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Unique Properties of Heat Generation in Nanoscale Systems

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Chinese Physics Letters 2011年第12期28卷 303-305页

作者： zhou li-ling Department of Physics Jiujiang UniversityJiujiang 332005

We study the unique properties of current-induced heat generation Q in nanostructures and its absence in macroscopic bulks.A lead−quantum dot-lead system is taken into consideration and it is found that its unique properties stem from energy quantization of the system and arise only under conditions of low temperature and weak dot-lead *** relation of Q∝I(I is the system current)fails in nanosystems,while the Q peaks align with peaks of phonon−assisted current under small *** a result,one can expect a large current accompanied by relatively small Q when the elastic current peak does not coincide with the phonon-assisted one,the ideal working condition for a nanostructure.

关键词： system macroscopic relation

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光散射法测定兰索拉唑原料药粒度及粒度分布

中国处方药 2024年第6期22卷 16-20页

作者：张新芹周礼玲六安市市场监管综合行政执法支队安徽六安237000 六安市食品药品检验中心安徽六安237000

目的建立兰索拉唑原料药粒度及粒度分布测定方法。方法采用光散射法,颗粒折射率为1.57,颗粒吸收率为0.1,振动进样速度为60%,分散气压为3.0 Bar,遮光度为0.5%~6%。结果该方法重复性好,6次结果的RSD分别是:d(0.1)为2.0%,d(0.5)为2.1%,d(0... 详细信息

目的建立兰索拉唑原料药粒度及粒度分布测定方法。方法采用光散射法,颗粒折射率为1.57,颗粒吸收率为0.1,振动进样速度为60%,分散气压为3.0 Bar,遮光度为0.5%~6%。结果该方法重复性好,6次结果的RSD分别是:d(0.1)为2.0%,d(0.5)为2.1%,d(0.9)为0.7%,D(4,3)为0.7%;中间精密度良好,12次结果的RSD分别是:d(0.1)为1.5%,d(0.5)为1.8%,d(0.9)为1.4%,D(4,3)为0.9%。结论该方法可靠、准确,可用于兰索拉唑原料药粒度及粒度分布的测定。

关键词：光散射法兰索拉唑粒度粒度分布

In-depth insights into critical role of aromatic C（sp2）–H on li+ storage

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Rare Metals 2024年第10期43卷 5449-5452页

作者： ling Qin Ye zhou China-UK Low Carbon College Shanghai Jiao Tong University

The development of high-sloping-capacity carbons enables the creation of high-power lithium-ion batteries and capacitors （liBs/liCs）.Among the various heteroatomdoped carbon materials,hydrogen-rich carbon appears to be a promising candidate due to its facile synthesis and high capacity for li+***,conclusive data are still lacking to elucidate the fundamental function of the hydrogen-terminated groups （C-H configuration） in li+*** and his co-workers have utilized an ion-catalyzed self-template method to synthesize the hydrogen-rich carbon nanoribbon （HCNR） with high specific and rate *** HCNR?s li+storage mechanism is clarified by the use of in situ spectroscopy methods,which reveals that the sp2-hybridization of the

关键词： Aromatization

髓样分化蛋白-2调控AMPK介导肥胖所致心肌损伤的研究

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中国临床药理学杂志 2024年第10期40卷 1458-1462页

作者：黄成坷周伶俐孙未林晓东陈瑞杰温州医科大学附属第二医院药学部浙江温州325027 温州医科大学附属第二医院病理科浙江温州325027

目的探讨髓样分化蛋白-2(MD-2)通过调控AMP依赖的蛋白激酶(AMPK)介导肥胖引起的心肌损伤中的作用。方法用高脂饲料喂养制备肥胖小鼠模型。将野生型和MD-2基因敲除小鼠随机分为野生型对照组(正常饲养)、野生型模型组(高脂饲料)、敲除对照... 详细信息

