市级卫健委、中华口腔医学会等相关疫情防控指导文件,结合科室情况,制定一系列口腔科预检分诊管理方案并实施,观察实施效果。结... 详细信息

目的探讨新型冠状病毒肺炎疫情常态化防控期间综合医院口腔科门诊预检分诊管理方案实施效果。方法根据国家及市级卫健委、中华口腔医学会等相关疫情防控指导文件,结合科室情况,制定一系列口腔科预检分诊管理方案并实施,观察实施效果。结果2020年6月—8月安全有序接诊3821名口腔门诊患者,无疑似或新冠肺炎患者,未启动口腔科应急管理预案,未发生诊室交叉感染事件。结论新冠肺炎疫情期间口腔科实施预检分诊管理方案,基于流行病学调查登记和口腔诊疗风险分类,有利于筛查高风险就诊患者,在保护医患双方的前提下,最大限度安全有序地恢复口腔门诊诊疗秩序,为患者提供口腔诊疗服务。

关键词：新型冠状病毒肺炎口腔门诊预检分诊发热急诊

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瑶药水石榴的质量标准研究

中国现代应用药学 2021年第1期38卷 8-13页

作者：陈子隽段猷琼李金洲魏江存阙祖亮庞丹清刘玟君黄周艳陈勇桂林南药股份有限公司广西桂林541000 广西中医药大学南宁530001 桂林市人民医院广西桂林541000 广西国际壮医医院南宁530022

目的建立瑶药水石榴的质量标准。方法建立瑶药水石榴的性状、显微特征、薄层鉴别及含量测定方法;根据中国药典2015年版第四部通则中的方法对瑶药水石榴的水分、灰分、酸不溶性灰分及浸出物等项目进行测定。结果瑶药水石榴在性状、显微... 详细信息

目的建立瑶药水石榴的质量标准。方法建立瑶药水石榴的性状、显微特征、薄层鉴别及含量测定方法;根据中国药典2015年版第四部通则中的方法对瑶药水石榴的水分、灰分、酸不溶性灰分及浸出物等项目进行测定。结果瑶药水石榴在性状、显微特征和薄层色谱方面均具有专属性特征。药材水分含量为7.38%~12.25%,灰分含量为5.81%~10.69%,酸不溶物含量为0.09%~3.87%,浸出物为18.91%~32.29%。异荭草苷在2.7504~45.8μg·mL^−1(r=0.99997)内线性关系良好,平均加样回收率为104.6%。10批药材样品中异荭草苷的含量为0.0105%~0.1390%。结论建立的水石榴药材质量标准具有很好的专属性和准确性,研究结果可为瑶药水石榴质量标准的建立及其药材的推广使用提供科学依据。

关键词：瑶药水石榴质量标准含量测定

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当归藤补血有效部位的筛选及其补血机制研究

中国药房 2020年第3期31卷 293-297页

作者：刘玟君阙祖亮李金洲陈子隽黄周艳庞丹清陈良妮陈勇广西中医药大学药学院

目的:考察当归藤不同提取部位对血虚模型小鼠的补血作用,并探索其作用机制。方法:将70只小鼠随机分为空白对照组(水)、模型对照组(水)、阳性对照组(当归补血口服液,324 g/kg)和当归藤石油醚部位、乙酸乙酯部位、正丁醇部位、水部位组(... 详细信息

