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广州市老年人23价肺炎球菌多糖疫苗接种意愿及影响因素分析

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中国预防医学杂志 2024年第3期25卷 372-378页

作者：王雯张春焕张周斌余文周广州市疾病预防控制中心广东广州510440 中国疾病预防控制中心免疫规划中心

目的了解广州市老年人23价肺炎球菌多糖疫苗(23-valent pneumococcal polysaccharide vaccine,PPV23)的接种意愿、接种率及其影响因素,为广州市制定老年人肺炎疫苗接种策略提供依据。方法于2022年7月10-31日在广州市11个区采取方便抽... 详细信息

目的了解广州市老年人23价肺炎球菌多糖疫苗(23-valent pneumococcal polysaccharide vaccine,PPV23)的接种意愿、接种率及其影响因素,为广州市制定老年人肺炎疫苗接种策略提供依据。方法于2022年7月10-31日在广州市11个区采取方便抽样开展调查,以≥60岁老年人作为调查对象,采用多因素logistic回归分析老年人PPV23的接种意愿和接种率的影响因素。结果共调查1316人,其中1 157人(87.92%)表示愿意接种PPV23,186人(14.13%)接种了PPV23。老年人愿意接种PPV23的原因主要为可有效减少患肺炎的可能性(82.80%)、肺炎疫苗安全可靠(60.67%)和临床医生推荐接种(47.28%);老年人更关注肺炎疫苗是否有效(77.81%)、是否安全(76.44%)和自身能否接种(68.62%),更希望通过接种门诊工作人员(64.06%)、电视或广播(54.18%)和临床医生(51.22%)获得肺炎疫苗的信息。多因素分析结果显示,过去一年出现发热伴咳嗽、咳痰情况(OR=1.68,95%CI:1.09~2.59)、既往接种过流感疫苗(OR=2.99,95%CI:1.76~5.09)、具有较好的肺炎(OR=2.41,95%CI:1.58~3.68)和肺炎疫苗(OR=4.37,95%CI:2.83~6.72)认知水平的老年人PPV23的接种意愿更高;年龄较高(OR=2.43, 95%CI:1.42~4.16)、既往接种过流感疫苗(OR=4.27, 95%CI:2.96~6.17)、具有较好的肺炎疫苗(OR=3.81,95%CI:2.44~5.93)认知水平的老年人PPV23的接种率更高。结论广州市老年人PPV23的接种意愿较高,但接种率较低,通过加强肺炎疫苗预防效果和安全性的健康教育,鼓励医务人员向老年人推荐疫苗接种,同时改进老年人预防接种服务的可及性和便利性,将有助于提升老年人肺炎疫苗的接种率。

关键词： 23价肺炎球菌多糖疫苗接种意愿接种率老年人

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“天问二号”任务科学目标和有效载荷配置

深空探测学报（中英文） 2024年第3期11卷 304-310页

作者：李春来刘建军任鑫严韦张舟斌李海英欧阳自远中国科学院月球与深空探测重点实验室北京100101 中国科学院国家天文台北京100101

回顾了近30年国际上小行星探测任务的科学目标和载荷配置。在总结小行星探测主要科学问题的基础上,对中国行星探测工程“天问二号”探测任务的对象选择、科学目标和有效载荷配置进行了论述。围绕实现科学目标探测,并提出了相应的科学研... 详细信息

回顾了近30年国际上小行星探测任务的科学目标和载荷配置。在总结小行星探测主要科学问题的基础上,对中国行星探测工程“天问二号”探测任务的对象选择、科学目标和有效载荷配置进行了论述。围绕实现科学目标探测,并提出了相应的科学研究内容和有效载荷技术指标。

关键词：天问二号小行星探测科学目标有效载荷

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一种基于多重PCR的基孔肯雅病毒全基因组高通量测序方法的建立

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中华预防医学杂志 2024年第4期58卷 489-496页