目的探讨髓样分化蛋白-2(MD-2)通过调控AMP依赖的蛋白激酶(AMPK)介导肥胖引起的心肌损伤中的作用。方法用高脂饲料喂养制备肥胖小鼠模型。将野生型和MD-2基因敲除小鼠随机分为野生型对照组(正常饲养)、野生型模型组(高脂饲料)、敲除对照组(正常饲养)和敲除模型组(高脂饲料),每组8只。用试剂盒测定血清肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)水平,用小动物超声检测左心室射血分数(LVEF)和左短轴缩短率(LVFS),用苏木精-伊红(HE)染色法和Masson染色法观察心肌组织病理变化,用蛋白质印迹法检测心肌组织中磷酸化AMPK(p-AMPK)蛋白的表达情况。结果HE染色和Masson染色结果发现野生型模型组小鼠心肌组织出现明显变性坏死和纤维化,而敲除模型组心肌细胞变性坏死与心肌组织纤维化明显减轻。野生型对照组、野生型模型组、敲除对照组和敲除模型组的LVEF值分别为(83.98±7.58)%、(52.03±4.91)%、(76.42±3.89)%和(73.71±4.22)%,LVFS值分别为(53.61±8.51)%、(24.56±3.76)%、(48.14±5.00)%和(44.07±3.74)%,CK-MB值分别为(49.83±15.49)、(83.75±11.90)、(54.03±18.66)和(66.85±12.98)U·L^(-1),LDH值分别为(12.24±3.20)、(27.90±6.10)、(13.55±3.55)和(15.53±2.58)U·L^(-1),p-AMPK蛋白相对表达水平分别为221.31±88.76、46.29±10.07、148.66±32.02和161.49±78.11。野生型模型组的上述指标与野生型对照组比较,敲除模型组的上述指标与野生型模型组比较,在统计学上差异均有统计学意义(均P<0.05)。结论高脂饲料通过MD-2抑制AMPK活性介导了肥胖小鼠的心肌损伤。

关键词：髓样分化蛋白-2 AMP依赖的蛋白激酶肥胖心肌损伤

气相色谱内标法测定甲氧基、乙氧基、羟丙氧基实验室方法验证结果分析

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广州化工 2024年第10期52卷 75-77,90页

作者：李秀春周礼玲赵成张祖亮六安市食品药品检验中心安徽六安237001

参照《中国药典》2020年版四部通则0712《甲氧基、乙氧基与羟丙氧基测定法》中气相色谱法分别测定三种成分含量,并依据四部通则9101《分析方法验证指导原则》中有关方法验证相关的规定对测定方法进行验证,验证过程涉及方法重复性、线性... 详细信息

参照《中国药典》2020年版四部通则0712《甲氧基、乙氧基与羟丙氧基测定法》中气相色谱法分别测定三种成分含量,并依据四部通则9101《分析方法验证指导原则》中有关方法验证相关的规定对测定方法进行验证,验证过程涉及方法重复性、线性范围及定量限、专属性、准确度、耐用性及中间精密度六个项目,并对验证结果进行分析。

关键词：甲氧基乙氧基羟丙氧基方法验证结果分析

Target inhibition of caspase-8 alleviates brain damage after subarachnoid hemorrhage

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Neural Regeneration Research 2020年第7期15卷 1283-1289页

作者： Da-Qiang Ke Zhi-Yang Chen zhou-ling li Xia Huang Hui liang Department of Neurology First Affiliated Hospital School of Medicine Zhejiang University

Caspase-8 plays an important role in the mediation of inflammation and the effect of its role in subarachnoid hemorrhage remains *** nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome has been postulated to mediate inflammation during *** aim of the present study was to investigate the effects of caspase-8 inhibition on SAH injury and further elucidate the molecular *** this study,a subarachnoid hemorrhage model was established by endovascular perforation process in adult male Sprague-Dawley rats.Z-IETD-FMK(0.5,1,2 mg/kg;an inhibitor of caspase-8)was delivered via intravenous(tail vein)injection immediately after subarachnoid *** 12 hours of subarachnoid hemorrhage,western blot assay showed that the expression of cleaved caspase-8 was significantly increased at 12 hours,peaked at 24 hours,and then decreased at 72 hours after subarachnoid *** staining demonstrated that caspase-8 was expressed in microglia after subarachnoid hemorrhage.Z-IETDFMK significantly improved neurological deficits and reduced brain water content 24 hours after subarachnoid *** Morris water maze and rotarod test confirmed that Z-IETD-FMK significantly improved spatial learning and memory abilities and motor coordination at 21–27 days after subarachnoid ***,inhibition of caspase-8 activation reduced the expression of pyrin domain-containing 3,caspase-1,and interleukin-1βafter subarachnoid *** conclusion,our findings suggest that caspase-8 inhibition alleviates subarachnoid hemorrhage-induced brain injuries by suppressing *** study was approved by the Institutional Animal Ethics Committee of the First Affiliated Hospital,School of Medicine,Zhejiang University,China(approval No.2016-193)on February 25,2016.

