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Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai bo Sun Huijun Wang Yi Zheng Siyu zhou Huixin Li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(Dbo)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with Dbo show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original Dbo,the R and RPD of models with the improved Dbo increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

A Novel Self-Supervised Learning Network for Binocular Disparity Estimation

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 209-229页

作者： Jiawei Tian Yu zhou Xiaobing Chen Salman A.AlQahtani Hongrong Chen bo Yang Siyu Lu Wenfeng Zheng Department of Computer Science and Engineering Major in Bio Artificial IntelligenceHanyang UniversityAnsan-si15577Republic of Korea School of Electrical and Computer Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11574Saudi Arabia School of Automation University of Electronic Science and Technology of ChinaChengdu610054China

Two-dimensional endoscopic images are susceptible to interferences such as specular reflections and monotonous texture illumination,hindering accurate three-dimensional lesion reconstruction by surgical *** study proposes a novel end-to-end disparity estimation model to address these *** approach combines a Pseudo-Siamese neural network architecture with pyramid dilated convolutions,integrating multi-scale image information to enhance robustness against lighting *** study introduces a Pseudo-Siamese structure-based disparity regression model that simplifies left-right image comparison,improving accuracy and *** model was evaluated using a dataset of stereo endoscopic videos captured by the Da Vinci surgical robot,comprising simulated silicone heart sequences and real heart video *** results demonstrate significant improvement in the network’s resistance to lighting interference without substantially increasing ***,the model exhibited faster convergence during training,contributing to overall performance *** study advances endoscopic image processing accuracy and has potential implications for surgical robot applications in complex environments.

关键词： Parallax estimation parallax regression model self-supervised learning Pseudo-Siamese neural network pyramid dilated convolution binocular disparity estimation

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia zhou bo Ma Yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang zhou-bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan zhou Gaoxiong duan Ying Liu Bei Peng Xiaoyan zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

PEI介导的凋亡DNA胞内递送及其对原代巨噬细胞活化的作用

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现代免疫学 2009年第2期29卷 95-99页

作者：周倩高波段志坚陈敏徐薇熊思东复旦大学免疫生物学研究所、复旦大学上海医学院免疫学系上海200032

观察以多聚乙烯亚胺(polyethylenimine,PEI)为载体,介导活化并发生凋亡的淋巴细胞来源的DNA(凋亡DNA)的胞内递送,探讨凋亡DNA对原代巨噬细胞活化的影响。采用PEI为载体,介导凋亡DNA和正常淋巴细胞来源的DNA(正常DNA)进入胞内,以ELISA方... 详细信息

观察以多聚乙烯亚胺(polyethylenimine,PEI)为载体,介导活化并发生凋亡的淋巴细胞来源的DNA(凋亡DNA)的胞内递送,探讨凋亡DNA对原代巨噬细胞活化的影响。采用PEI为载体,介导凋亡DNA和正常淋巴细胞来源的DNA(正常DNA)进入胞内,以ELISA方法检测巨噬细胞IL-6、TNF-α的分泌;分析各种因素对PEI胞内递送效率的影响,并评价其对原代巨噬细胞的安全使用剂量。结果显示:PEI可介导DNA对原代巨噬细胞的胞内递送;凋亡DNA进入胞内后,可以刺激巨噬细胞活化,诱导炎症因子IL-6和TNF-α的分泌;相同的条件下,正常DNA却不能引起这些变化。进一步观察发现PEI与DNA的质量比为2或3时胞内递送效率最佳;小于10μg/ml的PEI用量并于转染6 h后换液对原代巨噬细胞毒性较小。上述结果表明,PEI作为载体,可以有效介导对原代巨噬细胞的基因(哺乳动物DNA或质粒)递送;进入胞内的凋亡DNA可促进巨噬细胞活化并分泌大量炎性细胞因子,这对于研究系统性红斑狼疮(SLE)的发病机制具有意义。