作者：苏文哲李岩陆维智谢华萍李魁彪狄飚聂凯王环宇张周斌许松涛广州市疾病预防控制中心病毒免疫部广州510440 山东省疾病预防控制中心传染病防制所济南250000 中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室北京102206 广州市疾病预防控制中心主任室广州510440

目的:建立基于多重PCR的基孔肯雅病毒全基因组高通量测序方法。方法:通过NCBI网站检索和下载CHIKV的各基因型序列,经序列比对筛选出备选参考序列,使用Primalscheme和Geneious Prime等软件进行引物方案的设计、筛选和人工优化,并使用7份C... 详细信息

目的:建立基于多重PCR的基孔肯雅病毒全基因组高通量测序方法。方法:通过NCBI网站检索和下载CHIKV的各基因型序列,经序列比对筛选出备选参考序列,使用Primalscheme和Geneious Prime等软件进行引物方案的设计、筛选和人工优化,并使用7份CHIKV阳性样品对实验流程进行评估。结果:本研究所设计的引物方案可对各阳性样品进行成功扩增;在样品Ct值小于33时,可获得完整编码区序列;样品Ct值达到35时,可获得99.38%的编码区序列;使用多次迭代,逐步校正的拼接策略可将拼接成功率提高5.70%~25.43%。结论:建立的基于多重PCR的基孔肯雅病毒全基因组高通量测序方法操作简单,对多个浓度的基孔肯雅病毒阳性临床样品均表现良好。

关键词：基孔肯雅病毒全基因组测序多重PCR 高通量测序

新冠疫情大流行期间广州市H3N2流感病毒分子流行特征分析

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中华预防医学杂志 2024年第3期58卷 351-357页

作者：曹蓝周腾飞陈艺韵马蒙蒙夏丹刘艳慧李魁彪狄飚秦鹏哲张周斌广州市疾病预防控制中心病毒免疫部广州510440 广州市疾病预防控制中心传染病预防控制部广州510440 广州市疾病预防控制中心主任室广州510440

分析新型冠状病毒疫情(新冠疫情)大流行期间广州市H3N2流感病毒分子变异特征。收集流感监测哨点医院流感样病例样本,进行病毒分离和全基因组高通量测序。结果显示,新冠疫情大流行期间广州市在2022年第二季度出现了一次H3N2流感流行高峰... 详细信息

分析新型冠状病毒疫情(新冠疫情)大流行期间广州市H3N2流感病毒分子变异特征。收集流感监测哨点医院流感样病例样本,进行病毒分离和全基因组高通量测序。结果显示,新冠疫情大流行期间广州市在2022年第二季度出现了一次H3N2流感流行高峰(阳性率为52.23%),流行强度和持续时间均高于2019年H3N2流感流行期。2022年流行株HA基因和NA基因均属于3C.2a1b.2a.1a.1分支,与2019年冬季的H3N2流行株进化分支(Group-3 毒株3C.2a1b.1a)不同。2022年流行株抗原位点变异主要发生在C区I48T位,HA蛋白受体结合位点与疫苗株一致。大部分流行株在HA蛋白上带有13个糖基化位点,一起暴发疫情分离株发生24-NST处糖基化位点的缺失。综上,新冠疫情大流行期间,引起广州市2022年H3N2流感流行的病毒株属于新衍生进化分支,进化起源上并非由2019年广州市毒株直接传播进化而来。

关键词： H3N2流感病毒分子变异遗传特征新型冠状病毒监测

基于纳米孔测序技术对新型重组H3N2禽流感病毒的测序鉴定及其基因特征分析

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中华流行病学杂志 2024年第4期45卷 574-578页

