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Polylactic-co-glycolic acid microspheres containing three neurotrophic factors promote sciatic nerve repair after injury

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Neural Regeneration Research 2015年第9期10卷 1491-1497页

作者： Qun Zhao Zhi-yue Li Ze-peng Zhang zhou-yun mo Shi-jie Chen Si-yu Xiang Qing-shan Zhang Min Xue Health Management Center Third Xiangya Hospital of Central South University Department of Orthopedics Third Xiangya Hospital of Central South University Department of Orthopedics Yiyang Municipal Central Hospital Department of Gynecology Third Xiangya Hospital of Central South University

A variety of neurotrophic factors have been shown to repair the damaged peripheral nerve. However, in clinical practice, nerve growth factor, neurotrophin-3 and brain-derived neuro- trophic factor are all peptides or proteins that may be rapidly deactivated at the focal injury site; their local effective concentration time following a single medication cannot meet the required time for spinal axons to regenerate and cross the glial scar. In this study, we produced polymer sustained-release microspheres based on the polylactic-co-glycolic acid copolymer; the micro- spheres at 300-pm diameter contained nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor. Six microspheres were longitudinally implanted into the sciatic nerve at the anastomosis site, serving as the experimental group; while the sciatic nerve in the control group was subjected to the end-to-end anastomosis using 10/0 suture thread. At 6 weeks after implanta- tion, the lower limb activity, weight of triceps surae muscle, sciatic nerve conduction velocity and the maximum amplitude were obviously better in the experimental group than in the control group. Compared with the control group, more regenerating nerve fibers were observed and dis- tributed in a dense and ordered manner with thicker myelin sheaths in the experimental group. more angiogenesis was also visible. Experimental findings indicate that polylactic-co-glycolic acid composite microspheres containing nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor can promote the restoration of sciatic nerve in rats after injury.

关键词： nerve regeneration biological compatibility microspheres nervepolylactic-co-glycolic acid copolymer nerve growth facwr neurotrophin-3 brainfactorinjury nerve repazr .derived neurotrophic

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang zhou Ying mo Biao Zheng Miaomiao Han Qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang Lei Qian Xiaofei Hu Ting Zhang Chaoyu Xiang Yu‑mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line widthmodulation(55.9%),and durability(>3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

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Discovery of a new family member of arsenic–vanadium polyoxometalates with high catalytic performance for one-pot coupling of CO2, epoxides and amines

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Tungsten 2025年第1期7卷 80-87页

作者： Fang-Qian Wang Yin Zhang Wei-Wei Wang Mei-Qian Fu Hong-Bing mo Wei-Dong Yu Chao Liu Jun Yan College of Chemistry and Chemical Engineering Central South University Junior Education Department Changsha Normal University School of Science Hunan University of Technology and Business

Arsenic-vanadium polyoxometalates（POMs） represent a family of tremendous potential catalysts owing to their peculiar physical and chemical *** in CO2conversion,using POMs to catalyze the conversion of CO2and epoxide into chemical intermediates is the research ***,A new family number of arsenic-vanadium POMs,[N（CH3）4]4[As8V12O38（H2O）]·2H2O({As8V12O38}),was reported and characterized by single-crystal X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,*** from other allotropicity,{As8V12O38}shows a different structure pattern with an I-43d *** obtained {As8V12O38} was employed as a catalyst for the *** initial catalytic reaction confirmed that {As8V12O38} can catalyze the formation of epoxy carbonate by using 1.01 kPa CO2and epoxide at 70℃.Furtherly,when added amine in the catalytic system,oxazolidinone could be obtained by high yields,which provides an efficient way to convert CO2into profitable ***,a possible catalytic reaction mechanism was proposed by using different characterization analyses.{As8V12O38} first catalyzes the epoxide and CO2to form an epoxy carbonate and then catalyzes epoxy carbonate and benzylamine into oxazolidinone.

关键词： Arsenic CO2 conversion Oxazolidinone Polyoxometalates Vanadium

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circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen mo Chunmei Fan Yi He Pan Chen Ming zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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社会资本在农村劳动力流动中的负面效应分析

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江汉大学学报（人文科学版） 2004年第3期23卷 5-8页

作者：周运清刘莫鲜武汉大学社会学系湖北武汉430072 成都理工大学社会学系四川成都610059

社会资本在农村劳动力流动中有其负面效应,具体表现为:1.从总体上看,社会网络的高度同质性导致该群体垂直流动受阻;2.网络成员的内讧导致部分个体正常利益受损;3.最为典型的是,相当一部分外出农村女性受亲友、同乡之骗被拐卖或被迫从事... 详细信息

社会资本在农村劳动力流动中有其负面效应,具体表现为:1.从总体上看,社会网络的高度同质性导致该群体垂直流动受阻;2.网络成员的内讧导致部分个体正常利益受损;3.最为典型的是,相当一部分外出农村女性受亲友、同乡之骗被拐卖或被迫从事卖淫活动等。

关键词：农村劳动力非农职业流动社会资本

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Dynamics of soil inorganic nitrogen and their responses to nitrogen additions in three subtropical forests, south China