关键词：多聚乙烯亚胺(PEI) 凋亡DNA 巨噬细胞 SLE

Experience report:investigating bug fixes in machine learning frameworks/libraries

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Frontiers of Computer Science 2021年第6期15卷 43-58页

作者： Xiaobing SUN Tianchi zhou Rongcun WANG Yucong duan Lili bo Jianming CHANG School of Information Engineering Yangzhou UniversityYangzhou 225100China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China Jiangsu Engineering Research Center of Knowledge Management and Intelligent Service Yangzhou University Yangzhou 225127China School of Computer Science and Technology China University of Mining and TechnologyXuzhou 221116China School of Computer Science and Cyberspace Security Hainan UniversityHaikou 570228China

Machine learning(ML)techniques and algorithms have been successfully and widely used in various areas including software engineering *** other software projects,bugs are also common in ML projects and *** order to more deeply understand the features related to bug fixing in ML projects,we conduct an empirical study with 939 bugs from five ML projects by manually examining the bug categories,fixing patterns,fixing scale,fixing duration,and types of *** results show that(1)there are commonly seven types of bugs in ML programs;(2)twelve fixing patterns are typically used to fix the bugs in ML programs;(3)68.80%of the patches belong to micro-scale-fix and small-scale-fix;(4)66.77%of the bugs in ML programs can be fixed within one month;(5)45.90%of the bug fixes belong to corrective activity from the perspective of software ***,we perform a questionnaire survey and send them to developers or users of ML projects to validate the results in our empirical *** results of our empirical study are basically consistent with the feedback from *** findings from the empirical study provide useful guidance and insights for developers and users to effectively detect and fix bugs in MLprojects.

关键词： bug fixing machine learning project empirical study questionnaire survey

Finite-time composite guidance law with input constraint and dynamics compensation

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Chinese Journal of Aeronautics 2020年第2期33卷 664-671页

作者： Meijun duan Di zhou School of Astronautics Harbin Institute of TechnologyHarbin 150001China

Guidance laws are proposed for a near space interceptor with on-off type thrust as *** target-interceptor engagement kinematics is integrated with the first-order dynamics of thruster to design guidance *** bang-bang type guidance law with linear sliding mode is proposed to deal with thruster dynamics,and the sufficient condition for finite time convergence is rigorously proved based on the finite-time convergence *** to the sufficient condition,a sliding mode guidance law with hysteresis-band switching is introduced to reduce the switching frequency of *** two guidance laws are combined into a composite guidance law to improve the guidance *** results show that the line-of-sight angular rate can converge to a neighborhood of the equilibrium point before the final time of the guidance process,and the composite guidance law has better performance than typical guidance laws.

关键词： Dynamics Finite-time convergence Guidance Hysteresis-band switching Near space interceptor Output constraint

Fully Actuated System Approach for Linear Systems Control:A Frequency-Domain Solution

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Journal of Systems Science & Complexity 2022年第6期35卷 2046-2061页

作者： duan Guang-Ren zhou Bin The Center for Control Science and Technology Southern University of Science and TechnologyShenzhen 518055China The Center for Control Theory and Guidance Technology Harbin Institute of TechnologyHarbin 150001China

This note studies fully actuated linear systems in the frequency domain in terms of polynomial matrix description(PMD).For a controllable first-order linear state-space system model,by using the right coprime factorization of its transfer function matrix,under the condition that the denominator matrix in the right coprime factorization is column reduced,it is equivalently transformed into a fully actuated PMD model,whose time-domain expression is just a high-order fully actuated(HOFA)system *** method is a supplement to the previous one in the time-domain,and reveals a connection between the controllability of the first-order linear state-space system model and the fullactuation of its PMD *** continuous-time and discrete-time linear systems are *** numerical examples are worked out to illustrate the effectiveness of the proposed approaches.

关键词： Column reduced factorization first-order linear state-space systems high-order fully actuated systems polynomial matrix description right coprime