作者：曹蓝夏丹陈艺韵周腾飞殷尚晖刘艳慧李魁彪狄飚张周斌秦鹏哲广州市疾病预防控制中心广州510440

目的利用纳米孔测序技术对新型重组H3N2禽流感病毒进行测序鉴定并分析病毒的基因特征。方法对2021年广州市某农贸市场外环境H3N2禽流感阳性样本进行鸡胚培养,联合病毒全基因组序列靶向扩增和纳米孔测序技术进行病毒高通量测序。通过生... 详细信息

目的利用纳米孔测序技术对新型重组H3N2禽流感病毒进行测序鉴定并分析病毒的基因特征。方法对2021年广州市某农贸市场外环境H3N2禽流感阳性样本进行鸡胚培养,联合病毒全基因组序列靶向扩增和纳米孔测序技术进行病毒高通量测序。通过生物信息学软件,分析病毒基因特点。结果系统发育进化树显示,该毒株各基因片段均属于欧亚进化分支,宿主来源均为禽源。其HA基因与我国H3N6禽流感病毒亲缘关系较近。NA基因与2017-2020年我国H3N2禽流感病毒亲缘关系较近。PB1基因与2016-2022年我国广西壮族自治区、福建省H5N6禽流感病毒亲缘关系较近,与广州市H5N6禽流感流行株PB1基因亲缘关系较远。其余内部基因片段来源复杂,具有明显的遗传多样性。分子特征显示,该毒株具有典型的低致病性禽流感病毒分子特征,倾向结合禽源受体。生物特性相关重要蛋白位点上,该毒株发生PB2-L89V、PB1-L473V、NP-A184K、M1-N30D/T215A、NS1-P42S/N205S等致病性增强突变。结论本研究通过纳米孔测序鉴定一株新型重组H3N2禽流感病毒,分析发现该病毒与H5N6禽流感病毒发生了基因重组。目前该病毒跨种传播能力较低,但有必要密切关注H3亚型禽流感病毒的流行和变异。

关键词：禽流感病毒基因重组纳米孔测序

Scientific data and their release of Chang'E-1 and Chang'E-2

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Chinese Journal Of Geochemistry 2014年第1期33卷 24-44页

作者： ZUO Wei LI Chunlai zhang zhoubin The Science and Application Center for Moon and Deepspace Exploration National Astronomical ObservatoriesChinese Academy of Sciences

The Chang'E-1 and Chang'E-2 missions have successfully obtained a huge amount of lunar scientific data, through the seven onboard instruments including a CCD stereo camera, a laser altimeter, an interference imaging spectrometer, an X-ray spectrometer, a microwave radiometer, a high-energy particle detector and a solar-wind ion detector. Most of the Chang'E data are now publicly available to the science community, and this article serves as an official guide on how these data are classified and organized, and how they can be retrieved from http://159.***.88.59:7779/CE1OutENGWeb/. This article also presents the detailed specifications of various instruments and gives examples of research progress made based on these instruments.

关键词：科学数据嫦娥一号 X射线光谱仪激光高度计离子探测器立体相机成像技术微波辐射

Nomenclature for lunar features at the Chang＇e-3 landing site

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Acta Geochimica 2017年第2期36卷 213-223页

作者： zhoubin zhang Chunlai Li Wei Zuo Xingguo Zeng Key Laboratory of Lunar and Deep Space Exploration Chinese Academy of Sciences Beijing 100012 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China College of Astronomy and Space Sciences University of Chinese Academy of Sciences Beijing 100049 China

Nomenclatures for lunar features always accompany the progresses of human lunar exploration,which has an important dual meaning in culture and science. The naming of lunar features not only can commemorate the outstanding contributions of academics,masters in various fields, and popularize the traditional cultures of ethnic groups all over the world, but also have a critical function of providing accurate indicative information on features with special morphology, origin, nature and scientific value. However, nomenclature for features at the Chang'e-3 landing site, which has a more arbitrary form without many constrains posed by a uniformed system, is unlike the features for other morphological *** paper originated from the actual needs for the description of scientific exploration activities, interpretation of scientific research and dissemination of scientific results. Some prominent morphological units with great scientific importance and identification purpose were chosen from the images taken by the terrain camera, panorama cameras and landing camera onboard the Chang'e lander and Yutu rover. A nomenclature system was established under the three enclosures, four quadrants and twenty-eight lunar lodges' system of the Chinese ancient sky division method. Finally, a standard feature names set waspublished after some necessary approval procedures by the International Astronomical Union.