关键词： brain water content caspase-8 inflammation Morris water maze neurological function neuroprotection pyrin domain-containing 3 rotarod test subarachnoid hemorrhage Z-IETD-FMK

AN INVESTIGATION OF RETINEX ALGORITHMS FOR IMAGE ENHANCEMENT

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Journal of Electronics(China) 2007年第5期24卷 696-700页

作者： Lei ling zhou Yinqing li Jingwen 201 Lab Beijing University of Aeronautics and Astronautics Beijing 100083 China

This letter introduces color constancy and Retinex theory for image *** clas- sifies Retinex algorithms into four categories and provides their principles and implementations in *** experimental results of Frankle-McCann,MSR (Multi-Scale Retinex) and PNSD (Pro- jected Normalized Steepest Descent) Retinex algorithms are presented and ***, variance and average gradient are proposed to evaluate the performance of the different algorithms.

关键词： Color constancy Retinex Frankle-McCann MSR (Multi-Scale Retinex) PNSD (Pro-jected Normalized Steepest Descent)

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中药谱效关系在中药中应用进展

中南药学 2024年第9期22卷 2398-2404页

作者：周玲利刘刚刘育辰穆开朗贵州中医药大学贵阳550025

中药谱效关系是利用数据分析技术将有效物质群特征峰与中药药效信息关联,反映中药物质成分与功效强度间复杂关系的一种方法。自中药谱效关系被提出后,由于其在中药活性成分群整体特征精细表达与中药多指标、多靶点作用机制联系上表现出... 详细信息

中药谱效关系是利用数据分析技术将有效物质群特征峰与中药药效信息关联,反映中药物质成分与功效强度间复杂关系的一种方法。自中药谱效关系被提出后,由于其在中药活性成分群整体特征精细表达与中药多指标、多靶点作用机制联系上表现出的显著优势,现已被广泛应用于中药的质量控制、药效物质基础、炮制前后药效研究及有效部位筛选等研究领域。本文通过整理近十年中药谱效关系研究的相关文献资料,在中药谱效关系研究不断拓展、完善的新形势下,对中药谱效关系的研究策略及在中药多领域中的研究现状进行梳理与提炼,同时针对当前中药谱效关系研究存在的核心问题,进行初步分析展望,以期为谱效关系在中药多领域的深入研究提供参考。

关键词：中药谱效关系应用进展指纹图谱药效物质基础质量控制

Experimental and numerical investigation of two blended blade and endwall configurations

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Chinese Journal of Aeronautics 2024年第9期37卷 150-163页

作者： Tongtong MENG Xin li ling zhou Lucheng JI Institute for Aero Engine Tsinghua UniversityBeijing 100084China Schoolof Aerospace Engineering Bejing Institute of TechnologyBeijing 0081China

The Blended Blade and Endwall(BBEW)technique has proven to be effective in control-ling the intersection of boundary layer in corner region of the compressor *** this study,the experiment and analysis of two different BBEW designs are ***,based on a linear cas-cade with 0.7 Mach number inflow,two different configurations,BBEW 1 and BBEW 2,are well ***,according to the experimental result,control effects of these two BBEW configu-rations are validated and compared subsequently under various working *** results demonstrate a reduction in total pressure loss of 12.8%and 29%at the design point for BBEW 1 and BBEW 2,***,the BBEW technique proves effective in suppressing the development of the boundary layer and preventing corner *** by detailed numerical analysis,improvements around the corner region,especially for the boundary layer,are extracted to show the mechanisms and distinctions between the two *** results indicate that BBEW 1 significantly restrains the development of boundary layer before separation occurs,while BBEW 2 directly controls the strength and scale of the corner separation.

关键词： Aerodynamic Computational fluid dynamic Experiment Corner separation Blended Blade and Endwall(BBEW)