目的:考察当归藤不同提取部位对血虚模型小鼠的补血作用,并探索其作用机制。方法:将70只小鼠随机分为空白对照组(水)、模型对照组(水)、阳性对照组(当归补血口服液,324 g/kg)和当归藤石油醚部位、乙酸乙酯部位、正丁醇部位、水部位组(给药剂量依次为4.2、10.64、22.07、5.0 g/kg,以提取部位浸膏计),每组10只。小鼠均灌胃给药,每天1次,连续给药14 d。除空白对照组外,其余各组小鼠均于开始给药的第12、13天时腹腔注射环磷酰胺(80 mg/kg)复制血虚模型。末次给药30 min后,采用全自动血细胞分析仪检测小鼠外周血象指标[白细胞计数(WBC)、红细胞计数(RBC)、红细胞压积(HCT)、血小板计数(PLT)和血红蛋白浓度(HGB)]水平;采用酶联免疫吸附法测定小鼠血清中白细胞介素2(IL-2)、IL-3、IL-6、促红细胞生成素(EPO)、粒细胞集落刺激因子(G-CSF)、巨噬细胞集落刺激因子(M-CSF)、血管细胞黏附分子1(VCAM-1)水平;计算小鼠胸腺指数与脾指数。结果:与空白对照组比较,模型对照组小鼠各血象指标水平、血清中IL-2、IL-3、IL-6、EPO、G-CSF、M-CSF、VCAM-1水平以及胸腺指数均显著降低,脾指数显著升高(P0.05);当归藤乙酸乙酯部位组小鼠外周血RBC、HGB、PLT水平、血清中IL-2、IL-6、G-CSF、M-CSF、VCAM-1水平以及胸腺指数显著升高(P0.05);除当归藤水部位组小鼠WBC升高不显著外,当归藤正丁醇部位、水部位组小鼠上述各血象指标和血清因子水平及胸腺指数均显著升高,脾指数均显著降低(P<0.05或P<0.01)。结论:当归藤乙酸乙酯、正丁醇和水部位均可提高血虚模型小鼠的免疫功能和造血因子的表达,具有一定的补血作用。

关键词：当归藤补血作用部位筛选环磷酰胺造血因子免疫功能小鼠

Discussion on the Green Tax Stimulation Measure of Nitrogen Fertilizer Non-Point Source Pollution Control-Taking the Dongting Lake Area in China as a Case

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Agricultural Sciences in China 2007年第6期6卷 732-741页

作者： XIANG Ping-an zhouyan huang huang ZHENG Hua College of Agronomy Hunan Agricultural University Changsha 410128 P.R.China Technical Center of Changsha Cigarette Factory Changsha 410014 P.R.China Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 P.R.China

A study on designing the tax of nitrogen fertilizer can provide a new method for controlling nitrogen fertilizer non-point source pollution. The tax design of nitrogen fertilizer was discussed by utilizing the external theory and the demand elasticity theory. The results indicated that the coefficient of price elasticity of nitrogen fertilizer demand is -0.21, which instructed that the market demand is in lack of elasticity in the short period and the impact of nitrogen fertilizer manufacturers is subtle. The 11 counties （cities and boroughs） in the Dongting Lake area in China, where the farmland nitrogen application surpassed the average ecological fertilization dosage, is listed to the taxation scope of nitrogen fertilizer tax. The environment loss will reduce 0.07 hundred million RMB yuan and the revenue will increase 0.89 hundred million RMB yuan in the country after levying on nitrogen fertilizer. The loss, which was brought by the decreasing food supplies production, will be 0.58 hundred million RMB yuan and the net social benefit will be 0.38 hundred million RMB yuan following revenue collection. The variation scope of the increasing expenditure of farmers will range from 0.95 to 1.49%. The variation scope of the income of farmers will range from -8.41 to 6.44%. The 5 areas, Yunxi Borough, Junshan Borough, Hanshou County, Jinshi City, and Ziyang Borough, had an increase in food supplies production after the revenue collection. The environment loss will reduce 0.01 hundred million RMB yuan and the revenue will increase 0.16 hundred million RMB yuan in the country after levying on nitrogen fertilizer. The economic benefits, which was brought by the increasing cereals production, will be 0.67 hundred million RMB yuan and the net social benefit will be 0.84 hundred million RMB yuan after revenue collection. The variation scope of the increasing expenditure of farmers will range from 0.95 to 1.06%. The variation scope of the increasing income of farmers will range

关键词： nitrogen fertilizer non-point source pollution tax Dongting Lake area