关键词： Moon Chang'e-3 Landing site Lunarfeature nomenclature

An Imported Case and an Infected Close Contact of the Omicron Variant of SARS-CoV-2—Guangdong Province,China,December 13,2021

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China CDC weekly 2022年第5期4卷 96-97页

作者： Kuibiao Li Zhonghua Zheng Xiang Zhao Qing Zeng Tengfei Zhou Qianfang Guo Yao Hu Wenbo Xu zhoubin zhang Baisheng Li Institute of Public Health Guangzhou Medical University&Guangzhou Center for Disease Control and PreventionGuangzhouGuangdongChina Guangdong Provincial Center for Disease Control and Prevention GuangzhouGuangdongChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

On November 27,2021,a 67-year-old male returning from Canada via airplane was transferred to the central isolation hotel in *** the quarantine,his 1st,4th,7th,and 14th days of specimens returned negative for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19).On December 11,he completed 14 days of centralized isolation and returned to Guangzhou from Shanghai via airplane,then he was closed-loop transferred to Yuexiu District for a 7-day home *** December 12,the local Community Health Service Center routinely collected his throat swab and the result returned to COVID-19 positive on December 13,*** was transported to the Guangzhou Eighth People’s Hospital for isolated treatment by negative pressure ambulance on the same *** patient had two inflamed lungs according to the chest computed tomography(CT)examination,but his most recently updated condition was *** estimated 600 close contacts were identified and were placed in centralized *** December 16,one of the close contacts,a 70-year-old female also tested positive for *** lived on the lower floor of the same type of apartment as the imported case and spent 19 hours in the same building.

关键词： transferred Canada Guangzhou

In-flight calibration of the magnetometer on the Mars orbiter of Tianwen-1

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Science China(Technological Sciences) 2023年第8期66卷 2396-2405页

作者： ZOU ZhuXuan WANG YuMing zhang TieLong WANG GuoQiang XIAO SuDong PAN ZongHao zhang zhoubin YAN Wei DU Yang CHI YuTian CHENG Long WU ZhiYong HAO XinJun LI YiRen LIU Kai CHEN ManMing SU ZhenPeng SHEN ChengLong XU MengJiao GUO JingNan School of Earth and Space Sciences/Deep Space Exploration Laboratory University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China Space Research Institute Austrian Academy of SciencesGraz 8010Austria Institute of Space Science and Applied Technology Harbin Institute of TechnologyShenzhen 518055China National Astronomical Observatories Chinese Academy of SciencesBeijing 100080China Shanghai Institute of Satellite Engineering Shanghai 200240China Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230026China

Mars orbiter magnetometer(MOMAG)is one of seven science payloads onboard Tianwen-1’s *** most of the satellites,Tianwen-1’s orbiter is not magnetically cleaned,and the boom where placed the magnetometer’s sensors is not long *** pose many challenges to the magnetic field data *** this study,we introduce the in-flight calibration process of the Tianwen-1/*** magnetic interference including spacecraft generated dynamic field and the slowlychanging zero offsets are cleaned in *** the calibrated magnetic field data are compared with the data from the Mars atmosphere and volatile Evolutio N(MAVEN).We find that some physical structures in the solar wind are consistent between the two data sets,and the distributions of the magnetic field strength in the solar wind are very *** results suggest that the in-flight calibration of the MOMAG is successful and the MOMAG provides reliable data for scientific research.

关键词： magnetometer in-flight calibration Martian magnetic field Tianwen-1