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Journal of Environmental Sciences 2006年第4期18卷 752-759页

作者： FANG yun-ting ZHU Wei-xing mo Jiang-ming zhou Guo-yi GUNDERSEN Per Dinghushan Forest Ecosystem Research Station South China Botanical Garden Chinese Academy of Sciences Zhaoqing 526070 China Biological Sciences Binghamton University-SUNY Binghamton NY 13902-6000 USA Forest and Landscape Denmark Hoersholm Kongevej 11 2970 Denmark The Graduate School of the Chinese Academy of Sciences Beijing 100039 China

Three forests with different historical land-use, forest age, and species assemblages in subtropical China were selected to evaluate current soil N status and investigate the responses of soil inorganic N dynamics to monthly ammonium nitrate additions. Results showed that the mature monsoon evergreen broadleaved forest that has been protected for more than 400 years exhibited an advanced soil N status than the pine （Pinus massoniana） and pine-broadleaf mixed forests, both originated from the 1930＇s clear-cut and pine plantation. Mature forests had greater extractable inorganic N pool, lower N retention capacity, higher inorganic N leaching, and higher soil C/N ratios. Mineral soil extractable NH4^＋-N and NO3-N concentrations were significantly increased by experimental N additions on several sampling dates, but repeated ANOVA showed that the effect was not significant over the whole year except NH4^＋-N in the mature forest. In contrast, inorganic N （both NH4^＋-N and NO3^--N） in soil 20-cm below the surface was significantly elevated by the N additions. From 42% to 74% of N added was retained by the upper 20 cm soils in the pine and mixed forests, while 0%-70% was retained in the mature forest. Our results suggest that land-use history, forest age and species composition were likely to be some of the important factors that determine differing forest N retention responses to elevated N deposition in the study region.

关键词： N deposition N saturation extractable inorganic N soil solution inorganic N subtropical China

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法治是中国式现代化的重要保障

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 7-16,F0002页

作者：莫纪宏中国社会科学院法学研究所北京100720

党的二十届三中全会审议通过的《中共中央关于进一步全面深化改革、推进中国式现代化的决定》明确提出“法治是中国式现代化的重要保障”,对法治与现代化之间的辩证关系从理论与实践相结合的角度作出系统阐述,对不断完善和健全法治在保... 详细信息

党的二十届三中全会审议通过的《中共中央关于进一步全面深化改革、推进中国式现代化的决定》明确提出“法治是中国式现代化的重要保障”,对法治与现代化之间的辩证关系从理论与实践相结合的角度作出系统阐述,对不断完善和健全法治在保障中国式现代化中的能力,推动法治与现代化同频共振、并肩前行发挥了政策引领作用。从法理层面准确认识法治对中国式现代化的保障机制和制度功能,要从历史维度、政治维度、理论维度、比较维度和实践维度“五个维度”有机统一的角度认识中国式现代化的具体特征和制度形态,针对不同层面的中国式现代化目标采取不同性质的法治应对和保障措施。法治在中国式现代化进程中,通过保障制度现代化推进中国式现代化。其中,法治自身也需要现代化。没有法治现代化就没有社会主义现代化。法治在推进中国式现代化过程中,通过不断提升自身效能和保障能力,逐步实现自身的现代化,成为中国式现代化事业的重要组成部分。

关键词：法治中国式现代化历史维度政治维度理论维度比较维度实践维度

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Quality and Internal Characteristics of Huanghua Pears (Pyrus Pyrifolia Nakai,***) Treated with Different Kinds of Coatings during Long-Term Storage

Quality and Internal Characteristics of Huanghua Pears (Pyru...

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中国园艺学会第八届青年学术讨论会暨现代园艺论坛

作者： Ran zhou~1 yun mo~2 yunfei Li~(2*) Yanyun Zhao~3 Guixiang Zhang~4 yunsheng Hu~4 (1 Institute of Refrigeration & Cryogenic Engineering,Shanghai Jiao Tong University,Shanghai,China 2 Department of Food Science & Technology,School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,China 3 Department of Food Science & Technology,Oregon State University,Corvallis,USA 4 Department of Radiology,Shanghai Jiao Tong University Affiliated First People’s Hospital,Shanghai,China)

We studied the quality of and internal changes in Huanghua pears (Pyrus pyrifolia Nakai,***) coated with shellac,SemperfreshTM (sucrose polyester base coating),and carboxymethyl chitosan (CMC) during cold storage (4℃). The changes in respiration rate,weight loss,cell membrane permeability and texture profile analysis (TPA) such as hardness, brittleness and chewiness were recorded periodically for up to 60 days after harvest to compare the effects of the applied coatings. Magnetic resonance imaging was used to inspect the internal characteristics of pears after *** soluble solid contents (SSCs),titratahle acidity,ascorbic acid concentration,and taste scores were also *** data suggested that shellac coating was more effective in reducing the respiration rate and weight loss and in maintaining the quality of pears than Semperfresh and CMC coatings.

关键词： Huanghua pears Coatings Cold storage Quality TPA Magnetic resonance imaging

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